Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  International Journal of Biological Macromolecules

• Publication date

  2018-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ijbiomac.2018.01.070PMID 29343453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumour-associated macrophages as treatment targets in oncology

  2017cited by this paper
• Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

  2017cited by this paper
• TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a

  2017cited by this paper
• Immunomodulatory effect of APS and PSP is mediated by Ca2+-cAMP and TLR4/NF-κB signaling pathway in macrophage.

  2017cited by this paper
• Identification and Analysis of Mitogen-Activated Protein Kinase (MAPK) Cascades in Fragaria vesca

  2017cited by this paper
• Chemical characterization, antioxidant, immune-regulating and anticancer activities of a novel bioactive polysaccharide from Chenopodium quinoa seeds.

  2017cited by this paper
• Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages.

  2017cited by this paper
• Cancer statistics, 2017

  2017cited by this paper
• Huaiqihuang Granules (槐杞黄颗粒) reduce proteinuria by enhancing nephrin expression and regulating necrosis factor κB signaling pathway in adriamycin-induced nephropathy

  2017cited by this paper
• Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model

  2017cited by this paper
• Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo

  2017cited by this paper
• RAW264.7 Cell Activating Glucomannans Extracted from Rhizome of Polygonatum sibiricum

  2016cited by this paper
• MAPK Cascades in Guard Cell Signal Transduction

  2016cited by this paper
• Synergy in traditional Chinese medicine.

  2016cited by this paper
• Inflammatory MAPK and NF-κB signaling pathways differentiated hepatitis potential of two agglomerated titanium dioxide particles.

  2016cited by this paper
• Anti-Tumor Effects of the Polysaccharide Isolated from Tarphochlamys Affinis in H22 Tumor-Bearing Mice

  2016cited by this paper
• Polysaccharides from Polygonatum Inhibit the Proliferation of Prostate Cancer-Associated Fibroblasts.

  2016cited by this paper
• The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor Efficacy

  2016cited by this paper
• Effects of Polygonatum sibiricum rhizome ethanol extract in high-fat diet-fed mice

  2015cited by this paper
• Identification of potential therapeutic targets for lung cancer by bioinformatics analysis

  2015cited by this paper
• Rethinking traditional Chinese medicines for cancer.

  2015cited by this paper
• A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.

  2015cited by this paper
• Macrophages and cancer: from mechanisms to therapeutic implications.

  2015cited by this paper
• Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways.

  2015cited by this paper
• Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

  2014cited by this paper
• Analysis of water-soluble polysaccharides in an edible medicinal plant Epimedium: method development, validation, and application.

  2014cited by this paper
• Optimized extraction of polysaccharides from Cymbopogon citratus and its biological activities.

  2014cited by this paper
• A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

  2014cited by this paper
• Platycodon grandiflorum polysaccharide induces dendritic cell maturation via TLR4 signaling.

  2014cited by this paper
• Antitumor efficacy in H22 tumor bearing mice and immunoregulatory activity on RAW 264.7 macrophages of polysaccharides from Talinum triangulare.

  2014cited by this paper
• Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.

  2013cited by this paper
• Molecular basis of NF-κB signaling.

  2013cited by this paper
• Macrophage biology in development, homeostasis and disease

  2013cited by this paper
• Tissue distribution of 2-methoxyestradiol nanosuspension in rats and its antitumor activity in C57BL/6 mice bearing lewis lung carcinoma

  2012cited by this paper
• IL-29 and IFNα differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNγ receptor expression.

  2011cited by this paper
• Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.

  2011cited by this paper
• TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

  2011cited by this paper
• Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats.

  2011cited by this paper
• Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states

  2011cited by this paper
• TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

  2010cited by this paper
• Signal integration by JNK and p38 MAPK pathways in cancer development

  2009cited by this paper
• Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.

  2009cited by this paper
• Shared principles in NF-kappaB signaling.

  2008cited by this paper
• Structural investigation of two neutral polysaccharides isolated from rhizome of Polygonatum sibiricum

  2007cited by this paper
• Myeloid differentiation factor 88-independent Toll-like receptor pathway: Sustaining inflammation or promoting tolerance?

  2007cited by this paper
• From traditional Chinese medicine to rational cancer therapy.

  2007cited by this paper
• Role for MyD88-Independent, TRIF Pathway in Lipid A/TLR4-Induced Endotoxin Tolerance1

  2007cited by this paper
• TLR signaling.

  2006cited by this paper
• A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

  2006cited by this paper
• [Determination of relative molecular mass and composition for Polygonatum sibiricum polysaccharide by high performance liquid chromatography].

  2005cited by this paper
• A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells

  2005cited by this paper
• Toll-like receptor signalling

  2004cited by this paper
• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

  2003cited by this paper
• Mice Lacking Myeloid Differentiation Factor 88 Display Profound Defects in Host Resistance and Immune Responses to Mycobacterium avium Infection Not Exhibited by Toll-Like Receptor 2 (TLR2)- and TLR4-Deficient Animals

  2003cited by this paper
• How we detect microbes and respond to them: the Toll‐like receptors and their transducers

  2003cited by this paper
• cAMP elevators inhibit LPS-induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in Murine Peritoneal Macrophages

  2002cited by this paper
• Tlr4: central component of the sole mammalian LPS sensor.

  2000cited by this paper
• Liposomal doxorubicin and conventionally fractionated radiotherapy in the treatment of locally advanced non-small-cell lung cancer and head and neck cancer.

  1999cited by this paper
• Unresponsiveness of MyD88-deficient mice to endotoxin.

  1999cited by this paper
• Steroidal saponins from the rhizomes of Polygonatum sibiricum.

  1990cited by this paper

• Polygonati Rhizoma: Geographic Distribution, Traditional Use, Component Transformation, Pharmacological Activity, and Clinical Application.

  2026cites this paper
• Polygonatum cyrtonema Hua endophytic bacterium Bacillus amyloliquefaciens HJ9 and its degenerate strain dHJ9: Antifungal activity and mechanisms

  2026cites this paper
• Lemon gum (Citrus x latifolia) enhances IL-1Β expression and suppresses colon tumor growth in vivo with a favorable safety profile.

  2026cites this paper
• Structural Analysis and Immunoenhancing Activity of Polysaccharides Derived From Imperatae rhizoma

  2026cites this paper
• Dietary polysaccharides extracted and purified in different methods: structural characteristics, biological activities and application progress

  2026cites this paper
• Immunomodulatory effects of Abelmoschus esculentus L. flower polysaccharide on spleen lymphocytes via TLR4-MAPK-NF-κB signaling pathways

  2025cites this paper
• Three polysaccharides from Roughhaired Holly Root with immune-enhancing activity via activation of TLR receptor.

  2025cites this paper
• Polygonatum sibiricum polysaccharide attenuates cyclophosphamide-induced testicular damages and sperm defects in male mice via Nrf2 mediating antioxidant protective mechanisms.

  2025cites this paper
• Geographical variations in Polygonatum polysaccharides and saponins biosynthesis in Polygonatum species

  2025cites this paper
• Preparation, Structure, Function, and Application of Dietary Polysaccharides from Polygonatum sibiricum in the Food Industry: A Review

  2025influential citation
• Integrated transcriptomics and network pharmacology to reveal the mechanism of Physochlainae Radix in the treatment of asthma.

  2025cites this paper
• Preparation, analysis, biological activity of Polygonati Rhizoma polysaccharides: A review

  2025cites this paper
• 黄精多糖的生物学活性及其在相关疾病防治中的作用

  2025cites this paper
• The antitumor potential of Polygonatum spp.: a narrative review of traditional uses, bioactive metabolites, and multi-targeted mechanisms

  2025cites this paper
• Complementary efficacy and molecular insights of Polygonati rhizoma polysaccharide for glycemic and lipid abnormalities in type 2 diabetes mellitus: a comprehensive review

  2025cites this paper
• Anoectochilus roxburghii polysaccharide alleviates DSS-induced ulcerative colitis by modulating the MAPK/NF-κB signaling pathway and gut microbiota

  2025cites this paper
• Recent Advances in Polygonatum sibiricum Polysaccharides: Structural Insights, Bioactivities in Vitro and In Vivo, and Therapeutic Potential in Human and Animal Models – A Review

  2025cites this paper
• Antiviral effects of flavonoids on animal viruses.

  2025cites this paper
• Polygonatum sibiricum polysaccharides combat fatty liver haemorrhage syndrome in hens via regulation of lipid metabolism, oxidative stress and inflammatory response.

  2025cites this paper
• Network-based pharmacological and experimentally validated study on the therapeutic effects and mechanisms of Polygonatum Rhizoma Ginseng Formula in immunocompromised mice.

  2025cites this paper
• Structural characterization and bioactivity evaluation of a soluble polysaccharide (PCHP-1A) from Polygonatum cyrtonema Hua: antioxidant and α-glucosidase inhibitory activities

  2025cites this paper
• Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review

  2025cites this paper
• Research Progress on the Extraction, Structure Elucidation, Biological Activities, and Drug Carrier Applications of Polygonati Rhizom Polysaccharides

  2025cites this paper
• Study on the components changes of polysaccharides and saponins during nine steaming and drying of Polygonatum sibiricum.

  2024cites this paper
• Kidney-tonifying blood-activating decoction delays ventricular remodeling in rats with chronic heart failure by regulating gut microbiota and metabolites and p38 mitogen-activated protein kinase/p65 nuclear factor kappa-B/aquaporin-4 signaling pathway.

  2024cites this paper
• Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate‐protein kinase G signaling in diabetic mice

  2024cites this paper
• Synthesis of Pseudostellaria heterophylla polysaccharide‐gold nanocomposites and their antitumor effect through immunomodulation

  2024cites this paper
• Research progress on medicinal components and pharmacological activities of polygonatum sibiricum.

  2024cites this paper
• Polygonati Rhizoma: A review on the extraction, purification, structural characterization, biosynthesis of the main secondary metabolites and anti-aging effects.

  2024cites this paper
• Isolation, Purification, Fractionation, and Hepatoprotective Activity of Polygonatum Polysaccharides

  2024cites this paper
• Network pharmacology analysis, molecular docking integrated experimental verification reveal β-sitosterol as the active anti-NSCLC ingredient of Polygonatum cyrtonema Hua by suppression of PI3K/Akt/HIF-1α signaling pathway.

  2024cites this paper
• Phyllanthus emblica polysaccharide (PEP) attenuates cyclophosphamide-induced immunosuppression through microbiota-dependent or –independent regulation of immune responses

  2024cites this paper
• Isolation, purification, and physicochemical characterization of Polygonatum polysaccharide and its protective effect against CCl4-induced liver injury via Nrf2 and NF-κB signaling pathways.

  2024cites this paper
• Review of studies on polysaccharides, lignins and small molecular compounds from three Polygonatum Mill. (Asparagaceae) spp. in crude and processed states.

  2024cites this paper
• Pharmacological properties of Polygonatum and its active ingredients for the prevention and treatment of cardiovascular diseases

  2024cites this paper
• Antipyretic effect of inhaled Tetrastigma hemsleyanum polysaccharide on substance and energy metabolism in yeast-induced pyrexia mice via TLR4/NF-κb signaling pathway.

  2024cites this paper
• The structure-function relationships and interaction between polysaccharides and intestinal microbiota: A review.

  2024cites this paper
• Establishment of an Idiosyncratic Drug-Induced Liver Injury Model on a Stacked Array Chip for Identification of CCL5-Mediated Paracrine Dynamics.

  2024cites this paper
• Polygonatum Sibiricum Polysaccharides: A Promising Strategy in the Treatment of Neurodegenerative Disease.

  2024cites this paper
• Potential antitumor effect of polysaccharides extracted from Polygonatum sibiricum on human prostate cancer PC‑3 cells

  2024cites this paper
• Influence of fertilizer rates, planting density and light transmittance on yield and quality of P. cyrtonema

  2024cites this paper
• Natural plant-derived polysaccharides targeting macrophage polarization: a promising strategy for cancer immunotherapy

  2024cites this paper
• Targeted discovery of gut microbiome-remodeling compounds for the treatment of systemic inflammatory response syndrome

  2024cites this paper
• Gut Microbiota and Its Metabolites: A Potential Approach for Traditional Chinese Medicine-Derived Non-starch Polysaccharides to Delay Aging and Prevent Age-related Diseases – A review

  2024cites this paper
• Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review

  2024cites this paper
• Whey protein and flaxseed gum co-encapsulated fucoxanthin promoted tumor cells apoptosis based on MAPK-PI3K/Akt regulation on Huh-7 cell xenografted nude mice.

  2024cites this paper
• Effect of Huo Li Su Oral Solution Combined with Zopiclone in the Treatment of Insomnia Symptoms

  2024cites this paper
• Antitumor activity of Polygonatum sibiricum polysaccharides

  2024cites this paper
• Pre-column Derivative HPLC and LC–Orbitrap-MS Analysis of Monosaccharides and Non-polysaccharides in Polygonati Rhizoma

  2024cites this paper
• Polygonati Rhizoma varieties and origins traceability based on multivariate data fusion combined with an artificial intelligence classification algorithm.

  2024cites this paper
• Comparison of Polygonatum sibiricum Polysaccharides Found in Young and Mature Rhizomes

  2024cites this paper
• Polygonatum sibiricum polysaccharide inhibits the proliferation of endometrial cancer cells by promoting cell death

  2024cites this paper
• A polysaccharide PRCP from Rosa cymosa Tratt fruit: Structural characteristics and immunomodulatory effects via MAPK pathway modulation in vitro.

  2024cites this paper
• The Polysaccharides from Pinellia ternata and Their Derivatives: Preparation, Structure Characteristics, and Activities in Vitro

  2024cites this paper
• Historical evolution and processing mechanism of ‘nine steaming and nine drying’ of traditional Chinese medicine preparation

  2024cites this paper
• Green Synthesis of Gold Nanoparticles from Polygahatous Polysaccharides and Their Anticancer Effect on Hepatic Carcinoma through Immunoregulation

  2024cites this paper
• Superior hemostatic and wound-healing properties of tetrastigma polysaccharide

  2024cites this paper
• A comprehensive review on the potential applications of medicine Polygonatum species in the food sector

  2024cites this paper
• Coixol ameliorates Toxoplasma gondii infection-induced lung injury by interfering with T. gondii HSP70/TLR4/NF-κB signaling pathway.

  2023cites this paper
• Untargeted components and in vivo metabolites analyses of Polygonatum under different processing times

  2023cites this paper
• Review on the genus Polygonatum polysaccharides: Extraction, purification, structural characteristics and bioactivities.

  2023cites this paper
• Characterization of Metabolite Landscape Distinguishes Wild from Cultivated Polygonati Rhizomes by UHPLC-Q-TOF-MS Untargeted Metabolomics

  2023cites this paper
• Polygonati Rhizoma with the homology of medicine and food: A review of ethnopharmacology, botany, phytochemistry, pharmacology and applications.

  2023cites this paper
• Recent advances in polysaccharides from the genus Polygonatum: Isolation, structures, bioactivities, and application

  2023cites this paper
• Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.

  2023cites this paper
• Study on the preparation and biological activities of low molecular weight squid ink polysaccharide from Sepiella maindroni.

  2023cites this paper
• Metabolic Composition and Quality Traits of Polygonatum cyrtonema Hua from Different Germplasms and Age Sections Based on Widely Targeted Metabolomics Analysis

  2023cites this paper
• Lipopolysaccharide-induced immune stress negatively regulates broiler chicken growth via the COX-2-PGE2-EP4 signaling pathway

  2023cites this paper
• Huangjing—From medicine to healthy food and diet

  2023cites this paper
• The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

  2023cites this paper
• Phenolic Composition, Antioxidant, and α-Glucosidase Inhibitory Activities of Extracts from Polygonatum sibiricum

  2023cites this paper
• Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro

  2023cites this paper
• The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.

  2023cites this paper
• Effects of Polygonatum sibiricum on Physicochemical Properties, Biological Compounds, and Functionality of Fermented Soymilk

  2023cites this paper
• Polygonatum sibiricum Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway.

  2023cites this paper
• Research progress on the anticancer activity of plant polysaccharides.

  2023cites this paper
• Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825

  2023cites this paper
• MiR-525-5p inhibits diffuse large B cell lymphoma progression via the Myd88/NF-κB signaling pathway

  2023cites this paper
• Transcriptome analysis of three medicinal plants of the genus Polygonatum: identification of genes involved in polysaccharide and steroidal saponins biosynthesis

  2023cites this paper
• Polysaccharides regulate Th1/Th2 balance: A new strategy for tumor immunotherapy.

  2023cites this paper
• Preparation, structural characterization, bioactivities, and applications of Crataegus spp. polysaccharides: A review.

  2023cites this paper
• Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism.

  2023cites this paper
• The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review

  2023cites this paper
• Hepatocytes-derived Prdx1 regulates macrophage phenotypes via TLR4 activation in acute liver injury.

  2023cites this paper
• Polygonatum Polysaccharide Regulates Macrophage Polarization and Improves LPS-Induced Acute Lung Injury through TLR4-MAPK/NF-κB Pathway

  2022cites this paper
• Integrated miRNA and mRNA omics reveal dioscin suppresses migration and invasion via MEK/ERK and JNK signaling pathways in human endometrial carcinoma in vivo and in vitro.

  2022cites this paper
• Polygonatum sibiricum saponin Exerts Beneficial Hypoglycemic Effects in Type 2 Diabetes Mice by Improving Hepatic Insulin Resistance and Glycogen Synthesis-Related Proteins

  2022cites this paper
• Comparative Study of the Phytochemical Profiles of the Rhizomes of Cultivated and Wild-Grown Polygonatum sibiricum

  2022cites this paper
• The polysaccharide from Camellia oleifera fruit shell enhances immune responses via activating MAPKs and NF-κB signaling pathways in RAW264.7 macrophages

  2022cites this paper
• Identification of Polygonati Rhizoma in three species and from different producing areas of each species using HS-GC-IMS

  2022cites this paper
• Polysaccharides from Chinese materia medica: Perspective towards cancer management.

  2022cites this paper
• Shashen-Maidong Decoction inhibited cancer growth under intermittent hypoxia conditions by suppressing oxidative stress and inflammation.

  2022cites this paper
• Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material

  2022cites this paper
• UHPLC-Q-Orbitrap-MS-Based Metabolomics Reveals Chemical Variations of Two Types of Rhizomes of Polygonatum sibiricum

  2022cites this paper
• Purification, structural characterization and immunoregulatory mechanism of PSPW-3-a isolated from wine-processed Polygonatum sibiricum

  2022cites this paper
• Synergistic Effect of Polydatin and Polygonatum sibiricum Polysaccharides in Combating Atherosclerosis via Suppressing TLR4-Mediated NF-κB Activation in ApoE-Deficient Mice

  2022cites this paper
• Anti-cancer Potential of Polysaccharide Extracted From Polygonatum sibiricum on HepG2 Cells via Cell Cycle Arrest and Apoptosis

  2022cites this paper
• Physicochemical properties, immunostimulatory and antioxidant activities of a novel polysaccharide isolated from Mirabilis himalaica (Edgew) Heim

  2022cites this paper
• Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade

  2022cites this paper
• ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-κB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation

  2022cites this paper