SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Prostaglandins, Leukotrienes and Essential Fatty Acids

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.plefa.2015.04.008PMID 25959085
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice.

  2014influential reference
• What we talk about when we talk about fat.

  2014cited by this paper
• Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis

  2014cited by this paper
• Lifelong exposure to n-3 PUFA affects pubertal mammary gland development.

  2014cited by this paper
• Individual Saturated and Monounsaturated Fatty Acids Trigger Distinct Transcriptional Networks in Differentiated 3T3-L1 Preadipocytes

  2013cited by this paper
• Adipocyte and adipogenesis.

  2013cited by this paper
• Palmitoleate Is a Mitogen, Formed upon Stimulation with Growth Factors, and Converted to Palmitoleoyl-phosphatidylinositol*

  2012cited by this paper
• Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity[S]

  2012cited by this paper
• Fatty acid–gene interactions, adipokines and obesity

  2011cited by this paper
• Adipose tissue remodeling and obesity.

  2011cited by this paper
• Lipogenic enzymes as therapeutic targets for obesity and diabetes.

  2011cited by this paper
• Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue.

  2010cited by this paper
• Membrane topology of human AGPAT3 (LPAAT3).

  2010cited by this paper
• De Novo Lipogenesis and Stearoyl-CoA Desaturase Are Coordinately Regulated in the Human Adipocyte and Protect against Palmitate-induced Cell Injury*

  2009cited by this paper
• Biochemical and physiological function of stearoyl-CoA desaturase.

  2009cited by this paper
• Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.

  2009cited by this paper
• Metabolic phenotyping of a model of adipocyte differentiation.

  2009cited by this paper
• Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids.

  2009cited by this paper
• Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

  2008cited by this paper
• Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

  2008influential reference
• The adipocyte as an endocrine cell.

  2008cited by this paper
• Lipid mediators of insulin resistance.

  2007cited by this paper
• Loss of Stearoyl-CoA Desaturase-1 Improves Insulin Sensitivity in Lean Mice but Worsens Diabetes in Leptin-Deficient Obese Mice

  2007cited by this paper
• Polymorphisms in the SCD1 Gene: Associations With Body Fat Distribution and Insulin Sensitivity

  2007cited by this paper
• Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis Published, JLR Papers in Press, June 2, 2006.

  2006cited by this paper
• Stearoyl-CoA Desaturase 1 Deficiency Increases CTP:Choline Cytidylyltransferase Translocation into the Membrane and Enhances Phosphatidylcholine Synthesis in Liver*

  2005cited by this paper
• Stearoyl-CoA Desaturase 1 Gene Expression Is Necessary for Fructose-mediated Induction of Lipogenic Gene Expression by Sterol Regulatory Element-binding Protein-1c-dependent and -independent Mechanisms*

  2004cited by this paper
• Effects of sterculic acid on stearoyl-CoA desaturase in differentiating 3T3-L1 adipocytes.

  2003cited by this paper
• Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

  2002cited by this paper
• Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism DOI 10.1194/jlr.M100433-JLR200

  2002cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid in HepG2 cells.

  2001cited by this paper
• The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1*

  2000cited by this paper
• Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites.

  1999cited by this paper
• Molecular regulation of adipocyte differentiation.

  1999cited by this paper
• Regulation of stearoyl-CoA desaturase genes: role in cellular metabolism and preadipocyte differentiation.

  1999cited by this paper
• Regulation of Stearoyl-CoA Desaturase 1 mRNA Stability by Polyunsaturated Fatty Acids in 3T3-L1 Adipocytes*

  1996cited by this paper
• Transcriptional regulation of gene expression during adipocyte differentiation.

  1995cited by this paper
• Transcriptional control of the stearoyl-CoA desaturase-1 gene by polyunsaturated fatty acids.

  1994cited by this paper
• Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

  1991cited by this paper
• Hormonal regulation of stearoyl coenzyme A desaturase activity and lipogenesis during adipose conversion of 3T3-L1 cells.

  1982cited by this paper
• A rapid method of total lipid extraction and purification.

  1959cited by this paper

• Conjugated linoleic acid decreases milk fat globule size by regulating lipid droplet proteins and diameter in dairy goat mammary glands.

  2025cites this paper
• Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells

  2025cites this paper
• Maternal high-fat diet exposure impairs LKB1-TGFβ1 inflammatory pathway and increases hypothalamic 5HT receptors gene expression and somatic growth in young rats.

  2025cites this paper
• Stearoyl‐CoA Desaturase 1 Regulates Metabolism and Inflammation in Mouse Perivascular Adipose Tissue in Response to a High‐Fat Diet

  2025cites this paper
• Fatty acid composition of lipid fractions in white- and brown-like adipocytes derived from human mesenchymal stem cells

  2025cites this paper
• Characterization of cancer-associated adipocytes by Raman spectroscopy and trajectory inference

  2024cites this paper
• Bone marrow adipocytes alteration in an in vitro model of Gaucher Disease

  2023cites this paper
• Trajectory Interference for Unraveling Dynamic Biological Processes from Raman Spectral Data.

  2023cites this paper
• Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin Signaling

  2022influential citation
• Bone Marrow Adiposity in Models of Radiation‐ and Aging‐Related Bone Loss Is Dependent on Cellular Senescence

  2022cites this paper
• Roles of cellular senescence in driving bone marrow adiposity in radiation- and aging-associated bone loss

  2021cites this paper
• A small molecule modulating monounsaturated fatty acids and Wnt signaling confers maintenance to induced pluripotent stem cells against endodermal differentiation

  2021cites this paper
• Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1.

  2021cites this paper
• Milk fat as a source of bioactive compounds

  2021cites this paper
• A small molecule modulating monounsaturated fatty acids and Wnt signaling confers maintenance to induced pluripotent stem cells against endodermal differentiation

  2021cites this paper
• Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway

  2020cites this paper
• Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction

  2020cites this paper
• Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARγ Receptor.

  2020cites this paper
• New Amphiphilic Squalene Derivative Improves Metabolism of Adipocytes Differentiated From Diabetic Adipose-Derived Stem Cells and Prevents Excessive Lipogenesis

  2020cites this paper
• Mouse Embryonic Fibroblast Adipogenic Potential: A Comprehensive Transcriptome Analysis

  2020cites this paper
• Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring

  2019cites this paper
• Fatty acid synthase and stearoyl-CoA desaturase-1 are conserved druggable cofactors of Old World Alphavirus genome replication.

  2019cites this paper
• Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism

  2019cites this paper
• Differences in the lipid patterns during maturation of 3T3-L1 adipocytes investigated by thin-layer chromatography, gas chromatography, and mass spectrometric approaches

  2019cites this paper
• Deep Lipidomics and Molecular Imaging of Unsaturated Lipid Isomers: A Universal Strategy Initiated by mCPBA Epoxidation.

  2019cites this paper
• Structural Lipidomics and Molecular Imaging of C=C Positional Isomers Enabled by mCPBA Epoxidation with Tandem Mass Spectrometry

  2019cites this paper
• Identification of the potential key genes for adipogenesis from human mesenchymal stem cells by RNA‐Seq

  2019cites this paper
• Gangjihwan, a polyherbal composition, inhibits fat accumulation through the modulation of lipogenic transcription factors SREBP1C, PPARγ and C/EBPα.

  2018cites this paper
• Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism.

  2017cites this paper
• Modulation of adipogenesis-related gene expression by ethanol extracts of Detam 1 soybean and Jati belanda leaf in 3T3-L1 cells

  2016cites this paper
• Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes

  2016cites this paper
• Stearoyl-CoA desaturase-1 and adaptive stress signaling.

  2016cites this paper
• SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: Effects on cellular stress, inflammatory markers and fatty acid elongation.

  2016cites this paper
• Elucidating the roles of stearoyl-CoA desaturase 1 in adipocyte fatty acid metabolism and cellular function.

  2015cites this paper