Identification of two strains of cultured canine renal epithelial cells (MDCK cells) which display entirely different physiological properties.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Quarterly Journal of Experimental Physiology

• Publication date

  1981-01-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/EXPPHYSIOL.1981.SP002529PMID 6911762
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural and functional membrane polarity in cultured monolayers of MDCK cells

  2005cited by this paper
• Occluding junctions in a cultured transporting epithelium: Structural and functional heterogeneity

  1980cited by this paper
• Distribution of Na+-pump sites in transporting epithelia.

  1979cited by this paper
• The effects of theophylline and choleragen on sodium and chloride ion movements within isolated rabbit ileum.

  1979cited by this paper
• The Feldberg Lecture 1976. Solute transport across epithelia: what can we learn from micropuncture studies in kidney tubules?

  1979cited by this paper
• Demonstration of protein asymmetries in the plasma membrane of cultured renal (MDCK) epithelial cells by lactoperoxidase‐mediated iodination

  1979cited by this paper
• Distribution of Na+-pump sites in transporting epithelia.

  1979cited by this paper
• Dog kidney cell monolayers can display properties similar to high-resistance epithelia [proceedings].

  1979cited by this paper
• Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK)

  1979cited by this paper
• Hormone-specific responses and biosynthesis of sulfolipids in cell lines derived from mammalian kidney.

  1978cited by this paper
• Specific binding of deoxycorticosterone by canine kidney cells in culture.

  1978cited by this paper
• The cellular distribution of oubain-binding sites in monolayer cultures of dog kidney cells [proceedings].

  1978cited by this paper
• A cell strain cultured from porcine kidney increases cyclic AMP content upon exposure to calcitonin or vasopressin.

  1978cited by this paper
• Polarized monolayers formed by epithelial cells on a permeable and translucent support

  1978cited by this paper
• Renal enzymes in kidney cells selected by D‐valine medium

  1977cited by this paper
• Anion selectivity in biological systems.

  1977cited by this paper
• Bidirectional sodium ion movements via the paracellular and transcellular routes across short-circuited rabbit ileum.

  1976cited by this paper
• Transepithelial transport in cell culture.

  1976cited by this paper
• Lanthanum permeability of tight junctions along the collecting duct of the rat.

  1975cited by this paper
• Evidence for the genetic control of the sodium pump density in HeLa cells

  1974cited by this paper
• Blockage of cation permeability across the tight junctions of gallbladder and other leaky epithelia

  1974cited by this paper
• Edge damage effect on electrical measurements of frog skin.

  1973cited by this paper
• Ionic Conductances of Extracellular Shunt Pathway in Rabbit Ileum

  1972cited by this paper
• Electrophysiology of proximal and distal tubules in the autoperfused dog kidney.

  1971cited by this paper
• Edge damage effect in in vitro frog skin preparations.

  1968cited by this paper
• Intracellular Electrical Potentials in Frog Skin

  1965cited by this paper

• Bufalin‐Induced Epithelial‐to‐Mesenchymal Transition in Kidney Epithelial Cells

  2025cites this paper
• Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome

  2023cites this paper
• Cranberry, but not D-mannose and ibuprofen, prevents against uropathogenic Escherichia coli-induced cell damage and cell death in MDCK cells

  2023cites this paper
• Recent advances in the in vitro and in vivo methods to assess impact of P‐glycoprotein and breast cancer resistance protein transporters in central nervous system drug disposition

  2023cites this paper
• Antimicrobial, Insecticidal and Cytotoxic Activity of Linear Venom Peptides from the Pseudoscorpion Chelifer cancroides

  2022cites this paper
• Transepithelial potential difference governs epithelial homeostasis by electromechanics

  2022cites this paper
• Transepithelial potential difference governs epithelial homeostasis by electromechanics

  2021cites this paper
• Depth correction of 3D NanoSIMS images using secondary electron pixel intensities.

  2021cites this paper
• Sequence dynamics of three influenza A virus strains grown in different MDCK cell lines, including those expressing different sialic acid receptors

  2021cites this paper
• A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2−/− phenotype

  2020cites this paper
• Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability

  2020cites this paper
• Influenza A viruses serially passaged in different MDCK cell lines exhibit limited sequence variation across their genomes, with the exception of the hemagglutinin gene

  2020cites this paper
• A Polarizing Issue: Diversity in the Mechanisms Underlying Apico-Basolateral Polarization In Vivo.

  2019cites this paper
• Expression of 9-O- and 7,9-O-Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses

  2019cites this paper
• Increased osmolality enhances the tight junction‐mediated barrier function in a cultured renal epithelial cell line

  2019cites this paper
• Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication

  2018cites this paper
• Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

  2018cites this paper
• Acute and chronic exposure to high levels of glucose modulates tight junction-associated epithelial barrier function in a renal tubular cell line.

  2017cites this paper
• Role of autophagy in the regulation of epithelial cell junctions

  2016cites this paper
• Functional linkage between the transport characteristics of the MDCK1 cell monolayer and their actin cytoskeleton organization

  2016cites this paper
• Synthetically derived bat influenza A-like viruses reveal a cell type- but not species-specific tropism

  2016cites this paper
• AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

  2016cites this paper
• Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia

  2015cites this paper
• Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation*

  2015cites this paper
• Autophagy and Tight Junction 1 Autophagy Enhancement of Intestinal Epithelial Tight Junction Barrier Function by targeting Claudin-2 degradation

  2015cites this paper
• Renal Cell Culture

  2014cites this paper
• Differential Sensitivity of Epithelial Cells to Extracellular Matrix in Polarity Establishment

  2014influential citation
• Heterogeneity of the MDCK Cell Line and Its Applicability for Influenza Virus Research

  2013cites this paper
• junctions.modification of intercellular by Salmonella typhimurium is associated with Rapid disruption of epithelial barrier function

  2013cites this paper
• BCRP (ABCG2) expression, function and regulation in model and intestinal epithelial cells

  2011cites this paper
• The MDCK variety pack: choosing the right strain

  2011cites this paper
• STAMP2 : subcellular localization and effect on synthesis and sulfation of glycans

  2010cites this paper
• The Investigation of cis- and trans-Interactions Between Claudins

  2010cites this paper
• Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity

  2010cites this paper
• Cloning and assessment of tumorigenicity and oncogenicity of a Madin-Darby canine kidney (MDCK) cell line for influenza vaccine production.

  2010cites this paper
• Arginine-vasopressin-induced structural alterations in MDCK cells

  2009cites this paper
• Virus Infection of Polarized Epithelial Cells

  2008cites this paper
• Tight junctions as a target for permeation enhancement

  2007cites this paper
• Modulation of the epithelial barrier by dexamethasone and prolactin in cultured Madin—Darby canine kidney (MDCK) cells

  2006cites this paper
• Subkloning og proteinanalyser av rGH-varianter i MDCK II-celler

  2006cites this paper
• K+ transport in ‘Tight’ epithelial monolayers of MDCK cells

  2005cites this paper
• Protamine-induced epithelial barrier disruption involves rearrangement of cytoskeleton and decreased tight junction-associated protein expression in cultured MDCK strains.

  2005cites this paper
• Voltage and Ca2+-Activated K+ channel in cultured epithelial cells (MDCK)

  2005cites this paper
• Urea transport in MDCK cells that are stably transfected with UT-A1.

  2004cites this paper
• Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers.

  2003cites this paper
• Paracellular ion channel at the tight junction.

  2003cites this paper
• Disruption of epithelial barrier function by H2O2: distinct responses of Caco-2 and Madin-Darby canine kidney (MDCK) strains.

  2003cites this paper
• Purinergic-Induced Ion Current in Monolayers of C7-MDCK Cells: Role of Basolateral and Apical Ion Transporters

  2002cites this paper
• Evaluation of Na+ Active Transport and Morphological Changes for Bioartificial Renal Tubule Cell Device Using Madin-Darby Canine Kidney Cells

  2002cites this paper
• Impairment of the cell-to-matrix adhesion and cytotoxicity induced by Bothrops moojeni snake venom in cultured renal tubular epithelia.

  2002cites this paper
• Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco‐2) cells

  2002cites this paper
• A morphological study of the expression of the small G protein RhoA in resting and activated MDCK cells

  2000cites this paper
• Stable, polarised, functional expression of Kir1.1b channel protein in Madin‐Darby canine kidney cell line

  2000cites this paper
• Peptide-mediated transcytosis of phage display vectors in MDCK cells.

  2000cites this paper
• The MDCK cell line is made up of populations of cells with diverse resistive and transport properties.

  2000cites this paper
• Na+-independent proton secretion in MDCK–C11 cells

  2000cites this paper
• Cell-substrate contact: another factor may influence transepithelial electrical resistance of cell layers cultured on permeable filters.

  1999cites this paper
• Purinergic Modulation of Na+,K+,Cl− Cotransport and MAP Kinases is Limited to C11-MDCK Cells Resembling Intercalated Cells from Collecting Ducts

  1999cites this paper
• Regulation of the MDCK Cell Tight Junction

  1998cites this paper
• Co-culture of two MDCK strains with distinct junctional protein expression: a model for intercellular junction rearrangement and cell sorting

  1998cites this paper
• Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia.

  1998cites this paper
• H+ ATPase and Cl− Interaction in Regulation of MDCK Cell pH

  1998cites this paper
• The rat mucosal mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin.

  1998cites this paper
• Fluoroquinolone ( cipro ̄ oxacin ) secretion by human intestinal epithelial ( Caco-2 ) cells

  1997cites this paper
• Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco‐2) cells

  1997cites this paper
• Measurement of paracellular epithelial conductivity by conductance scanning

  1997cites this paper
• 4 – In Vitro Models for Nephrotoxiciry Screening and Risk Assessment

  1996cites this paper
• ARPE-19, a human retinal pigment epithelial cell line with differentiated properties.

  1996cites this paper
• Promotion of Salmonella typhimurium adherence and membrane ruffling in MDCK epithelia by staurosporine.

  1996cites this paper
• Evidence for a rapid, direct effect on epithelial monolayer integrity and transepithelial transport in response to Salmonella invasion

  1996cites this paper
• Rapid disruption of epithelial barrier function by Salmonella typhimurium is associated with structural modification of intercellular junctions

  1995cites this paper
• Cyclic‐AMP deficient MDCK cells form tubules

  1995cites this paper
• MHV-A59 Enters Polarized Murine Epithelial Cells through the Apical Surface but Is Released Basolaterally

  1995cites this paper
• Subtypes of Madin-Darby canine kidney (MDCK) cells defined by immunocytochemistry: Further evidence for properties of renal collecting duct cells

  1994cites this paper
• Paracellular barrier and junctional protein distribution depend on basolateral extracellular Ca2+ in cultured epithelia.

  1994cites this paper
• Junctional uvomorulin/E-cadherin and phosphotyrosine-modified protein content are correlated with paracellular permeability in Madin-Darby canine kidney (MDCK) epithelia

  1994influential citation
• Polycation-induced enhancement of epithelial paracellular permeability is independent of tight junctional characteristics.

  1993cites this paper
• Renal epithelial Cl‐ secretion

  1993cites this paper
• Established human renal cell lines: Phenotypic characteristics define suitability for use in in vitro models for predictive toxicology.

  1993cites this paper
• Transepithelial secretion, cellular accumulation and cytotoxicity of vinblastine in defined MDCK cell strains.

  1993cites this paper
• Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell Lines

  1993cites this paper
• Constitutive secretion of a bacterial enzyme by polarized epithelial cells.

  1992cites this paper
• Fluid transport in a cultured cell model of kidney epithelial cyst enlargement.

  1992cites this paper
• The effect of hyperosmotic challenge upon ion transport in cultured renal epithelial layers (MDCK)

  1992cites this paper
• Polarized efflux of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers.

  1992cites this paper
• Isolation and characterisation of clones from the Caco-2 cell line displaying increased taurocholic acid transport.

  1991cites this paper
• Measurement of cell volume and fluid transport in MDCK cysts by video microscopy

  1991cites this paper
• The effect of hypo-osmolarity upon transepithelial ion transport in cultured renal epithelial layers (MDCK)

  1991cites this paper
• Chloride secretion stimulated by prostaglandin E1 and by forskolin in a canine renal epithelial cell line.

  1991cites this paper
• Transepithelial vinblastine secretion mediated by P-glycoprotein is inhibited by forskolin derivatives.

  1991cites this paper
• Established Renal Epithelial Cell Lines: Experimental Panacea or Artifact?

  1990cites this paper
• Transport Physiology of Renal and Intestinal Cell Culture Models

  1990cites this paper
• A cultured human renal epithelioid cell line responsive to vasoactive intestinal peptide

  1990cites this paper
• Vasoactive intestinal peptide control of renal adenylate cyclase: in vitro studies of canine renal membranes and cultured canine renal epithelial (MDCK) cells.

  1989cites this paper
• Characterization of subclones of Madin-Darby canine kidney renal epithelial cell line.

  1989cites this paper
• Epithelial cells in tissue culture.

  1988cites this paper
• [3H]bumetanide binding and inhibition of Na+ + K+ + Cl- co-transport: demonstration of specificity by the use of MDCK cells deficient in co-transport activity.

  1988cites this paper
• Neonatal rabbit kidney cortex in culture as tool for the study of collecting duct formation and nephron differentiation.

  1987cites this paper
• Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells.

  1987cites this paper
• MDCK cysts: An in vitro model of epithelial cyst formation and growth

  1986cites this paper