Pancreas Transplantation Restores Epinephrine Response and Symptom Recognition During Hypoglycemia in Patients With Long-Standing Type I Diabetes and Autonomic Neuropathy

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Diabetes

• Publication date

  1997-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/diab.46.2.249PMID 9000702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus.

  1998influential reference
• Effects of Recent, Short-Term Hyperglycemia on Responses to Hypoglycemia in Humans: Relevance to the Pathogenesis of Hypoglycemia Unawareness and Hyperglycemia-Induced Insulin Resistance

  1995cited by this paper
• Hypoglycemia: The Limiting Factor in the Management of IDDM

  1994cited by this paper
• Hypoglycemia

  1994cited by this paper
• Recovery of epinephrine response but not hypoglycemic symptom threshold after intensive therapy in type 1 diabetes.

  1994cited by this paper
• Pancreas Transplantation in Diabetic Humans Normalizes Hepatic Glucose Production During Hypoglycemia

  1994cited by this paper
• Long-term metabolic control with pancreatic transplantation.

  1994cited by this paper
• Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM

  1994cited by this paper
• Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes.

  1994cited by this paper
• Reversal of Hypoglycemia Unawareness, But Not Defective Glucose Counterregulation, in IDDM

  1994influential reference
• Persistence of counter‐regulatory abnormalities in insulin‐dependent diabetes mellitus after pancreas transplantation

  1994cited by this paper
• Hypoglycemia-Induced Autonomic Failure in IDDM is Specific for Stimulus of Hypoglycemia and Is Not Attributable to Prior Autonomic Activation

  1994cited by this paper
• Cyclosporine therapy after cardiac transplantation causes hypertension and renal vasoconstriction without sympathetic activation.

  1993cited by this paper
• Meticulous Prevention of Hypoglycemia Normalizes the Glycemic Thresholds and Magnitude of Most of Neuroendocrine Responses to, Symptoms of, and Cognitive Function During Hypoglycemia in Intensively Treated Patients With Short-Term IDDM

  1993cited by this paper
• Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits.

  1993cited by this paper
• Induction of Hypoglycemia Unawareness by Asymptomatic Nocturnal Hypoglycemia

  1993cited by this paper
• Reversibility of unawareness of hypoglycemia in patients with insulinomas.

  1993influential reference
• Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia.

  1993cited by this paper
• Iatrogenic Hypoglycemia as a Cause of Hypoglycemia-Associated Autonomic Failure in IDDM: A Vicious Cycle

  1992cited by this paper
• Intermittent Hypoglycemia Impairs Glucose Counterregulation

  1992cited by this paper
• Seminars in medicine of the Beth Israel Hospital, Boston: Pancreatic and islet transplantation for diabetes--cures or curiosities?

  1992cited by this paper
• Reduced Neuroendocrine and Symptomatic Responses to Subsequent Hypoglycemia After 1 Episode of Hypoglycemia in Nondiabetic Humans

  1991cited by this paper
• Epidemiology of severe hypoglycemia in the diabetes control and complications trial. The DCCT Research Group.

  1991cited by this paper
• Effect of pancreas transplantation on glucose counterregulation in insulin‐dependent diabetic patients prone to severe hypoglycaemia

  1991cited by this paper
• NEUROENDOCRINOLOGY OF CHRONIC RENAL FAILURE AND RENAL TRANSPLANTATION

  1991cited by this paper
• Long-term glucose control in patients with pancreatic transplants.

  1991cited by this paper
• Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts.

  1990cited by this paper
• Unawareness of Hypoglycaemia in Insulin‐treated Diabetic Patients: Prevalence and Relationship to Autonomic Neuropathy

  1990cited by this paper
• Effect of Intensive Insulin Therapy on Glycemic Thresholds for Counterregulatory Hormone Release

  1988cited by this paper
• Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus.

  1987cited by this paper
• Defective Epinephrine and Growth Hormone Responses in Type I Diabetes Are Stimulus Specific

  1987cited by this paper
• Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy.

  1983cited by this paper
• Reduced epinephrine secretion and hypoglycemia unawareness in diabetic autonomic neuropathy.

  1982cited by this paper
• Comparison of double- and single-isotope enzymatic derivative methods for measuring catecholamines in human plasma.

  1978cited by this paper

• Guía de práctica clínica sobre Diabetes Mellitus Tipo 1

  2026cites this paper
• The impact of closed-loop automated insulin delivery systems on hypoglycaemia awareness in people living with type 1 diabetes: A systematic review and meta-analysis

  2024cites this paper
• Hypoglycemia in Adults.

  2023cites this paper
• Current and future therapies to treat impaired awareness of hypoglycemia

  2023cites this paper
• Preferences for Risks and Benefits of Islet Cell Transplantation for Persons With Type 1 Diabetes With History of Episodes of Severe Hypoglycemia: A Discrete-Choice Experiment to Inform Regulatory Decisions

  2022cites this paper
• Pathophysiology and management of hypoglycemia in diabetes

  2022cites this paper
• Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events: Overview

  2022cites this paper
• First World Consensus Conference on pancreas transplantation: Part II – recommendations

  2021cites this paper
• Clinical approaches to treat impaired awareness of hypoglycaemia

  2021cites this paper
• Diabetic kidney disease and transplantation options

  2021cites this paper
• Challenges, highlights, and opportunities in cellular transplantation: A white paper of the current landscape

  2021cites this paper
• Diabetes Management Experience and the State of Hypoglycemia: National Online Survey Study

  2020cites this paper
• Reversal of secondary complications of type 1 diabetes (nephropathy, neuropathy, retinopathy, and cardiopathy)

  2020cites this paper
• Diabetes Management Experience and the State of Hypoglycemia: National Data Sample from an Online Survey

  2020cites this paper
• Health App Use and Its Correlates Among Individuals With and Without Type 2 Diabetes: Nationwide Population-Based Survey (e14396)

  2020cites this paper
• Treating diabetes with islet cell transplantation: Lessons from the Edmonton experience

  2020cites this paper
• Pancreas Retransplant After Pancreas Graft Failure in Simultaneous Pancreas-kidney Transplants Is Associated With Better Kidney Graft Survival

  2019cites this paper
• Outcomes after simultaneous kidney‐pancreas versus pancreas after kidney transplantation in the current era

  2019cites this paper
• Islet Cell Transplantation

  2019cites this paper
• Roles of catechol neurochemistry in autonomic function testing

  2018cites this paper
• Hypoglycemia.

  2018cites this paper
• S3-Leitlinie Therapie des Typ-1-Diabetes

  2018cites this paper
• Anatomy and Physiology of the Pancreas

  2018cites this paper
• Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events

  2018cites this paper
• Clinical pancreatic islet transplantation

  2017cites this paper
• Principles of Diabetes Mellitus

  2017cites this paper
• AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON TESTING FOR AUTONOMIC AND SOMATIC NERVE DYSFUNCTION.

  2017cites this paper
• First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Chapter 6: patient selection for pilot clinical trials of islet xenotransplantation

  2016cites this paper
• Alternative Quantitative Tools in the Assessment of Diabetic Peripheral and Autonomic Neuropathy.

  2016cites this paper
• Pancreas and Beta Islet Cell Transplantation - Evidence Base and Outcomes

  2016cites this paper
• Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

  2016cites this paper
• Long-term effects of islet transplantation

  2016cites this paper
• Chapter 34 – Glucagon and the Glucagon-Like Peptides

  2016cites this paper
• Impact of Pancreas Transplant on Diabetic Complications: Retinoparhy, Gastroparesis and Automatic Dysregulation

  2016cites this paper
• Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia

  2015influential citation
• Life after pancreas transplantation: reversal of diabetic lesions

  2014cites this paper
• Islet cell transplantation.

  2014cites this paper
• Kidney and Pancreas Transplantation

  2014cites this paper
• Long‐term Outcomes after Islet Transplantation

  2014cites this paper
• Neurologic complications of pancreas and small bowel transplantation.

  2014cites this paper
• Restoration of Self-Awareness of Hypoglycemia in Adults With Long-Standing Type 1 Diabetes

  2013cites this paper
• Hypoglycemia.

  2013cites this paper
• Restoration of Self-awareness of Hypoglycemia in AdultsWith Long-standing Type 1 Diabetes Hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial

  2013cites this paper
• DIABETIC STUDIES The Review of Chapter V . 1 Islet Transplantation in Type 1 Diabetes : Ongoing Challenges , Refined Procedures , and Long-Term Outcome

  2013cites this paper
• Islet transplantation in type 1 diabetes: ongoing challenges, refined procedures, and long-term outcome.

  2012cites this paper
• A Historical Perspective on Experimental and Clinical Islet Transplantation

  2012cites this paper
• Recovery of Endocrine Function After Islet and Pancreas Transplantation

  2012cites this paper
• “Brittleness” in Diabetes: Easier Spoken than Broken

  2012cites this paper
• Chapter 47 – Pancreas and Islet Cell Transplantation

  2012cites this paper
• Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Pancreas Transplantation

  2011cites this paper
• Clinical Islet Transplantation

  2011cites this paper
• Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation

  2011cites this paper
• Assessment of glycemic lability and severity of hypoglycemia in Korean patients with type 1 diabetes.

  2011cites this paper
• Regulation of human pancreas hormone secretion by autonomic innervation

  2011cites this paper
• Stomach Dysfunction in Diabetes Mellitus: Emerging Technology and Pharmacology

  2010cites this paper
• Hypoglycemia in Diabetes Mellitus

  2010cites this paper
• Update on transplanting beta cells for reversing type 1 diabetes.

  2010cites this paper
• Use of Continuous Glucose Monitoring System in the Management of Severe Hypoglycemia

  2009cites this paper
• Pancreas transplantation.

  2009cites this paper
• Restoration of Hypoglycemia Awareness After Islet Transplantation

  2008cites this paper
• Pancreas and Kidney Transplantation for Diabetic Nephropathy

  2008cites this paper
• 47 – Islet Cell Transplantation

  2008cites this paper
• Pancreatic islet cell transplant for treatment of diabetes.

  2007cites this paper
• Transplantation chez les patients diabétiques insuffisants rénaux

  2007cites this paper
• Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients.

  2007cites this paper
• Pancreas and Islet Cell Transplantation

  2006cites this paper
• Diabetes and Autonomic Neuropathy

  2006cites this paper
• Avoiding hypoglycaemia when treating type 1 diabetes

  2005cites this paper
• 2005 update: impact of pancreas and islet transplants on acute and chronic complications of diabetes

  2005cites this paper
• Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes.

  2005cites this paper
• Islet Auto‐Transplantation into an Omental or Splenic Site Results in a Normal Beta Cell but Abnormal Alpha Cell Response to Mild Non‐Insulin‐Induced Hypoglycemia

  2005cites this paper
• Diabetic neuropathies.

  2004cites this paper
• Beta-cell replacement therapy (pancreas and islet transplantation) for treatment of diabetes mellitus: an integrated approach.

  2004cites this paper
• [Pancreatic transplantation: 1. Indications and results].

  2004cites this paper
• Beta-cell replacement therapy (pancreas and islet transplantation) for treatment of diabetes mellitus: an integrated approach.

  2004cites this paper
• Pancreas transplantation: an overview

  2004cites this paper
• Endocrine Function and Metabolic Outcomes in Pancreas and Islet Transplantation

  2004cites this paper
• Effects of Pancreas Transplantation on Secondary Complications of Diabetes

  2004cites this paper
• Limitations of Nontransplant Treatment Options for Type 1 Diabetes Mellitus

  2004cites this paper
• Renal replacement therapy for diabetic patients

  2004cites this paper
• La transplantation pancréatique : 1. Indications et résultats

  2004cites this paper
• Psychiatric aspects of pancreas and islet cell transplantation

  2004cites this paper
• Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation.

  2004cites this paper
• Islet Transplantation in Patients with Type 1 Diabetes Mellitus

  2004cites this paper
• Transplantation of the Pancreas

  2004cites this paper
• Islet transplantation in patients with type 1 diabetes mellitus.

  2004cites this paper
• Consequences on beta-cell function and reserve after long-term pancreas transplantation.

  2004cites this paper
• The assessment of human islets for transplantation and the effect of the immunosuppressant rapamycin on MIN-6 cells, rat and human islets

  2004cites this paper
• Pancreas transplantation: indications and consequences.

  2004cites this paper
• Islet transplantation 2003: questions about its future

  2003cites this paper
• Clinical islet transplantation

  2003cites this paper
• Glucagon, catecholamine, and symptom responses to hypoglycemia in living donors of pancreas segments.

  2003cites this paper
• Clinical islet transplant: current and future directions towards tolerance

  2003cites this paper
• Stable α‐ and β‐Islet Cell Function After Tolerance Induction to Pancreatic Islet Allografts in Diabetic Primates

  2003cites this paper
• The role of beta-adrenergic sensitivity in the pathogenesis of hypoglycaemia unawareness.

  2002cites this paper
• Islet transplantation: Travels up the learning curve

  2002influential citation
• HLA matching for simultaneous pancreas-kidney transplantation in the United States: a multivariable analysis of the UNOS data.

  2002cites this paper
• Hypoglycemia unawareness.

  2002cites this paper
• Pancreas and islet cell transplantation.

  2002cites this paper
• Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence.

  2002influential citation