Gene expression profiling of 17beta-estradiol and genistein effects on mouse thymus.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Toxicological Sciences

• Publication date

  2005-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/TOXSCI/KFI219PMID 15947025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones.

  2005cited by this paper
• Potential of p38 MAP kinase inhibitors in the treatment of cancer.

  2003cited by this paper
• Functional Requirements for Interactions Between CD84 and Src Homology 2 Domain-Containing Proteins and Their Contribution to Human T Cell Activation 1

  2003cited by this paper
• The immune system of geriatric mice is modulated by estrogenic endocrine disruptors (diethylstilbestrol, alpha-zearalanol, and genistein): effects on interferon-gamma.

  2003cited by this paper
• The phytoestrogen genistein suppresses cell-mediated immunity in mice.

  2003cited by this paper
• The immune system of geriatric mice is modulated by estrogenic endocrine disruptors (diethylstilbestrol, α-zearalanol, and genistein): Effects on interferon-γ

  2003cited by this paper
• Signaling Life and Death in the Thymus: Timing Is Everything

  2003cited by this paper
• The soy isoflavone genistein decreases adipose deposition in mice.

  2003cited by this paper
• The main function of IL‐2 is to promote the development of T regulatory cells

  2003cited by this paper
• Effect of dietary genistein on cell replication indices in C57BL6 mice.

  2003cited by this paper
• Surface Expression of Notch1 on Thymocytes: Correlation with the Double-Negative to Double-Positive Transition 1

  2003cited by this paper
• T(h)1/T(h)2 cell differentiation of developing CD4 single-positive thymocytes.

  2002cited by this paper
• Androgens and Estrogens Modulate the Immune and Inflammatory Responses in Rheumatoid Arthritis

  2002cited by this paper
• Control of IL-2Rα gene expression: structural changes within the proximal enhancer/core promoter during T-cell development

  2002cited by this paper
• The phytoestrogen genistein induces thymic and immune changes: A human health concern?

  2002influential reference
• Notch signaling in hematopoiesis and early lymphocyte development

  2002cited by this paper
• Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats.

  2002cited by this paper
• Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.

  2002cited by this paper
• Early Exposure to Genistein Exerts Long-Lasting Effects on the Endocrine and Immune Systems in Rats

  2002cited by this paper
• Cytokines and autoimmunity

  2002influential reference
• Role of death receptor pathway in estradiol-induced T-cell apoptosis in vivo.

  2002cited by this paper
• T Lymphocytes Potentiate Murine Dendritic Cells to Produce IL-121

  2002cited by this paper
• Thymopoiesis requires Pax9 function in thymic epithelial cells

  2002cited by this paper
• Interleukin-2 signaling and the maintenance of self-tolerance.

  2002cited by this paper
• Controlling CD4 gene expression during T cell lineage commitment.

  2002cited by this paper
• Immune Status of Infants Fed Soy-Based Formulas With or Without Added Nucleotides for 1 Year: Part 2: Immune Cell Populations

  2002cited by this paper
• Glucocorticoid-Induced Leucine Zipper Inhibits the Raf-Extracellular Signal-Regulated Kinase Pathway by Binding to Raf-1

  2002cited by this paper
• Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development.

  2002cited by this paper
• Modulation of T‐lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1

  2002cited by this paper
• Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development.

  2002cited by this paper
• Immune Status of Infants Fed Soy-Based Formulas With or Without Added Nucleotides for 1 Year: Part 1: Vaccine Responses, and Morbidity

  2002cited by this paper
• ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells

  2002cited by this paper
• A high isoflavone soy protein diet and intravenous genistein delay rejection of rat cardiac allografts.

  2002cited by this paper
• Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice.

  2001cited by this paper
• IL-2-induced tumor necrosis factor (TNF)-β expression : further analysis in the IL-2 knockout model, and comparison with TNF-α, lymphotoxin-β, TNFR1 and TNFR2 modulation

  2001cited by this paper
• H2-Mβ1 and H2-Mβ2 Heterodimers Equally Promote CLIP Removal in I-Aq Molecules from Autoimmune-prone DBA/1 Mice*

  2001cited by this paper
• Role of oestrogen receptors α and β in immune organ development and in oestrogen‐mediated effects on thymus

  2001cited by this paper
• Sex differences in autoimmune disease

  2001cited by this paper
• A Requirement for IL-2/IL-2 Receptor Signaling in Intrathymic Negative Selection1

  2001cited by this paper
• H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.

  2001cited by this paper
• CD84 Functions as a Homophilic Adhesion Molecule and Enhances IFN-γ Secretion: Adhesion Is Mediated by Ig-Like Domain 11

  2001cited by this paper
• Induction of Apoptosis by a Secreted Lipocalin That is Transcriptionally Regulated by IL-3 Deprivation

  2001cited by this paper
• IL-2-induced tumor necrosis factor (TNF)-beta expression: further analysis in the IL-2 knockout model, and comparison with TNF-alpha, lymphotoxin-beta, TNFR1 and TNFR2 modulation.

  2001cited by this paper
• Expression of Mad1 in T cells leads to reduced thymic cellularity and impaired mitogen-induced proliferation

  2001cited by this paper
• ICOS is essential for effective T-helper-cell responses

  2001cited by this paper
• Interleukin-9 induces 24P3 lipocalin gene expression in murine T cell lymphomas.

  2001cited by this paper
• Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus.

  2001cited by this paper
• Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus.

  2001cited by this paper
• The Role of the Fas/Fas Ligand System in Estrogen‐Induced Thymic Alteration

  2001cited by this paper
• Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.

  2001cited by this paper
• Sexual dimorphism in immune function: the role of prenatal exposure to androgens and estrogens.

  2000cited by this paper
• Transcription Factor PU.1 Is Necessary for Development of Thymic and Myeloid Progenitor-Derived Dendritic Cells1

  2000cited by this paper
• Normal development of thymus in male and female mice requires estrogen/estrogen receptor-α signaling pathway

  2000cited by this paper
• Constitutive activation of NF‐κB and T‐cell leukemia/lymphoma in Notch3 transgenic mice

  2000cited by this paper
• The Myc/Max/Mad network and the transcriptional control of cell behavior.

  2000cited by this paper
• Chemokines define distinct microenvironments in the developing thymus

  2000cited by this paper
• The immune system as a potential target for environmental estrogens (endocrine disrupters): a new emerging field.

  2000cited by this paper
• Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations.

  1999cited by this paper
• Multiple gamma c-dependent cytokines regulate T-cell development.

  1999cited by this paper
• Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development.

  1999cited by this paper
• Gender and risk of autoimmune diseases: possible role of estrogenic compounds.

  1999cited by this paper
• Environmentally induced autoimmune diseases: potential mechanisms.

  1999cited by this paper
• Sin meets NuRD and other tails of repression.

  1999cited by this paper
• Multiple γc-dependent cytokines regulate T-cell development

  1999cited by this paper
• Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

  1999cited by this paper
• Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.

  1999cited by this paper
• CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor

  1998cited by this paper
• Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.

  1998cited by this paper
• Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako).

  1998cited by this paper
• Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans.

  1998cited by this paper
• In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development.

  1998cited by this paper
• Chemokines: understanding their role in T-lymphocyte biology.

  1998cited by this paper
• Interleukin-6 and CAAT/enhancer binding protein beta-deficient mice act as tools to dissect the IL-6 signalling pathway and IL-6 regulation.

  1997cited by this paper
• Exposure of infants to phyto-oestrogens from soy-based infant formula.

  1997cited by this paper
• Individual and combinatory effects of soy isoflavones on the in vitro potentiation of lymphocyte activation.

  1997cited by this paper
• A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death.

  1997cited by this paper
• Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation.

  1996cited by this paper
• Gonadal steroids and immunity.

  1996cited by this paper
• Functional diversity of helper T lymphocytes

  1996cited by this paper
• Sex steroid hormones and macrophage function.

  1996cited by this paper
• A REVIEW OF THE CLINICAL EFFECTS OF PHYTOESTROGENS

  1996cited by this paper
• Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

  1996cited by this paper
• The different responses of the female mouse thymus to estrogen after treatment of neonatal, prepubertal, and adult animals.

  1996cited by this paper
• Estrogen effects on lymphoid tissue in neonatal and adult female mice.

  1995cited by this paper
• Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance

  1995cited by this paper
• Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells.

  1995cited by this paper
• How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway.

  1995cited by this paper
• Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

  1995cited by this paper
• Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

  1994cited by this paper
• Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system.

  1994cited by this paper
• Impaired immune and acute-phase responses in interleukin-6-deficient mice

  1994cited by this paper
• Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II.

  1993cited by this paper
• MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

  1993cited by this paper
• Estrogen administration activates extrathymic T cell differentiation in the liver

  1992cited by this paper
• Localization of estrogen receptors and estrogen receptor-mRNA in female mouse thymus.

  1992cited by this paper
• New class ll-like genes in the murine MHC

  1991cited by this paper
• In vivo modulation of the distribution of thymocyte subsets: effects of estrogen on the expression of different T cell receptor V beta gene families in CD4-, CD8- thymocytes.

  1991cited by this paper
• Enhancement of in vivo humoral immunity by estrogen: permissive effect of a thymic factor.

  1991cited by this paper
• T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation.

  1990cited by this paper
• Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation.

  1990cited by this paper

• Benefit delayed immunosenescence by regulating CD4 +T cells: A promising therapeutic target for aging‐related diseases

  2024cites this paper
• The Role of Genistein in Mammalian Reproduction

  2023cites this paper
• iTRAQ‐based proteomic analysis of 17β‐Estradiol‐induced anti‐proliferation and apoptosis in mouse thymic epithelial cells by disturbing ribosomal biogenesis

  2022cites this paper
• HPTE-Induced Embryonic Thymocyte Death and Alteration of Differentiation Is Not Rescued by ERα or GPER Inhibition but Is Exacerbated by Concurrent TCR Signaling

  2021cites this paper
• Proteomic changes in the extracellular environment of sea bass thymocytes exposed to 17α-ethinylestradiol in vitro.

  2021cites this paper
• Estrogens as immunotoxicants: 17α-ethinylestradiol exposure retards thymus development in zebrafish (Danio rerio).

  2021cites this paper
• Immunomodulation de la fonction thymique et de la différentiation des lymphocytes T chez le bar européen, Dicentrarchus labrax : une perspective évolutive et écotoxicologique

  2018cites this paper
• Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome.

  2018cites this paper
• Effect of endocrine disruptor phytoestrogens on the immune system: Present and future.

  2018cites this paper
• The immunomodulatory role of the hypothalamus-pituitary-gonad axis: Proximate mechanism for reproduction-immune trade offs?

  2017cites this paper
• Isoflavones, their Glycosides and Glycoconjugates. Synthesis and Biological Activity

  2016cites this paper
• Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review.

  2016cites this paper
• Isoflavones: Source and Metabolism

  2016cites this paper
• Estrogen Receptor Alpha Modulates Mesangial Cell Responses to Toll-Like Receptor Ligands

  2014cites this paper
• Reannotation and consolidation of microarray probes for the meta-analysis of gene expression across multiple cell types

  2014cites this paper
• Genistein modulation of streptozotocin diabetes in male B6C3F1 mice can be induced by diet.

  2014cites this paper
• Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

  2013cites this paper
• Next generation text-mining applied to toxicogenomics data analysis = Next-generation text-mining toegepast op toxicogenomics data analyse

  2012cites this paper
• Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis

  2012cites this paper
• Genistein Derivatization – From a Dietary Supplement to a Pharmaceutical Agent

  2011influential citation
• Endocrine disrupting compounds: can they target the immune system of fish?

  2011cites this paper
• The Influence of Estrogen on the Immunologic Function of T Lymphocytes.

  2009cites this paper
• Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines

  2008cites this paper
• Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice.

  2008cites this paper
• Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non‐obese diabetic (NOD) mice

  2008cites this paper
• Estrogen and CD4+ T cells

  2007cites this paper
• Genistein, estrogen receptors, and the acquired immune response.

  2006cites this paper
• Xenobiotic‐induced alterations in thymocyte development

  2006cites this paper
• Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: evidence of thymic regulation.

  2006cites this paper
• Symposium : Nutrients , Nuclear Receptors , Inflammation , and Immunity Genistein , Estrogen Receptors , and the Acquired Immune Response 1 , 2

  2006cites this paper
• Immunotoxicology Specialty Section Newsletter

  2004cites this paper
• Open Access Research Article Predicting Environmental Chemical Factors Associated with Disease-related Gene Expression Data

  year unknowncites this paper