VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Bioenergetics and Biomembranes

• Publication date

  2008-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10863-008-9142-1PMID 18670869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Study of PTPC Composition during Apoptosis for Identification of Viral Protein Target

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• Cell death regulation by the Bcl‐2 protein family in the mitochondria

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• Cardiolipin and apoptosis.

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• The expanding role of mitochondria in apoptosis.

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• Regulation of apoptosis by respiration: cytochrome c release by respiratory substrates

  2001cited by this paper
• Life-or-death decisions by the Bcl-2 protein family.

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• Erucylphosphocholine-induced apoptosis in chemoresistant glioblastoma cell lines: involvement of caspase activation and mitochondrial alterations.

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• VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

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  2000cited by this paper
• Enigma of the peripheral benzodiazepine receptor.

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