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MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma.

Ru-ting Xie,Xianling Cong,Xiaoming Zhong,P. Luo,Huiqiong Yang,Gaixia Lu,P. Luo,Zhengyan Chang,R. Sun,Tingmiao Wu,Zhongwei Lv,D. Fu,Yushui Ma

Published 2018 in Oncology Letters

ABSTRACT

In order to examine the prognostic significance of miR-33a in patients with hepatocellular carcinoma (HCC), total RNA was extracted from 149 HCC biopsies, 36 of which were paired with para-carcinoma tissues, and miR-33a expression was measured by reverse transcription-quantitative polymerase chain reaction. The results demonstrated that miR-33a expression was decreased in HCC biopsies compared with normal liver tissue samples. It was also demonstrated that miR-33a expression was significantly associated with tumor foci number. Furthermore, overall and progression-free survival time was decreased in patients expressing low miR-33a with multiple tumor foci. Taken together, the low expression of miR-33a may be a potential risk factor for HCC.

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