Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

Several genetic causes of autism spectrum disorder (ASD) have been identified. However, more recent work has highlighted that certain environmental exposures early in life may also account for some cases of autism. Environmental insults during pregnancy, such as infection or malnutrition, seem to dramatically impact brain development. Maternal viral or bacterial infections have been characterized as disruptors of brain shaping, even if their underlying mechanisms are not yet fully understood. Poor nutritional diversity, as well as nutrient deficiency, is strongly associated with neurodevelopmental disorders in children. For instance, imbalanced levels of essential fatty acids, and especially polyunsaturated fatty acids (PUFAs), are observed in patients with ASD and other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder (ADHD) and schizophrenia). Interestingly, PUFAs, and specifically n-3 PUFAs, are powerful immunomodulators that exert anti-inflammatory properties. These prenatal dietary and immunologic factors not only impact the fetal brain, but also affect the microbiota. Recent work suggests that the microbiota could be the missing link between environmental insults in prenatal life and future neurodevelopmental disorders. As both nutrition and inflammation can massively affect the microbiota, we discuss here how understanding the crosstalk between these three actors could provide a promising framework to better elucidate ASD etiology.

• Publication year

  2016

• Venue

  Journal of Neural Transplantation and Plasticity

• Publication date

  2016-10-20

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2016/3597209PMID 27840741PMCID 5093279
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gut microbiota, metabolites and host immunity

  2016cited by this paper
• An emerging cause of concern in Europe: Zika virus, the developing CNS and the pediatric neurologist.

  2016cited by this paper
• The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

  2016cited by this paper
• Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition.

  2016cited by this paper
• Maternal TH17 cells take a toll on baby's brain

  2016cited by this paper
• Zika Virus Infection in Pregnant Women in Rio de Janeiro — Preliminary Report

  2016cited by this paper
• Expression and Sequence Variants of Inflammatory Genes; Effects on Plasma Inflammation Biomarkers Following a 6-Week Supplementation with Fish Oil

  2016cited by this paper
• Nutritional n‐3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long‐Term Potentiation

  2016cited by this paper
• Dietary docosahexaenoic acid alleviates autistic-like behaviors resulting from maternal immune activation in mice.

  2016cited by this paper
• Unexpected role of interferon-γ in regulating neuronal connectivity and social behavior

  2016cited by this paper
• Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study

  2016cited by this paper
• Zika Virus Infection in Pregnant Women in Rio de Janeiro.

  2016cited by this paper
• Abnormal fatty acids in Canadian children with autism.

  2016cited by this paper
• Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells.

  2016cited by this paper
• Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study

  2016cited by this paper
• Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.

  2016cited by this paper
• Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring.

  2016cited by this paper
• Maternal exposure to fish oil primes offspring to harbor intestinal pathobionts associated with altered immune cell balance

  2015cited by this paper
• Epigenetics of Autism-related Impairment: Copy Number Variation and Maternal Infection

  2015cited by this paper
• Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment

  2015cited by this paper
• Association between polymorphisms in phospholipase A2 genes and the plasma triglyceride response to an n-3 PUFA supplementation: a clinical trial

  2015cited by this paper
• Meta-analysis of differentially expressed genes in autism based on gene expression data.

  2015cited by this paper
• Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model

  2015cited by this paper
• Host microbiota constantly control maturation and function of microglia in the CNS

  2015cited by this paper
• Autism Spectrum Disorders: Translating human deficits into mouse behavior

  2015cited by this paper
• Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study

  2015cited by this paper
• A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia

  2015cited by this paper
• Role of Microglia in Autism: Recent Advances

  2015cited by this paper
• Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism

  2015cited by this paper
• Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications

  2015cited by this paper
• N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota

  2015cited by this paper
• Maternal lipopolysaccharide treatment differentially affects 5-HT(2A) and mGlu2/3 receptor function in the adult male and female rat offspring.

  2015cited by this paper
• Disrupted fatty acid distribution in HDL and LDL according to apolipoprotein E allele.

  2015cited by this paper
• Transgenic Increase in n-3/n-6 Fatty Acid Ratio Protects Against Cognitive Deficits Induced by an Immune Challenge through Decrease of Neuroinflammation

  2015cited by this paper
• Evidence supporting an altered immune response in ASD.

  2015cited by this paper
• A possible association between elevated serum levels of brain-specific auto-antibodies and reduced plasma levels of docosahexaenoic acid in autistic children.

  2015cited by this paper
• Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

  2015cited by this paper
• Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore

  2015cited by this paper
• Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders.

  2015cited by this paper
• Maternal immune activation in nonhuman primates alters social attention in juvenile offspring.

  2015cited by this paper
• Immune mediators in the brain and peripheral tissues in autism spectrum disorder

  2015cited by this paper
• More than a Gut Feeling: the Microbiota Regulates Neurodevelopment and Behavior

  2015cited by this paper
• A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism

  2015cited by this paper
• Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life

  2015cited by this paper
• Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells

  2015cited by this paper
• Special Section on DrugMetabolism and the Microbiome—Perspective Microbiome Disturbances and Autism Spectrum Disorders

  2015cited by this paper
• Prenatal administration of lipopolysaccharide induces sex-dependent changes in glutamic acid decarboxylase and parvalbumin in the adult rat brain.

  2015cited by this paper
• Microglia modulate wiring of the embryonic forebrain.

  2014cited by this paper
• Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

  2014cited by this paper
• Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion

  2014cited by this paper
• Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems.

  2014cited by this paper
• The role of microbiome in central nervous system disorders.

  2014cited by this paper
• Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice.

  2014cited by this paper
• Etiologies underlying sex differences in Autism Spectrum Disorders.

  2014cited by this paper
• Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats.

  2014cited by this paper
• Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors

  2014cited by this paper
• Maternal immune activation and abnormal brain development across CNS disorders

  2014cited by this paper
• Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring.

  2014cited by this paper
• Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood

  2014cited by this paper
• Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

  2014cited by this paper
• Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?

  2014cited by this paper
• The effect of alpha-linolenic acid supplementation on ADHD symptoms in children: a randomized controlled double-blind study

  2014cited by this paper
• Polyunsaturated fatty acids and their metabolites in brain function and disease

  2014cited by this paper
• Minocycline alleviates behavioral deficits and inhibits microglial activation in the offspring of pregnant mice after administration of polyriboinosinic-polyribocytidilic acid.

  2014influential reference
• Pre- and Neonatal Exposure to Lipopolysaccharide or the Enteric Metabolite, Propionic Acid, Alters Development and Behavior in Adolescent Rats in a Sexually Dimorphic Manner

  2014cited by this paper
• Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies

  2014cited by this paper
• Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain

  2014cited by this paper
• Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study

  2014cited by this paper
• Named Series : Diet , Inflammation and the Brain Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes

  2014cited by this paper
• Autistic-like behavioural and neurochemical changes in a mouse model of food allergy.

  2014cited by this paper
• Biological sex affects the neurobiology of autism

  2013cited by this paper
• Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism.

  2013cited by this paper
• Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.

  2013cited by this paper
• Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders

  2013cited by this paper
• Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

  2013cited by this paper
• Fatty acid and phospholipase A2 plasma levels in children with autism.

  2013cited by this paper
• Monogenic mouse models of social dysfunction: implications for autism.

  2013cited by this paper
• Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

  2013cited by this paper
• Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: a brief review.

  2013cited by this paper
• Maternal omega-3 fatty acid intake increases placental labyrinthine antioxidant capacity but does not protect against fetal growth restriction induced by placental ischaemia-reperfusion injury.

  2013cited by this paper
• Epigenetic changes at gene promoters in response to immune activation in utero.

  2013cited by this paper
• Diets rich in n-6 PUFA induce intestinal microbial dysbiosis in aged mice

  2013cited by this paper
• Brain IL-6 and autism.

  2013cited by this paper
• Microglial activation in young adults with autism spectrum disorder.

  2013cited by this paper
• Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age.

  2013cited by this paper
• SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

  2013cited by this paper
• Microglia in the Cerebral Cortex in Autism

  2012cited by this paper
• Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice.

  2012cited by this paper
• The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

  2012cited by this paper
• Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders

  2012cited by this paper
• Prenatal infection, maternal immune activation, and risk for schizophrenia

  2012cited by this paper
• Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study

  2012cited by this paper
• Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: Relation to autoimmunity

  2012cited by this paper
• Hypoactivity of the central dopaminergic system and autistic‐like behavior induced by a single early prenatal exposure to lipopolysaccharide

  2012cited by this paper
• Gastrointestinal Conditions in Children With Autism Spectrum Disorder: Developing a Research Agenda

  2012cited by this paper
• Prenatal exposure to bacterial endotoxin reduces the number of GAD67- and reelin-immunoreactive neurons in the hippocampus of rat offspring.

  2012cited by this paper
• Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice

  2012cited by this paper
• Prenatal Immune Activation Interacts with Genetic Nurr1 Deficiency in the Development of Attentional Impairments

  2012cited by this paper
• Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism.

  2012influential reference
• Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice

  2012cited by this paper

• Kefir-derived probiotic mixture for children with autism spectrum disorder: a double-blind randomized clinical trial.

  2026cites this paper
• Research on Influencing Factors of Sibling Relationships in Two-child Families based on Family Ecosystem Theory

  2025cites this paper
• Interplay Between VCAM-1 and PGE2 Levels and Autism Spectrum Disorder Severity in Children—A Preliminary Single-Center Analysis

  2025cites this paper
• Pathophysiological Mechanisms Fostering Developmental and Epileptic Encephalopathies (DEE): a Complex Interplay between Genetics, Inflammation and Neurodegeneration

  2025cites this paper
• Nesfatin1 attenuates autism-like behavior via antioxidant, anti-inflammatory activities in a prenatal valproic acid-induced rat model of autism.

  2025cites this paper
• Harnessing the microbiota-gut–brain axis to prevent and treat pediatric neurodevelopmental disorders: translational insights and strategies

  2025cites this paper
• Gut-Brain Axis: Understanding the Interlink Between Alterations in the Gut Microbiota and Autism Spectrum Disorder

  2025influential citation
• Emerging Epigenetic Therapeutics and Diagnostics for Autism Spectrum Disorder

  2025cites this paper
• Gut microbiota and autism spectrum disorder: advances in dietary intervention strategies based on the microbiota-gut-brain axis mechanism

  2025cites this paper
• Gut dysbiosis as a driver of neuroinflammation in attention-deficit/hyperactivity disorder: A review of current evidence.

  2025influential citation
• Nutritional behaviours, feeding problems and meal patterns of children diagnosed with autism Spectrum disorder: A cross-sectional study

  2025cites this paper
• Sex‐Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data

  2025cites this paper
• Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with autism and attention deficit hyperactivity disorder

  2025cites this paper
• Gut-immune-brain interactions during neurodevelopment: from a brain-centric to a multisystem perspective

  2025cites this paper
• Mechanisms of angiotensin II to induce depression in diabetes

  2025cites this paper
• The New Phytocomplex AL0042 Extracted from Red Orange By-Products Inhibits the Minimal Hepatic Encephalopathy in Mice Induced by Thioacetamide

  2025cites this paper
• The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders

  2025cites this paper
• Pre- and post-operative administration of omega-3 polyunsaturated fatty acids in cardiac surgery patients. A narrative review

  2025cites this paper
• Drug discovery strategy for TAK-418, a specific inhibitor of LSD1 enzyme activity, as a novel therapy for autism.

  2025cites this paper
• Chemogenetic induction of CA1 hyperexcitability triggers indistinguishable autistic traits in asymptomatic mice differing in Ambra1 expression and sex

  2025cites this paper
• Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment

  2024cites this paper
• Impact of gut microbiota on the central nervous system relevance in neurodegenerative and psychiatric diseases

  2024cites this paper
• tVNS alters inflammatory response in adult VPA‐induced mouse model of autism: evidence for sexual dimorphism

  2024cites this paper
• Gut Microbiome in Autistic Spectrum Disorders

  2024cites this paper
• Unravelling the critical role of neuroinflammation in epilepsy-associated neuropsychiatric comorbidities: A review.

  2024cites this paper
• Decoding the genetic landscape of autism: A comprehensive review

  2024cites this paper
• The early life exposome and autism risk: a role for the maternal microbiome?

  2024cites this paper
• Harnessing the Gut Microbiome: To What Extent Can Pre-/Probiotics Alleviate Immune Activation in Autism Spectrum Disorder?

  2024cites this paper
• An integrative exploration of environmental stressors on the microbiome-gut-brain axis and immune mechanisms promoting neurological disorders

  2024cites this paper
• Eating disorders in preschool and primary school children with autism spectrum disorder and its clinical significance

  2024cites this paper
• Des-Arg(9) bradykinin as a causal metabolite for autism spectrum disorder

  2024cites this paper
• Functional Nutrition as Integrated Intervention for In- and Outpatient with Schizophrenia

  2023cites this paper
• Eating disorder in children: Impact on quality of life, with a spotlight on autism spectrum disorder.

  2023cites this paper
• Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes

  2023cites this paper
• Independent and combined effects of astaxanthin and omega-3 on behavioral deficits and molecular changes in a prenatal valproic acid model of autism in rats

  2023cites this paper
• Microbial Reprogramming in Obsessive–Compulsive Disorders: A Review of Gut–Brain Communication and Emerging Evidence

  2023cites this paper
• IFN-γ mediated neuroinflammation and behaviour abnormality after maternal exposure to low dose mixture of food additives and pesticides

  2023cites this paper
• The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain

  2023cites this paper
• Effect of cesarean section on the risk of autism spectrum disorders/attention deficit hyperactivity disorder in offspring: a meta-analysis

  2023cites this paper
• Exploring potential impacts of pregnancy-related maternal immune activation and extracellular vesicles on immune alterations observed in autism spectrum disorder

  2023cites this paper
• Role of gastrointestinal health in managing children with autism spectrum disorder

  2023cites this paper
• Prepregnancy BMI, gestational weight gain, and susceptibility to autism‐related traits: the EARLI and HOME studies

  2023cites this paper
• Intestinal Barrier Dysfunction and Microbiota–Gut–Brain Axis: Possible Implications in the Pathogenesis and Treatment of Autism Spectrum Disorder

  2023influential citation
• Maternal Intake of Polyunsaturated Fatty Acids in Autism Spectrum Etiology and Its Relation to the Gut Microbiota: What Do We Know?

  2023cites this paper
• Docosahexaenoic and Eicosapentaenoic Intervention Modifies Plasma and Erythrocyte Omega-3 Fatty Acid Profiles But Not the Clinical Course of Children With Autism Spectrum Disorder: A Randomized Control Trial

  2022cites this paper
• Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review

  2022influential citation
• Gut-brain axis and the risk of autism spectrum disorders

  2022cites this paper
• N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice

  2022cites this paper
• Genetic and environmental mouse models of autism reproduce the spectrum of the disease

  2022cites this paper
• Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood

  2022cites this paper
• Birth related parameters are important contributors in autism spectrum disorders

  2022cites this paper
• Fetal Brain Damage during Maternal COVID-19: Emerging Hypothesis, Mechanism, and Possible Mitigation through Maternal-Targeted Nutritional Supplementation

  2022cites this paper
• Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder

  2022cites this paper
• A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions.

  2022cites this paper
• Understanding the Role of the Gut Microbiome in Brain Development and Its Association With Neurodevelopmental Psychiatric Disorders

  2022cites this paper
• Oxidative Stress in Autism Spectrum Disorder—Current Progress of Mechanisms and Biomarkers

  2022cites this paper
• Alpha Lipoic Acid Ameliorates Detrimental Effects of Maternal Lipopolysaccharides Exposure on Prefrontal White Matter in Adult Male Offspring Rats.

  2021cites this paper
• LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models

  2021influential citation
• Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders

  2021cites this paper
• The evolution of knowledge on genes associated with human diseases

  2021cites this paper
• The Prenatal Hormone Milieu in Autism Spectrum Disorder

  2021cites this paper
• The severity of inflammation in major neuropsychiatric disorders: comparison of neutrophil–lymphocyte and platelet–lymphocyte ratios between schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and obsessive compulsive disorder

  2021cites this paper
• Impact of maternal nutrition in viral infections during pregnancy

  2021cites this paper
• The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders.

  2021cites this paper
• N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development

  2021cites this paper
• The gut-microbiota-brain axis in autism: what Drosophila models can offer?

  2021cites this paper
• Neuroinflammation in Autism and Supplementation Based on Omega-3 Polyunsaturated Fatty Acids: A Narrative Review

  2021cites this paper
• Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder

  2021cites this paper
• Kawasaki Disease in Childhood and Psychiatric Disorders: A Population-Based Case-Control Prospective Study in Taiwan.

  2021cites this paper
• The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder

  2021cites this paper
• ISSN: 2525-8761

  2021cites this paper
• Microbiota‐gut‐brain axis as a regulator of reward processes

  2020cites this paper
• Could autism spectrum disorders be a risk factor for COVID-19?

  2020cites this paper
• Prenatal maternal C-reactive protein prospectively predicts child executive functioning at ages 4-6 years.

  2020cites this paper
• Dysregulation of synaptic pruning as a possible link between intestinal microbiota dysbiosis and neuropsychiatric disorders

  2020cites this paper
• Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: focus on biological pathways and epigenetic mechanisms.

  2020cites this paper
• Targeting gut microbiota as a possible therapeutic intervention in autism

  2020cites this paper
• Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota

  2020influential citation
• Nutritional and environmental contributions to Autism Spectrum Disorders: Focus on nutrigenomics as complementary therapy.

  2020cites this paper
• Effect on Adipose Tissue of Diabetic Mice Supplemented with n-3 Fatty Acids Extracted from Microalgae

  2020cites this paper
• Probing disrupted neurodevelopment in autism using human stem cell‐derived neurons and organoids: An outlook into future diagnostics and drug development

  2020cites this paper
• Associations Between Broader Autism Phenotype and Dietary Intake: A Cross-Sectional Study (Japan Environment & Children’s Study)

  2020cites this paper
• Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone?

  2020cites this paper
• Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?

  2020cites this paper
• Neuropathobiology of COVID-19: The Role for Glia

  2020cites this paper
• Human-Derived Brain Models: Windows into Neuropsychiatric Disorders and Drug Therapies

  2020cites this paper
• Association Between Gestational Weight Gain and Autism Spectrum Disorder in Offspring: A Meta‐Analysis

  2020cites this paper
• Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime

  2020influential citation
• n-3 Long-Chain PUFA-Containing Phospholipids and Neuroprotection

  2019cites this paper
• Speech-Stimulating Substances in Autism Spectrum Disorders

  2019cites this paper
• Inflammatory domains modulate autism spectrum disorder susceptibility during maternal nutritional programming

  2019cites this paper
• The role of marine omega-3 in human neurodevelopment, including Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder – a review

  2019cites this paper
• Improving autism perinatal risk factors: A systematic review.

  2019cites this paper
• The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder

  2019influential citation
• Role of gut microbiota in pathogenesis of selected chronic diseases

  2019cites this paper
• The effects of bioavailable omega-3 polyunsaturated fatty acids, delivered at bedtime, on brain function, sleep, cognition and mood in healthy adults

  2019cites this paper
• Role of Mushrooms in Autism

  2019cites this paper
• Noncoding de novo mutations contribute to autism spectrum disorder via chromatin interactions

  2019cites this paper
• Functional Food and Nutrition for the Management of Autism Spectrum Disorders and Schizophrenia

  2019cites this paper
• Oral microbiota and autism spectrum disorder (ASD)

  2019cites this paper