ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Nature

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1038/35005523
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Monocyte reprogramming by nociceptors impedes T cell-mediated tumor immunity

  2026cites this paper
• The role of immune checkpoint molecules in cancers

  2026cites this paper
• Advancing ICOS agonism in solid tumors: lessons from INDUCE-1

  2026cites this paper
• Inducible Costimulator and Its Ligand Promote Proliferation and Migration of Tumor Cells in Cutaneous T-Cell Lymphoma

  2026cites this paper
• Primary Cutaneous CD4+ Small/Medium-Sized T-Cell Lymphoproliferative Disorder: A Retrospective Cohort Study of 40 Adult Patients

  2025cites this paper
• ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis

  2025cites this paper
• Clec7a-mediated regulation of Killer-like Lectin Receptor expression controls T cell immunity

  2025cites this paper
• Moniezia benedeni infection promoting ICOS+ T cell proliferation in sheep (Ovis aries) small intestine

  2025cites this paper
• Correlation between Tregs and ICOS-induced M2 macrophages polarization in colorectal cancer progression

  2024cites this paper
• An Infusible Extracellular Matrix Biomaterial Improves Survival in a Model of Severe Systemic Inflammation

  2024cites this paper
• Anti-PD-L1-Based Bispecific Antibodies Targeting Co-Inhibitory and Co-Stimulatory Molecules for Cancer Immunotherapy

  2024cites this paper
• A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals

  2024cites this paper
• Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity

  2024cites this paper
• Converging cytokine and metabolite networks shape asymmetric T cell fate at the term human maternal-fetal interface

  2024influential citation
• Costimulatory receptors in the channel catfish: CD28 family members and their ligands

  2024cites this paper
• Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation

  2023cites this paper
• Versatile roles of innate lymphoid cells at the mucosal barrier: from homeostasis to pathological inflammation

  2023cites this paper
• Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells

  2023cites this paper
• Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma

  2023cites this paper
• Divergent CD4+ T-cell profiles are associated with anti-HLA alloimmunization status in platelet-transfused AML patients

  2023cites this paper
• ICOS gene polymorphisms in systemic lupus erythematosus: A case–control study

  2023cites this paper
• Lung Cancer Immunotherapy: Beyond Common Immune Checkpoints Inhibitors

  2022cites this paper
• MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves’ disease by targeting ICOS

  2022cites this paper
• Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy

  2022cites this paper
• Inflammatory Cytokine-Neutralizing Antibody Treatment Prevented Increases in Follicular Helper T Cells and Follicular Regulatory T Cells in a Mouse Model of Arthritis

  2022cites this paper
• Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component

  2022cites this paper
• The Glycosylation of Immune Checkpoints and Their Applications in Oncology

  2022cites this paper
• Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells

  2022cites this paper
• First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response

  2022influential citation
• Transcriptome profile and clinical characterization of ICOS expression in brain gliomas

  2022influential citation
• More key players in the game for myeloma prognosis and therapy

  2022cites this paper
• Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing

  2022cites this paper
• Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models

  2022cites this paper
• Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy

  2022cites this paper
• Expression of ICOS in the salivary glands of patients with primary Sjogren's syndrome and its molecular mechanism

  2022cites this paper
• ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells

  2022cites this paper
• The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

  2022cites this paper
• Mifepristone inhibited the expression of B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis

  2021influential citation
• Differential gene expression analysis of ankylosing spondylitis shows deregulation of the HLA-DRB, HLA-DQB, ITM2A, and CTLA4 genes

  2021cites this paper
• Molecular Imaging in Immunotherapy: A Systematic Review

  2021cites this paper
• Glycosylation of Immune Receptors in Cancer

  2021cites this paper
• Clinical Insights Into Novel Immune Checkpoint Inhibitors

  2021cites this paper
• Altered follicular regulatory T (Tfr)‐ and helper T (Tfh)‐cell subsets are associated with autoantibody levels in microscopic polyangiitis patients

  2021cites this paper
• B Cell Aberrance in Lupus: the Ringleader and the Solution

  2021cites this paper
• Evolutionary Inference Predicts Novel ACE2 Protein Interactions Relevant to COVID-19 Pathologies

  2021cites this paper
• Comprehensive Immunoprofiling of High-Risk Oral Proliferative and Localized Leukoplakia

  2021cites this paper
• Immune Checkpoints and Innate Lymphoid Cells—New Avenues for Cancer Immunotherapy

  2021cites this paper
• ALPN-101 (Acazicolcept) a Dual ICOS/CD28 Antagonist, Demonstrates Efficacy in Systemic Sclerosis Preclinical Mouse Models

  2021cites this paper
• The multifaceted role of CD4(+) T cells in CD8(

  2021cites this paper
• The role of immune checkpoint inhibitors in triple-negative breast cancer: recent developments and future perspectives

  2021cites this paper
• Lactiplantibacillus plantarum HNU082 inhibited the growth of Fusobacterium nucleatum and alleviated the inflammatory response introduced by F. nucleatum invasion.

  2021cites this paper
• Altered expression of costimulatory molecules in dementias

  2021influential citation
• A narrative review of immune checkpoint mechanisms and current immune checkpoint therapy

  2021cites this paper
• T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function

  2021cites this paper
• Immune checkpoints and the multiple faces of B cells in systemic lupus erythematosus

  2021cites this paper
• Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy

  2021cites this paper
• Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum

  2021influential citation
• Role of endocytosis and trans‐endocytosis in ICOS costimulator‐induced downmodulation of the ICOS Ligand

  2021cites this paper
• A Patient with Novel ICOS Mutation Presented with Progressive Loss of B Cells

  2020influential citation
• OTT_A_282530 11869..11882

  2020cites this paper
• ICOS Ligation Recruits the p50alpha PI3K Regulatory Subunit to the Immunological Synapse

  2020influential citation
• An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

  2020influential citation
• Effect of Cellular-Based Artificial Antigen Presenting Cells Expressing ICOSL, in T-cell Subtypes Differentiation and Activation

  2020cites this paper
• Effects of skin-resident regulatory T cells on wound healing after burn injury

  2020cites this paper
• Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating TFH/B cell axis

  2020cites this paper
• Targeting co-stimulatory molecules in autoimmune disease

  2020cites this paper
• SARS-CoV-2-specific T cells exhibit phenotypic features reflecting robust helper function, lack of terminal differentiation, and high proliferative potential

  2020cites this paper
• Friend or Foe: Prognostic and Immunotherapy Roles of BTLA in Colorectal Cancer

  2020cites this paper
• Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929)

  2020cites this paper
• ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue

  2020cites this paper
• Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells

  2020cites this paper
• Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells

  2020cites this paper
• T cell receptor signaling defines the fate and pathway of ICOS internalization

  2020cites this paper
• ICOS Is an Indicator of T-cell–Mediated Response to Cancer Immunotherapy

  2020cites this paper
• Regulation of Cancer Immune Checkpoints: Molecular and Cellular Mechanisms and Therapy

  2020cites this paper
• Co-Stimulatory Receptors in Cancers and Their Implications for Cancer Immunotherapy

  2020influential citation
• The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy

  2020cites this paper
• Immune Monitoring in Thoracic Malignancies

  2020cites this paper
• Targeting co-stimulatory molecules in autoimmune disease

  2020cites this paper
• The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity

  2020cites this paper
• Immunological markers and Helicobacter pylori in patients with stomach cancer: Expression and correlation

  2020cites this paper
• Defining and targeting combination immunotherapies in mouse models of cancer

  2019influential citation
• [Loss of human ICOSLG results in combined immunodeficiency].

  2019cites this paper
• ICOS deficiency hampers the homeostasis, development and function of NK cells

  2019cites this paper
• High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

  2019cites this paper
• miR-29b Reverses T helper 1 cells/T helper 2 cells Imbalance and Alleviates Airway Eosinophils Recruitment in OVA-Induced Murine Asthma by Targeting Inducible Co-Stimulator

  2019cites this paper
• Systems pharmacology in modelling complex scenarios: Opportunities and challenges

  2019cites this paper
• Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population

  2019cites this paper
• A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression

  2019cites this paper
• Regulatory roles of IL-10–producing human follicular T cells

  2019cites this paper
• Regulation of Inflammation in Autoimmune Disease

  2019cites this paper
• CD4 regulatory T cells: their requirement for CD80 and CD86 costimulation and their role in autoimmune hepatitis

  2019cites this paper
• Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases

  2019cites this paper
• Soluble immune checkpoint molecules: Serum markers for cancer diagnosis and prognosis

  2019cites this paper
• Considering B7-CD28 as a family through sequence and structure

  2019cites this paper
• Cancer immunotherapy: broadening the scope of targetable tumours

  2018cites this paper
• Rôles des facteurs de transcription Foxo3 et Eomes dans la différenciation et les fonctions des lymphocytes T CD4

  2018cites this paper
• VOLARE: visual analysis of disease-associated microbiome-immune system interplay

  2018cites this paper
• IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection

  2018cites this paper
• T cell-dependent B cell hyperactivity in primary Sjögren's syndrome: Biomarker and target for treatment

  2018cites this paper