Dysregulated stress signal sensitivity and inflammatory disinhibition as a pathophysiological mechanism of stress-related chronic fatigue.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Neuroscience and Biobehavioral Reviews

• Publication date

  2016-09-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neubiorev.2016.05.008PMID 27208412
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of early childhood trauma on hypothalamic-pituitary-adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome.

  2015cited by this paper
• Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return from military deployment.

  2015cited by this paper
• Reciprocal relationship between acute stress and acute fatigue in everyday life in a sample of university students.

  2015cited by this paper
• Acute psychosocial stress induces differential short-term changes in catecholamine sensitivity of stimulated inflammatory cytokine production.

  2015influential reference
• Cortisol augmentation of a psychological treatment for warfighters with posttraumatic stress disorder: Randomized trial showing improved treatment retention and outcome.

  2015cited by this paper
• Stimulation of Systemic Low-Grade Inflammation by Psychosocial Stress

  2014cited by this paper
• The role of hypocortisolism in chronic fatigue syndrome.

  2014cited by this paper
• Host stress hormone norepinephrine stimulates pneumococcal growth, biofilm formation and virulence gene expression

  2014cited by this paper
• Innate immune activation in neurodegenerative disease

  2014cited by this paper
• Potential bias in research of heart rate variability in fibromyalgia and chronic fatigue syndrome.

  2014cited by this paper
• Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans

  2014cited by this paper
• Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers.

  2014cited by this paper
• Circadian endocrine rhythms: the hypothalamic–pituitary–adrenal axis and its actions

  2014cited by this paper
• Cortisol output in adolescents with chronic fatigue syndrome: pilot study on the comparison with healthy adolescents and change after cognitive behavioural guided self-help treatment.

  2014cited by this paper
• Early-Life Stress, HPA Axis Adaptation, and Mechanisms Contributing to Later Health Outcomes

  2014cited by this paper
• Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review.

  2013cited by this paper
• Salivary α-amylase response to endotoxin administration in humans.

  2013cited by this paper
• Dexmedetomidine suppresses proinflammatory mediator production in human whole blood in vitro

  2013cited by this paper
• Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD

  2013cited by this paper
• Conscientiousness and stress exposure and reactivity: a prospective study of adolescent females

  2013influential reference
• Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD.

  2013cited by this paper
• Norepinephrine and epinephrine responses to physiological and pharmacological stimulation in chronic fatigue syndrome.

  2013influential reference
• Glucocorticoid sensitivity in health and disease

  2013cited by this paper
• Unstimulated cortisol secretory activity in everyday life and its relationship with fatigue and chronic fatigue syndrome: a systematic review and subset meta-analysis.

  2013cited by this paper
• Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.

  2013cited by this paper
• Effort-reward-imbalance in healthy teachers is associated with higher LPS-stimulated production and lower glucocorticoid sensitivity of interleukin-6 in vitro.

  2013influential reference
• Hypothalamic–pituitary–adrenal axis dysfunction in chronic fatigue syndrome

  2012cited by this paper
• Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems --2011 Curt Richter Award Winner.

  2012influential reference
• Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner.

  2012cited by this paper
• Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin.

  2012cited by this paper
• Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis

  2012cited by this paper
• Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: A prospective study.

  2012cited by this paper
• Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data.

  2012cited by this paper
• Understanding long-term outcomes of chronic fatigue syndrome.

  2012cited by this paper
• Immune system to brain signaling: neuropsychopharmacological implications.

  2011cited by this paper
• Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

  2011cited by this paper
• When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders.

  2011cited by this paper
• Determinants of fatigue and stress

  2011cited by this paper
• Personality and chronic fatigue syndrome: The role of the five-factor model.

  2011cited by this paper
• Reciprocal regulation of the neural and innate immune systems

  2011cited by this paper
• Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans

  2011cited by this paper
• Neuroendocrine and Immune Contributors to Fatigue

  2010cited by this paper
• Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis

  2010cited by this paper
• The role of the glucocorticoid receptor in inflammation and immunity.

  2010cited by this paper
• A formal analysis of cytokine networks in chronic fatigue syndrome.

  2010cited by this paper
• Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

  2010cited by this paper
• Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders.

  2010cited by this paper
• Fatigue and chronic fatigue syndrome-like complaints in the general population.

  2010cited by this paper
• As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders.

  2009cited by this paper
• Biologic cost of caring for a cancer patient: dysregulation of pro- and anti-inflammatory signaling pathways.

  2009influential reference
• Neural regulation of endocrine and autonomic stress responses

  2009cited by this paper
• Plasma cytokines in women with chronic fatigue syndrome

  2009cited by this paper
• Neuroendocrine and Immunological Correlates of Chronic Stress in ‘Strictly Healthy’ Populations

  2009cited by this paper
• Stressful Life-Events and Fatigue in a Nonclinical Sample

  2009cited by this paper
• The moderating role of personal mastery on the relationship between caregiving status and multiple dimensions of fatigue

  2009cited by this paper
• Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection and Immunopathology

  2009cited by this paper
• An fMRI study of cytokine-induced depressed mood and social pain: The role of sex differences

  2009cited by this paper
• A hard day’s night: a longitudinal study on the relationships among job demands and job control, sleep quality and fatigue

  2009cited by this paper
• Vagal tone and the inflammatory reflex

  2009cited by this paper
• Determinants of the NF-kappaB response to acute psychosocial stress in humans.

  2009cited by this paper
• Association of peripheral inflammatory markers with chronic fatigue in a population-based sample.

  2009cited by this paper
• Reflex control of immunity

  2009cited by this paper
• From inflammation to sickness and depression: when the immune system subjugates the brain

  2008cited by this paper
• Sleep loss activates cellular inflammatory signaling.

  2008cited by this paper
• Glucocorticoid sensitivity of immune cells in severely fatigued adolescent girls: a longitudinal study.

  2008cited by this paper
• Attenuated morning salivary cortisol concentrations in a population-based study of persons with chronic fatigue syndrome and well controls.

  2008cited by this paper
• A longitudinal study of the relationship between psychological distress and recurrence of upper respiratory tract infections in chronic fatigue syndrome.

  2008cited by this paper
• Mechanisms and functional implications of adult neurogenesis.

  2008cited by this paper
• Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers.

  2008cited by this paper
• A 5-year longitudinal study of the relationships between stress, coping, and immune cell beta(2)-adrenergic receptor sensitivity.

  2008influential reference
• A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling.

  2008influential reference
• Alterations in Diurnal Salivary Cortisol Rhythm in a Population-Based Sample of Cases With Chronic Fatigue Syndrome

  2008cited by this paper
• Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome.

  2008cited by this paper
• Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study.

  2007cited by this paper
• If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans.

  2007cited by this paper
• Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids.

  2007influential reference
• Abnormal Thermoregulatory Responses in Adolescents With Chronic Fatigue Syndrome: Relation to Clinical Symptoms

  2007cited by this paper
• Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder

  2007cited by this paper
• Receptor regulation in neuroendocrine-immune communication: current knowledge and future perspectives.

  2007cited by this paper
• Psychometric Properties of the Early Trauma Inventory–Self Report

  2007cited by this paper
• Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time

  2007cited by this paper
• The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis.

  2007cited by this paper
• Autonomic innervation and regulation of the immune system (1987-2007).

  2007cited by this paper
• Modern Fatigue: A Historical Perspective

  2006cited by this paper
• Premorbid predictors of chronic fatigue.

  2006cited by this paper
• Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study.

  2006cited by this paper
• Glucocorticoid receptor isoforms generate transcription specificity.

  2006cited by this paper
• Hypothesis: Cytokines may be activated to cause depressive illness and chronic fatigue syndrome

  2005cited by this paper
• The prevalence of self-reported chronic fatigue in a U.S. twin registry.

  2005cited by this paper
• Central nervous system injury-induced immune deficiency syndrome

  2005cited by this paper
• Decreased dehydroepiandrosterone sulfate but normal insulin-like growth factor in chronic fatigue syndrome (CFS): relevance for the inflammatory response in CFS.

  2005cited by this paper
• Diurnal patterns of salivary cortisol and cortisone output in chronic fatigue syndrome.

  2005cited by this paper
• A new view on hypocortisolism.

  2005cited by this paper
• Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome.

  2005cited by this paper
• Social stress and the regulation of tumor necrosis factor-alpha secretion.

  2005cited by this paper
• Acute inflammation and negative mood: mediation by cytokine activation.

  2005cited by this paper
• Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

  2005cited by this paper
• Chronic fatigue syndrome: a clinical and laboratory study with a well‐matched control group

  2004cited by this paper
• Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder.

  2004cited by this paper
• Stress-induced enhancement of NF-jB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution

  2004cited by this paper

• Impact of risk assessment nursing combined with psychological care on SAS scores, SDS scores, and patient compliance in patients in the surgical intensive care unit: a single-center, randomized controlled trial

  2026cites this paper
• Fatigue, sleep quality, depression symptoms, and antiseizure medication resistance in patients with newly diagnosed epilepsy

  2025cites this paper
• Recognition of Suboptimal Health Status Based on Electrocardiogram and Three-Dimensional Acceleration

  2025cites this paper
• Fatigue and its Longitudinal Associations with Mood, Stress, Anxiety, and Hair Cortisol During the Lockdowns of the COVID-19 Pandemic: A Cohort Study with Ecological Momentary Assessment.

  2025cites this paper
• Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long COVID: results from an intensive longitudinal cohort study

  2025cites this paper
• Molecular Aspects of Geriatric Pharmacotherapy

  2025cites this paper
• The effects of chronic fatigue and chronic stress on alterations in immune cell responses to acute psychosocial stress.

  2024cites this paper
• Immunologische Aspekte und Stressregulation bei Fatigue

  2024cites this paper
• Association of perceived stress with working memory, visuospatial and global cognitive function in elderly Egyptians.

  2023cites this paper
• Heat-killed Lactobacillus helveticus improves mood states: a randomised, double-blind, placebo-controlled study.

  2023cites this paper
• Three Pathways Into Chronic Lack of Energy as a Mental Health Complaint

  2022cites this paper
• Chronic stress exposure in men and women, and implications for the course of fatigue after percutaneous coronary intervention; the THORESCI study.

  2021cites this paper
• Waterfall Forest Environment Regulates Chronic Stress via the NOX4/ROS/NF-κB Signaling Pathway

  2021cites this paper
• Cardiac and vascular disorders as para-occupational diseases - a Polish perspective.

  2021cites this paper
• Resilience during uncertainty? Greater social connectedness during COVID‐19 lockdown is associated with reduced distress and fatigue

  2020cites this paper
• „Old Friends“, Immunregulation und Stressresilienz

  2020cites this paper
• Fatigue, Pain, Sleep Difficulties, and Depressive Symptoms in Mexican Americans and Chinese Americans with Type 2 Diabetes

  2020cites this paper
• The Mediating Role of Self-Regulation Processes in Relation between Perceived Stress and Destructive Effects of Stress in Mothers with Children Suffering from Cancer

  2020cites this paper
• Nesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamus

  2020influential citation
• „Old Friends“, Immunregulation und Stressresilienz

  2020cites this paper
• Stress Reactivity Patterns in Breast Cancer Survivors and the Implications of Various Psychosocial Factors

  2019cites this paper
• Neuroendokrinologie – Körperliche Folgen von Burnout

  2018cites this paper
• Chronic pain: a consequence of dysregulated protective action

  2018cites this paper
• Old Friends, immunoregulation, and stress resilience

  2018cites this paper
• Diurnal cortisol and alpha-amylase in the daily lives of older adults with vital exhaustion.

  2018cites this paper
• Disease- and treatment-associated acquired glucocorticoid resistance

  2018cites this paper
• Hair and salivary cortisol in a cohort of women with chronic fatigue syndrome

  2018cites this paper
• Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus

  2018cites this paper
• Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses

  2017cites this paper
• Influence of stress systems and physical activity on different dimensions of fatigue in female fibromyalgia patients.

  2017cites this paper
• Chronic Fatigue Syndrome: Cognitive, Behavioural and Emotional Processing Vulnerability Factors

  2017cites this paper
• Journal Pre-proofs

  year unknowncites this paper