Negative regulation of PI 3‐kinase by Ruk, a novel adaptor protein

No abstract is available for this paper.

• Publication year

  2000

• Venue

  EMBO Journal

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/emboj/19.15.4015PMID 10921882PMCID PMC306608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.

  2000cited by this paper
• Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p.

  1999cited by this paper
• Intermolecular Interactions of the p85a Regulatory Subunit of Phosphatidylinositol 3-Kinase*

  1999cited by this paper
• Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils

  1999cited by this paper
• Signaling by distinct classes of phosphoinositide 3-kinases.

  1999cited by this paper
• Intermolecular Interactions of the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase*

  1999cited by this paper
• Signalling through phosphoinositide 3-kinases: the lipids take centre stage.

  1999cited by this paper
• New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

  1999cited by this paper
• Phosphatidylinositol 3-phosphate recognition by the FYVE domain.

  1999cited by this paper
• PTEN: a tumour suppressor that functions as a phospholipid phosphatase.

  1999cited by this paper
• CMS: an adapter molecule involved in cytoskeletal rearrangements.

  1999cited by this paper
• The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function*

  1999cited by this paper
• Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells

  1999cited by this paper
• Differential mRNA expression and subcellular locations of PI3‐kinase isoforms in sympathetic and sensory neurons

  1999cited by this paper
• Congenital nephrotic syndrome in mice lacking CD2-associated protein.

  1999cited by this paper
• Phosphoinositide binding domains: embracing 3-phosphate.

  1999cited by this paper
• The role of PI 3-kinase in insulin action.

  1998cited by this paper
• Mechanisms and consequences of activation of protein kinase B/Akt.

  1998cited by this paper
• FYVE fingers bind PtdIns(3)P

  1998cited by this paper
• Phosphoinositide kinases.

  1998cited by this paper
• Ras signalling and apoptosis.

  1998cited by this paper
• The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate*

  1998cited by this paper
• Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

  1998cited by this paper
• Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System

  1998cited by this paper
• A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.

  1998cited by this paper
• Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

  1998cited by this paper
• p21 Ras and Phosphatidylinositol-3 Kinase Are Required for Survival of Wild-Type and NF1 Mutant Sensory Neurons

  1998cited by this paper
• Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes*

  1998cited by this paper
• The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.

  1998cited by this paper
• Identification and analysis of PH domain‐containing targets of phosphatidylinositol 3‐kinase using a novel in vivo assay in yeast

  1998cited by this paper
• Mechanism of activation and function of protein kinase B.

  1998cited by this paper
• Structure and function of phosphoinositide 3-kinases.

  1998cited by this paper
• Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains.

  1998cited by this paper
• Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains*

  1998cited by this paper
• A functional PtdIns(3)P-binding motif

  1998cited by this paper
• Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

  1997cited by this paper
• Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

  1997cited by this paper
• In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-βNGF

  1997cited by this paper
• Signal transduction by the neutrophin receptors

  1997cited by this paper
• Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.

  1997cited by this paper
• Phosphoinositide 3-kinases: a conserved family of signal transducers.

  1997cited by this paper
• PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.

  1997cited by this paper
• Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase.

  1997cited by this paper
• Akt Signaling--Linking Membrane Events to Life and Death Decisions

  1997cited by this paper
• A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains*

  1997cited by this paper
• In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-betaNGF.

  1997cited by this paper
• Signal transduction by the neurotrophin receptors.

  1997cited by this paper
• Using structure to define the function of phosphoinositide 3‐kinase family members

  1997cited by this paper
• Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

  1997cited by this paper
• P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.

  1997cited by this paper
• Lack of Correlation between Activation of Jun–NH2-terminal Kinase and Induction of Apoptosis after Detachment of Epithelial Cells

  1997cited by this paper
• Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase

  1997cited by this paper
• p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells (*)

  1996cited by this paper
• Expression and function of TrkB variants in developing sensory neurons.

  1996cited by this paper
• Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways.

  1996cited by this paper
• Endosomal Localization of the Autoantigen EEA1 Is Mediated by a Zinc-binding FYVE Finger*

  1996cited by this paper
• Identification of amino acid residues required for a specific interaction between Src‐tyrosine kinase and proline‐rich region of phosphatidylinositol‐3′ kinase

  1996cited by this paper
• Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

  1996cited by this paper
• [Cloning of genes, differentially expressed in the cerebellum during postnatal rat development].

  1996cited by this paper
• Recognition and specificity in protein tyrosine kinase-mediated signalling.

  1995cited by this paper
• Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase(*)

  1995cited by this paper
• Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.

  1995cited by this paper
• PI 3‐kinase: structural and functional analysis of intersubunit interactions.

  1994cited by this paper
• Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development

  1994cited by this paper
• Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

  1994cited by this paper
• Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development.

  1994cited by this paper
• The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.

  1994cited by this paper
• Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.

  1994cited by this paper
• Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

  1994cited by this paper
• A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.

  1993cited by this paper
• Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

  1993cited by this paper
• The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis.

  1993cited by this paper
• The GTPase dynamin binds to and is activated by a subset of SH3 domains.

  1993cited by this paper
• The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

  1993cited by this paper
• Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns.

  1992cited by this paper
• Interaction of the p85 subunit of PI 3‐kinase and its N‐terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.

  1992cited by this paper
• Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.

  1992cited by this paper
• Differential splicing creates a diversity of transcripts from a neurospecific developmentally regulated gene encoding a protein with new zinc-finger motifs.

  1992cited by this paper
• Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.

  1992cited by this paper
• Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

  1992cited by this paper
• The scanning model for translation: an update

  1989cited by this paper
• Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

  1985cited by this paper

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• PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures

  2024cites this paper
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• High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma

  2020cites this paper
• Unraveling details of CIN85/CD2AP assistance to SLP65-mediated B cell activation

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• High expression of CIN 85 promotes proliferation and invasion of human esophageal squamous cell carcinoma

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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• Adaptor protein Ruk/CIN85 modulates resistance to doxorubicin of murine 4T1 breast cancer cells

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  2016cites this paper
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• CIN85: Implications for the Development of Proteinuria in Diabetic Nephropathy

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• Reconstruction of the molecular interactome of glutamatergic synapses

  2015cites this paper
• CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface

  2015cites this paper
• Relationship between PI3K Mutation and Sodium-Iodide Symporter in Anaplastic Thyroid Carcinoma

  2015cites this paper
• Multimolecular adaptor protein complexes in B cell receptor signaling

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• Significance of CIN85 Analysis in Nutritional Study Journal of Nutritional Biology

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