Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Oncogene

• Publication date

  1995-10-05

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 7478565
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibitors of mammalian G1 cyclin-dependent kinases.

  1995cited by this paper
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  1995cited by this paper
• A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation.

  1995cited by this paper
• Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

  1995cited by this paper
• Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity

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• Inhibition of ras-induced proliferation and cellular transformation by p16INK4

  1995cited by this paper
• Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

  1995cited by this paper
• p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

  1995cited by this paper
• p21-containing cyclin kinases exist in both active and inactive states.

  1994cited by this paper
• Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.

  1994cited by this paper
• p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.

  1994cited by this paper
• Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle.

  1994cited by this paper
• Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

  1994cited by this paper
• Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.

  1994cited by this paper
• Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.

  1994cited by this paper
• Interaction of c‐Myc with the pRb‐related protein p107 results in inhibition of c‐Myc‐mediated transactivation.

  1994cited by this paper
• Repression of cyclin D1: a novel function of MYC.

  1994cited by this paper
• Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

  1994cited by this paper
• c‐Myc‐induced apoptosis in fibroblasts is inhibited by specific cytokines.

  1994cited by this paper
• p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

  1994cited by this paper
• Induction of WAF1/CIP1 by a p53-independent pathway.

  1994cited by this paper
• Braking the cycle.

  1993cited by this paper
• p21 is a universal inhibitor of cyclin kinases

  1993cited by this paper
• Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

  1993cited by this paper
• The c‐Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

  1993cited by this paper
• Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

  1993cited by this paper
• Distinct roles for cyclin-dependent kinases in cell cycle control.

  1993cited by this paper
• Differential modulation of cyclin gene expression by MYC.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Induction of apoptosis in fibroblasts by c-myc protein.

  1992cited by this paper
• Abrogation by c-myc of Gl phase arrest induced by RB protein but not by p53

  1992cited by this paper
• The MYC protein activates transcription of the alpha‐prothymosin gene.

  1991cited by this paper
• Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

  1990cited by this paper
• Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens

  1980cited by this paper

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  2014cites this paper
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• Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer

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• The interplay between MYCN and the DNA damage response : modulation of MYCN expression, its interactions with components of the DNA damage response and cellular responses to N-myc following genotoxic stress

  2012cites this paper
• Kaposi Sarcoma-associated Herpesvirus vIRF-3 Protein Binds to F-box of Skp2 Protein and Acts as a Regulator of c-Myc Protein Function and Stability*

  2012cites this paper
• Determinants of cell cycle progression in human mammary epithelial MCF12 cells

  2012cites this paper
• Myc down‐regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line

  2009cites this paper
• The c-MYC-AP4-p21 cascade

  2009cites this paper
• Analysis of p53 and c-MYC, two key transcription factors involved in tumorigenesis

  2008cites this paper
• Thermosensitization by parthenolide in human lung adenocarcinoma A549 cells and p53- and hsp72-independent apoptosis induction via the nuclear factor-kappaB signal pathway.

  2008cites this paper
• AP4 encodes a c-MYC-inducible repressor of p21

  2008cites this paper
• Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells

  2007cites this paper
• c-MYC Delays Prometaphase by Direct Transactivation of MAD2 and BubR1: Identification of Mechanisms Underlying c-MYC-Induced DNA Damage and Chromosomal Instability

  2007cites this paper
• Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts

  2007cites this paper
• Stimulation of c-Myc Transcriptional Activity by vIRF-3 of Kaposi Sarcoma-associated Herpesvirus*

  2007cites this paper
• Transcriptional targets of p53 that regulate cellular proliferation.

  2007cites this paper
• Defects in @ 21 WAF 1 / CIP 1 , Rb , and c-myc Signaling in Phorbol Ester-resistant Cancer Cells

  2006cites this paper
• Advances in Brief Differential Regulation of Cell Cycle Characteristics and Apoptosis in MMTV-myc and MMTV-ras Mouse Mammary Tumors '

  2006cites this paper
• MYC Can Enforce Cell Cycle Transit from G1 to S and G2 to S, But not Mitotic Cellular Division, Independent of p27 Inhibition of Cyclin E/CDK2

  2006cites this paper
• Prognostic Value of 21 wAF 1 and p 53 Expression in Breast Carcinoma : An Immunohistochemical Study in 261 Patients with Long-Term Follow-Up

  2005cites this paper
• p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle Arrest

  2005cites this paper
• Negative Control of the Myc Protein by the Stress-Responsive Kinase Pak2

  2004cites this paper
• Estrogen and Progestin Regulation of Cell Cycle Progression

  2004cites this paper
• Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals.

  2004cites this paper
• P21WAF1, P27KIP1, TP53 and C-MYC analysis in 204 ovarian carcinomas treated with platinum-based regimens.

  2003cites this paper
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  2003cites this paper
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  2003cites this paper
• P 21 WAF 1 , P 27 KIP 1 , TP 53 and C-MYC analysis in 204 ovarian carcinomas treated with platinum-based regimens

  2003cites this paper
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  2003cites this paper
• c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability.

  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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• A p53 mutation is required for stable transformation of REF52 cells by themyc andras oncogenes

  2000cites this paper
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• Induced p21WAF1 expression acts to reverse myc myelomonocytic cell transformation

  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
• NOTE TO USERS

  1999cites this paper
• Advances in Brief Quantitation of MYC Gene Expression in Sporadic Breast Tumors with a Real-Time Reverse Transcription-PCR Assay 1

  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998cites this paper
• Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes.

  1998cites this paper
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  1998cites this paper
• SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors

  1998cites this paper
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  1998cites this paper
• No correlation of c-myc overexpression and p53 mutations in liposarcomas

  1998cites this paper
• Myc and the cell cycle.

  1998cites this paper
• Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instability

  1998cites this paper
• Mechanisms of Cyclin-Dependent Kinase Inactivation by Progestins

  1998cites this paper
• Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

  1998cites this paper
• c-Myc or Cyclin D1 Mimics Estrogen Effects on Cyclin E-Cdk2 Activation and Cell Cycle Reentry

  1998cites this paper
• Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development.

  1998cites this paper
• Regulation of Apoptosis-Associated Genes in the Regenerating Liver

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• Ras versus cyclin-dependent kinase inhibitors.

  1998cites this paper
• Induction of wild‐type p53, Bax, and acidic endonuclease during somatostatin‐signaled apoptosis in MCF‐7 human breast cancer cells

  1998cites this paper
• Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

  1998cites this paper
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  1998cites this paper
• Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells.

  1997cites this paper
• Cell Cycle Control

  1997cites this paper
• HPV-16 E 7 ? oncoprotein Inhibition of CDK activity and PCNA-dependent DNA replication

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• CIP 1 and Cdc 25 A : Competition between an Inhibitor and an Activator of Cyclin-Dependent Kinases

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• Inactivation by Progestins Mechanisms of Cyclin-Dependent Kinase

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  1997cites this paper
• Zellzykluskontrolle, genetische Instabilität und Krebs

  1997cites this paper
• Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein.

  1997influential citation
• p21 CIP1 and Cdc25A: Competition between an Inhibitor and an Activator of Cyclin-Dependent Kinases

  1997cites this paper
• [Cell cycle control, genetic instability and cancer].

  1997cites this paper
• Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma.

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• Cyclin dependent kinase inhibitors.

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