Transcription regulation by the Mediator complex

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2017-12-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrm.2017.115PMID 29209056
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mediator Complex

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• Biomolecular condensates: organizers of cellular biochemistry

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• Core Mediator structure at 3.4 Å extends model of transcription initiation complex

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• Understanding nucleosome dynamics and their links to gene expression and DNA replication

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• A Phase Separation Model for Transcriptional Control.

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• Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters

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• Dynamic Encounters of Genes and Transcripts with the Nuclear Pore.

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• A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

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• Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.

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• Epigenetic transcriptional memory

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• Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

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• Eukaryotic Transcription Regulation: Getting to the Heart of the Matter: Commentary on Mediator Architecture and RNA Polymerase II Function by Plaschka et al.

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• Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo

  2015cited by this paper
• Evolution of disorder in Mediator complex and its functional relevance

  2015cited by this paper
• Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C.

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• The S. cerevisiae SUMO stress response is a conjugation-deconjugation cycle that targets the transcription machinery.

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• Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML

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• The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

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• Architecture of the RNA polymerase II–Mediator core initiation complex

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• Molecular architecture of the yeast Mediator complex

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• The Mediator complex: a central integrator of transcription

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• Mechanisms of epigenetic memory.

  2014cited by this paper
• Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex.

  2014cited by this paper
• Redefining the modular organization of the core Mediator complex

  2014cited by this paper
• Mediator, TATA-binding Protein, and RNA Polymerase II Contribute to Low Histone Occupancy at Active Gene Promoters in Yeast*

  2014cited by this paper
• Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.

  2014cited by this paper
• TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.

  2014cited by this paper
• Reconstitution of active human core Mediator complex reveals a pivotal role of the MED14 subunit

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• Coupling mRNA processing with transcription in time and space

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• Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export

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• A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

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• Kin28 regulates the transient association of Mediator with core promoters

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• Involvement of Mediator complex in malignancy.

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• Model of the Mediator middle module based on protein cross-linking

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• The Mediator complex and transcription regulation

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• Super-enhancers in the control of cell identity and disease.

  2013cited by this paper
• Selective inhibition of tumor oncogenes by disruption of super-enhancers.

  2013cited by this paper
• Master transcription factors and mediator establish super-enhancers at key cell identity genes.

  2013cited by this paper
• The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

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• Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics.

  2013cited by this paper
• Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment

  2013cited by this paper
• Mediator-regulated transcription through the +1 nucleosome.

  2012cited by this paper
• Structure of the Mediator head module

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• Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions*

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• Proteomic Analysis Demonstrates Activator- and Chromatin-specific Recruitment to Promoters*

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• The RNA polymerase II CTD coordinates transcription and RNA processing.

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• A structural perspective on Mediator function.

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• MED23 Mutation Links Intellectual Disability to Dysregulation of Immediate Early Gene Expression

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• The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.

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• The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.

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• Structure and VP16 binding of the Mediator Med25 activator interaction domain

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• Genome-wide structure and organization of eukaryotic pre-initiation complexes

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• Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

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• Direct Interaction of RNA Polymerase II and Mediator Required for Transcription in Vivo

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• Histone modifications influence mediator interactions with chromatin

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• Mediator and human disease.

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• MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer

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• Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitro

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• Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

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• Architecture of the Mediator head module

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• A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces.

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• Malleable Machines in Transcription Regulation: The Mediator Complex

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