SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: Effects on cellular stress, inflammatory markers and fatty acid elongation.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Nutritional Biochemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.jnutbio.2015.09.011PMID 26481476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation

  2015cited by this paper
• SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition.

  2015cited by this paper
• Role of p38 mitogen‐activated protein kinase in linking stearoyl‐CoA desaturase‐1 activity with endoplasmic reticulum homeostasis

  2015influential reference
• Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function

  2015cited by this paper
• Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis

  2014cited by this paper
• Palmitate induces COX-2 expression via the sphingolipid pathway-mediated activation of NF-κB, p38, and ERK in human dermal fibroblasts

  2014cited by this paper
• Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction.

  2014cited by this paper
• 3T3-L1 Preadipocytes Exhibit Heightened Monocyte-Chemoattractant Protein-1 Response to Acute Fatty Acid Exposure

  2014cited by this paper
• Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes.

  2014cited by this paper
• Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation.

  2013cited by this paper
• Individual Saturated and Monounsaturated Fatty Acids Trigger Distinct Transcriptional Networks in Differentiated 3T3-L1 Preadipocytes

  2013cited by this paper
• The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes

  2013cited by this paper
• EPA and DHA Levels in Whole Blood Decrease More Rapidly when Stored at −20 °C as Compared with Room Temperature, 4 and −75 °C

  2013cited by this paper
• Association between fast food purchasing and the local food environment

  2012cited by this paper
• Stearic acid content of abdominal adipose tissues in obese women

  2012cited by this paper
• Comparative analysis of standardised and common modifications of methods for lipid extraction for the determination of fatty acids

  2012cited by this paper
• Stearoyl CoA desaturase 1: role in cellular inflammation and stress.

  2011cited by this paper
• The inhibitory effects of PKCθ on adiponectin expression is mediated by ERK in 3T3-L1 adipocytes.

  2011cited by this paper
• Fatty acid–gene interactions, adipokines and obesity

  2011cited by this paper
• The inhibitory effects of PKCθ on adiponectin expression is mediated by ERK in 3T3-L1 adipocytes

  2011cited by this paper
• The role of stearoyl‐CoA desaturase in obesity, insulin resistance, and inflammation

  2011cited by this paper
• Activation of Peroxisome Proliferator–Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes

  2011cited by this paper
• The autocrine and paracrine roles of adipokines.

  2010cited by this paper
• Loss of Stearoyl-CoA Desaturase-1 Attenuates Adipocyte Inflammation: Effects of Adipocyte-Derived Oleate

  2010cited by this paper
• Metabolic phenotyping of a model of adipocyte differentiation.

  2009cited by this paper
• Normalization of Obesity-Associated Insulin Resistance through Immunotherapy: CD4+ T Cells Control Glucose Homeostasis

  2009cited by this paper
• Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications.

  2009cited by this paper
• Fatty acid‐induced induction of Toll‐like receptor‐4/nuclear factor‐κB pathway in adipocytes links nutritional signalling with innate immunity

  2009cited by this paper
• A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome.

  2009cited by this paper
• De Novo Lipogenesis and Stearoyl-CoA Desaturase Are Coordinately Regulated in the Human Adipocyte and Protect against Palmitate-induced Cell Injury*

  2009cited by this paper
• Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

  2008cited by this paper
• Dietary Fatty Acids Differentially Regulate Production of TNF‐α and IL‐10 by Murine 3T3‐L1 Adipocytes

  2008cited by this paper
• The adipocyte as an endocrine cell.

  2008cited by this paper
• Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes.

  2007cited by this paper
• Altered signalling and gene expression associated with the immune system and the inflammatory response in obesity

  2007cited by this paper
• Adipocytokines: mediators linking adipose tissue, inflammation and immunity

  2006cited by this paper
• TLR4 links innate immunity and fatty acid-induced insulin resistance.

  2006cited by this paper
• Palmitate Activates the NF-κB Transcription Factor and Induces IL-6 and TNFα Expression in 3T3-L1 Adipocytes

  2005cited by this paper
• Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes.

  2005cited by this paper
• The role of MAPKs in adipocyte differentiation and obesity.

  2005cited by this paper
• Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor.

  2004cited by this paper
• The role of stearoyl-CoA desaturase in body weight regulation.

  2004cited by this paper
• Targeting JNK for therapeutic benefit: from junk to gold?

  2003cited by this paper
• Serine phosphorylation of STATs

  2000cited by this paper
• The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1*

  2000cited by this paper
• Regulation of stearoyl-CoA desaturase genes: role in cellular metabolism and preadipocyte differentiation.

  1999cited by this paper
• Molecular regulation of adipocyte differentiation.

  1999cited by this paper
• Evaluation of reference ranges for fatty acids in serum

  1994cited by this paper
• Hormonal regulation of stearoyl coenzyme A desaturase activity and lipogenesis during adipose conversion of 3T3-L1 cells.

  1982cited by this paper
• A rapid method of total lipid extraction and purification.

  1959cited by this paper
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper

• Fatty acid composition of lipid fractions in white- and brown-like adipocytes derived from human mesenchymal stem cells

  2025cites this paper
• The mutual effects of stearoyl-CoA desaturase and cancer-associated fibroblasts: a focus on cancer biology.

  2025cites this paper
• Investigation of Aldose Reductase Inhibitors: Implications for Therapeutic Targets in Diabetic Retinopathy

  2025cites this paper
• Organ-Specific Responses to Chronic High-Fat Diets in Mice: Insights into Phospholipid Fatty Acid Distribution

  2025cites this paper
• Investigating the effect of stearoyl-coenzyme desaturase 1 Inhibition on inflammatory and anti-inflammatory patterns in luminal A breast cancer patients’ peripheral blood mononuclear cells

  2025cites this paper
• Lung cancer cells upregulate stearoyl-CoA desaturase 1 in microglia by activating the STAT3 pathway to change microglial inflammatory response in lung-to-brain metastases

  2025cites this paper
• Effect of stearoyl-coenzyme a desaturase 1 (SCD1) on the function of mast cells

  2024cites this paper
• Leonurine Inhibits Hepatic Lipid Synthesis to Ameliorate NAFLD via the ADRA1a/AMPK/SCD1 Axis

  2024cites this paper
• Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice

  2024cites this paper
• BACE1 and SCD1 are associated with neurodegeneration

  2023cites this paper
• Desaturation of sebaceous‐type saturated fatty acids through the SCD1 and the FADS2 pathways impacts lipid neosynthesis and inflammatory response in sebocytes in culture

  2023cites this paper
• SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors.

  2023cites this paper
• The Past and Present Lives of the Intraocular Transmembrane Protein CD36

  2022cites this paper
• LPS and palmitic acid Co-upregulate microglia activation and neuroinflammatory response

  2021cites this paper
• Proximity labeling of Snx14 reveals a functional interaction with Δ -9 desaturase SCD1 to maintain ER homeostasis

  2020cites this paper
• Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease

  2020cites this paper
• Microbiome Transfer Partly Overrides Lack of IL-1RI Signalling to Alter Hepatic but not Adipose Tissue Phenotype and Lipid Handling following a High-Fat Diet Challenge.

  2020cites this paper
• SCD1 promotes lipid mobilization in subcutaneous white adipose tissue

  2020cites this paper
• Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis

  2020cites this paper
• Monounsaturated Fatty Acids in Obesity-Related Inflammation

  2020influential citation
• Proximity labeling of Snx14 reveals a functional interaction with Δ -9 desaturase SCD1 to maintain ER homeostasis

  2020cites this paper
• Interaction of palmitate and LPS regulates cytokine expression and apoptosis through sphingolipids in human retinal microvascular endothelial cells

  2019cites this paper
• Low Oleic/Stearic Desaturation Index in Great Blue Herons ( Ardea herodias) with Steatitis in Southern California.

  2019cites this paper
• Implantation of Neural Probes in the Brain Elicits Oxidative Stress

  2018cites this paper
• Estratégias para as opções dietéticas de combate à obesidade relacionadas com a morbilidade cardiometabolica

  2017cites this paper
• 1 Reduced SCD 1 activity alters markers of fatty acid re-esterification , glyceroneogenesis , and 1 lipolysis in murine white adipose tissue and 3 T 3L 1 adipocytes 2 3

  2017cites this paper
• Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes.

  2017cites this paper
• Reduced SCD 1 activity alters markers of fatty acid reesterification , glyceroneogenesis , and lipolysis in murine white adipose tissue and 3 T 3L 1 adipocytes

  2017cites this paper
• The therapeutic landscape of non‐alcoholic steatohepatitis

  2017cites this paper
• Reduced SCD 1 activity decreases fatty acid re-esterification and alters markers of glyceroneogenesis and lipolysis in murine white adipose tissue and 3 T 3L 1 adipocytes by Steven

  2017cites this paper
• Fatty Acids and NLRP3 Inflammasome-Mediated Inflammation in Metabolic Tissues.

  2017cites this paper
• Stearoyl-CoA desaturase-1 and adaptive stress signaling.

  2016cites this paper
• Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue.

  2016cites this paper