Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes1

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Immunology

• Publication date

  2006-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.176.7.4337PMID 16547271
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Toll-like receptors and innate immunity

  2006influential reference
• CATERPILLER: a novel gene family important in immunity, cell death, and diseases.

  2005influential reference
• Toll-Like Receptor 2 Is Required for Optimal Control of Listeria monocytogenes Infection

  2004cited by this paper
• Immune responses to Listeria monocytogenes

  2004influential reference
• Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

  2004cited by this paper
• A specific gene expression program triggered by Gram-positive bacteria in the cytosol.

  2004cited by this paper
• Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

  2004influential reference
• Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.

  2004cited by this paper
• ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules

  2004cited by this paper
• NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

  2004cited by this paper
• Cell death and immunity: NODs: intracellular proteins involved in inflammation and apoptosis

  2003cited by this paper
• Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*

  2003cited by this paper
• Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

  2003cited by this paper
• An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

  2003cited by this paper
• Innate recognition of bacteria by a macrophage cytosolic surveillance pathway

  2002cited by this paper
• MyD88-Dependent but Toll-Like Receptor 2-Independent Innate Immunity to Listeria: No Role for Either in Macrophage Listericidal Activity1

  2002cited by this paper
• Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice1

  2002cited by this paper
• The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

  2002cited by this paper
• Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1*

  2001cited by this paper
• The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

  2001cited by this paper
• ASC, a Novel 22-kDa Protein, Aggregates during Apoptosis of Human Promyelocytic Leukemia HL-60 Cells*

  1999cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme a

  1998cited by this paper
• Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop

  1993cited by this paper
• Molecular determinants of Listeria monocytogenes pathogenesis

  1992cited by this paper
• Characterization of a Functional NF-KdB Site in the Human Interleukin 13 Promoter: Evidence for a Positive Autoregulatory Loop

  year unknowncited by this paper

• Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.

  2026cites this paper
• Innate immune sensor NLRP3 drives PANoptosome formation and PANoptosis

  2025cites this paper
• Listeria monocytogenes: Host-pathogen interactions and innate immune response.

  2025cites this paper
• Infection induced inflammation impairs wound healing through IL-1β signaling

  2024cites this paper
• NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress

  2024cites this paper
• Defining PANoptosis: Biochemical and Mechanistic Evaluation of Innate Immune Cell Death Activation

  2024cites this paper
• Cytosolic DNA sensor AIM2 promotes KRAS‐driven lung cancer independent of inflammasomes

  2024cites this paper
• Intestinal edema induced by LPS-induced endotoxemia is associated with an inflammasome adaptor ASC

  2023influential citation
• Activation of inflammasomes and mechanisms for intracellular recognition of Listeria monocytogenes

  2023cites this paper
• Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.

  2022cites this paper
• Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method

  2022cites this paper
• The Inflammasome Contributes to Depletion of the Ovarian Reserve During Aging in Mice

  2021cites this paper
• TLR2 Regulates Mast Cell IL-6 and IL-13 Production During Listeria monocytogenes Infection

  2021cites this paper
• The revisited role of interleukin-1 alpha and beta in autoimmune and inflammatory disorders and in comorbidities.

  2021cites this paper
• ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.

  2021influential citation
• AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense

  2021cites this paper
• Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction

  2020cites this paper
• Anakinra: efficacy in the management of fever during neutropenia and mucositis in autologous stem cell transplantation (AFFECT-2)—study protocol for a multicenter randomized double-blind placebo-controlled trial

  2020cites this paper
• Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling.

  2020cites this paper
• ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)

  2020cites this paper
• Interaction of Macrophages and Cholesterol-Dependent Cytolysins: The Impact on Immune Response and Cellular Survival

  2020cites this paper
• Caspase-1: Past and Future of this Major Player in Cell Death and Inflammation

  2020cites this paper
• A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

  2020cites this paper
• Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

  2020cites this paper
• NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet

  2020cites this paper
• HYPOXIA-INDUCED PULMONARY HYPERTENSION AND CARDIAC DYSFUNCTION; THE ROLE OF INFLAMMASOMES AND RELATED CYTOKINES

  2019cites this paper
• Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles

  2019cites this paper
• NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity

  2019cites this paper
• The effect of NLRP inflammasome on the regulation of AGEs-induced inflammatory response in human periodontal ligament cells.

  2019cites this paper
• Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome

  2018cites this paper
• A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

  2018cites this paper
• The Role of Interleukin-1 Beta in Mediating LPS-Induced Reverse Transendothelial Migration of Intimal Dendritic Cells

  2018cites this paper
• Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism.

  2018cites this paper
• Cell wall mannan of Candida krusei mediates dendritic cell apoptosis and orchestrates Th17 polarization via TLR-2/MyD88-dependent pathway

  2018cites this paper
• NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction.

  2018cites this paper
• TLR2/MyD88/NF-κB signaling pathway regulates IL-1β production in DF-1 cells exposed to Mycoplasma gallisepticum LAMPs.

  2018cites this paper
• Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.

  2017cites this paper
• LC3-associated phagocytosis in microbial pathogenesis.

  2017cites this paper
• Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guérin (BCG) via Synergistic Activation of Innate Immune Receptors.

  2017cites this paper
• Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy : Activation and Functions of the Innate Immune Receptors.

  2017cites this paper
• Leishmania donovani inhibits inflammasome‐dependent macrophage activation by exploiting the negative regulatory proteins A20 and UCP2

  2017cites this paper
• Multi-receptor detection of individual bacterial products by the innate immune system

  2017cites this paper
• Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy

  2017cites this paper
• A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis

  2016cites this paper
• Receptors of primary human macrophages for phagocytosis of Listeria monocytogenes - ruling out TLR2 and identification of potential candidates

  2016cites this paper
• NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective.

  2016cites this paper
• Listeria monocytogenes and the Inflammasome: From Cytosolic Bacteriolysis to Tumor Immunotherapy.

  2016cites this paper
• Interleukin-1 function and role in rheumatic disease

  2016cites this paper
• FcγR mediates TLR2‐ and Syk‐dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes

  2016cites this paper
• Inflammasome Signaling and Bacterial Infections

  2016cites this paper
• Cells on Fire: Regulation of the NLRP3 Inflammasome via Endoplasmic Reticulum and Mitochondrial Crosstalk.

  2015influential citation
• Cell-autonomous responses in Listeria monocytogenes infection.

  2015cites this paper
• Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.

  2015cites this paper
• Inflammasome-independent regulation of IL-1-family cytokines.

  2015cites this paper
• RNase L activates the NLRP3 inflammasome during viral infections.

  2015cites this paper
• Bacterial Exotoxins and the Inflammasome

  2015cites this paper
• Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.

  2015cites this paper
• Endoplasmic Reticulum stress activates the inflammasome via NLRP 3-caspase-2 driven mitochondrial damage

  2015influential citation
• Detection of cytosolic bacteria by inflammatory caspases.

  2014cites this paper
• in Macrophage Cytokine Responses s Spore Structures Bacillus anthraci Role of

  2014cites this paper
• This information is current as Expression of the Chemokine CCL 8 Curbs Host Defenses by Suppressing The Transcriptional Repressor BLIMP 1

  2014cites this paper
• Tracing innate immune defences along the path of Listeria monocytogenes infection

  2014cites this paper
• This information is current as Expression of the Chemokine CCL 8 Curbs Host Defenses by Suppressing The Transcriptional Repressor BLIMP 1

  2014cites this paper
• Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux

  2014cites this paper
• Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome.

  2014cites this paper
• The nuclear factor kappa B (NF-κB) activation is required for phagocytosis of staphylococcus aureus by RAW 264.7 cells.

  2014cites this paper
• Investigation of caspase-1 activity and interleukin-1β production in murine macrophage cell lines infected with Leishmania major.

  2014cites this paper
• The Transcriptional Repressor BLIMP1 Curbs Host Defenses by Suppressing Expression of the Chemokine CCL8

  2014cites this paper
• Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ

  2014cites this paper
• Inflammasome Activity COPs and POPs: Modulators of

  2013cites this paper
• Innate immunity in host defense against Borrelia

  2013cites this paper
• IL-18 activation is dependent on Toll-like receptor 4 during renal obstruction.

  2013cites this paper
• Understanding the role of zinc in IL-1β production

  2013cites this paper
• Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling

  2013cites this paper
• TLR Agonists Stimulate Nlrp3-Dependent IL-1β Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo

  2013cites this paper
• The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.

  2013cites this paper
• An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages.

  2012cites this paper
• Integrated Clinical, Pathologic, Virologic, and Transcriptomic Analysis of H5N1 Influenza Virus-Induced Viral Pneumonia in the Rhesus Macaque

  2012cites this paper
• Protective Role of Commensals against Clostridium difficile Infection via an IL-1β–Mediated Positive-Feedback Loop

  2012cites this paper
• Role of Inflammasomes in Host Defense against Citrobacter rodentium Infection*

  2012cites this paper
• and In Vivo Purinergic P2X7 Receptor in Dendritic Cells Production Independently of the b IL-1TLR Agonists Stimulate Nlrp3-Dependent

  2012cites this paper
• In Vivo Purinergic P 2 X 7 Receptor in Dendritic Cells Production Independently of the β IL-1 TLR Agonists Stimulate Nlrp 3-Dependent

  2012cites this paper
• Immune Recognition and Host Cell Response during Chlamydia Infection

  2012cites this paper
• Dendritic cells in Listeria monocytogenes infection.

  2012cites this paper
• Addendum: Defective Dock2 expression in a subset of ASC-deficient mouse lines

  2012cites this paper
• Sensing and reacting to microbes through the inflammasomes

  2012cites this paper
• TLR2 Signaling Contributes to Rapid Inflammasome Activation during F. novicida Infection

  2011cites this paper
• Forward genetics to identify Listeria monocytogenes components that activate mammalian cytosolic surveillance pathways

  2011cites this paper
• Characterization of Listeria monocytogenes Peptidoglycan N-Deacetylase and O-Acetylase Mutations and the Role of Lysozyme Resistance During Infection

  2011cites this paper
• Enhancement of tolerogenic or immunostimulatory potential of dendritic cells for therapeutic goals.

  2011cites this paper
• Manipulation of autophagy by bacteria for their own benefit

  2011cites this paper
• Borrelia species induce inflammasome activation and IL‐17 production through a caspase‐1‐dependent mechanism

  2011cites this paper
• The inflammasome regulatory pathway and infections: role in pathophysiology and clinical implications.

  2011cites this paper
• Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

  2011cites this paper
• Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure

  2011cites this paper
• Caspase-1 Protein Induces Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain (ASC)-mediated Necrosis Independently of Its Catalytic Activity*

  2011cites this paper
• Cell biology and immunology of Listeria monocytogenes infections: novel insights

  2011cites this paper
• The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond

  2011cites this paper
• Mutations of the Listeria monocytogenes Peptidoglycan N-Deacetylase and O-Acetylase Result in Enhanced Lysozyme Sensitivity, Bacteriolysis, and Hyperinduction of Innate Immune Pathways

  2011cites this paper
• The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization

  2011cites this paper