Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Nature

• Publication date

  1994-01-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/367277A0PMID 8121493
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• Induction of apoptosis in fibroblasts by c-myc protein.

  1992cited by this paper
• Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors.

  1992cited by this paper
• Apoptosis and programmed cell death in immunity.

  1992cited by this paper
• Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

  1992cited by this paper
• The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.

  1992cited by this paper
• Bcl-2: a repressor of lymphocyte death.

  1992cited by this paper
• Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

  1992cited by this paper
• Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.

  1992cited by this paper
• Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression

  1992cited by this paper
• Apoptosis: The Molecular Basis of Cell Death

  1991cited by this paper
• Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

  1991cited by this paper
• Cell death during development of the nervous system.

  1991cited by this paper
• An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

  1991cited by this paper
• Identification of the DNA binding site for NGFI-B by genetic selection in yeast.

  1991cited by this paper
• bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.

  1991cited by this paper
• The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.

  1991cited by this paper
• Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation.

  1990cited by this paper
• Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

  1989cited by this paper
• Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

  1989cited by this paper
• The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

  1989cited by this paper
• The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: genomic structure and expression in rat brain after seizure induction

  1989cited by this paper
• Eukaryotic expression vectors for the analysis of mutant proteins.

  1989cited by this paper
• Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

  1988cited by this paper
• A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

  1988cited by this paper
• A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.

  1988cited by this paper
• Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

  1988cited by this paper
• Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

  1988cited by this paper
• A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

  1988cited by this paper
• A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

  1987cited by this paper
• Ia molecule-associated selectivity in T cell recognition of a 23-amino- acid peptide of lysozyme

  1986cited by this paper

• Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice

  2025influential citation
• NR4A Receptors in Immunity: Bridging Neuroendocrine and Inflammatory Pathways

  2025cites this paper
• Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis

  2025cites this paper
• Nur77 protects the bladder urothelium from intracellular bacterial infection

  2024cites this paper
• Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands

  2024cites this paper
• Nuclear corepressors NCOR1 and NCOR2 entrain thymocyte signaling, selection, and emigration

  2023cites this paper
• Nr4a nuclear receptors: markers and modulators of antigen receptor signaling.

  2023cites this paper
• Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators

  2023cites this paper
• Comparison Between Nr4a Transcription Factor Regulation and Function in Lymphoid and Tumor Treg Cells

  2022cites this paper
• SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells.

  2022cites this paper
• Role of Nuclear Receptors in Controlling Erythropoiesis

  2022cites this paper
• NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance *

  2022cites this paper
• Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells.

  2022cites this paper
• Cytokine exposure mediates transcriptional activation of the orphan nuclear receptor Nur77 in hematopoietic cells

  2021cites this paper
• Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

  2021cites this paper
• Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunity

  2021cites this paper
• NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity

  2021cites this paper
• Bioinformatic Analysis of Transcriptional Regulation by Nur77 in Central Nervous System and Immune System

  2021cites this paper
• Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer

  2021cites this paper
• Novel NR4A1 Arg293Ser Mutation in Patients With Familial Crohn’s Disease

  2021cites this paper
• Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

  2021cites this paper
• The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer

  2020cites this paper
• ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

  2020cites this paper
• Bioinformatics approach reveals Nur77-regulated genes common to the central nervous and immune systems

  2020cites this paper
• “A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two”

  2020cites this paper
• Epinephrine May Contribute to the Persistence of Traumatic Memories in a Post-traumatic Stress Disorder Animal Model

  2020cites this paper
• Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

  2020cites this paper
• Orphan nuclear receptor Nurr1 promotes Helicobacter pylori-associated gastric carcinogenesis by directly enhancing CDK4 expression

  2020cites this paper
• Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway.

  2020cites this paper
• Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength

  2020cites this paper
• Very rapid cloning, expression and identifying specificity of T-cell receptors for T-cell engineering

  2020cites this paper
• Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery

  2019cites this paper
• BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway

  2019cites this paper
• Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77

  2019cites this paper
• TCR Signal Strength Controls Dynamic NFAT Activation Threshold and Graded IRF4 Expression in CD8+ T Cells

  2019influential citation
• FAIM: An Antagonist of Fas-Killing and Beyond

  2019cites this paper
• Self‐reactivity on a spectrum: A sliding scale of peripheral B cell tolerance

  2019cites this paper
• B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors

  2018cites this paper
• The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer

  2018cites this paper
• Modulation of T-cell apoptosis by small molecule compounds targeting the nuclear orphan receptor Nur 77

  2018cites this paper
• NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling.

  2018cites this paper
• Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1

  2018cites this paper
• Nr4a1 plays a crucial modulatory role in Th1/Th17 cell responses and CNS autoimmunity.

  2018cites this paper
• Development of Novel Chemical Probes for the Elucidation of Bacterial and Viral Pathogenesis and Mechanisms of Infection

  2018cites this paper
• Drug Targeting of NR4A Nuclear Receptors for Treatment of Acute Myeloid Leukemia

  2018cites this paper
• Alterations in the Thymic Selection Threshold Skew the Self-Reactivity of the TCR Repertoire in Neonates

  2017cites this paper
• Cell death and thymic tolerance

  2017cites this paper
• Nur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells

  2017cites this paper
• FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ( PHD ) THE ROLE OF MOLECULES PRODUCED IN AN EFFEROCYTOSIS-DEPENDENT MANNER BY MACROPHAGES IN THE REGULATION OF THE APOPTO-PHAGOCYTOSIS

  2017cites this paper
• Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells

  2017cites this paper
• SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death

  2017cites this paper
• Pituitary NR4A1 is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptors on the gene.

  2017cites this paper
• Real-time Visualization of Lung Function : from Micro to Macro Nur 77 attenuates endothelin-1 expression via downregulation of NF-B and p 38 MAPK in A 549 cells and in an ARDS rat model

  2016cites this paper
• Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes

  2016cites this paper
• The Function of Retinoid X Receptor α in Cancer Cells

  2016cites this paper
• T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells

  2016cites this paper
• Differential function and regulation of orphan nuclear receptor TR3 isoforms in endothelial cells

  2016cites this paper
• Nuclear receptor 4A (NR4A) family - orphans no more.

  2016cites this paper
• Transcriptional modulation of regulatory T cell development by novel regulators NR4As

  2016cites this paper
• CALL FOR PAPERS Real-time Visualization of Lung Function: from Micro to Macro Nur77 attenuates endothelin-1 expression via downregulation of NF- B and p38 MAPK in A549 cells and in an ARDS rat model

  2016cites this paper
• Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model

  2016cites this paper
• TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles

  2016cites this paper
• Transcriptional modulation of regulatory T cell development by novel regulators NR4As

  2016cites this paper
• Retinoids induce Nur77-dependent apoptosis in mouse thymocytes.

  2015cites this paper
• NR4A Orphan Receptors as Drug Targets

  2015cites this paper
• Nur77 Was Essential for Neurite Outgrowth and Involved in Schwann Cell Differentiation After Sciatic Nerve Injury

  2015cites this paper
• Nuclear Receptor TR3/Nur77 and Cancer Therapy

  2015cites this paper
• Ubiquitous Self-Antigen Thymocyte Clonal Deletion Induced by Differential Roles for Bim and Nur77 in

  2015cites this paper
• Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy

  2015cites this paper
• Differential Roles for Bim and Nur77 in Thymocyte Clonal Deletion Induced by Ubiquitous Self-Antigen

  2015cites this paper
• Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis*

  2015cites this paper
• Non-genomic effects of the NR4A1/Nur77/TR3/NGFIB orphan nuclear receptor.

  2015cites this paper
• Prostaglandin E2 Regulates Neutrophil Survival Via EP2/PKA/NR4A2 Signalling in the Context of COPD

  2015cites this paper
• Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line

  2015cites this paper
• NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar

  2014cites this paper
• Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling

  2014cites this paper
• Cyclosporin A ameliorates early brain injury after subarachnoid hemorrhage through inhibition of a Nur77 dependent apoptosis pathway.

  2014cites this paper
• The adaptor protein SAP regulates type II NKT‐cell development, cytokine production, and cytotoxicity against lymphoma

  2014cites this paper
• PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis

  2014cites this paper
• Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.

  2014influential citation
• The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages

  2014cites this paper
• Les lymphocytes T régulateurs périphériques qui recirculent dans le thymus inhibent le développement de leurs précurseurs

  2014cites this paper
• Towards understanding the role of orphan nuclear receptor NR4A2 in Th17 cell‐mediated central nervous system autoimmunity: An experimental approach using an animal model of multiple sclerosis

  2014cites this paper
• The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ.

  2013cites this paper
• Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice[S]

  2013cites this paper
• Comparative mapping of E2-host interactions unravels new roles of E2 in human papillomavirus-induced pathogenesis

  2013cites this paper
• Induce Apoptosis TCR to β α Opposite Ability of Pre-TCR and

  2013cites this paper
• Functional redundancy of the Nur 77 and Nor-1 orphan steroid receptors in T-cell apoptosis

  2013cites this paper
• Theoretical Investigation of the D83V Mutation within the Myocyte-Specific Enhancer Factor-2 Beta and Its Role in Cancer

  2013cites this paper
• Programmed Cell Death in T Cell Development

  2013cites this paper
• NR4A orphan nuclear receptors in glucose homeostasis: a minireview.

  2013cites this paper
• Analysis of 20alpha-hydroxysteroid dehydrogenase expression in the corpus luteum of the buffalo cow: effect of prostaglandin F2-alpha treatment on circulating 20alpha-hydroxyprogesterone levels

  2013cites this paper
• NGF-Induced Cell Differentiation and Gene Activation Is Mediated by Integrative Nuclear FGFR1 Signaling (INFS)

  2013cites this paper
• Non-genomic events determining the sensitivity of hemopoietic malignancies to glucocorticoid-induced apoptosis

  2013cites this paper
• Angelica sinensis: A Chinese herb for brain cancer therapy

  2012cites this paper
• Purine anti-metabolite attenuates nuclear factor κB and related pro-inflammatory cytokines in experimental vasospasm

  2012cites this paper
• Genome-wide profiling reveals transcriptional repression of MYC as a core component of NR4A tumor suppression in acute myeloid leukemia

  2012cites this paper
• Topoisomerases and Apoptosis

  2012cites this paper
• The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network

  2012cites this paper
• Nur77: a potential therapeutic target in cancer

  2012cites this paper