ICOS is essential for effective T-helper-cell responses

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature

• Publication date

  2001-01-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/35051113PMID 11343123
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of Human Inducible Costimulator Ligand Expression and Function1

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• Regulation of allergic mucosal sensitization by interleukin-12 gene transfer to the airway.

  1999cited by this paper
• T cell co-stimulatory molecules other than CD28.

  1999cited by this paper
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  1999cited by this paper
• ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

  1999cited by this paper
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• ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• The role of B7 co‐stimulation in activation and differentiation ofCD4+and CD8+T cells

  1998cited by this paper
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  1997cited by this paper
• Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86.

  1997cited by this paper
• Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation.

  1997cited by this paper
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  1996cited by this paper
• The expanding universe of T-cell subsets: Th1, Th2 and more.

  1996cited by this paper
• CD28/B7 system of T cell costimulation.

  1996cited by this paper
• T cell-independent antigens type 2.

  1995cited by this paper
• Immune responses in MHC class II-deficient mice.

  1995cited by this paper
• Humoral immune responses in CD40 ligand-deficient mice

  1994cited by this paper
• T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

  1994cited by this paper
• The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.

  1994cited by this paper
• Mice deficient for the CD40 ligand.

  1994cited by this paper
• Germinal centers.

  1994cited by this paper
• Differential T cell costimulatory requirements in CD28-deficient mice.

  1993cited by this paper
• Generation and analysis of interleukin-4 deficient mice.

  1991cited by this paper
• Lymphokine control of in vivo immunoglobulin isotype selection.

  1990cited by this paper
• TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

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  1988cited by this paper
• Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production.

  1987cited by this paper

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