Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics.

Functional imaging refers broadly to the visualization of organ or tissue physiology using medical image modalities. In load-bearing tissues of the body, including articular cartilage lining the bony ends of joints, changes in strain, stress, and material properties occur in osteoarthritis (OA), providing an opportunity to probe tissue function through the progression of the disease. Here, biomechanical measures in cartilage and related joint tissues are discussed as key imaging biomarkers in the evaluation of OA. Emphasis will be placed on the (1) potential of radiography, ultrasound, and magnetic resonance imaging to assess early tissue pathomechanics in OA, (2) relative utility of kinematic, structural, morphological, and biomechanical measures as functional imaging biomarkers, and (3) improved diagnostic specificity through the combination of multiple imaging biomarkers with unique contrasts, including elastography and quantitative assessments of tissue biochemistry. In comparison to other modalities, magnetic resonance imaging provides an extensive range of functional measures at the tissue level, with conventional and emerging techniques available to potentially to assess the spectrum of preclinical to advance OA.

• Publication year

  2014

• Venue

  Osteoarthritis and Cartilage

• Publication date

  2014-10-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1016/j.joca.2014.05.016PMID 25278049PMCID PMC4185127
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Osteoarthritis: The Disease

  2016cited by this paper
• Meniscus body position and its change over four years in asymptomatic adults: a cohort study using data from the Osteoarthritis Initiative (OAI)

  2014cited by this paper
• Comparative validation of the WOMAC osteoarthritis and Lequesne algofunctional indices in Greek patients with hip or knee osteoarthritis

  2014cited by this paper
• Sensitivity and specificity of bell-hammer tear as an indirect sign of partial anterior cruciate ligament rupture on magnetic resonance imaging

  2014cited by this paper
• Nocturnal Knee Pain Increases With the Severity of Knee Osteoarthritis, Disturbing Patient Sleep Quality

  2014cited by this paper
• Significance of Preradiographic Magnetic Resonance Imaging Lesions in Persons at Increased Risk of Knee Osteoarthritis

  2014cited by this paper
• Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons

  2014cited by this paper
• Age-related differences in sagittal-plane knee function at heel-strike of walking are increased in osteoarthritic patients.

  2014cited by this paper
• In Vivo Kinematics of the Thumb Carpometacarpal Joint During Three Isometric Functional Tasks

  2014cited by this paper
• Noninvasive assessment of osteoarthritis severity in human explants by multicontrast MRI

  2014cited by this paper
• Significance of pre-radiographic mri lesions in persons at higher risk for knee osteoarthritis

  2014cited by this paper
• Multibanded anterior talofibular ligaments in normal ankles and sprained ankles using 3D isotropic proton density-weighted fast spin-echo MRI sequence.

  2014cited by this paper
• Quantitative cerebral blood flow measurements using MRI.

  2014cited by this paper
• Intervertebral disc internal deformation measured by displacements under applied loading with MRI at 3T

  2014cited by this paper
• A technique for in vivo mapping of myocardial creatine kinase metabolism

  2014cited by this paper
• Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees.

  2013cited by this paper
• Dynamic ultrasound assessment of medial meniscal subluxation in knee osteoarthritis.

  2013cited by this paper
• Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: Perspectives from stem cell biology and molecular medicine

  2013cited by this paper
• Quantitative 3D ultrashort time-to-echo (UTE) MRI and micro-CT (μCT) evaluation of the temporomandibular joint (TMJ) condylar morphology

  2013cited by this paper
• Focal knee lesions in knee pairs of asymptomatic and symptomatic subjects with OA risk factors--data from the Osteoarthritis Initiative.

  2013cited by this paper
• Noninvasive dualMRI-based strains vary by depth and region in human osteoarthritic articular cartilage.

  2013cited by this paper
• Osteoarthritis as a disease of mechanics.

  2013cited by this paper
• The role of ACL injury in the development of posttraumatic knee osteoarthritis.

  2013cited by this paper
• Contrast-enhanced nanofocus computed tomography images the cartilage subtissue architecture in three dimensions.

  2013cited by this paper
• Subject-specific analysis of joint contact mechanics: application to the study of osteoarthritis and surgical planning.

  2013cited by this paper
• Direct measurement of intranuclear strain distributions and RNA synthesis in single cells embedded within native tissue.

  2013cited by this paper
• Clinical evaluation during the acute exacerbation of knee osteoarthritis: the impact of diagnostic ultrasonography

  2013cited by this paper
• Patterns of femoral cartilage thickness are different in asymptomatic and osteoarthritic knees and can be used to detect disease-related differences between samples.

  2013cited by this paper
• Probing articular cartilage damage and disease by quantitative magnetic resonance imaging

  2013cited by this paper
• Dual inversion recovery ultrashort echo time (DIR-UTE) imaging and quantification of the zone of calcified cartilage (ZCC).

  2013cited by this paper
• Physical activity in relation to knee cartilage T2 progression measured with 3 T MRI over a period of 4 years: data from the Osteoarthritis Initiative.

  2013cited by this paper
• High body mass index is associated with increased diurnal strains in the articular cartilage of the knee.

  2013cited by this paper
• In vivo patellofemoral contact mechanics during active extension using a novel dynamic MRI-based methodology.

  2013cited by this paper
• Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells

  2012cited by this paper
• Gait differs between unilateral and bilateral knee osteoarthritis.

  2012cited by this paper
• Transient and Microscale Deformations and Strains Measured under Exogenous Loading by Noninvasive Magnetic Resonance

  2012influential reference
• The Effect of Modified Broström-Gould Repair for Lateral Ankle Instability on In Vivo Tibiotalar Kinematics

  2012cited by this paper
• Quantitative magnetic resonance imaging (MRI) morphological analysis of knee cartilage in healthy and anterior cruciate ligament-injured knees

  2012cited by this paper
• Incidence of bilateral scapholunate dissociation in symptomatic and asymptomatic wrists.

  2012cited by this paper
• A methodology to accurately quantify patellofemoral cartilage contact kinematics by combining 3D image shape registration and cine-PC MRI velocity data.

  2012cited by this paper
• In Vivo Tibiofemoral Kinematics During 4 Functional Tasks of Increasing Demand Using Biplane Fluoroscopy

  2012cited by this paper
• Characterization of Engineered Cartilage Constructs Using Multiexponential T2 Relaxation Analysis and Support Vector Regression

  2012cited by this paper
• Three-dimensional delayed gadolinium-enhanced magnetic resonance imaging of hip joint cartilage at 3T: a prospective controlled study.

  2012cited by this paper
• Tribological altruism: A sacrificial layer mechanism of synovial joint lubrication in articular cartilage.

  2012cited by this paper
• In vivo tibiofemoral cartilage‐to‐cartilage contact area of females with medial osteoarthritis under acute loading using MRI

  2011cited by this paper
• Gait patterns during different walking conditions in older adults with and without knee osteoarthritis--results from the Baltimore Longitudinal Study of Aging.

  2011cited by this paper
• In vivo knee kinematics in patients with bilateral total knee arthroplasty of 2 designs.

  2011cited by this paper
• Population-based normative values for the Western Ontario and McMaster (WOMAC) Osteoarthritis Index: part I.

  2011cited by this paper
• Dynamic CT technique for assessment of wrist joint instabilities.

  2011cited by this paper
• The effects of femoral graft placement on in vivo knee kinematics after anterior cruciate ligament reconstruction.

  2011cited by this paper
• Cell Transplantation for Articular Cartilage Defects: Principles of Past, Present, and Future Practice

  2011cited by this paper
• Stress distributions and material properties determined in articular cartilage from MRI-based finite strains.

  2011influential reference
• What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta‐analysis of observational studies

  2011cited by this paper
• Second-generation autologous chondrocyte transplantation: MRI findings and clinical correlations at a minimum 5-year follow-up.

  2011cited by this paper
• Asymmetric loading and bone mineral density at the asymptomatic knees of patients with unilateral hip osteoarthritis.

  2011cited by this paper
• Does arthroscopic partial meniscectomy result in knee osteoarthritis? A systematic review with a minimum of 8 years' follow-up.

  2011cited by this paper
• Acute articular fracture severity and chronic cartilage stress challenge as quantitative risk factors for post-traumatic osteoarthritis: illustrative cases.

  2010cited by this paper
• Multispectral quantitative photoacoustic imaging of osteoarthritis in finger joints.

  2010cited by this paper
• In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds.

  2010cited by this paper
• A novel and non-destructive method to examine meniscus architecture using 9.4 Tesla MRI

  2010cited by this paper
• Increased friction coefficient and superficial zone protein expression in patients with advanced osteoarthritis.

  2010cited by this paper
• Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running.

  2010cited by this paper
• Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis initiative.

  2010cited by this paper
• Atomic force microscope investigation of the boundary-lubricant layer in articular cartilage.

  2010cited by this paper
• Hyaluronan oligosaccharide treatment of chondrocytes stimulates expression of both HAS-2 and MMP-3, but by different signaling pathways.

  2010cited by this paper
• Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-microCT.

  2010cited by this paper
• Ultrashort echo time MR imaging of osteochondral junction of the knee at 3 T: identification of anatomic structures contributing to signal intensity.

  2010cited by this paper
• Effects of Exercise Intervention on Knee Morphology in Middle-Aged Women: A Longitudinal Analysis Using Magnetic Resonance Imaging

  2010cited by this paper
• Tibiofemoral Joint Kinematics of the Anterior Cruciate Ligament-Reconstructed Knee During a Single-Legged Hop Landing

  2010cited by this paper
• In situ deformation of cartilage in cyclically loaded tibiofemoral joints by displacement-encoded MRI.

  2009cited by this paper
• A critical role for collagen II in cartilage matrix degradation: Collagen II induces pro‐inflammatory cytokines and MMPs in primary human chondrocytes

  2009cited by this paper
• Ultrasound elastography to determine the layered mechanical properties of articular cartilage and the importance of such structural characteristics under load

  2009cited by this paper
• Classification of degraded cartilage through multiparametric MRI analysis.

  2009cited by this paper
• Mechanical Injury and Cytokines Cause Loss of Cartilage Integrity and Upregulate Proteins Associated with Catabolism, Immunity, Inflammation, and Repair*

  2009cited by this paper
• Role of alignment and biomechanics in osteoarthritis and implications for imaging.

  2009cited by this paper
• Subchondral fluid dynamics in a model of osteoarthritis: use of dynamic contrast-enhanced magnetic resonance imaging.

  2009cited by this paper
• Characterization of engineered tissue construct mechanical function by magnetic resonance imaging

  2009cited by this paper
• Clinical value of (99m)Tc-methylene diphosphonate (MDP) bone single photon emission computed tomography (SPECT) in patients with knee osteoarthritis.

  2008cited by this paper
• In vivo cartilage contact deformation of human ankle joints under full body weight

  2008cited by this paper
• Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon–Schuss radiography

  2008cited by this paper
• Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging.

  2008cited by this paper
• Clinical value of 99mTc-methylene diphosphonate (MDP) bone single photon emission computed tomography (SPECT) in patients with knee osteoarthritis

  2008cited by this paper
• Characterization of the dynamic shear properties of hyaline cartilage using high‐frequency dynamic MR elastography

  2008cited by this paper
• Displacement encoding for the measurement of cartilage deformation

  2008cited by this paper
• Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis.

  2007cited by this paper
• Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration.

  2007cited by this paper
• Developments in dynamic MR elastography for in vitro biomechanical assessment of hyaline cartilage under high‐frequency cyclical shear

  2007cited by this paper
• Relationship between pain and medial knee joint loading in mild radiographic knee osteoarthritis.

  2007cited by this paper
• Quantification of ankle articular cartilage topography and thickness using a high resolution stereophotography system.

  2007cited by this paper
• The association between patella alignment and knee pain and function: an MRI study in persons with symptomatic knee osteoarthritis.

  2007cited by this paper
• Gene therapy for articular cartilage repair

  2007cited by this paper
• High-Resolution Ultrasound Elastography of Articular Cartilage in Vitro

  2006cited by this paper
• MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers.

  2006cited by this paper
• Causes of mechanically induced collagen damage in articular cartilage

  2006cited by this paper
• Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis.

  2006cited by this paper
• Imaging Ultrasound imaging for the rheumatologist XLI . Sonographic assessment of the hip in OA patients

  2006influential reference
• Osteoarthritis cartilage histopathology: grading and staging.

  2006cited by this paper
• Determination of in-vivo articular cartilage contact areas of human talocrural joint under weightbearing conditions.

  2006cited by this paper
• MRI‐based technique for determining nonuniform deformations throughout the volume of articular cartilage explants

  2005cited by this paper
• Effectiveness and safety of repeat courses of hylan G-F 20 in patients with knee osteoarthritis.

  2005cited by this paper

• Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.

  2025cites this paper
• Associations Between Body Mass Index, Gait Biomechanics, and In Vivo Cartilage Function After Exercise in Those With Anterior Cruciate Ligament Reconstruction

  2024cites this paper
• Evaluation of the impact of ultra-trail running on knee cartilage using magnetic resonance imaging t2 mapping.

  2024cites this paper
• Quantitative Cartilage T2 and T1rho Mapping: Is There a Clinical Role? From the AJR Special Series on Quantitative Imaging.

  2024cites this paper
• Characteristics of Acute Cartilage Response After Mechanical Loading in Patients with Early-Mild Knee Osteoarthritis

  2024cites this paper
• Design of a double acting pneumatic cartilage loading device for magnetic resonance imaging.

  2023cites this paper
• Imaging evaluation of physical activity effect on knee articular cartilage

  2023cites this paper
• Ultrashort echo time adiabatic T1ρ (UTE-Adiab-T1ρ) is sensitive to human cadaveric knee joint deformation induced by mechanical loading and unloading.

  2021cites this paper
• Model for in-vivo estimation of stiffness of tibiofemoral joint using MR imaging and FEM analysis

  2021cites this paper
• Longitudinal T2 Mapping and Texture Feature Analysis in the Detection and Monitoring of Experimental Post-Traumatic Cartilage Degeneration

  2021cites this paper
• Quantitative ultrashort echo time magnetization transfer (UTE-MT) for diagnosis of early cartilage degeneration: comparison with UTE-T2* and T2 mapping.

  2020cites this paper
• Detecting Articular Cartilage and Meniscus Deformation Effects Using Magnetization Transfer Ultrashort Echo Time (MT-UTE) Modeling during Mechanical Load Application: Ex Vivo Feasibility Study

  2020cites this paper
• Identifying the Imaging Correlates of Cartilage Functionality Based on Quantitative MRI Mapping - The Collagenase Exposure Model.

  2020cites this paper
• Toward diagnostic relevance of the αVβ5, αVβ3, and αVβ6 integrins in OA: expression within human cartilage and spinal osteophytes

  2020cites this paper
• A serial multiparametric quantitative magnetic resonance imaging study to assess proteoglycan depletion of human articular cartilage and its effects on functionality

  2020cites this paper
• Finite deformation elastography of articular cartilage and biomaterials based on imaging and topology optimization

  2020cites this paper
• An MRI-compatible varus–valgus loading device for whole-knee joint functionality assessment based on compartmental compression: a proof-of-concept study

  2020cites this paper
• Magnetic resonance imaging (MRI) studies of knee joint under mechanical loading: Review.

  2020cites this paper
• Low field magnetic resonance imaging of the equine distal interphalangeal joint: Comparison between weight-bearing and non-weight-bearing conditions

  2019cites this paper
• Peptidomic analysis of cartilage and subchondral bone in OA patients

  2019cites this paper
• Detection of Early-Stage Degeneration in Human Articular Cartilage by Multiparametric MR Imaging Mapping of Tissue Functionality

  2019cites this paper
• Towards Patient-Specific Computational Modelling of Articular Cartilage on the Basis of Advanced Multiparametric MRI Techniques

  2019cites this paper
• Differentiation of human cartilage degeneration by functional MRI mapping—an ex vivo study

  2019cites this paper
• A multi-purpose force-controlled loading device for cartilage and meniscus functionality assessment using advanced MRI techniques.

  2019cites this paper
• Advances toward multiscale computational models of cartilage mechanics and mechanobiology

  2019cites this paper
• A comparison of patellofemoral cartilage morphology and deformation in anterior cruciate ligament deficient versus uninjured knees.

  2018cites this paper
• Functional MRI can detect changes in intratissue strains in a full thickness and critical sized ovine cartilage defect model.

  2018cites this paper
• Chapter 4 – Image-Driven Constitutive Modeling for FE-Based Simulation of Soft Tissue Biomechanics

  2018cites this paper
• Multiparametric MRI and Computational Modelling in the Assessment of Human Articular Cartilage Properties: A Comprehensive Approach

  2018cites this paper
• Chondrale und osteochondrale Defekte

  2017cites this paper
• T2 MR imaging vs. computational modeling of human articular cartilage tissue functionality.

  2017cites this paper
• Functional MR Imaging Mapping of Human Articular Cartilage Response to Loading.

  2017cites this paper
• Non-invasive T1ρ mapping of the human cartilage response to loading and unloading.

  2017cites this paper
• WITHDRAWN: 3D visualization and pathological characteristics of cartilage and subchondral bone changes in the lumbar facet joint of an Ovariectomized mouse model.

  2017cites this paper
• Three‐dimensional imaging technologies: a priority for the advancement of tissue engineering and a challenge for the imaging community

  2017cites this paper
• Assessing Cartilage Biomechanical Properties: Techniques for Evaluating the Functional Performance of Cartilage in Health and Disease.

  2017cites this paper
• Three-dimensional visualization and pathologic characteristics of cartilage and subchondral bone changes in the lumbar facet joint of an ovariectomized mouse model.

  2017cites this paper
• Quantitative in vivo CT arthrography of the human osteoarthritic knee to estimate cartilage sulphated glycosaminoglycan content: correlation with ex-vivo reference standards.

  2016cites this paper
• Towards Optical Coherence Tomography-based elastographic evaluation of human cartilage.

  2016cites this paper
• MR elastography for evaluating regeneration of tissue‐engineered cartilage in an ectopic mouse model

  2016cites this paper
• Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration

  2016cites this paper
• Is T1ρ Mapping an Alternative to Delayed Gadolinium-enhanced MR Imaging of Cartilage in the Assessment of Sulphated Glycosaminoglycan Content in Human Osteoarthritic Knees? An in Vivo Validation Study.

  2016cites this paper
• In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee

  2016cites this paper
• Stiffness Mapping in Biological Materials based on MRI Imaging and Topology Optimization

  2016cites this paper
• Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration

  2016cites this paper
• Preclinical Positron Emission Tomographic Imaging of Acute Hyperoxia Therapy of Chronic Hypoxia during Pregnancy

  2015cites this paper
• Preclinical Positron Emission Tomographic Imaging of Acute Hyperoxia Therapy of Chronic Hypoxia during Pregnancy.

  2015cites this paper
• Quantitative Imaging Biomarkers of Knee Cartilage Composition

  2015cites this paper
• Multibanded anterior talofibular ligaments in normal ankles and sprained ankles using 3D isotropic proton density-weighted fast spin-echo MRI sequence.

  2014cites this paper