Disease tolerance and immunity in host protection against infection

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature reviews. Immunology

• Publication date

  2017-01-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nri.2016.136PMID 28044057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity.

  2016cited by this paper
• Different effects of the three polymorphisms on 15q25.1 onlung cancer risk: Evidence from published literatures.

  2016cited by this paper
• A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis

  2016cited by this paper
• Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

  2016cited by this paper
• Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.

  2016cited by this paper
• From pathogens to microbiota: How Drosophila intestinal stem cells react to gut microbes.

  2016cited by this paper
• Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism.

  2016cited by this paper
• Crystal Formation in Inflammation.

  2016cited by this paper
• Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

  2016cited by this paper
• Macrophages and Iron Metabolism

  2016cited by this paper
• Amino acid auxotrophy as a system of immunological control nodes

  2016cited by this paper
• Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.

  2016cited by this paper
• Composition of the gut microbiota modulates the severity of malaria

  2016cited by this paper
• Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

  2016cited by this paper
• Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes

  2016cited by this paper
• Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

  2016cited by this paper
• Tracking Resilience to Infections by Mapping Disease Space

  2016cited by this paper
• Macrophages and Iron Metabolism.

  2016cited by this paper
• Innate sensing of oxidation-specific epitopes in health and disease

  2016cited by this paper
• Reparative inflammation takes charge of tissue regeneration

  2016cited by this paper
• Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage.

  2015cited by this paper
• The Iron age of host–microbe interactions

  2015cited by this paper
• Nrf2 as a master regulator of tissue damage control and disease tolerance to infection

  2015cited by this paper
• Endoplasmic reticulum stress in immunity.

  2015cited by this paper
• IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis

  2015cited by this paper
• Metabolic reprogramming in macrophages and dendritic cells in innate immunity

  2015cited by this paper
• IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions

  2015cited by this paper
• The immunology of influenza virus-associated bacterial pneumonia.

  2015cited by this paper
• Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling

  2015cited by this paper
• Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

  2015cited by this paper
• Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration

  2015cited by this paper
• A Distinct Function of Regulatory T Cells in Tissue Protection.

  2015cited by this paper
• Pore-forming toxins: ancient, but never really out of fashion

  2015cited by this paper
• Innate immune memory: a paradigm shift in understanding host defense

  2015cited by this paper
• Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.

  2015cited by this paper
• The biology of innate lymphoid cells

  2015cited by this paper
• Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation.

  2015cited by this paper
• Necroptosis and its role in inflammation

  2015cited by this paper
• Tissue biology perspective on macrophages

  2015cited by this paper
• Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin.

  2015cited by this paper
• Stimulation of Brain AMP-Activated Protein Kinase Attenuates Inflammation and Acute Lung Injury in Sepsis

  2015cited by this paper
• Myeloid HIF-1 Is Protective in Helicobacter pylori–Mediated Gastritis

  2015cited by this paper
• Homeostasis, inflammation, and disease susceptibility.

  2015cited by this paper
• T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.

  2015cited by this paper
• Type 2 cytokines: mechanisms and therapeutic strategies

  2015cited by this paper
• Tissue damage control in disease tolerance.

  2014cited by this paper
• Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.

  2014cited by this paper
• Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission

  2014cited by this paper
• Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.

  2014cited by this paper
• Aryl hydrocarbon receptor control of a disease tolerance defence pathway

  2014cited by this paper
• The Alarmin IL-33 Promotes Regulatory T Cell Function in the Intestine

  2014cited by this paper
• Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness

  2014cited by this paper
• Pro-resolving lipid mediators are leads for resolution physiology

  2014cited by this paper
• Nucleotide signalling during inflammation

  2014cited by this paper
• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  2014cited by this paper
• Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

  2014cited by this paper
• Tailored Immune Responses: Novel Effector Helper T Cell Subsets in Protective Immunity

  2014cited by this paper
• Whole-Animal Chemical Screen Identifies Colistin as a New Immunomodulator That Targets Conserved Pathways

  2014cited by this paper
• Neutrophil Elastase Causes Tissue Damage That Decreases Host Tolerance to Lung Infection with Burkholderia Species

  2014cited by this paper
• The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection

  2014cited by this paper
• What's the damage? The impact of pathogens on pathways that maintain host genome integrity.

  2014cited by this paper
• Control of disease tolerance to malaria by nitric oxide and carbon monoxide.

  2014cited by this paper
• CD73-Generated Adenosine Is Critical for Immune Regulation during Toxoplasma gondii Infection

  2014cited by this paper
• The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.

  2014cited by this paper
• Stress, inflammation, and defense of homeostasis.

  2014cited by this paper
• Activation and regulation of the inflammasomes

  2013cited by this paper
• Mitonuclear protein imbalance as a conserved longevity mechanism

  2013cited by this paper
• Animals in a bacterial world, a new imperative for the life sciences

  2013cited by this paper
• Ibuprofen therapy resulted in significantly decreased tissue bacillary loads and increased survival in a new murine experimental model of active tuberculosis.

  2013cited by this paper
• A special population of regulatory T cells potentiates muscle repair.

  2013cited by this paper
• Microbiota-mediated colonization resistance against intestinal pathogens

  2013cited by this paper
• Metabolism of inflammation limited by AMPK and pseudo-starvation

  2013cited by this paper
• FOXO Transcription Factors Regulate Innate Immune Mechanisms in Respiratory Epithelial Cells

  2013cited by this paper
• p53 integrates host defense and cell fate during bacterial pneumonia

  2013cited by this paper
• Dietary Cholesterol Modulates Pathogen Blocking by Wolbachia

  2013cited by this paper
• FOXOs: signalling integrators for homeostasis maintenance

  2013cited by this paper
• Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection

  2013cited by this paper
• The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

  2013cited by this paper
• Metabolite damage and its repair or pre-emption.

  2013cited by this paper
• IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

  2013cited by this paper
• Tissue-resident macrophages

  2013cited by this paper
• Commensal bacteria at the interface of host metabolism and the immune system

  2013cited by this paper
• Autophagy in infection, inflammation and immunity

  2013cited by this paper
• Toward clinical application of the Keap1-Nrf2 pathway.

  2013cited by this paper
• IL‐22 in tissue‐protective therapy

  2013cited by this paper
• Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

  2013cited by this paper
• Inflammasome-microbiota interplay in host physiologies.

  2013cited by this paper
• Tolerance of infections.

  2012cited by this paper
• Regulatory T cells: mechanisms of differentiation and function.

  2012cited by this paper
• Metabolic adaptation to tissue iron overload confers tolerance to malaria.

  2012cited by this paper
• Infection with Wolbachia protects mosquitoes against Plasmodium‐induced mortality in a natural system

  2012cited by this paper
• The good, bad, and ugly?

  2012cited by this paper
• Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.

  2012cited by this paper
• Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

  2012cited by this paper
• The updated biology of hypoxia‐inducible factor

  2012cited by this paper
• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  2012cited by this paper
• Disease Tolerance as a Defense Strategy

  2012cited by this paper
• JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection.

  2012cited by this paper
• Sepsis-induced urinary concentration defect is related to nitric oxide–dependent inactivation of TonEBP/NFAT5, which downregulates renal medullary solute transport proteins and aquaporin-2*

  2012cited by this paper
• The perpetual challenge of infectious diseases.

  2012cited by this paper

• Current understanding and advances regarding the adipose-immune-metabolic axis in disease tolerance during sepsis

  2026cites this paper
• α2-macroglobulin function of thioester-containing proteins guards Drosophila from a bacterial protease via two immune-induced peptides.

  2026cites this paper
• Rab43 mitigates the inflammatory response in acute lung injury via MyD88 ubiquitination

  2026cites this paper
• Severe community-acquired pneumonia: an integral approach

  2026cites this paper
• Low-replication influenza virus mediates high pathogenicity through an inflammation-driven lung–heart–brain axis in mice

  2026cites this paper
• Lactate and lactylation in macrophage polarization of sepsis

  2026cites this paper
• The different meanings of tolerating the gut microbiome

  2026cites this paper
• Crosstalk of mitochondrial dysfunction and macrophage polarization in sepsis.

  2026cites this paper
• Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection.

  2026cites this paper
• Genital herpes shedding episodes associate with alterations in the spatial organization and activation of mucosal immune cells

  2025cites this paper
• Differential disease tolerance mediates sex-biased illness severity in sepsis

  2025cites this paper
• Amphibian cellular immune response to chytridiomycosis at metamorphic climax

  2025cites this paper
• STAT Signature Dish: Serving Immunity with a Side of Dietary Control

  2025cites this paper
• Sex bias determines MERS-CoV infection outcomes in a mouse model of differential pathogenicity

  2025influential citation
• Dermal fibroblast cultures recapitulate differences between deermice and mice in responses to a Toll-like receptor agonist

  2025cites this paper
• N460S in PB2 and I163T in nucleoprotein synergistically enhance the viral replication and pathogenicity of influenza B virus

  2025cites this paper
• Investigating the differential microRNAs expression in young and aged Drosophila melanogaster following Flock House Virus infection

  2025cites this paper
• Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model

  2025cites this paper
• FGF21 acting on the noradrenergic nervous system protects against influenza virus infection

  2025cites this paper
• Population-level Antibodies Seroprevalence to Parasitic Infections in the Etsako Region, Northern Edo State, Nigeria: A Localized Analysis

  2025cites this paper
• Prevalence and characterization of β-lactamase-producing bacteria in gingivitis among diabetic and non-diabetic patients: a comparative microbiological study

  2025cites this paper
• Pathogenicity difference analysis of novel duck reovirus NY01 between in semi-muscovy duck and shelduck

  2025cites this paper
• JAK/STAT inhibition protects glucocorticoid receptor knockout mice from lethal malaria-induced hypoglycemia and hyperinflammation

  2025cites this paper
• Unveiling Antioxidant Mechanisms: Novel Gene Expression Profiling Reveals How Carboxylated Cellulose Nanocrystal/ZnO Bio-nanohybrid Counteracts Babesiosoma-Induced Oxidative Stress in Catfish

  2025cites this paper
• Transcriptomic signatures of disease tolerance and environmental persistence in a mosquito-microsporidian system

  2025cites this paper
• Defense strategies for plant health: disease resistance and tolerance.

  2025cites this paper
• Behavioural Indicators of Infectious Disease in Managed Animals

  2025cites this paper
• Genital herpes shedding episodes associate with altered spatial organization and activation of mucosal immune cells

  2025cites this paper
• Impact of Nasal Glucocorticoid Therapy on Exhaled Nitric Oxide and Symptom Relief in Chronic Rhinosinusitis with Nasal Polyps: A Randomized Prospective Study

  2025cites this paper
• Sepsis and high-density lipoproteins: Pathophysiology and potential new therapeutic targets.

  2025cites this paper
• ACR-16/α7-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria.

  2025cites this paper
• Avoiding the tragedies of parasite tolerance in Darwinian beekeeping

  2025cites this paper
• Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived macrophages during influenza A infection.

  2025cites this paper
• The serine protease homolog Skanda modulates Toll-Phenoloxidase-mediated immunity in Drosophila

  2025cites this paper
• ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan

  2025cites this paper
• A host-pathogen metabolic synchrony that facilitates disease tolerance

  2025cites this paper
• Biological and clinical implications of a model of surveillance immunity

  2025cites this paper
• Investigation Role of Toll-like Receptor-9 Gene and miR-155 Expression Levels in Acute Myeloid Leukemia via Quantitative Real-Time PCR

  2025cites this paper
• Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial Sepsis

  2025cites this paper
• The Sirt1 Activator SRT1720 Mitigates Human Monocyte Activation and Improves Outcome During Gram-Negative Pneumosepsis in Mice

  2025cites this paper
• Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections

  2025cites this paper
• The impact of climate, weather, seasonal transitions, and diurnal rhythms on gut microbiota and immune homeostasis

  2025cites this paper
• A 'green' toolbox: non-chemotherapeutic approaches for gastrointestinal nematode control in ruminants.

  2025cites this paper
• Mitochondrial ROS–ER Stress Axis Governs IL-10 Production in Neutrophils and Regulates Inflammation in Murine Chlamydia pneumoniae Lung Infection

  2025cites this paper
• Synergistic enhancement effect of straw-earthworms in the reduction of sulfamethoxazole and antibiotic resistance genes.

  2025cites this paper
• Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae

  2024cites this paper
• Schistosomiasis–Microbiota Interactions: A Systematic Review and Meta-Analysis

  2024cites this paper
• Facing stress and inflammation: From the cell to the planet

  2024cites this paper
• Immunometabolic Regulation of Bacterial Infection, Biofilms, and Antibiotic Susceptibility

  2024cites this paper
• Single-cell transcriptome landscape of the kidney reveals potential innate immune regulation mechanisms in hybrid yellow catfish after Aeromonas hydrophila infection.

  2024cites this paper
• Ketogenesis favors oxidative phosphorylation to promote disease tolerance.

  2024cites this paper
• Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial

  2024cites this paper
• Thermoregulation and survival during sepsis: insights from the cecal ligation and puncture experimental model

  2024cites this paper
• Phagostimulant MTSG supplementation benefits growth-promoting and defensive effects of Rhodobacter azotoformans on Chinese mitten crab Eriocheir sinensis.

  2024cites this paper
• Hepatic Nrf1 (Nfe2l1) promotes VLDL dependent liver defense against sepsis

  2024influential citation
• A comprehensive review and recent advances of vitamin C: Overview, functions, sources, applications, market survey and processes

  2024cites this paper
• Recombinant protein transaldolase of Bifidobacterium bifidum E3 and its anti-inflammatory activity

  2024cites this paper
• The conceptual foundations of innate immunity: Taking stock 30 years later.

  2024cites this paper
• Chlormequat Chloride Inhibits TM3 Leydig Cell Growth via Ferroptosis-Initiated Inflammation

  2024cites this paper
• p16High immune cell - controlled disease tolerance as a broad defense and healthspan extending strategy

  2024cites this paper
• The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria

  2024cites this paper
• A complex immune communication between eicosanoids and pulmonary macrophages.

  2024cites this paper
• PATHOLOGY OF CHRONIC MYCOPLASMA OVIPNEUMONIAE CARRIERS IN A DECLINING BIGHORN SHEEP (OVIS CANADENSIS) POPULATION

  2024cites this paper
• Ferritin heavy chain supports stability and function of the regulatory T cell lineage

  2024cites this paper
• Effects of Combined Treatment with Sodium Dichloroacetate and Sodium Valproate on the Genes in Inflammation- and Immune-Related Pathways in T Lymphocytes from Patients with SARS-CoV-2 Infection with Pneumonia: Sex-Related Differences

  2024cites this paper
• New Insights into Hepatic and Intestinal Microcirculation and Pulmonary Inflammation in a Model of Septic Shock and Venovenous Extracorporeal Membrane Oxygenation in the Rat

  2024cites this paper
• Alleviating protein-condensation-associated damage at the endoplasmic reticulum enhances plant disease tolerance.

  2024cites this paper
• Angiopoietin-like 4 protects against endothelial dysfunction during bacterial sepsis

  2024cites this paper
• Physiologic disruption and metabolic reprogramming in infection and sepsis.

  2024cites this paper
• Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems

  2024cites this paper
• The cytochrome P4501A1 (CYP1A1) inhibitor bergamottin enhances host tolerance to multidrug-resistant Vibrio vulnificus infection

  2024cites this paper
• Inflammasomes as regulators of non-infectious disease.

  2023cites this paper
• Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter

  2023cites this paper
• Histone demethylases in the regulation of immunity and inflammation

  2023cites this paper
• Central carbon flux controls growth/damage balance for Streptococcus pyogenes

  2023cites this paper
• Sugar restriction and blood ingestion shape divergent immune defense trajectories in the mosquito Aedes aegypti

  2023cites this paper
• Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization

  2023cites this paper
• Amphibian infection tolerance to chytridiomycosis

  2023influential citation
• Fecal microbiota transplantation in hematopoietic cell transplant and cellular therapy recipients: lessons learned and the path forward

  2023cites this paper
• Hematophagous ectoparasites affect nestling size and physiology, but not apparent survival

  2023cites this paper
• Pretreatment with Eupatilin Attenuates Inflammation and Coagulation in Sepsis by Suppressing JAK2/STAT3 Signaling Pathway

  2023cites this paper
• The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection

  2023cites this paper
• Intraspecific genetic variation in host vigour, viral load and disease tolerance during Drosophila C virus infection

  2023cites this paper
• Impact of Chronic Infection on Resistance and Tolerance to Secondary Infection in Drosophila melanogaster

  2023cites this paper
• Modeling of adaptive immunity uncovers disease tolerance mechanisms.

  2023cites this paper
• Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis.

  2023cites this paper
• A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium

  2023cites this paper
• Disease tolerance: a protective mechanism of lung infections

  2023cites this paper
• Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen

  2023cites this paper
• Infection burdens and virulence under heat stress: ecological and evolutionary considerations

  2023cites this paper
• Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis

  2023cites this paper
• Reprogramming Short-Chain Fatty Acid Metabolism Mitigates Tissue Damage for Streptococcus pyogenes Necrotizing Skin Infection

  2023cites this paper
• CELL DEATH: A MODERN VIEW OF APOPTOSIS AND AUTOPHAGY

  2023cites this paper
• International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

  2023cites this paper
• How did antibiotic growth promoters increase growth and feed efficiency in poultry?

  2023cites this paper
• The Tolerance Model of Non-Inflammatory Immune Competence in Acute Pediatric Malnutrition: Origins, Evidence, Test of Fitness and Growth Potential

  2023influential citation
• Clinical and Biochemical Study of Pregnancy Toxemia in Iraqi Ewes.

  2023cites this paper
• IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections.

  2023cites this paper
• Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection.

  2023cites this paper
• Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways

  2023cites this paper