A balance between circular and linear forms of the dengue virus genome is crucial for viral replication.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  RNA: A publication of the RNA Society

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1261/rna.2120410PMID 20980673PMCID PMC2995394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interplay of RNA Elements in the Dengue Virus 5′ and 3′ Ends Required for Viral RNA Replication

  2010influential reference
• RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs

  2009cited by this paper
• Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells.

  2009cited by this paper
• The 3' end of Turnip crinkle virus contains a highly interactive structure including a translational enhancer that is disrupted by binding to the RNA-dependent RNA polymerase.

  2009cited by this paper
• Genome cyclization as strategy for flavivirus RNA replication.

  2009cited by this paper
• Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

  2009influential reference
• The 3 9 end of Turnip crinkle virus contains a highly interactive structure including a translational enhancer that is disrupted by binding to the RNA-dependent RNA polymerase

  2009cited by this paper
• La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus replication.

  2009cited by this paper
• A Discontinuous RNA Platform Mediates RNA Virus Replication: Building an Integrated Model for RNA–based Regulation of Viral Processes

  2009cited by this paper
• Structural Plasticity and Rapid Evolution in a Viral RNA Revealed by In Vivo Genetic Selection

  2008cited by this paper
• Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication

  2008cited by this paper
• Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein.

  2008cited by this paper
• A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS 5 B †

  2008cited by this paper
• Conformational Changes in the Solution Structure of the Dengue Virus 5′ End in the Presence and Absence of the 3′ Untranslated Region

  2008cited by this paper
• West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions.

  2008cited by this paper
• A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B

  2008cited by this paper
• Genome 3'-end repair in dengue virus type 2.

  2008cited by this paper
• Functional analysis of dengue virus cyclization sequences located at the 5' and 3'UTRs.

  2008influential reference
• A complex RNA motif defined by three discontinuous 5-nucleotide-long strands is essential for Flavivirus RNA replication.

  2008cited by this paper
• The RNAz web server: prediction of thermodynamically stable and evolutionarily conserved RNA structures

  2007cited by this paper
• Flaviviridae :T he Viruses and Their Replication

  2007cited by this paper
• 3′ RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U)

  2007cited by this paper
• Y Box-binding Protein-1 Binds to the Dengue Virus 3′-Untranslated Region and Mediates Antiviral Effects*

  2007cited by this paper
• Genetic Interactions between an Essential 3′ cis-Acting RNA Pseudoknot, Replicase Gene Products, and the Extreme 3′ End of the Mouse Coronavirus Genome

  2007cited by this paper
• Mosquito La protein binds to the 3' untranslated region of the positive and negative polarity dengue virus RNAs and relocates to the cytoplasm of infected cells.

  2007cited by this paper
• RNA consensus structure prediction with RNAalifold.

  2007cited by this paper
• Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications?

  2007cited by this paper
• Clustal W and Clustal X version 2.0

  2007cited by this paper
• A 5' RNA element promotes dengue virus RNA synthesis on a circular genome.

  2006influential reference
• Long-distance RNA-RNA interactions between terminal elements and the same subset of internal elements on the potato virus X genome mediate minus- and plus-strand RNA synthesis.

  2006cited by this paper
• Functional Analysis of the Tick-Borne Encephalitis Virus Cyclization ElementsIndicates Major Differences between Mosquito-Borne and Tick-Borne Flaviviruses

  2006cited by this paper
• Conformational changes involved in initiation of minus-strand synthesis of a virus-associated RNA.

  2006cited by this paper
• Long-Range RNA-RNA Interactions Circularize the Dengue Virus Genome

  2005influential reference
• Mutual Interference between Genomic RNA Replication and Subgenomic mRNA Transcription in Brome Mosaic Virus

  2005cited by this paper
• Role of RNA structures present at the 3'UTR of dengue virus on translation, RNA synthesis, and viral replication.

  2005influential reference
• The Hantavirus Nucleocapsid Protein Recognizes Specific Features of the Viral RNA Panhandle and Is Altered in Conformation upon RNA Binding

  2005cited by this paper
• Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication

  2005cited by this paper
• Structure and Function of the 3′ Terminal Six Nucleotides of the West Nile Virus Genome in Viral Replication

  2004cited by this paper
• 5′- and 3′-noncoding regions in flavivirus RNA

  2004cited by this paper
• La protein binds to NS5 and NS3 and to the 5' and 3' ends of Dengue 4 virus RNA.

  2004cited by this paper
• 5′-3′ RNA-RNA Interaction Facilitates Cap- and Poly(A) Tail-independent Translation of Tomato Bushy Stunt Virus mRNA

  2004cited by this paper
• Conserved RNA secondary structures in Flaviviridae genomes.

  2004cited by this paper
• Characterization of the RNA Components of a Putative Molecular Switch in the 3′ Untranslated Region of the Murine Coronavirus Genome

  2004cited by this paper
• Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus

  2004cited by this paper
• A complex network of RNA–RNA interactions controls subgenomic mRNA transcription in a tombusvirus

  2004cited by this paper
• The RNA Replication Enhancer Element of Tombusviruses Contains Two Interchangeable Hairpins That Are Functional during Plus-Strand Synthesis

  2003cited by this paper
• Long-range RNA-RNA interaction between the 5' nontranslated region and the core-coding sequences of hepatitis C virus modulates the IRES-dependent translation.

  2003cited by this paper
• Cellular Proteins from Human Monocytes Bind to Dengue 4 Virus Minus-Strand 3′ Untranslated Region RNA

  2003cited by this paper
• Fine Mapping of a cis-Acting Sequence Element in Yellow Fever Virus RNA That Is Required for RNA Replication and Cyclization

  2003cited by this paper
• Functional Analysis of Mosquito-Borne Flavivirus Conserved Sequence Elements within 3′ Untranslated Region of West Nile Virus by Use of a Reporting Replicon That Differentiates between Viral Translation and RNA Replication

  2003cited by this paper
• Enhancer-Like Activity of a Brome Mosaic Virus RNA Promoter

  2003cited by this paper
• A replication silencer element in a plus‐strand RNA virus

  2003cited by this paper
• Mfold web server for nucleic acid folding and hybridization prediction

  2003influential reference
• Bis(azido-kappaN)[(6R,7S,8S,14S)-(-)-sparteine-kappa2N,N']copper(II).

  2003cited by this paper
• Cell Proteins TIA-1 and TIAR Interact with the 3′ Stem-Loop of the West Nile Virus Complementary Minus-Strand RNA and Facilitate Virus Replication

  2002cited by this paper
• Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA.

  2002cited by this paper
• Long-Distance Base Pairing in Flock House Virus RNA1 Regulates Subgenomic RNA3 Synthesis and RNA2 Replication

  2002cited by this paper
• Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis.

  2001cited by this paper
• Base-pairing between untranslated regions facilitates translation of uncapped, nonpolyadenylated viral RNA.

  2001cited by this paper
• Two alternating structures of the HIV-1 leader RNA.

  2001cited by this paper
• Essential Role of Cyclization Sequences in Flavivirus RNA Replication

  2001influential reference
• Mov34 Protein from Mouse Brain Interacts with the 3′ Noncoding Region of Japanese Encephalitis Virus

  2000cited by this paper
• Interactions of Viral Protein 3CD and Poly(rC) Binding Protein with the 5′ Untranslated Region of the Poliovirus Genome

  2000cited by this paper
• Identification of an RNA Hairpin in Poliovirus RNA That Serves as the Primary Template in the In Vitro Uridylylation of VPg

  2000cited by this paper
• FUNCTIONS OF THE 3'-UNTRANSLATED REGIONS OF POSITIVE STRAND RNA VIRAL GENOMES.

  1999cited by this paper
• A Novel in Vitro Replication System for Dengue Virus

  1999cited by this paper
• Long-distance RNA-RNA interactions and conserved sequence elements affect potato virus X plus-strand RNA accumulation.

  1999cited by this paper
• A long-range pseudoknot in Qbeta RNA is essential for replication.

  1999cited by this paper
• A long-range pseudoknot in Q RNA is essential for replication 1 1 Edited by D. E. Draper

  1999cited by this paper
• The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication.

  1998cited by this paper
• Switch from translation to RNA replication in a positive-stranded RNA virus.

  1998cited by this paper
• Translation elongation factor-1 alpha interacts with the 3' stem-loop region of West Nile virus genomic RNA

  1997cited by this paper
• A viral sequence in the 3′‐untranslated region mimics a 5′ cap in facilitating translation of uncapped mRNA

  1997cited by this paper
• TreeView: an application to display phylogenetic trees on personal computers

  1996cited by this paper
• Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA.

  1996cited by this paper
• Requirement of a 3'-terminal stem-loop in in vitro transcription by an RNA-dependent RNA polymerase.

  1995cited by this paper
• Sequencing the termini of capped viral RNA by 5'-3' ligation and PCR.

  1991cited by this paper
• Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA

  1990cited by this paper
• A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA.

  1990cited by this paper
• Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences.

  1987cited by this paper
• 5 (cid:1) -3 (cid:1) RNA-RNA Interaction Facilitates Cap- and Poly(A) Tail-independent Translation of Tomato Bushy Stunt Virus mRNA A POTENTIAL COMMON MECHANISM FOR TOMBUSVIRIDAE*

  year unknowncited by this paper

• The influence of natural adaptation of the DCS-PK structure on the replication efficiency of Zika virus.

  2026cites this paper
• Suboptimal dengue genome leverages non-canonical translation mechanisms

  2025cites this paper
• Conserved long-range interactions are required for stable folding of orthoflaviviral genomic RNA

  2025influential citation
• Dengue and severe dengue

  2025cites this paper
• Cellular Biology: Virus-Host Interactions and RNA Structure and Function.

  2025cites this paper
• A conserved RNA structure at the capsid-coding sequence of Zika virus genome is required for viral replication in a host-dependent manner

  2025cites this paper
• Viral RNA blocks circularization to evade host codon usage control

  2025cites this paper
• West Nile virus unmasked: from gene variability to future challenges

  2025cites this paper
• The myriad roles of RNA structure in the flavivirus life cycle

  2024influential citation
• GCRV-encoded circRNA circ_20 forms a ternary complex with BIP and PERK to delay virus replication by inhibiting the PERK-eIF2α pathway.

  2024cites this paper
• Structure of Essential RNA Regulatory Elements in the West Nile Virus 3'-Terminal Stem Loop.

  2024cites this paper
• The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles

  2024cites this paper
• Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states.

  2024cites this paper
• Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes

  2023cites this paper
• Specialized cis-Acting RNA Elements Balance Genome Cyclization to Ensure Efficient Replication of Yellow Fever Virus

  2023cites this paper
• Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies

  2023cites this paper
• Subgenomic Flaviviral RNAs of Dengue Viruses

  2023cites this paper
• Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies

  2022cites this paper
• Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity

  2022cites this paper
• Structure of the dengue virus RNA promoter

  2022cites this paper
• Interactions of host miRNAs in the flavivirus 3´UTR genome: From bioinformatics predictions to practical approaches

  2022cites this paper
• Broad-spectrum anti-flavivirus activity and chemistry of compounds containing sulfur and oxygen chalcogens.

  2022cites this paper
• Phylogenetic Characterisation of the Full Genome of a Bagaza Virus Isolate from Bird Fatalities in South Africa

  2022cites this paper
• Evolutionary traits of Tick-borne encephalitis virus: Pervasive non-coding RNA structure conservation and molecular epidemiology

  2021cites this paper
• Structural evolution of SLA promoter in mosquito-borne flaviviruses: A sequence-structure based phylogenetic framework.

  2021cites this paper
• Molecular Insights into the Flavivirus Replication Complex

  2021cites this paper
• Dengue virus 2 capsid protein chaperones the strand displacement of 5′-3′ cyclization sequences

  2021cites this paper
• Genetic Variation in the Domain II, 3′ Untranslated Region of Human and Mosquito Derived Dengue Virus Strains in Sri Lanka

  2021cites this paper
• Dengue virus 2 capsid protein chaperones strand displacement without altering the capsid-coding region hairpin element’s structural functionality

  2021cites this paper
• Dengue virus strain 2 capsid protein switches the annealing pathway and reduces intrinsic dynamics of the conserved 5’ untranslated region

  2021cites this paper
• An RNA Thermometer Activity of the West Nile Virus Genomic 3′-Terminal Stem-Loop Element Modulates Viral Replication Efficiency during Host Switching

  2020cites this paper
• Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

  2020cites this paper
• Universal RNA Secondary Structure Insight Into Mosquito-Borne Flavivirus (MBFV) cis-Acting RNA Biology

  2020cites this paper
• A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of <italic toggle='yes'>Flaviviridae</italic>

  2020cites this paper
• A new subclass of exoribonuclease resistant RNA found in multiple Flaviviridae genera

  2020cites this paper
• A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae

  2020cites this paper
• An epigenetic ‘extreme makeover’: the methylation of flaviviral RNA (and beyond)

  2020cites this paper
• NMR structure of Dengue West Nile viruses stem-loop B: A key cis-acting element for flavivirus replication.

  2020cites this paper
• Latest Updates in Dengue Fever Therapeutics: Natural, Marine, and Synthetic Drugs.

  2020cites this paper
• Structure and function of cis‐acting RNA elements of flavivirus

  2019cites this paper
• Effects of deletion at the TTTSTTT motif of Hibiscus latent Singapore virus coat protein on viral replication and long-distance movement.

  2019cites this paper
• RNA Structure Duplication in the Dengue Virus 3′ UTR: Redundancy or Host Specificity?

  2019cites this paper
• Functional RNA Structures in the 3′UTR of Tick-Borne, Insect-Specific and No-Known-Vector Flaviviruses

  2019cites this paper
• Structure mapping of dengue and Zika viruses reveals functional long-range interactions

  2019cites this paper
• Adaptive Reactions of Winter Wheat (Triticum aestivum L.) Affected by Eyespot Causal Agent under the Action of Bacillus subtilis Bacterial Isolates

  2019cites this paper
• Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation

  2019cites this paper
• Conserve Nucleotide Motifs within Tobamovirus Genomic Promoters

  2019cites this paper
• Endless Forms: Within-Host Variation in the Structure of the West Nile Virus RNA Genome during Serial Passage in Bird Hosts

  2019cites this paper
• Structural and phenotypic analysis of Chikungunya virus RNA replication elements

  2019cites this paper
• Circularization of flavivirus genomic RNA inhibits de novo translation initiation

  2019cites this paper
• Different Degrees of 5'-to-3' DAR Interactions Modulate Zika Virus Genome Cyclization and Host-Specific Replication

  2019influential citation
• Dengue Virus

  2019cites this paper
• Biochemistry and Molecular Biology of Flaviviruses.

  2018cites this paper
• Genome-wide discovery of local RNA structural elements in Zika virus

  2018cites this paper
• Musashi binding elements in Zika and related Flavivirus 3′UTRs: A comparative study in silico

  2018cites this paper
• What Does the Future Hold for Yellow Fever Virus? (II)

  2018cites this paper
• What Does the Future Hold for Yellow Fever Virus? (I)

  2018cites this paper
• The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis

  2018cites this paper
• ScanFold: an approach for genome-wide discovery of local RNA structural elements—applications to Zika virus and HIV

  2018cites this paper
• Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein Synthesis

  2018cites this paper
• Zika virus: An emerging flavivirus

  2017cites this paper
• The 5′ and 3′ Untranslated Regions of the Flaviviral Genome

  2017cites this paper
• Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes

  2017cites this paper
• Translation-mediated stress responses : mining of ribosome profiling data

  2017cites this paper
• Insights into the coordinated interplay of the sHP hairpin and its co-existing and mutually-exclusive dengue virus terminal RNA elements for viral replication.

  2017influential citation
• Structural alteration of a BYDV-like translation element (BTE) that attenuates p35 expression in three mild Tobacco bushy top virus isolates

  2017cites this paper
• Estudios de estructuras de ARN que regulan la replicación del virus del dengue en humanos y mosquitos

  2016cites this paper
• Functional analysis of replication determinantsin classical swine fever virus

  2016cites this paper
• Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication*

  2016cites this paper
• Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

  2016influential citation
• RNA structure through multidimensional chemical mapping

  2016cites this paper
• Genomic characterization and phylogenetic analysis of Zika virus circulating in the Americas.

  2016cites this paper
• Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45

  2016cites this paper
• A Brief Review of West Nile Virus Biology.

  2016cites this paper
• Uncontrolled Citrus psorosis virus infection in Citrus sinensis transgenic plants expressing a viral 24K-derived hairpin that does not trigger RNA silencing

  2016cites this paper
• Global Virology I - Identifying and Investigating Viral Diseases

  2015cites this paper
• Overlapping Local and Long-Range RNA-RNA Interactions Modulate Dengue Virus Genome Cyclization and Replication

  2015cites this paper
• Diverse roles and interactions of RNA structures during the replication of positive-stranded RNA viruses of humans and animals.

  2015cites this paper
• Flaviviruses: Introduction to Dengue Viruses

  2015cites this paper
• Functions of the 3' and 5' genome RNA regions of members of the genus Flavivirus.

  2015cites this paper
• Flavivirus RNA synthesis in vitro.

  2015cites this paper
• New hypotheses derived from the structure of a flaviviral Xrn1-resistant RNA: Conservation, folding, and host adaptation

  2015cites this paper
• Nuclear proteins hijacked by mammalian cytoplasmic plus strand RNA viruses

  2015influential citation
• Rich RNA Structure Landscapes Revealed by Mutate-and-Map Analysis

  2015cites this paper
• RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA

  2014cites this paper
• Regulation of Flavivirus RNA synthesis and replication.

  2014cites this paper
• Functional long-range RNA–RNA interactions in positive-strand RNA viruses

  2014influential citation
• Contents category: Positive-strand RNA viruses

  2014cites this paper
• Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology.

  2014cites this paper
• Inhibition of Dengue Virus 3 in Mammalian Cell Cult ure by Synthetic Small Interfering RNAs Targeting Highly Conserved Sequences Ummar Raheel * and Najam Us

  2014cites this paper
• AUF1 p45 Promotes West Nile Virus Replication by an RNA Chaperone Activity That Supports Cyclization of the Viral Genome

  2014cites this paper
• Molecular Archaeology of Flaviviridae Untranslated Regions: Duplicated RNA Structures in the Replication Enhancer of Flaviviruses and Pestiviruses Emerged via Convergent Evolution

  2014cites this paper
• Inhibition of Dengue Virus 3 in Mammalian Cell Culture by Synthetic Small Interfering RNAs Targeting Highly Conserved Sequences

  2014cites this paper
• Interação vírus-vetor: caracterização da região 3' não- codificante (NC) de vírus dengue tipo 3 (DENV-3), isolados de mosquitos e humanos, após a infecção experimental sucessiva e simultânea em mosquitos

  2014cites this paper
• Differential RNA Sequence Requirement for Dengue Virus Replication in Mosquito and Mammalian Cells

  2013cites this paper
• Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome

  2013influential citation
• Replication Cycle and Molecular Biology of the West Nile Virus

  2013cites this paper
• Norovirus Genome Circularization and Efficient Replication Are Facilitated by Binding of PCBP2 and hnRNP A1

  2013cites this paper
• Do RNA viruses require genome cyclisation for replication?

  2013cites this paper
• Rôle de la structure du génome viral sur la réplication du virus de l’hépatite C

  2013cites this paper