Interleukin-6 and CAAT/enhancer binding protein beta-deficient mice act as tools to dissect the IL-6 signalling pathway and IL-6 regulation.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Immunobiology

• Publication date

  1997-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0171-2985(97)80035-6PMID 9442386
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Impaired Stat3 activation following localized inflammatory stimulus in IL-6-deficient mice.

  1998cited by this paper
• C/EBPbeta is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-alpha, but not Interleukin-6, regulation.

  1996cited by this paper
• Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice

  1996cited by this paper
• Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice.

  1995cited by this paper
• Lymphoproliferative disorder and imbalanced T‐helper response in C/EBP beta‐deficient mice.

  1995cited by this paper
• Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis.

  1995cited by this paper
• Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.

  1995cited by this paper
• Interleukin-6 family of cytokines and gp130.

  1995cited by this paper
• Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.

  1995cited by this paper
• Separate Signaling Mechanisms Are Involved in the Control of STAT Protein Activation and Gene Regulation via the Interleukin 6 Response Element by the Box 3 Motif of gp130 (*)

  1995cited by this paper
• Defective inflammatory response in interleukin 6-deficient mice

  1994cited by this paper
• Impaired immune and acute-phase responses in interleukin-6-deficient mice

  1994cited by this paper
• Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.

  1994cited by this paper
• Transcriptional regulation of acute phase genes by IL-6 and related cytokines.

  1994cited by this paper
• Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.

  1994cited by this paper
• Liver Gene Expression

  1994cited by this paper
• Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody.

  1994cited by this paper
• Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.

  1994cited by this paper
• Multicentric Castleman's disease.

  1993cited by this paper
• A common nuclear signal transduction pathway activated by growth factor and cytokine receptors.

  1993cited by this paper
• Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector.

  1991cited by this paper
• IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP.

  1990cited by this paper
• A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

  1990cited by this paper
• Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

  1990cited by this paper
• Biological and clinical aspects of interleukin 6.

  1990cited by this paper
• Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease.

  1989cited by this paper
• Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

  1989cited by this paper
• Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

  1986cited by this paper
• Tissue-specific in vitro transcription from the mouse albumin promoter.

  1986cited by this paper
• Human tumor necrosis factor. Production, purification, and characterization.

  1985cited by this paper

• Retrospective cohort evaluation of renal involvement in non-HIV castleman disease patients from a single academic center in Beijing, China

  2026cites this paper
• Integration of genetic and chromatin modification data pinpoints autoimmune-specific remodeling of enhancer landscape in CD4+ T cells.

  2024cites this paper
• Abnormal expression of CEBPB promotes the progression of renal cell carcinoma through regulating the generation of IL-6

  2023cites this paper
• Cell specific peripheral immune responses predict survival in critical COVID-19 patients

  2022cites this paper
• Cell specific peripheral immune responses predict survival in critical COVID-19 patients

  2022cites this paper
• Novel Functions and Virus-Host Interactions Implicated in Pathogenesis and Replication of Human Herpesvirus 8.

  2021cites this paper
• Castleman Disease

  2019cites this paper
• STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

  2018cites this paper
• Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease.

  2018cites this paper
• Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease.

  2018cites this paper
• Castleman Disease Pathogenesis.

  2018cites this paper
• Identifying Predictors of Taxane-Induced Peripheral Neuropathy Using Mass Spectrometry-Based Proteomics Technology

  2015cites this paper
• Stromal Fibroblasts Induce CCL20 through IL6/C/EBPβ to Support the Recruitment of Th17 Cells during Cervical Cancer Progression.

  2015cites this paper
• into biology, pathogenesis, and therapy HHV-8-negative, idiopathic multicentric Castleman disease: novel insights

  2014cites this paper
• HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy.

  2014cites this paper
• insights into biology, pathogenesis, and therapy HHV-8-negative, idiopathic multicentric Castleman disease: novel

  2014cites this paper
• Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass.

  2013cites this paper
• CCAAT/enhancing binding protein β deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet‐induced nonalcoholic steatohepatitis

  2007cites this paper
• IL-6/gpl30/Stat3

  2005cites this paper
• Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis.

  2005cites this paper
• Gene Expression Profiling of 17 b -Estradiol and Genistein Effects on Mouse Thymus

  2005influential citation
• Gene expression profiling of 17beta-estradiol and genistein effects on mouse thymus.

  2005cites this paper
• Liver-Enriched Transcription Factors in Liver Function and Development. Part II: the C/EBPs and D Site-Binding Protein in Cell Cycle Control, Carcinogenesis, Circadian Gene Regulation, Liver Regeneration, Apoptosis, and Liver-Specific Gene Regulation

  2004cites this paper
• C/EBP-delta induction by gp130 signaling. Role in transition to myelin gene expressing phenotype in a melanoma cell line model.

  2004cites this paper
• Surfactant Protein A Modulates the Inflammatory Response in Macrophages during Tuberculosis

  2004cites this paper
• Cell-specific pituitary gene expression profiles after treatment with leukemia inhibitory factor reveal novel modulators for proopiomelanocortin expression.

  2004cites this paper
• Functional analysis of interleukin 6 response elements (IL-6REs) on the human gamma-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with transactivation potential of type II IL-6REs.

  2003cites this paper
• Influenza Virus Infection Induces Metallothionein Gene Expression in the Mouse Liver and Lung by Overlapping but Distinct Molecular Mechanisms

  2001cites this paper
• Distinct Molecular Mechanisms Mouse Liver and Lung by Overlapping but Metallothionein Gene Expression in the Influenza Virus Infection Induces

  2001cites this paper
• Transcriptional regulation of hemopoiesis.

  2001cites this paper
• Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis.

  2001cites this paper
• Traitements therapeutiques pour des deficiences en cellules sanguines

  2000cites this paper
• REGULATION OF TNF-α EXPRESSION IN NORMAL MACROPHAGES: THE ROLE OF C/EBPβ

  2000cites this paper
• EBP κ the Dominant Role for NF-Rheumatoid Arthritis Synovial Fibroblasts : Regulation of IL-6 and IL-8 Expression in

  2000cites this paper
• Regulation of IL-6 and IL-8 Expression in Rheumatoid Arthritis Synovial Fibroblasts: the Dominant Role for NF-κB But Not C/EBPβ or c-Jun1

  2000cites this paper
• Regulation of TNF-alpha expression in normal macrophages: the role of C/EBPbeta.

  2000cites this paper
• Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression.

  2000cites this paper
• New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?

  1999cites this paper
• Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression.

  1999cites this paper
• Expression of Murine Inducible Nitric Oxide Synthase for Cytokine and Iron-Mediated Regulation Central Role of Transcription Factor NF-IL 6

  1999cites this paper
• Roles of CCAAT/Enhancer-binding Proteins in Regulation of Liver Regenerative Growth*

  1998cites this paper