The Trk family of neurotrophin receptors.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of Neurobiology

• Publication date

  1994-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/NEU.480251107PMID 7852993
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

  1994cited by this paper
• Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.

  1994cited by this paper
• Neurotrophic factors: from molecule to man.

  1994cited by this paper
• Dependence on p75 for innervation of some sympathetic targets.

  1994cited by this paper
• Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system

  1994cited by this paper
• Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

  1994cited by this paper
• Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.

  1994cited by this paper
• Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

  1994cited by this paper
• Transient elevation in catalytic trkB mRNA during postnatal development of the rat brain.

  1993cited by this paper
• Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear.

  1993cited by this paper
• The pathway to signal achievement

  1993cited by this paper
• Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve

  1993cited by this paper
• Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.

  1993cited by this paper
• Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus

  1993cited by this paper
• Sympathetic neuroblasts undergo a developmental switch in trophic dependence.

  1993cited by this paper
• Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia

  1993cited by this paper
• Developing rat retinal ganglion cells express the functional NGF receptor p140trkA.

  1993cited by this paper
• trkC encodes multiple neurotrophin‐3 receptors with distinct biological properties and substrate specificities.

  1993cited by this paper
• Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors

  1993cited by this paper
• TrkA NGF receptor expression by non-cholinergic thalamic neurons.

  1993cited by this paper
• High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain.

  1993cited by this paper
• Expression of p75NGFR in the olfactory system following peripheral deafferentation.

  1993cited by this paper
• Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

  1993cited by this paper
• trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.

  1993cited by this paper
• Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation.

  1993cited by this paper
• Increased production of the TrkB protein tyrosine kinase receptor after brain insults.

  1993cited by this paper
• Alternative forms of rat TrkC with different functional capabilities.

  1993cited by this paper
• Expression of functional trk protooncogene in human monocytes.

  1993cited by this paper
• Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve.

  1993cited by this paper
• The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells.

  1993cited by this paper
• Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death.

  1993cited by this paper
• Tissue-specific alternative splicing generates two isoforms of the trkA receptor.

  1993cited by this paper
• Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones.

  1993cited by this paper
• Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury

  1993cited by this paper
• SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells

  1993cited by this paper
• Nerve growth factor: a tale of two receptors.

  1993cited by this paper
• Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.

  1993cited by this paper
• Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.

  1992cited by this paper
• Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains.

  1992cited by this paper
• Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system.

  1992cited by this paper
• Growth factor signaling by receptor tyrosine kinases.

  1992cited by this paper
• Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases.

  1992cited by this paper
• K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.

  1992cited by this paper
• The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.

  1992cited by this paper
• Nerve growth factor stimulation of the Ras-guanine nucleotide exchange factor and GAP activities.

  1992cited by this paper
• NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk.

  1992cited by this paper
• Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase.

  1992cited by this paper
• Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

  1992cited by this paper
• p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.

  1992cited by this paper
• Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells.

  1992cited by this paper
• The trkB tyrosine protein kinase is a receptor for neurotrophin-4.

  1992cited by this paper
• The nerve growth factor family of receptors.

  1992cited by this paper
• A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

  1992cited by this paper
• Inflammatory sensory polyganglionopathies.

  1992cited by this paper
• Nerve growth factor mediates signal transduction through trk homodimer receptors.

  1992cited by this paper
• Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

  1992cited by this paper
• Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero.

  1992cited by this paper
• Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.

  1991cited by this paper
• Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

  1991cited by this paper
• trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.

  1991cited by this paper
• trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors

  1991cited by this paper
• The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.

  1991cited by this paper
• Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

  1991cited by this paper
• trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.

  1991cited by this paper
• Nerve growth factor stimulates the tyrosine phosphorylation of MAP2 kinase in PC12 cells.

  1991cited by this paper
• The trk proto-oncogene encodes a receptor for nerve growth factor.

  1991cited by this paper
• Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain.

  1991cited by this paper
• The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.

  1991cited by this paper
• A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.

  1991cited by this paper
• High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

  1991cited by this paper
• NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation.

  1991cited by this paper
• The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.

  1991cited by this paper
• Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C γ1

  1991cited by this paper
• The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.

  1991cited by this paper
• The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.

  1991cited by this paper
• Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

  1991cited by this paper
• Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C gamma 1.

  1991cited by this paper
• Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain

  1990cited by this paper
• Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

  1990cited by this paper
• Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.

  1990cited by this paper
• Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sjögren's syndrome

  1990cited by this paper
• The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain.

  1990cited by this paper
• trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

  1989cited by this paper
• Molecular and biochemical characterization of the human trk proto-oncogene

  1989cited by this paper
• The nerve growth factor 35 years later.

  1987cited by this paper
• A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

  1986cited by this paper

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