53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

Meitinger et al. perform a genome-wide CRISPR/Cas9 screen for centrinone resistance and identify a 53BP1-USP28 module as critical for communicating mitotic challenges to the p53 circuit and TRIM37 as an enforcer of the singularity of centrosome assembly.

• Publication year

  2016

• Venue

  Journal of Cell Biology

• Publication date

  2016-07-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201604081PMID 27432897PMCID 4949453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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