A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Organic and biomolecular chemistry

• Publication date

  2012-11-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/c2ob26022kPMID 23032938
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Time-gated luminescence assay using nonmetal probes for determination of protein kinase activity-based disease markers.

  2012cited by this paper
• ATP site-directed inhibitors of protein kinase CK2: an update.

  2011cited by this paper
• Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor.

  2011cited by this paper
• Identification of novel CK2 inhibitors with a benzofuran scaffold by novel non-radiometric in vitro assays

  2011cited by this paper
• Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.

  2011cited by this paper
• Multisite-directed inhibitors of protein kinase CK2: new challenges

  2011cited by this paper
• Antitumoral activity of allosteric inhibitors of protein kinase CK2

  2011cited by this paper
• Overview of the CCP4 suite and current developments

  2011cited by this paper
• Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.

  2011cited by this paper
• Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.

  2010cited by this paper
• Small-molecule FRET probes for protein kinase activity monitoring in living cells.

  2010cited by this paper
• CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy.

  2010cited by this paper
• Cellular regulators of protein kinase CK2

  2010cited by this paper
• Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications

  2010cited by this paper
• Features and development of Coot

  2010cited by this paper
• Protein Kinase CK2 in Health and Disease

  2009cited by this paper
• High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK.

  2009cited by this paper
• Protein Kinase CK2 in Health and Disease

  2009cited by this paper
• Extraordinary pleiotropy of protein kinase CK2 revealed by weblogo phosphoproteome analysis.

  2009cited by this paper
• Protein Kinase CK2 in Health and Disease

  2009cited by this paper
• Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.

  2009cited by this paper
• The selectivity of inhibitors of protein kinase CK2: an update.

  2008cited by this paper
• The ATP‐Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules

  2007cited by this paper
• Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction.

  2007cited by this paper
• Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases.

  2007cited by this paper
• Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases.

  2007cited by this paper
• Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits

  2006cited by this paper
• Fluorometric TLC assay for evaluation of protein kinase inhibitors.

  2005cited by this paper
• Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.

  2005cited by this paper
• Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.

  2003cited by this paper
• Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.

  2003cited by this paper
• research papers Acta Crystallographica Section D Biological

  2003cited by this paper
• Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

  2001cited by this paper
• Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 Å resolution

  1998cited by this paper
• The NTP phosphate donor in kinase reactions: is ATP a monopolist?

  1996cited by this paper
• How do protein kinases recognize their substrates?

  1996cited by this paper
• New fluorescent probes for protein kinase C. Synthesis, characterization, and application.

  1993cited by this paper
• Role of the beta subunit of casein kinase-2 on the stability and specificity of the recombinant reconstituted holoenzyme.

  1992cited by this paper
• Isolation and characterization of recombinant human casein kinase II subunits α and β from bacteria

  1991cited by this paper
• Isolation and characterization of recombinant human casein kinase II subunits alpha and beta from bacteria.

  1991cited by this paper
• Electronic Reprint Biological Crystallography Phenix : a Comprehensive Python-based System for Macromolecular Structure Solution

  year unknowncited by this paper

• Binding‐Site Switch for Protein Kinase CK2 Inhibitors

  2025cites this paper
• Novel fluoro-brominated benzotriazoles as potential CK2 inhibitors. How does fluorination affect the properties of benzotriazoles?

  2025cites this paper
• CK2 Inhibitors Targeting Inside and Outside the Catalytic Box

  2024cites this paper
• Designed dualsteric modulators: A novel route for drug discovery.

  2024cites this paper
• CK2 Chemical Probes: Past, Present, and Future

  2023cites this paper
• 5,6-diiodo-1H-benzotriazole: new TBBt analogue that minutely affects mitochondrial activity

  2021cites this paper
• Halogen Atoms in the Protein–Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2

  2021cites this paper
• Recent advances in development of hetero-bivalent kinase inhibitors.

  2021cites this paper
• Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

  2021cites this paper
• Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin.

  2021cites this paper
• Molecular Plasticity of Crystalline CK2α' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity.

  2021cites this paper
• Chemical probes targeting the kinase CK2: a journey outside the catalytic box.

  2021cites this paper
• Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.

  2020cites this paper
• Synthesis of Green/Blue Light Emitting Quinolines by Aza-D-A Reaction Using InCl3 Catalyst

  2020cites this paper
• Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.

  2020cites this paper
• Structural and mechanistic basis of the inhibitory potency of selected 2-aminothiazole compounds on protein kinase CK2.

  2020cites this paper
• Rational drug-design approach supported with thermodynamic studies — a peptide leader for the efficient bi-substrate inhibitor of protein kinase CK2

  2019cites this paper
• 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.

  2019cites this paper
• Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.

  2018cites this paper
• A Selective Biligand Inhibitor of CK2 Increases Caspase‐3 Activity in Cancer Cells and Inhibits Platelet Aggregation

  2017cites this paper
• Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′

  2017cites this paper
• Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2.

  2017cites this paper
• Development of protein kinase-responsive photoluminescent probes and cellular regulators of protein phosphorylation

  2016cites this paper
• Combining chemical and genetic approaches for photoluminescence assays of protein kinases

  2016cites this paper
• Casein kinases as potential therapeutic targets

  2016cites this paper
• LOODUS- JA TEHNOLOOGIATEADUSKOND MOLEKULAAR- JA RAKUBIOLOOGIA INSTITUUT

  2015cites this paper
• Identification of a novel potent, selective and cell permeable inhibitor of protein kinase CK2 from the NIH/NCI Diversity Set Library

  2015cites this paper
• FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases.

  2015cites this paper
• Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2α/CK2β interaction.

  2015cites this paper
• Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90β as a Novel Mechanism of Rifampin-induced MDR1 Expression*

  2015cites this paper
• Synthesis, biological activity and structural study of new benzotriazole-based protein kinase CK2 inhibitors

  2015cites this paper
• Thermodynamics parameters for binding of halogenated benzotriazole inhibitors of human protein kinase CK2α.

  2015cites this paper
• Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.

  2015cites this paper
• Acetoxymethyl Ester of Tetrabromobenzimidazole-Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells.

  2015cites this paper
• Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases.

  2014cites this paper
• A Computational Study of Allene Synthesis via the ZnI2‐Promoted Alleylation of Terminal Alkynes (ATA Reaction)

  2014cites this paper
• Chemical Biology and Proteomics for Hunting Drug Targets for Human Malaria: An Update

  2014cites this paper
• Prodrug approach for the cellular delivery of polyanionic inhibitors of protein kinase CK2

  2014cites this paper
• Shanshan Wu Optimization of ARC-Lum Based Time-Gated Photoluminescence Method for Determination of Affinities of Protein Kinase Inhibitors

  2014cites this paper
• Synthesis of novel chiral TBBt derivatives with hydroxyl moiety. Studies on inhibition of human protein kinase CK2α and cytotoxicity properties.

  2014cites this paper
• Chemical biology and proteomics for hunting drug targets for human malaria: an update

  2014cites this paper
• Selective Bisubstrate Inhibitors with Sub‐nanomolar Affinity for Protein Kinase Pim‐1

  2013cites this paper
• Kinase CK2 inhibition: an update.

  2013cites this paper