Deep Brain Stimulation of the Midbrain Locomotor Region Improves Paretic Hindlimb Function After Spinal Cord Injury in Rats

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Science Translational Medicine

• Publication date

  2013-10-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.1126/scitranslmed.3005972PMID 24154600
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The multifunctional mesencephalic locomotor region.

  2013influential reference
• Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

  2012cited by this paper
• Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats

  2012cited by this paper
• Fiji: an open-source platform for biological-image analysis

  2012cited by this paper
• Delayed Anti-Nogo-A Antibody Application after Spinal Cord Injury Shows Progressive Loss of Responsiveness

  2012cited by this paper
• Multi-system neurorehabilitative strategies to restore motor functions following severe spinal cord injury.

  2012cited by this paper
• Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.

  2012cited by this paper
• The pedunculopontine nucleus area: critical evaluation of interspecies differences relevant for its use as a target for deep brain stimulation.

  2011cited by this paper
• A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury

  2011cited by this paper
• Recovery of hindlimb locomotion after incomplete spinal cord injury in the cat involves spontaneous compensatory changes within the spinal locomotor circuitry.

  2011cited by this paper
• Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.

  2011cited by this paper
• Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study.

  2011cited by this paper
• Spinal projections from the presumptive midbrain locomotor region in the mouse

  2011cited by this paper
• Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion

  2010cited by this paper
• Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents

  2010cited by this paper
• Emerging Repair, Regeneration, and Translational Research Advances for Spinal Cord Injury

  2010cited by this paper
• Rewiring of hindlimb corticospinal neurons after spinal cord injury

  2010cited by this paper
• Anti‐Nogo on the go: from animal models to a clinical trial

  2010cited by this paper
• Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors

  2010cited by this paper
• Projections from the brain to the spinal cord in the mouse

  2010cited by this paper
• Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury.

  2009cited by this paper
• Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

  2009cited by this paper
• Imaging the spread of reversible brain inactivations using fluorescent muscimol

  2008cited by this paper
• Imaging the spread of reversible brain inactivations using fluorescent muscimol.

  2008cited by this paper
• Constraint-Induced Movement Therapy in the Adult Rat after Unilateral Corticospinal Tract Injury

  2008cited by this paper
• Bilateral pedunculopontine nuclei strokes presenting as freezing of gait

  2008cited by this paper
• Descending command systems for the initiation of locomotion in mammals.

  2008cited by this paper
• Ankle dexterity is less impaired than muscle strength in incomplete spinal cord lesion

  2008cited by this paper
• Characteristics and mechanisms of locomotion induced by intraspinal microstimulation and dorsal root stimulation in spinal cats.

  2007cited by this paper
• Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.

  2007cited by this paper
• Locomotor-Related Networks in the Lumbosacral Enlargement of the Adult Spinal Cat: Activation Through Intraspinal Microstimulation

  2006cited by this paper
• Contribution of spinal 5‐HT1A and 5‐HT7 receptors to locomotor‐like movement induced by 8‐OH‐DPAT in spinal cord‐transected mice

  2006cited by this paper
• Locomotor circuits in the mammalian spinal cord.

  2006cited by this paper
• Biological pattern generation: the cellular and computational logic of networks in motion.

  2006cited by this paper
• A randomized trial of deep-brain stimulation for Parkinson's disease.

  2006cited by this paper
• A form of motor cortical plasticity that correlates with recovery of function after brain injury.

  2006cited by this paper
• Hindlimb stepping movements in complete spinal rats induced by epidural spinal cord stimulation.

  2005cited by this paper
• Mechanisms for selection of basic motor programs--roles for the striatum and pallidum.

  2005cited by this paper
• Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease

  2005cited by this paper
• Midbrain ataxia: an introduction to the mesencephalic locomotor region and the pedunculopontine nucleus.

  2005cited by this paper
• Reversible cooling of the brainstem reveals areas required for mesencephalic locomotor region evoked treadmill locomotion

  2004influential reference
• Lumbar commissural interneurons with reticulospinal inputs in the cat: Morphology and discharge patterns during fictive locomotion

  2004influential reference
• Role of basal ganglia-brainstem pathways in the control of motor behaviors.

  2004cited by this paper
• Ontogeny of human locomotor control I. Infant stepping, supported locomotion and transition to independent locomotion

  2004cited by this paper
• Anatomical correlates of return of locomotor function after partial spinal cord lesions in cats

  2004cited by this paper
• The motor infrastructure: from ion channels to neuronal networks

  2003cited by this paper
• Bimodal Locomotion Elicited by Electrical Stimulation of the Midbrain in the Salamander Notophthalmus viridescens

  2003cited by this paper
• Do human bipeds use quadrupedal coordination?

  2002cited by this paper
• Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord.

  2002cited by this paper
• The pedunculopontine nucleus and Parkinson's disease.

  2000cited by this paper
• Role of the motor cortex in the control of visually triggered gait modifications.

  1996cited by this paper
• Locomotor capacities after complete and partial lesions of the spinal cord.

  1996cited by this paper
• Locomotor activity in spinal man.

  1994cited by this paper
• Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats.

  1993cited by this paper
• Activity of medullary reticulospinal neurons during fictive locomotion.

  1993cited by this paper
• The role of the motor cortex in the control of accuracy of locomotor movements in the cat.

  1993cited by this paper
• Comparison of the connectional properties of the two forelimb areas of the rat sensorimotor cortex: support for the presence of a premotor or supplementary motor cortical area.

  1993cited by this paper
• The role of the motor cortex in the control of vigour of locomotor movements in the cat.

  1993cited by this paper
• The effect of selective brainstem or spinal cord lesions on treadmill locomotion evoked by stimulation of the mesencephalic or pontomedullary locomotor regions

  1991influential reference
• Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

  1990cited by this paper
• Locomotion produced in mesencephalic cats by injections of putative transmitter substances and antagonists into the medial reticular formation and the pontomedullary locomotor strip

  1988cited by this paper
• Descending pathways to the spinal cord: A comparative study of 22 mammals

  1988cited by this paper
• The supraspinal control of mammalian locomotion.

  1988cited by this paper
• Recovery of locomotion after chronic spinalization in the adult cat.

  1987cited by this paper
• The mesencephalic locomotor region. II. Projections to reticulospinal neurons.

  1987cited by this paper
• Stimulation of the pontomedullary reticular formation initiates locomotion in decerebrate birds.

  1987cited by this paper
• The basal ganglia and the locomotor regions.

  1986cited by this paper
• Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat.

  1986cited by this paper
• Chemical activation of the mesencephalic locomotor region.

  1985cited by this paper
• The mesencephalic locomotor region (MLR) in the rat.

  1984cited by this paper
• Autoradiographic demonstration of the projections from the mesencephalic locomotor region.

  1984cited by this paper
• Connections of the mesencephalic locomotor region (MLR) II. Afferents and efferents.

  1983cited by this paper
• Locomotor control in macaque monkeys.

  1981cited by this paper
• Topographical organization in medullary reticulospinal systems as demonstrated by the horseradish peroxidase technique.

  1979cited by this paper
• Autoradiographic studies of the projections of the midbrain reticular formation: Descending projections of nucleus cuneiformis

  1975cited by this paper
• [Control of walking and running by means of electric stimulation of the midbrain].

  1966influential reference
• Control of walking and running by means of electric stimulation of the midbrain

  1966cited by this paper
• Motor performance of monkeys after bilateral partial and total cerebral decortications.

  1956cited by this paper
• ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 860: 83-93 (1998) Initiation of Locomotion in Mammals

  year unknowncited by this paper

• Stereotactic rodent-to-human approximation of the mesencephalic cuneiform nucleus to guide deep brain stimulation.

  2026cites this paper
• Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord

  2025cites this paper
• Combining cortical and spinal stimulation maximizes the improvement of gait after spinal cord injury

  2025cites this paper
• Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis

  2025influential citation
• Mechanisms of Parkinsonism Development and Novel Approaches to Multisystem Neurorehabilitation

  2025cites this paper
• Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia

  2025influential citation
• Deep brain stimulation for chronic pain: mechanisms, clinical applications, limitations, and future directions

  2025cites this paper
• Netrin-1 Therapy Restores Partial Hindlimb Movement in a Rat Model of High-Severity Chronic Spinal Cord Injury.

  2025cites this paper
• Deep brain stimulation of the mesencephalic locomotor region or lateral hypothalamus for facilitation of walking after spinal cord injury.

  2025cites this paper
• Deep Brain Stimulation and Brain–Spine Interface for Functional Restoration in Spinal Cord Injury

  2025influential citation
• The mesencephalic locomotor region in neurological disorders: A narrative review of evolutionary conservation, functional connectivity, and clinical translation

  2025cites this paper
• Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord

  2025cites this paper
• Frontier Integration in Spinal Cord Injury Repair: Engineering-Driven Mechanistic Exploration and a New Paradigm for Clinical Translation

  2025cites this paper
• Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice

  2025cites this paper
• Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats

  2025cites this paper
• Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease.

  2025cites this paper
• Harnessing spinal circuit reorganization for targeted functional recovery after spinal cord injury.

  2025cites this paper
• New Insights into Freezing of Gait in Parkinson's Disease from Spectral Dynamic Causal Modeling

  2024cites this paper
• Spatiotemporal spinal cord stimulation with real‐time triggering exoskeleton restores walking capability: a case report

  2024cites this paper
• DBS in the restoration of motor functional recovery following spinal cord injury

  2024cites this paper
• Hypothalamic deep brain stimulation augments walking after spinal cord injury

  2024cites this paper
• Microstimulation-based path tracking control of pigeon robots through parameter adaptive strategy

  2024cites this paper
• Efficacy and safety of deep brain stimulation in mesencephalic locomotor region for motor function in patients with post-stroke hemiplegia: a study protocol for a multi-center double-blind crossover randomized controlled trial

  2024cites this paper
• Magnetic Stimulation of Gigantocellular Reticular Nucleus with Iron Oxide Nanoparticles Combined Treadmill Training Enhanced Locomotor Recovery by Reorganizing Cortico-Reticulo-Spinal Circuit

  2024cites this paper
• Intracranial Neuromodulation for Neurologic Recovery

  2024cites this paper
• Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders

  2024cites this paper
• The Impact of Treadmill Training on Tissue Integrity, Axon Growth, and Astrocyte Modulation

  2024cites this paper
• Electrical stimulation of the cuneiform nucleus enhances the effects of rehabilitative training on locomotor recovery after incomplete spinal cord injury

  2024cites this paper
• Brain Plasticity in Patients with Spinal Cord Injuries: A Systematic Review

  2024cites this paper
• Brain region changes following a spinal cord injury.

  2024cites this paper
• Application and Mechanism of Electrical Neuromodulation Techniques for Rehabilitation of Spinal Cord Injury

  2024cites this paper
• Invasive Brain Computer Interface for Motor Restoration in Spinal Cord Injury: A Systematic Review.

  2023cites this paper
• Locomotor pattern generation and descending control: a historical perspective.

  2023cites this paper
• Grade-control outdoor turning flight of robo-pigeon with quantitative stimulus parameters

  2023cites this paper
• Dystonia-like behaviors and impaired sensory–motor integration following neurotoxic lesion of the pedunculopontine tegmental nucleus in mice

  2023cites this paper
• Application of Vagus Nerve Stimulation in Spinal Cord Injury Rehabilitation.

  2023cites this paper
• Neuromorphic bioelectronic medicine for nervous system interfaces: from neural computational primitives to medical applications

  2023cites this paper
• A bi-cortical neuroprosthesis to modulate locomotion after incomplete spinal cord injury

  2023cites this paper
• Integrated software for multi-dimensional analysis of motion using tracking, electrophysiology, and sensor signals

  2023cites this paper
• Stimulation of the cuneiform nucleus enables training and boosts recovery after spinal cord injury

  2022cites this paper
• From retina to motoneurons: A substrate for visuomotor transformation in salamanders

  2022cites this paper
• The History of Stereotactic and Functional Neurosurgery in Zurich

  2022cites this paper
• Corticospinal circuit neuroplasticity may involve silent synapses: Implications for functional recovery facilitated by neuromodulation after spinal cord injury

  2022cites this paper
• Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury

  2022cites this paper
• The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

  2022cites this paper
• Acute Hypobaric Hypoxia Exposure Causes Neurobehavioral Impairments in Rats: Role of Brain Catecholamines and Tetrahydrobiopterin Alterations

  2022cites this paper
• Cholinergic Modulation of Locomotor Circuits in Vertebrates

  2022cites this paper
• Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury

  2022cites this paper
• Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury

  2022cites this paper
• The Mesencephalic Locomotor Region: Beyond Locomotor Control

  2022cites this paper
• Targeting the motor cortex to restore walking after incomplete spinal cord injury

  2021influential citation
• Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson’s disease

  2021cites this paper
• Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

  2021cites this paper
• Restoring Sensorimotor Function Through Neuromodulation After Spinal Cord Injury: Progress and Remaining Challenges

  2021cites this paper
• Combined neuromodulatory approaches in the central nervous system for treatment of spinal cord injury

  2021cites this paper
• Deep brain stimulation for locomotion in incomplete human spinal cord injury (DBS-SCI): protocol of a prospective one-armed multi-centre study

  2021cites this paper
• Restoration of motor function after CNS damage: is there a potential beyond spontaneous recovery?

  2021cites this paper
• Corticospinal Motor Circuit Plasticity After Spinal Cord Injury: Harnessing Neuroplasticity to Improve Functional Outcomes

  2021cites this paper
• High-Resolution Focused Ultrasound Neuromodulation Induces Limb-Specific Motor Responses in Mice in Vivo.

  2021cites this paper
• Upregulation of breathing rate during running exercise by central locomotor circuits in mice

  2021cites this paper
• Deep brain stimulation of the Cuneiform nucleus for levodopa-resistant freezing of gait in Parkinson’s disease: study protocol for a prospective, pilot trial

  2020cites this paper
• Brainstem neurons that command mammalian locomotor asymmetries

  2020cites this paper
• Deep brain stimulation improves motor function in rats with spinal cord injury by increasing synaptic plasticity.

  2020cites this paper
• Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury

  2020cites this paper
• Independent respiratory and locomotor rhythms in running mice

  2020cites this paper
• The Gigantocellular Reticular Nucleus Plays a Significant Role in Locomotor Recovery after Incomplete Spinal Cord Injury

  2020cites this paper
• The Translesional Spinal Network and Its Reorganization after Spinal Cord Injury

  2020cites this paper
• Functional MRI Reveals Locomotion-Control Neural Circuits in Human Brainstem

  2020cites this paper
• Using mouse genetics to investigate supraspinal pathways of the brain important to locomotion

  2020cites this paper
• Neural control of swimming in lampreys

  2020cites this paper
• Spinal cord stimulation for the recovery of function following spinal cord injury

  2020cites this paper
• Motor cortex connections

  2020cites this paper
• The micropig model of neurosurgery and spinal cord injury in experiments of motor control

  2020cites this paper
• Absent phasing of respiratory and locomotor rhythms in running mice

  2020cites this paper
• Freely Behaving Mice Can Brake and Turn During Optogenetic Stimulation of the Mesencephalic Locomotor Region

  2020cites this paper
• [Movement Disorders: What Are You Doing? What Can We Do?]

  2020cites this paper
• Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse

  2019cites this paper
• Descending control of locomotor circuits

  2019cites this paper
• Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis

  2019cites this paper
• Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation

  2019cites this paper
• Brainstem Neurons that Command Left/Right Locomotor Asymmetries

  2019cites this paper
• Neurorestorative interventions involving bioelectronic implants after spinal cord injury

  2019cites this paper
• Spinal cord repair: advances in biology and technology

  2019cites this paper
• Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

  2019cites this paper
• Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Anatomy and Terminology

  2019cites this paper
• Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis

  2019cites this paper
• Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse.

  2018cites this paper
• Neuromodulation in the restoration of function after spinal cord injury.

  2018cites this paper
• Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

  2018cites this paper
• The kinematic recovery process of rhesus monkeys after spinal cord injury

  2018cites this paper
• Functional contribution of the mesencephalic locomotor region to locomotion

  2018cites this paper
• Surgical Neurostimulation for Spinal Cord Injury

  2017influential citation
• Nigral Glutamatergic Neurons Control the Speed of Locomotion

  2017cites this paper
• Development of a head-mounted wireless microstimulator for deep brain stimulation in rats.

  2017influential citation
• Graphene bioelectronics for long-term neuronal interfacing in-vivo

  2017influential citation
• 2.07 – The Vertebrate Brain Stem as the Primary Site of Behavior Command: Insights from an Amphibian

  2017cites this paper
• Brain-Controlled Neuroprosthetic Therapies And Mechanisms Of Recovery After Spinal Cord Injury

  2017influential citation
• Traumatic spinal cord injury

  2017cites this paper
• Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human

  2017cites this paper
• The “curved lead pathway” method to enable a single lead to reach any two intracranial targets

  2017cites this paper