Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Molecular and Cellular Cardiology

• Publication date

  2015-02-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.yjmcc.2014.12.001PMID 25497302PMCID PMC4301992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.

  2015cited by this paper
• Emerging role of protein kinase C in energy homeostasis: A brief overview.

  2014influential reference
• The many roles of PGC-1α in muscle--recent developments.

  2014cited by this paper
• A Role for Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

  2014cited by this paper
• Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling

  2013cited by this paper
• Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Signaling Regulates Mitochondrial Biogenesis and Respiration via Estrogen-related Receptor α (ERRα)*

  2013cited by this paper
• Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart.

  2013cited by this paper
• PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy

  2013cited by this paper
• Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway

  2013influential reference
• Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation

  2013influential reference
• Bioenergetics Failure and Oxidative Stress in Brain Stem Mediates Cardiovascular Collapse Associated with Fatal Methamphetamine Intoxication

  2012cited by this paper
• Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes*

  2012cited by this paper
• The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice

  2012cited by this paper
• Increased Expression of Fatty-Acid and Calcium Metabolism Genes in Failing Human Heart

  2012cited by this paper
• Lipid metabolism and toxicity in the heart.

  2012cited by this paper
• Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress.

  2012cited by this paper
• Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion

  2011cited by this paper
• Peroxisome Proliferator Activated Receptor-Alpha (PPARα) and PPAR Gamma Coactivator-1alpha (PGC-1α) Regulation of Cardiac Metabolism in Diabetes

  2011cited by this paper
• Telomere dysfunction induces metabolic and mitochondrial compromise

  2011cited by this paper
• Mitochondrial oxidative stress mediates induction of autophagy and hypertrophy in angiotensin-II treated mouse hearts

  2011cited by this paper
• Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis

  2011cited by this paper
• Fatty Acids Suppress Autophagic Turnover in β-Cells*

  2011cited by this paper
• Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation.

  2011influential reference
• Mitochondrial dynamics in heart failure.

  2011cited by this paper
• Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules.

  2011cited by this paper
• Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease

  2010cited by this paper
• Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes.

  2010cited by this paper
• Lipotoxicity in the heart.

  2010cited by this paper
• Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

  2009cited by this paper
• Mitochondrial Networking Protects Beta Cells from Nutrient Induced Apoptosis

  2009cited by this paper
• Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis

  2009cited by this paper
• Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications.

  2009cited by this paper
• High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates.

  2008cited by this paper
• Transcriptional paradigms in mammalian mitochondrial biogenesis and function.

  2008cited by this paper
• Diabetic cardiomyopathy revisited.

  2007cited by this paper
• Peroxisome Proliferator–Activated Receptor γ Coactivator-1 (PGC-1) Regulatory Cascade in Cardiac Physiology and Disease

  2007cited by this paper
• Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease.

  2007cited by this paper
• The failing heart--an engine out of fuel.

  2007cited by this paper
• Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging.

  2006cited by this paper
• Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.

  2006cited by this paper
• Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.

  2006cited by this paper
• Association of plasma free fatty acids and left ventricular diastolic function in patients with clinically severe obesity.

  2006cited by this paper
• Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related Receptor-α, and Mitofusin 2

  2006cited by this paper
• Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2.

  2006cited by this paper
• Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy.

  2006cited by this paper
• Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

  2005cited by this paper
• Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy

  2005cited by this paper
• Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

  2005cited by this paper
• Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes.

  2004cited by this paper
• Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle

  2004cited by this paper
• Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle.

  2004cited by this paper
• Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart

  2004cited by this paper
• A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content

  2003cited by this paper
• Overexpression of metallothionein reduces diabetic cardiomyopathy.

  2002cited by this paper
• Peroxisome Proliferator-activated Receptor Coactivator-1α (PGC-1α) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-α and -γ

  2002cited by this paper
• Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.

  2002cited by this paper
• Protein kinase C inhibits insulin-induced Akt activation in vascular smooth muscle cells.

  2001influential reference
• CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

  2001cited by this paper
• A novel mouse model of lipotoxic cardiomyopathy.

  2001cited by this paper
• The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

  2000cited by this paper
• Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.

  2000cited by this paper

• Cardiac Energy Substrate Utilization in Heart Failure with Preserved Ejection Fraction: Reconciling Conflicting Evidence on Fatty Acid and Glucose Metabolism.

  2025cites this paper
• Targeted Lipidomics and Transcriptomics Unveil Aberrant Lipid Metabolic Remodeling in Visceral and Subcutaneous Adipose Tissue under ER Stress.

  2025cites this paper
• Lipotoxicity as a therapeutic target in the type 2 diabetic heart.

  2025cites this paper
• Metabolic reprogramming in cardiometabolic syndrome: mechanisms, biomarkers, and therapeutic approaches.

  2025cites this paper
• The multifaceted role of mitochondria in cardiac function: insights and approaches

  2024cites this paper
• The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases

  2023cites this paper
• High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs

  2023cites this paper
• Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology

  2023cites this paper
• Evogliptin, a DPP-4 inhibitor, prevents diabetic cardiomyopathy by alleviating cardiac lipotoxicity in db/db mice

  2023cites this paper
• Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity.

  2022cites this paper
• The role of MEOX1 in non-neoplastic and neoplastic diseases.

  2022cites this paper
• Potential role of mitochondria in gastric cancer detection: Fission and glycolysis

  2021cites this paper
• Effects of Lipid Overload on Heart in Metabolic Diseases

  2021cites this paper
• Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes

  2021cites this paper
• Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases

  2021cites this paper
• Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity

  2021cites this paper
• CD36 Signaling in Diabetic Cardiomyopathy

  2021cites this paper
• The common characteristics and mutual effects of heart failure and atrial fibrillation: initiation, progression, and outcome of the two aging-related heart diseases

  2021cites this paper
• The Pathogenic Role of Very Low Density Lipoprotein on Atrial Remodeling in the Metabolic Syndrome

  2020cites this paper
• Mitochondrial shaping proteins as novel treatment targets for cardiomyopathies.

  2020cites this paper
• PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1

  2020cites this paper
• Short high‐fat diet interferes with the physiological maturation of the late adolescent mouse heart

  2020cites this paper
• Myo-inositol and D-chiro-inositol oral supplementation ameliorate cardiac dysfunction and remodeling in a mouse model of diet-induced obesity.

  2020cites this paper
• The role of metabolic diseases in cardiotoxicity associated with cancer therapy: What we know, what we would know.

  2020cites this paper
• Melatonin alleviates progression of uterine endometrial cancer by suppressing estrogen/ubiquitin C/SDHB-mediated succinate accumulation.

  2020cites this paper
• Death by lipids: The role of small nucleolar RNAs in metabolic stress

  2020cites this paper
• Altered mitochondrial metabolism in the insulin‐resistant heart

  2019cites this paper
• Obesity is a common soil for premature cardiac aging and heart diseases - Role of autophagy.

  2019cites this paper
• Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy

  2019cites this paper
• Biochemical Changes in the Malnourished Rats Serum and Liver Exposed to Dietary Monosodium Glutamate

  2019cites this paper
• The effect of venlafaxine on blood pressure and ECG in rats fed with high-fat-fructose diet

  2019cites this paper
• Profile of cardiac lipid metabolism in STZ-induced diabetic mice

  2018cites this paper
• Apolipoprotein E in Cardiovascular Diseases: Novel Aspects of an Old-fashioned Enigma.

  2018cites this paper
• Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity

  2018cites this paper
• Pyridostigmine protects against cardiomyopathy associated with adipose tissue browning and improvement of vagal activity in high-fat diet rats.

  2018cites this paper
• Manifestations and mechanisms of myocardial lipotoxicity in obesity

  2018cites this paper
• Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone deficiency through mitochondria apoptosis pathways

  2018cites this paper
• Ossabaw Pigs With a PCSK9 Gain‐of‐Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies

  2018cites this paper
• Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.

  2017cites this paper
• Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes

  2017cites this paper
• Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease

  2017cites this paper
• Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes: pathophysiological analysis for propofol infusion syndrome

  2017cites this paper
• Pleiotropic Effects of Chronic Phorbol Ester Treatment to Improve Glucose Transport in Insulin‐Resistant Cardiomyocytes

  2017cites this paper
• Mitochondrial dysfunction and its impact on diabetic heart.

  2017cites this paper
• How AMPK and PKA Interplay to Regulate Mitochondrial Function and Survival in Models of Ischemia and Diabetes

  2017cites this paper
• High fructose causes cardiac hypertrophy via mitochondrial signaling pathway.

  2016cites this paper
• Lipid Dynamics in a Mouse Model of Cardiac-Specific Overexpression of the Fatty Acid Transporter

  2016cites this paper
• MTUS1 silencing promotes E-selectin production through p38 MAPK-dependent CREB ubiquitination in endothelial cells.

  2016cites this paper
• Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases.

  2016influential citation
• Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.

  2016cites this paper
• Mitochondrial fission/fusion and cardiomyopathy.

  2016cites this paper
• Lipotoxicity in obesity and diabetes-related cardiac dysfunction.

  2016cites this paper
• Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet‐Induced Metabolic Heart Disease

  2016cites this paper
• Cardiac‐specific down‐regulation of carnitine palmitoyltransferase‐1b (CPT‐1b) prevents cardiac remodeling in obese mice

  2016cites this paper
• Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease

  2015cites this paper
• Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil.

  2015cites this paper
• Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis

  2015cites this paper
• Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge

  2015cites this paper