Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2004-01-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.BBRC.2003.12.079PMID 14715269
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), in human glioma cells

  2003cited by this paper
• Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.

  2003cited by this paper
• RUNX transcription factors as key targets of TGF-beta superfamily signaling.

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• RUNX transcription factors as key targets of TGF-β superfamily signaling

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• Causal relationship between the loss of RUNX3 expression and gastric cancer.

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• RUNX: a trilogy of cancer genes.

  2002cited by this paper
• The RUNX3 gene--sequence, structure and regulated expression.

  2001cited by this paper
• TGF-β signaling in tumor suppression and cancer progression

  2001cited by this paper
• TGF-beta signaling in tumor suppression and cancer progression.

  2001cited by this paper
• Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.

  2001cited by this paper
• Frequent allelic imbalance suggests involvement of a tumor suppressor gene at 1p36 in the pathogenesis of human lung cancers

  2000cited by this paper
• TGFbeta signaling in growth control, cancer, and heritable disorders.

  2000cited by this paper
• Cancer-epigenetics comes of age

  1999influential reference
• Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

  1999cited by this paper
• Interaction and Functional Cooperation of PEBP2/CBF with Smads

  1999cited by this paper
• Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

  1998cited by this paper
• Oncogenic transcription factors in the human acute leukemias.

  1997cited by this paper
• Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia.

  1997cited by this paper
• Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma.

  1997cited by this paper
• Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

  1996cited by this paper
• Genomic instability in Ip and human malignancies

  1996cited by this paper
• Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.

  1995cited by this paper
• Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain

  1995cited by this paper
• Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36.

  1995cited by this paper
• Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region.

  1993cited by this paper
• Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

  1991cited by this paper

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  2026cites this paper
• Epigenetic analysis in cancer research.

  2025cites this paper
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  2022cites this paper
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  2018influential citation
• Loss of expression rather than cytoplasmic mislocalization of RUNX3 predicts worse outcome in non-small cell lung cancer

  2018cites this paper
• Epigenome-Based Precision Medicine in Lung Cancer.

  2018cites this paper
• Emerging role of RUNX3 in the regulation of tumor microenvironment

  2018cites this paper
• Clinical Epigenetics of Lung Cancer

  2017cites this paper
• Epigenetic inactivation of RUNX3 in colorectal cancer

  2017cites this paper
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• Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators.

  2017cites this paper
• Molecular Detection of Lung Cancer Stem Cells

  2017cites this paper
• Epigenetics in cancer: Fundamentals and Beyond.

  2017cites this paper
• RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?

  2017cites this paper
• Alteration in the expression of MGMT and RUNX3 due to non-CpG promoter methylation and their correlation with different risk factors in esophageal cancer patients

  2017cites this paper
• Smoking-Related Lung Diseases

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
• Clinicopathological significance and potential drug target of RUNX3 in non-small cell lung cancer: a meta-analysis

  2015cites this paper
• Epigenetics of lung cancer.

  2015cites this paper
• Clinicopathological significance and potential drug target of rUnX3 in non-small cell lung cancer: a meta-analysis the mechanism of initiation, progression, and identification of prognostic markers

  2015cites this paper
• Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.

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• Analysis of Clinical Indexes and RUNX3, TBKBP1, PPARGC1B Polymorphisms in Chinese Han Patients with Ankylosing Spondylitis

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• Epigenetic reprogramming of human lung cancer cells with the extract of bovine parthenogenetic oocytes

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• Promoter hypermethylation-mediated down-regulation of RUNX3 gene in human brain tumors

  2014influential citation
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  2014influential citation
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• [Cancer stem cells: a new target for lung cancer treatment].

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  2009cites this paper
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