MICOS and phospholipid transfer by Ups2–Mdm35 organize membrane lipid synthesis in mitochondria

Mitochondria exert critical functions in lipid metabolism and promote the synthesis of major constituents of cellular membranes, such as phosphatidylethanolamine (PE). Here, Aaltonen et al. demonstrate that two pathways mediate PE synthesis: Ups2–Mdm35–dependent lipid transfer and MICOS-dependent membrane apposition.

• Publication year

  2016

• Venue

  Journal of Cell Biology

• Publication date

  2016-06-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201602007PMID 27241913PMCID 4896057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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