Gut Microbiota and Atherosclerosis

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Current Atherosclerosis Reports

• Publication date

  2017-08-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s11883-017-0675-9PMID 28842845
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
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• Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine Published, JLR Papers in Press, August 24, 2007.

  2007cited by this paper
• FXR Deficiency Causes Reduced Atherosclerosis in Ldlr−/− Mice

  2006cited by this paper
• A second class of chemosensory receptors in the olfactory epithelium

  2006cited by this paper
• Randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: CLARICOR trial

  2005cited by this paper
• Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice Published, JLR Papers in Press, September 26, 2005. DOI 10.1194/jlr.M500390-JLR200

  2005cited by this paper
• Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome.

  2005cited by this paper
• Azithromycin for the secondary prevention of coronary events.

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• Expression and activation of the farnesoid X receptor in the vasculature.

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• Counteraction of urea-induced protein denaturation by trimethylamine N-oxide: a chemical chaperone at atomic resolution.

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• Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.

  2004cited by this paper
• Azithromycin for the secondary prevention of coronary heart disease events: the WIZARD study: a randomized controlled trial.

  2003cited by this paper
• Effect of dialysis dose and membrane flux in maintenance hemodialysis.

  2002cited by this paper

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• Future Foods: How Modern Science Is Transforming the Way We Eat

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• Mass Spectrometry-Based Microbial Metabolomics: Techniques, Analysis, and Applications.

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  2018cites this paper
• Microbial impact on cholesterol and bile acid metabolism: current status and future prospects

  2018cites this paper
• Cholesterol cholelithiasis: part of a systemic metabolic disease, prone to primary prevention

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