Ionizing radiation and genetic risks. III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Mutation research

• Publication date

  1991-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/0165-1110(91)90029-UPMID 2023601
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Preferential location of x-ray induced chromosome breakage in the R-bands of human chromosomes.

  2009cited by this paper
• High resolution studies on the pattern of induced exchanges in the human karyotype

  2004cited by this paper
• Detection of the carrier state for an X-linked disorder, the Lesch-Nyhan syndrome, by the use of lymphocyte cloning

  2004cited by this paper
• Ionizing radiation and genetic risks. I. Epidemiological, population genetic, biochemical and molecular aspects of Mendelian diseases.

  1991cited by this paper
• Ionizing radiation and genetic risks. II. Nature of radiation-induced mutations in experimental mammalian in vivo systems.

  1991cited by this paper
• Assay for somatic mutation of human hemoglobins.

  1990cited by this paper
• Molecular nature of in vivo mutations in human cells at the autosomal HLA-A locus.

  1990cited by this paper
• The structure of mutation in mammalian cells.

  1990cited by this paper
• Human somatic mutation at the autosomal HLA-A locus.

  1990cited by this paper
• Southern-blot analyses of human T-lymphocyte mutants induced in vitro by γ-irradiation

  1990cited by this paper
• Human somatic mutation at the autosomal HLA-A locus.

  1990cited by this paper
• hprt mutations in vivo in human T-lymphocytes: frequencies, spectra and clonality.

  1990cited by this paper
• Review of the molecular characteristics of gene mutations of the germline and somatic cells of the human.

  1990cited by this paper
• Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells.

  1990cited by this paper
• Microdosimetric Constraints on Specific Adaption Mechanisms to Reduce DNA Damage Caused by Ionising Radiation

  1990cited by this paper
• Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells.

  1990cited by this paper
• Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.

  1990cited by this paper
• HPRT somatic mutation data.

  1990cited by this paper
• Mutations affecting RNA splicing in man are detected more frequently in somatic than in germ cells.

  1990cited by this paper
• Localization of deletion breakpoints in radiation-induced mutants of the hprt gene in hamster cells.

  1990cited by this paper
• Southern-blot analyses of human T-lymphocyte mutants induced in vitro by gamma-irradiation.

  1990cited by this paper
• Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells.

  1990cited by this paper
• Evidence for the dominance of direct excitation of DNA in the formation of strand breaks in cells following irradiation.

  1989cited by this paper
• Molecular characterization of thymidine kinase mutants of human cells induced by densely ionizing radiation.

  1989cited by this paper
• Endogenous DNA damage as related to cancer and aging.

  1989cited by this paper
• DNA sequence determination of γ-radiation-induced mutations of the hamster aprt locus

  1989cited by this paper
• 12 – Specific Sites of Chromosomal Radiation-induced Rearrangements

  1989cited by this paper
• 9 – Mutation at the hprt Locus in Human T-lymphocytes: In Vivo and In Vitro Studies

  1989cited by this paper
• Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.

  1989cited by this paper
• Detection of somatic mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors using a single beam flow sorter.

  1989cited by this paper
• Longitudinal study of the in vivo hprt mutant frequency in human T‐lymphocytes as determined by a cell cloning assay

  1989cited by this paper
• Molecular analysis of spontaneous and ethyl methanesulphonate-induced mutations of the hprt gene in hamster cells.

  1989cited by this paper
• Molecular analyses of in vivo hprt mutations in human T-lymphocytes. III. Longitudinal study of hprt gene structural alterations and T-cell clonal origins.

  1989cited by this paper
• DNA sequence determination of gamma-radiation-induced mutations of the hamster aprt locus.

  1989cited by this paper
• The nature of spontaneous mutations.

  1989cited by this paper
• The HLA-A mutation assay: improved technique and normal results.

  1989cited by this paper
• Detection of somatic mutants in man: HPRT mutations in lymphocytes and hemoglobin mutations in erythrocytes.

  1989cited by this paper
• Molecular analyses of in vivo hprt mutant T cells from atomic bomb survivors

  1989cited by this paper
• Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective.

  1989cited by this paper
• Multiple endpoints for somatic mutations in humans provide complementary views for biodosimetry, genotoxicity and health risks.

  1989cited by this paper
• Generation of oxy radicals in biosystems.

  1989cited by this paper
• Molecular basis of spontaneous mutation at the aprt locus of hamster cells.

  1989cited by this paper
• Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells.

  1988cited by this paper
• The CpG dinucleotide and human genetic disease

  1988cited by this paper
• Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level.

  1988cited by this paper
• Biochemical and cellular mechanisms of low-dose effects.

  1988cited by this paper
• Solitons and energy transfer in DNA

  1988cited by this paper
• Use of T cell cloning to detect in vivo mutations induced by cyclophosphamide.

  1988cited by this paper
• Mutations in human lymphocytes studied by an HLA selection system.

  1988cited by this paper
• DNA sequence analysis of X-ray-induced deletions at the white locus of Drosophila melanogaster.

  1988cited by this paper
• Human genome organization: Alu, lines, and the molecular structure of metaphase chromosome bands.

  1988cited by this paper
• DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.

  1988cited by this paper
• HLA disease associations: models for insulin dependent diabetes mellitus and the study of complex human genetic disorders.

  1988cited by this paper
• Molecular characterization of a beta zero-thalassemia resulting from a 1.4 kilobase deletion.

  1988cited by this paper
• Mapping large spontaneous deletion endpoints in the human HPRT gene.

  1988cited by this paper
• Ionizing radiation-induced mutagenesis.

  1988cited by this paper
• Oxidative damage to DNA: relation to species metabolic rate and life span.

  1988cited by this paper
• Mutagenicity monitoring in humans by autoradiographic assay for mutant T lymphocytes.

  1988cited by this paper
• Mutations in human lymphocytes commonly involve gene duplication and resemble those seen in cancer cels.

  1988cited by this paper
• Mutation rate of normal and malignant human lymphocytes.

  1987cited by this paper
• Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate

  1987cited by this paper
• DNA Repair in Specific Sequences in Mammalian Cells

  1987cited by this paper
• Sequence, structure and promoter characterization of the human thymidine kinase gene.

  1987cited by this paper
• Evidence for increased somatic cell mutations at the glycophorin A locus in atomic bomb survivors.

  1987cited by this paper
• Preferential DNA repair in expressed genes.

  1987cited by this paper
• Molecular and biochemical analyses of spontaneous and X-ray-induced mutants in human lymphoblastoid cells.

  1987cited by this paper
• The nature of mutants induced by ionising radiation in cultured hamster cells. III. Molecular characterization of HPRT-deficient mutants induced by gamma-rays or alpha-particles showing that the majority have deletions of all or part of the hprt gene.

  1986cited by this paper
• Molecular basis of X-ray-induced mutation at the HPRT locus in human lymphocytes.

  1986cited by this paper
• Southern analysis of genomic alterations in gamma-ray-induced aprt- hamster cell mutants.

  1986cited by this paper
• Spontaneous deletion formation at the aprt locus of hamster cells: the presence of short sequence homologies and dyad symmetries at deletion termini.

  1986cited by this paper
• Effect of gamma rays at the dihydrofolate reductase locus: Deletions and inversions

  1986cited by this paper
• X-rays mutate human lymphoblast cells at genetic loci that should respond only to point mutagens.

  1986cited by this paper
• Fine structure of the human hypoxanthine phosphoribosyltransferase gene

  1986cited by this paper
• Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

  1986cited by this paper
• Measurements of the frequency of human erythrocytes with gene expression loss phenotypes at the glycophorin A locus

  1986cited by this paper
• Spontaneous splicing mutations at the dihydrofolate reductase locus in Chinese hamster ovary cells

  1986cited by this paper
• Measurement of low levels of x-ray mutagenesis in relation to human disease.

  1986cited by this paper
• Structure and sequence of mutations induced by ionizing radiation at selectable loci in Chinese hamster ovary cells.

  1986cited by this paper
• Nucleotide sequence of hamster adenine phosphoribosyl transferase (aprt) gene.

  1986cited by this paper
• DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall.

  1985cited by this paper
• In vivo somatic mutations in human lymphocytes frequently result from major gene alterations

  1985cited by this paper
• Chemical changes induced in DNA by ionizing radiation.

  1985cited by this paper
• Microdosimetric Approach to the Analysis of Cell Responses at Low Dose and Low Dose Rate

  1985cited by this paper
• Abnormal distribution of double strand breaks in DNA after direct action of ionizing energy.

  1985cited by this paper
• The molecular nature of mutations in cultured mammalian cells: a review.

  1985cited by this paper
• Flow cytometric characterization of normal and variant cells with monoclonal antibodies specific for glycophorin A.

  1985cited by this paper
• Somatic gene mutations in vivo as indicated by the 6-thioguanine-resistant T-lymphocytes in human blood.

  1985cited by this paper
• Use of fluorescence-activated cell sorter to isolate mutant mammalian cells deficient in an internal protein, dihydrofolate reductase

  1985cited by this paper
• Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells

  1984cited by this paper
• Mutation frequency in human lymphocytes increases with age.

  1984cited by this paper
• Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

  1984cited by this paper
• Measurement of spontaneous and X-irradiation-induced 6-thioguanine-resistant human blood lymphocytes using a T-cell cloning technique.

  1984cited by this paper
• Mutations in human lymphocytes: effect of X- and UV-irradiation.

  1984cited by this paper
• Mutations in human lymphocytes effect of x irradiation and uv irradiation

  1984cited by this paper
• Unexpected relationships between four large deletions in the human beta-globin gene cluster.

  1983cited by this paper
• Structure of mutant alleles at the aprt locus of Chinese hamster ovary cells.

  1983cited by this paper
• Monoclonal antibodies specific for the M- and N-forms of human glycophorin A.

  1983cited by this paper
• Genomic cloning and preliminary characterization of the human thymidine kinase gene.

  1983cited by this paper
• Measurement of in vivo mutations in human lymphocytes

  1983cited by this paper
• Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells.

  1983cited by this paper

• Dose and LET-Dependence of Gastric Cancer Risk in Apc1638N/+ Mice Exposed to Space-Relevant Radiation Types

  2026cites this paper
• Development of Live Attenuated Salmonella Typhimurium Vaccine Strain Using Radiation Mutation Enhancement Technology (R-MET)

  2022cites this paper
• The effects of short-term calorie restriction on mutations in the spleen cells of infant-irradiated mice

  2020cites this paper
• Overview of biological mechanisms of human carcinogens

  2019cites this paper
• Characterization of genome-wide variations induced by gamma-ray radiation in barley using RNA-Seq

  2019cites this paper
• Radiation-induced DNA-protein cross-links: Mechanisms and biological significance.

  2017cites this paper
• Can consumption of raw vegetables decrease the count of sister chromatid exchange? Results from a cross-sectional study in Krakow, Poland

  2014cites this paper
• Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия

  2013cites this paper
• Ionizing radiation and genetic risks. XVII. Formation mechanisms underlying naturally occurring DNA deletions in the human genome and their potential relevance for bridging the gap between induced DNA double-strand breaks and deletions in irradiated germ cells.

  2013cites this paper
• Chronic exposure to the cytolethal distending toxins of Gram‐negative bacteria promotes genomic instability and altered DNA damage response

  2013cites this paper
• Chapter VIII Molecular analysis of in vivo irradiated blood for mutations in the nras, p53 and DNA repair genes – XRCC1 and XPD

  2012cites this paper
• Studies on the genoprotective/antioxidant potential of methanol extract of Anthocephalus cadamba (Roxb.) Miq

  2011cites this paper
• Ionising radiation and genetic risks. XVI. A genome-based framework for risk estimation in the light of recent advances in genome research

  2011cites this paper
• Experimental Models for Ionizing Radiation Research

  2011cites this paper
• Assessment of heritable genetic effects using new genetic tools and sentinels in an era of personalized medicine

  2011cites this paper
• Ionizing Radiation as a Carcinogen

  2010cites this paper
• Genetic variation in mutants of black gram (Vigna mungo (L.) Hepper) evaluated by RAPD markers

  2010cites this paper
• EMS mutant spectra generated by multi-parameter flow cytometry.

  2009cites this paper
• Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

  2009cites this paper
• What are the Long-Term Dangers of Radiation Fallout from Nuclear Weapons Testing?

  2009cites this paper
• Numt-Mediated Double-Strand Break Repair Mitigates Deletions during Primate Genome Evolution

  2008cites this paper
• Cancer Induction and Dose-Response Models

  2008cites this paper
• Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect.

  2008cites this paper
• Morphologic Characteristics of Chernobyl-Related Childhood Papillary Thyroid Carcinomas Are Independent of Radiation Exposure but Vary with Iodine Intake

  2008cites this paper
• Ultra Violet –B Induced DNA Damage in Human Leucocyte Cells

  2008cites this paper
• Effects on Genetic Material

  2008cites this paper
• Radiation carcinogenesis: lessons from Chernobyl

  2008cites this paper
• New approaches to assessing the effects of mutagenic agents on the integrity of the human genome.

  2007cites this paper
• Molecular characterisation of radiation-induced human HPRT mutant clones

  2007cites this paper
• Effects of organosulfurs, isothiocyanates and vitamin C towards hydrogen peroxide-induced oxidative DNA damage (strand breaks and oxidized purines/pyrimidines) in human hepatoma cells.

  2007cites this paper
• Analysis of Common Deletion (CD) and a novel deletion of mitochondrial DNA induced by ionizing radiation

  2007cites this paper
• Study of DNA damage induced by dental bleaching agents in vitro.

  2006cites this paper
• Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks.

  2006cites this paper
• Genetic effects of radiation in atomic-bomb survivors and their children: past, present and future.

  2006cites this paper
• Extreme cytotoxicity and susceptibility to hprt mutagenesis in Ku-deficient xrs-6 cells treated with bleomycin in plateau phase.

  2005cites this paper
• Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay.

  2005cites this paper
• Mutations in Lung Cancer following Radiation Therapy for Hodgkin ’ s Disease

  2005cites this paper
• Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response.

  2005cites this paper
• Genetic and epigenetic features in radiation sensitivity

  2005cites this paper
• Genetic and epigenetic features in radiation sensitivity

  2005cites this paper
• Nicotinamide "protects" resting lymphocytes exposed to hydrogen peroxide from necrosis but not from apoptosis

  2004cites this paper
• Molecular biology methods in assessing radiation-induced hereditary risks in humans

  2004cites this paper
• Prevention of oxidative injury in PC12 cells by a traditional Chinese medicine, Shengmai San, as a model of an antioxidant-based composite formula.

  2003cites this paper
• Acridine mutagenesis of zebrafish (Danio rerio).

  2003cites this paper
• Genetic susceptibility to thymic lymphomas and K‐ras gene mutation in mice after exposure to X‐rays and N‐ethyl‐N‐nitrosourea

  2002cites this paper
• CHILDHOOD LEUKAEMIA AND RADIATION: THE SELLAFIELD JUDGMENT

  2002cites this paper
• Cancer after nuclear fallout: lessons from the Chernobyl accident

  2002cites this paper
• Base Substitutions, Targeted Single-Base Deletions, and Chromosomal Translocations Induced by Bleomycin in Plateau-Phase Mammary Epithelial Cells

  2002cites this paper
• Hydrogen peroxide–induced DNA damage and DNA repair in lymphocytes from malnourished children

  2002cites this paper
• Heavy‐ion‐induced mutations in the gpt delta transgenic mouse: Comparison of mutation spectra induced by heavy‐ion, X‐ray, and γ‐ray radiation

  2002cites this paper
• Analysis of mutational effects at the HPRT locus in human G(0) phase lymphocytes irradiated in vitro with gamma rays.

  2001cites this paper
• Simulation of Exon Deletion Mutations Induced by Low-LET Radiation at the HPRT Locus

  2001cites this paper
• Multiple manifestations of X‐ray–induced genomic instability in Chinese hamster ovary (CHO) cells

  2001cites this paper
• Dose-Dependent Changes in the Spectrum of Mutations Induced by Ionizing Radiation

  2000cites this paper
• sources and effects of ionizing radiation

  2000cites this paper
• Radiation-induced mutations in the spleen and brain of lacZ transgenic mice.

  2000cites this paper
• Ionizing radiation and genetic risks. XIII. Summary and synthesis of papers VI to XII and estimates of genetic risks in the year 2000.

  2000cites this paper
• Gene rearrangement and Chernobyl related thyroid cancers

  2000cites this paper
• IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS

  2000cites this paper
• Ionizing radiation and genetic risks. X. The potential "disease phenotypes" of radiation-induced genetic damage in humans: perspectives from human molecular biology and radiation genetics.

  1999cites this paper
• Molecular nature of mutations induced by a high dose of x‐rays in spleen, liver, and brain of the lacZ‐transgenic mouse

  1999cites this paper
• Quantitative correlation between radiation‐induced mutagenesis in endogenous genes and transgenes of mouse spermatogonial stem cells

  1999cites this paper
• Chromosomal Damages and Mutagenesis in Mammalian and Human Cells Induced by Ionizing Radiation with Different LET

  1999cites this paper
• Polymerase chain reaction-based deletion screening of bisulfite (sulfur dioxide)-enhanced gpt-mutants in CHO-AS52 cells.

  1999cites this paper
• The protective activity of alpha-hederine against H2O2 genotoxicity in HepG2 cells by alkaline comet assay.

  1999cites this paper
• DNA synthesis on discontinuous templates by human DNA polymerases: implications for non-homologous DNA recombination.

  1998cites this paper
• Pooled analysis of p53 mutations in hematological malignancies

  1998cites this paper
• Deletion-pattern analysis of alpha-particle and X-ray induced mutations at the HPRT locus of V79 Chinese hamster cells.

  1998cites this paper
• Mutation studies in lacI transgenic mice after exposure to radiation or cyclophosphamide.

  1998cites this paper
• Enzymatic processing of radiation-induced free radical damage in DNA.

  1998cites this paper
• Genetic susceptibility to cancer. ICRP publication 79. Approved by the Commission in May 1997. International Commission on Radiological Protection.

  1998cites this paper
• Quantitative and qualitative comparisons of spontaneous and radiation-induced specific-locus mutation in the ad-3 region of heterokaryon 12 of Neurospora crassa.

  1997cites this paper
• Quantitative and qualitative comparison of spontaneous and chemical-induced specific-locus mutation in the ad-3 region of heterokaryon 12 of Neurospora crassa.

  1997cites this paper
• Study of DNA damage induction and repair capacity of fresh and cryopreserved lymphocytes exposed to H2O2 and gamma-irradiation with the alkaline comet assay.

  1997cites this paper
• X-ray- and ultraviolet-radiation-induced mutations in Muta mouse.

  1997cites this paper
• Molecular analysis of mutations in T‐lymphocytes from experienced Soviet cosmonauts

  1997cites this paper
• Mutation: Induction by Ionizing Radiation and Chemicals

  1997cites this paper
• Molecular evidence for the induction of large interstitial deletions on mouse chromosome 8 by ionizing radiation.

  1997cites this paper
• Genetic and cytogenetic markers of exposure to high-linear energy transfer radiation.

  1997cites this paper
• Molecular markers of ionizing radiation-induced gene mutations in mammalian cells.

  1996cites this paper
• Polymerase chain reaction-based deletion analysis of spontaneous and arsenite-enhanced gpt mutants in CHO-AS52 cells.

  1996cites this paper
• Mutation induction in gamma-irradiated primary human bronchial epithelial cells and molecular analysis of the HPRT- mutants.

  1996cites this paper
• p53 mutations in lung cancer following radiation therapy for Hodgkin's disease.

  1996cites this paper
• Environmental chemical mutagens and genetic risks: Lessons from radiation genetics

  1996cites this paper
• Biological mechanisms of radiation carcinogenesis.

  1996cites this paper
• Genomic instability induced by ionizing radiation.

  1996cites this paper
• The molecular nature of spontaneous mutations at the hprt locus in the radiosensitive CHO mutant xrs-5.

  1996cites this paper
• Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro.

  1995cites this paper
• Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system.

  1995cites this paper
• Radiation Injury and Radiation Carcinogenesis with Special Reference to Combination Effects with Chemical Agents

  1995cites this paper
• Leukaemia and Sellafield: is there a heritable link?

  1995cites this paper
• A kinetic model for subtractive hybridization

  1995cites this paper
• Ionizing radiation and genetic risks. V. Multifactorial diseases: a review of epidemiological and genetic aspects of congenital abnormalities in man and of models on maintenance of quantitative traits in populations.

  1994cites this paper
• The Seascale childhood leukaemia cases-the mutation rates implied by paternal preconceptional radiation doses

  1994cites this paper
• Childhood leukaemia and Sellafield: the legal cases

  1994cites this paper
• Working paper no. 6 Estimation of genetic risks of exposure to chemical mutagens: relevance of data on spontaneous mutations and of experience with ionizing radiation

  1994cites this paper
• DNA damages processed by base excision repair: biological consequences.

  1994cites this paper
• Multiplex polymerase chain reaction-based deletion analysis of spontaneous, gamma ray- and alpha-induced hprt mutants of CHO-K1 cells.

  1994cites this paper
• Southern blot and polymerase chain reaction exon analyses of HPRT- mutations induced by radon and radon progeny.

  1994cites this paper
• Isolation and quantification of class 1 MHC gene mutants in mouse T cells by immunoselection with a magnetic cell sorter (MACS).

  1994cites this paper