Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature Materials

• Publication date

  2017-10-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/nmat4997PMID 29035356
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection.

  2017cited by this paper
• Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA

  2017cited by this paper
• DNA methylation markers for diagnosis and prognosis of common cancers

  2017cited by this paper
• Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin.

  2016cited by this paper
• Information recovery from low coverage whole-genome bisulfite sequencing

  2016cited by this paper
• Identification of tissue-specific cell death using methylation patterns of circulating DNA

  2016cited by this paper
• A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative

  2016cited by this paper
• Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells

  2016cited by this paper
• Epigenetic Determinants of Cancer.

  2016cited by this paper
• The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.

  2016cited by this paper
• Global cancer statistics, 2012

  2015cited by this paper
• Detection and Dynamic Changes of EGFR Mutations from Circulating Tumor DNA as a Predictor of Survival Outcomes in NSCLC Patients Treated with First-line Intercalated Erlotinib and Chemotherapy

  2015cited by this paper
• Abstract 5606: Detection of circulating tumor DNA in early and late stage human malignancies

  2014cited by this paper
• Using Modified RECIST and Alpha-Fetoprotein Levels to Assess Treatment Benefit in Hepatocellular Carcinoma

  2014cited by this paper
• Genome-wide methylation profiles reveal quantitative views of human aging rates.

  2013cited by this paper
• Analysis of circulating tumor DNA to monitor metastatic breast cancer.

  2013cited by this paper
• An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

  2013cited by this paper
• Identification of active regulatory regions from DNA methylation data

  2013cited by this paper
• Library-free Methylation Sequencing with Bisulfite Padlock Probes

  2012cited by this paper
• Fast gapped-read alignment with Bowtie 2

  2012cited by this paper
• The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

  2012cited by this paper
• Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

  2012cited by this paper
• Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer

  2011cited by this paper
• Global cancer statistics

  2011cited by this paper
• Management of hepatocellular carcinoma: An update

  2011cited by this paper
• A decade of exploring the cancer epigenome — biological and translational implications

  2011cited by this paper
• Management of Hepatocellular Carcinoma : An Update

  2010cited by this paper
• Epigenetics in cancer.

  2010cited by this paper
• Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma

  2010cited by this paper
• The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

  2010cited by this paper
• Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

  2009cited by this paper
• Meta‐analysis: surveillance with ultrasound for early‐stage hepatocellular carcinoma in patients with cirrhosis

  2009cited by this paper
• Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

  2008cited by this paper
• Epigenetics in cancer.

  2008cited by this paper
• Circulating mutant DNA to assess tumor dynamics

  2008cited by this paper
• DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer

  2007cited by this paper
• Multiplex amplification of large sets of human exons

  2007cited by this paper
• Bioinformatics and Computational Biology Solutions Using R and Bioconductor

  2006cited by this paper
• Management of hepatocellular carcinoma

  2005cited by this paper
• limma: Linear Models for Microarray Data

  2005cited by this paper
• Patterns of linkage disequilibrium in the human genome

  2002cited by this paper
• Linkage disequilibrium in the human genome

  2001cited by this paper
• The Origin and Mechanism of Circulating DNA

  2000cited by this paper
• Role of alpha‐fetoprotein in the diagnosis and management of hepatocellular carcinoma

  1999cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper

• Targeting epigenetic methylation: emerging diagnosis and therapeutic strategies in cancer

  2026cites this paper
• The impact of circulating tumor DNA on the prognosis of liver cancer and its predictive value: a meta analysis.

  2026cites this paper
• Circulating biomarkers: Facilitating the diagnosis and treatment of cancer and other chronic diseases.

  2026cites this paper
• Liquid biopsies in precision oncology for older adults with cancer.

  2026cites this paper
• Clinical utilization of testing for cell-free DNA in hepatocellular cancer.

  2026cites this paper
• Finding a needle in a haystack: Measures of circulating tumor DNA (ctDNA) to guide treatment decisions in oncology.

  2026cites this paper
• Translating Fibrosis to Malignancy: Biomarkers and Therapeutic Opportunities in Liver Fibrosis and Hepatocellular Carcinoma

  2026cites this paper
• Research progress in the detection of tumor markers by field-effect transistor biosensors based on different biorecognition elements

  2026cites this paper
• Liquid biopsy in cancer diagnosis and prognosis: a paradigm shift in precision oncology

  2026cites this paper
• Dual tissue mRNA and serum protein signatures improve risk stratification in hepatocellular carcinoma

  2025cites this paper
• Research Advances in Hepatocellular Carcinoma Combined Diagnosis of Multiomics Biomarker

  2025cites this paper
• Amplification-free cancer diagnosis based on inhibition of Cas12a activity by site-specific 5mC-modified cfDNA

  2025cites this paper
• Insight into the role of DNA methylation in prognosis and treatment response prediction of gastrointestinal cancers

  2025influential citation
• Technical aspects of loop‐mediated isothermal amplification (LAMP) assay in cancer

  2025cites this paper
• Cerebrospinal Fluid Metabolomics and Proteomics Integration in Neurological Syndromes.

  2025cites this paper
• Decoding the epigenetic landscape: ctDNA methylation as a game-changer in hepatocellular carcinoma management.

  2025cites this paper
• NAFLD and NAFLD Related HCC: Emerging Treatments and Clinical Trials

  2025cites this paper
• Epigenetic dynamics in gastric cancer precancerous lesions: From molecular mechanisms to precision risk stratification

  2025cites this paper
• Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer

  2025cites this paper
• DNA methylation heterogeneity in complex tumor microenvironment: Quantitative methods, influencing factors, and clinical implications

  2025cites this paper
• DNA methylation and histone modifications: conserved, divergent, and synergistic epigenetic regulation across plants and animals

  2025cites this paper
• The biological and technical challenges facing utilizing circulating tumor DNA in non-metastatic breast cancer patients.

  2025cites this paper
• Decision-Making Biomarkers Guiding Therapeutic Strategies in Hepatocellular Carcinoma: From Prediction to Personalized Care

  2025cites this paper
• Roles of different methylation modifications in cardiovascular disease

  2025cites this paper
• Causality-driven candidate identification for reliable DNA methylation biomarker discovery

  2025cites this paper
• The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial

  2025cites this paper
• Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

  2025cites this paper
• Epigenetic modifications in drug‐induced liver injury: A systematic review

  2025cites this paper
• Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

  2025cites this paper
• Cell-Free DNA Versus Circulating Tumor Cells: A Pilot Study of Alpha-Fetoprotein Analysis for Diagnosis and Treatment Monitoring in Hepatocellular Carcinoma

  2025cites this paper
• Integrating cell-free DNA methylation of SEPT9 and SFRP2 into a machine learning model for early diagnosis of HCC.

  2025cites this paper
• Integrated transcriptomics and machine learning reveal REN as a dual regulator of tumor stemness and NK cell evasion in Wilms tumor progression

  2025cites this paper
• The advances of DNA methylation in the liquid biopsy for the detection of lung cancer

  2025cites this paper
• Efficient and accurate non-invasive tumor monitoring and diagnosis by interpretable deep learning

  2025cites this paper
• Genome-Wide Methylation Sequencing to Identify DNA Methylation Markers for Early-stage Hepatocellular Carcinoma in Liver and Blood

  2025cites this paper
• Establishment of liver cancer disease model via normothermic machine perfusion

  2025cites this paper
• Cell-free DNA testing for the detection and prognosis prediction of pancreatic cancer

  2025cites this paper
• Combining the DNA methylation markers of circulating tumor cells with immune infiltrating cells to assess recurrence and prognosis and to suggest a therapeutic strategy in stage III-IV colorectal cancer

  2025cites this paper
• DNA methylation biomarkers for the diagnosis and treatment management of breast cancer: where are we now?

  2025cites this paper
• Methylation Analyses in Liquid Biopsy of Lung Cancer Patients: A Novel and Intriguing Approach Against Resistance to Target Therapies and Immunotherapies

  2025cites this paper
• Development of a circulating tumor DNA methylation biomarker panel for hepatocellular carcinoma detection.

  2025cites this paper
• From concept to clinic: a roadmap for DNA methylation biomarkers in liquid biopsies

  2025cites this paper
• Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer

  2025cites this paper
• Novel Blood-Based Liquid Biopsy Approaches in Hepatocellular Carcinoma

  2025cites this paper
• Liquid Biopsy in Hepatocellular Carcinoma: ctDNA as a Potential Biomarker for Diagnosis and Prognosis

  2025cites this paper
• LCLAT1 as a Potential Biomarker for Predicting Clinical Prognosis, Tumor Immunity, and Therapeutic Efficacy in Hepatocellular Carcinoma

  2025cites this paper
• Machine Learning-Enhanced Cerebrospinal Fluid N-Glycome for the Diagnosis and Prognosis of Primary Central Nervous System Lymphoma.

  2025cites this paper
• Research Progress on Serological Markers for Early Diagnosis of Liver Cancer

  2025cites this paper
• A Comparative Analysis of the Roles of von Willebrand Factor and ADAMTS13 in Hepatocellular Carcinoma: A Bioinformatics and Microarray-Based Study

  2025cites this paper
• Noninvasive prognostication of hepatocellular carcinoma based on cell-free DNA methylation

  2025cites this paper
• Liquid Biopsy Entering Clinical Practice: Past Discoveries, Current Insights, and Future Innovations.

  2025cites this paper
• Exploring methylation signatures for high de novo recurrence risk in hepatocellular carcinoma

  2025cites this paper
• Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma

  2025cites this paper
• Mapping QTLs associated with resistance to Streptococcus agalactiae infection in the GIFT strain of Nile tilapia (Oreochromis niloticus) by QTLseq and methyl-QTLseq

  2025cites this paper
• LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses

  2025cites this paper
• Epigenetic modifications in early stage lung cancer: pathogenesis, biomarkers, and early diagnosis

  2025cites this paper
• Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders.

  2025cites this paper
• The epigenetic basis of hepatocellular carcinoma – mechanisms and potential directions for biomarkers and therapeutics

  2025cites this paper
• The Current Role of Circulating Cell-Free DNA in the Management of Hepatocellular Carcinoma

  2025influential citation
• Biological roles and clinical applications of EpCAM in HCC

  2025cites this paper
• The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA

  2025cites this paper
• Improved circulating tumor DNA identification for detection of esophageal squamous cell carcinoma by enzymatic methyl sequencing and hybrid neural network

  2025cites this paper
• Establishing Clinically Significant Prostate Cancer Diagnosis Models Based on Serum Methylation Levels of Four Genes

  2025cites this paper
• Bioinformatics screened of biomarkers for the prognosis of hepatocellular carcinoma

  2025cites this paper
• Clinical Utility and Future Perspectives of Circulating Tumor DNA in Hepatocellular Carcinoma

  2025cites this paper
• Liquid Biopsy in Solid Tumours: An Overview

  2025cites this paper
• Advances in application of serum biomarkers for screening and early diagnosis of hepatocellular carcinoma

  2025cites this paper
• Multi-omics analyses develop and validate the optimal prognostic model on overall survival prediction for resectable hepatocellular carcinoma

  2025cites this paper
• Discovery and validation of a novel dual-target blood test for the detection of hepatocellular carcinoma across stages from cirrhosis

  2025cites this paper
• Combination of radiotherapy and ICIs in advanced hepatocellular carcinoma: A systematic review of current evidence and future prospects (Review)

  2025cites this paper
• Genomic and Biomarker Innovations in Predicting Kidney Transplant Rejection

  2025cites this paper
• Epigenetic modifications in drug-induced liver injury: A systematic review.

  2025cites this paper
• Evaluation and verification of MPDZ as a prognostic biomarker for hepatocellular carcinoma through multiple databases

  2025cites this paper
• Comprehensive Bibliometric Analysis of Prediction Models for HCC: Current Trends and Future Prospects

  2025cites this paper
• Evaluation of serum hsa_tsr014055 as a potential biomarker for diagnosis and prognosis of hepatocellular carcinoma

  2025cites this paper
• Clinical performance evaluation of a plasma dual-target methylation test for the detection of primary liver cancer: a multicenter study

  2025cites this paper
• Advancements in DNA methylation technologies and their application in cancer diagnosis

  2025cites this paper
• A novel blocker displacement qMSP assay for DNA methylation analysis at single-base resolution.

  2025cites this paper
• Update on HCC Surveillance in Patient With Hepatitis B Virus Infection With Focus on Biomarkers

  2024cites this paper
• Novel Blood-Based Biomarkers for HCC

  2024cites this paper
• New progress in the treatment of diffuse midline glioma with H3K27M alteration

  2024cites this paper
• The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications

  2024cites this paper
• A Unified Framework for Systematic Curation and Evaluation of Aging Biomarkers

  2024cites this paper
• Liquid biopsy into the clinics: Current evidence and future perspectives

  2024cites this paper
• [Epigenetics and cancer: the role of DNA methylation].

  2024cites this paper
• The Diagnostic Utility of cfDNA and ctDNA in Liquid Biopsies for Gastrointestinal Cancers over the Last Decade

  2024influential citation
• Novel biomarkers for monitoring and management of hepatocellular carcinoma

  2024cites this paper
• Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)

  2024cites this paper
• The tissue and circulating cell‐free DNA‐derived genetic landscape of premalignant colorectal lesions and its application for early diagnosis of colorectal cancer

  2024cites this paper
• Peripheral Lymphocytes in Primary Liver Cancers: Elevated NK and CD8+ T Cells and Dysregulated Selenium Metabolism

  2024cites this paper
• Digital Quantitative Detection for Heterogeneous Protein and mRNA Expression Patterns in Circulating Tumor Cells

  2024cites this paper
• Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection

  2024cites this paper
• Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application

  2024cites this paper
• Plasma cell-free DNA as predictor of disease status in patients with differentiated thyroid cancer - a prospective study from a tertiary care institution

  2024cites this paper
• Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring.

  2024cites this paper
• Cell-free DNA Fragmentomics Assay to Discriminate the Malignancy of Breast Nodules and Evaluate Treatment Response

  2024cites this paper
• Blood biomarkers of hepatocellular carcinoma: a critical review

  2024cites this paper
• Liquid biopsy in hepatocellular carcinoma: Challenges, advances, and clinical implications

  2024cites this paper
• Versatile fluorescence biosensors based on CRISPR/Cas12a for determination of site-specific DNA methylation from blood and tissues.

  2024cites this paper
• Pathogenesis and Systemic treatment of Hepatocellular Carcinoma: Current Status and Prospects.

  2024cites this paper