Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector

No abstract is available for this paper.

• Publication year

  1987

• Venue

  Molecular and Cellular Biology

• Publication date

  1987-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.7.2.887-897.1987PMID 3029570PMCID PMC365147
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A restriction enzyme cleavage map of Tn5 and location of a region encoding neomycin resistance

  2004cited by this paper
• Correction of murine beta-thalassemia by gene transfer into the germ line.

  1986cited by this paper
• Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses.

  1986cited by this paper
• Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

  1986cited by this paper
• Negative regulation of viral enhancers in undifferentiated embryonic stem cells.

  1985cited by this paper
• Erythroid‐specific expression of human beta‐globin genes in transgenic mice.

  1985cited by this paper
• Expression of human adenosine deaminase using a transmissable murine retrovirus vector system.

  1985cited by this paper
• Secretion of human parathyroid hormone from rat pituitary cells infected with a recombinant retrovirus encoding preproparathyroid hormone.

  1984cited by this paper
• Expression of complete chicken thymidine kinase gene inserted in a retrovirus vector

  1984cited by this paper
• Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences.

  1984cited by this paper
• Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

  1984cited by this paper
• Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

  1984cited by this paper
• Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism.

  1984cited by this paper
• Construction and applications of a highly transmissible murine retrovirus shuttle vector.

  1984cited by this paper
• Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

  1984cited by this paper
• High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range.

  1984cited by this paper
• Cell-specified expression of a selectable hybrid gene.

  1984cited by this paper
• Infectious and selectable retrovirus containing an inducible rat growth hormone minigene.

  1984cited by this paper
• DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells.

  1984cited by this paper
• Immunoglobulin gene transcription is activated by downstream sequence elements.

  1983cited by this paper
• A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT.

  1983cited by this paper
• Regulated expression of the human β-globin gene family in murine erythroleukaemia cells

  1983cited by this paper
• Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus.

  1983cited by this paper
• The regulated expression of β-globin genes introduced into mouse erythroleukemia cells

  1983cited by this paper
• Retrovirus transduction: segregation of the viral transforming function and the herpes simplex virus tk gene in infectious Friend spleen focus-forming virus thymidine kinase vectors.

  1983cited by this paper
• A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

  1983cited by this paper
• Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events

  1983cited by this paper
• A foreign beta-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues.

  1983cited by this paper
• A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

  1983cited by this paper
• Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene

  1982cited by this paper
• Inhibitors of glycosylation reverse retroviral interference.

  1982cited by this paper
• Terminal differentiation of murine erythroleukemia cells: physical stabilization of end- stage cells

  1982cited by this paper
• Transfer of human globin genes to erythroleukemic mouse cells.

  1982cited by this paper
• Differences in human alpha-, beta- and delta-globin gene expression in monkey kidney cells.

  1982cited by this paper
• Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus

  1982cited by this paper
• Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

  1981cited by this paper
• Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

  1981cited by this paper
• The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.

  1981cited by this paper
• Introduction of a rabbit beta-globin gene into the mouse germ line.

  1981cited by this paper
• Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences.

  1981cited by this paper
• Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus.

  1981cited by this paper
• Introduction of a rabbit β-globin gene into the mouse germ line

  1981cited by this paper
• Activation of human beta-globin genes from nonerythroid cells by fusion with murine erythroleukemia cells.

  1980cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper
• Selective activation of human beta-but not gamma-globin gene in human fibroblast x mouse erythroleukaemia cell hybrids.

  1979cited by this paper
• Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA

  1979cited by this paper
• A change in the stability of globin mRNA during the induction of murine erythroleukemia cells.

  1978cited by this paper
• Mechanism of restriction of ecotropic and xenotropic murine leukemia viruses and formation of pseudotypes between the two viruses

  1977cited by this paper
• Enhanced autoradiographic detection of 32P and 125I using intensifying screens and hypersensitized film

  1977cited by this paper
• Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus.

  1975cited by this paper
• Globin gene expression in cultured erythroleukemic cells.

  1974cited by this paper
• A viral interference test for mouse leukemia viruses.

  1967cited by this paper

• Novel therapies in β‐thalassaemia

  2021cites this paper
• Gene therapy of hemoglobinopathies: progress and future challenges.

  2019cites this paper
• Gene therapy and gene editing strategies for hemoglobinopathies.

  2018cites this paper
• Genetic Therapies for Sickle Cell Disease.

  2018cites this paper
• A 36-base-pair core sequence of locus control region enhances retrovirally transferred human fl-globin gene expression (hypersensitive sites/NFE-2/AP-1/N2A vector/+,-2 and PA317 packaging cell lines)

  2016cites this paper
• Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

  2016cites this paper
• Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the βA(T87Q)-Globin Gene

  2016cites this paper
• Development of Gene Transfer Technology

  2014cites this paper
• Selective In Vivo Targeting of Human Liver Tumors by Optimized AAV3 Vectors in a Murine Xenograft Model

  2014cites this paper
• Gene therapy for hemoglobinopathies: the state of the field and the future.

  2014cites this paper
• Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models.

  2013cites this paper
• Novel approaches to thalassaemia gene therapy

  2013cites this paper
• cells stimulated with hematopoietic growth factors colony- stimulating factor receptor subunits in murine hematopoietic Enhanced expression of interleukin-3 and granulocyte-macrophage

  2013cites this paper
• Development of gene therapy for thalassemia.

  2012cites this paper
• Comparative analysis of FV vectors with human α- or β-globin gene regulatory elements for the correction of β-thalassemia

  2011cites this paper
• Μελέτη της δράσης φορέων τύπου spuma που εκφράζουν anti-α σφαιρίνης shRNA (short hairpin RNA) και β-σφαιρίνη σε πειραματικά μοντέλα θαλασσαιμίας

  2011cites this paper
• Gene Therapy in Thalassemia and Hemoglobinopathies

  2009cites this paper
• Hematopoietic cell transplantation for hemoglobinopathies.

  2008cites this paper
• Current status of globin gene therapy for the treatment of β‐thalassaemia

  2008cites this paper
• Towards the genetic treatment of b-thalassemia : new disease models , new vectors , new cells

  2008cites this paper
• Stem cell engineering for the treatment of severe hemoglobinopathies.

  2008cites this paper
• Molecular therapies in β‐thalassaemia

  2007cites this paper
• Versatile Retrovirus Vector Systems for Regulated Gene Expression In Vitro and In Vivo

  2007cites this paper
• Recent advances in globin gene transfer for the treatment of beta-thalassemia and sickle cell anemia

  2006cites this paper
• Progress toward the genetic treatment of the beta-thalassemias.

  2005cites this paper
• Progress Toward the Genetic Treatment of the β‐Thalassemias

  2005cites this paper
• Globin gene transfer for treatment of the β-thalassemias and sickle cell disease

  2004cites this paper
• Retroviral hybrid LTR vector strategy: functional analysis of LTR elements and generation of endothelial cell specificity

  2004cites this paper
• Globin gene transfer as a potential treatment for the β‐thalassaemias and sickle cell disease

  2004cites this paper
• Globin gene transfer for treatment of the beta-thalassemias and sickle cell disease.

  2004cites this paper
• Therapeutic globin gene delivery using lentiviral vectors.

  2002cites this paper
• The Advent of Lentiviral Vectors: Prospects for Cancer Therapy

  2002cites this paper
• Retroviral vectors for human gene delivery.

  2002cites this paper
• Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell‐based gene therapy

  2002cites this paper
• The beta‐globin locus control region versus gene therapy vectors: a struggle for expression

  2001cites this paper
• Issues in the manufacture and transplantation of genetically modified hematopoietic stem cells

  2000cites this paper
• Gene transfer to ankyrin-deficient bone marrow corrects spherocytosis in vitro.

  2000cites this paper
• Antitumoral effect of interleukin-12-secreting fibroblasts in a mouse model of ovarian cancer: Implications for the use of ovarian cancer biopsy-derived fibroblasts as a vehicle for regional gene therapy

  2000cites this paper
• Delivering erythropoietin through genetically engineered cells.

  2000cites this paper
• An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies

  2000cites this paper
• Position-independent human β-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken β-globin insulator

  1999cites this paper
• Endothelial Cell-Specific Transcriptional Targeting from a Hybrid Long Terminal Repeat Retrovirus Vector Containing Human Prepro-Endothelin-1 Promoter Sequences

  1999cites this paper
• Basic principles of gene transfer in hematopoietic stem cells.

  1999cites this paper
• Position-independent human beta-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken beta-globin insulator.

  1999cites this paper
• Parvoviral Vectors for Human Hematopoietic Gene Therapy

  1999cites this paper
• Targeted remodeling of human beta-globin promoter chromatin structure produces increased expression and decreased silencing.

  1999cites this paper
• Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease.

  1999cites this paper
• Gene transfer into hematopoietic cells: progress, problems and prospects.

  1998cites this paper
• Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing.

  1998cites this paper
• Development of a Condensed Locus Control Region Cassette and Testing in Retrovirus Vectors forAγ-Globin

  1998cites this paper
• Development of a condensed locus control region cassette and testing in retrovirus vectors for A gamma-globin.

  1998cites this paper
• Development of a Self-Inactivating Lentivirus Vector

  1998cites this paper
• Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

  1997cites this paper
• Versatile Retrovirus Vector Systems for Regulated Gene Expression In Vitro and In Vivo

  1997cites this paper
• A role for two hairpin structures as a core RNA encapsidation signal in murine leukemia virus virions

  1997cites this paper
• Analysis of enhancer function of the HS-40 core sequence of the human alpha-globin cluster.

  1997cites this paper
• Adeno-associated virus type 2-mediated transduction of murine hematopoietic cells with long-term repopulating ability and sustained expression of a human globin gene in vivo

  1997cites this paper
• Methoden der Genübertragung

  1997cites this paper
• Gene therapy for Parkinson's disease

  1997cites this paper
• Modulation of Erythropoietin Delivery from Engineered Muscles in Mice

  1997cites this paper
• Construction of Human Factor IX Expression Vectors in Retroviral Vector Frames Optimized for Muscle Cells

  1996cites this paper
• cis-active structural motifs involved in specific encapsidation of Moloney murine leukemia virus RNA

  1996cites this paper
• Production of genetically stable high-titer retroviral vectors that carry a human gamma-globin gene under the control of the alpha-globin locus control region.

  1996cites this paper
• A murine model for genetic manipulation of the T cell compartment.

  1996cites this paper
• Adeno-associated virus 2-mediated transduction and erythroid cell-specific expression of a human beta-globin gene.

  1996cites this paper
• Regulated expression of artificial chimeric genes contained in retroviral vectors: implications for virus-directed enzyme prodrug therapy (VDEPT) and other gene therapy applications.

  1996cites this paper
• Long-Term Secretion of Therapeutic Proteins from Genetically Modified Skeletal Muscles

  1996cites this paper
• Retroviral Vectors in Human Gene Therapy

  1995cites this paper
• Hepatoma cell‐specific expression of a retrovirally transferred gene is achieved by α‐fetoprotein but not insulinlike growth factor II regulatory sequences

  1995cites this paper
• Gene transfer into human hemopoietic progenitor cells.

  1995cites this paper
• A simplified general method for determination of recombinant retrovirus titers.

  1995cites this paper
• Retrovirus-Mediated Transduction of an Engineered Intron-Containing Purine Nucleoside Phosphorylase Gene

  1995cites this paper
• Viruses in Human Gene Therapy

  1995cites this paper
• The Current Status of Bone Marrow Transplantation and Gene Therapy in the Management of the Haemoglobinopathies

  1995cites this paper
• Rapid identification and isolation of transcriptionally active regions from mouse genomes.

  1995cites this paper
• Mutagenesis of retroviral vectors transducing human beta‐globin gene and beta‐globin locus control region derivatives results in stable transmission of an active transcriptional structure.

  1994cites this paper
• Viral vector systems for gene therapy.

  1994cites this paper
• Assessment of the Efficacy of Purging by Using Gene Marked Autologous Marrow Transplantation for Children with AML in First Complete Remission. St. Jude Children's Research Hospital, Memphis, Tennessee

  1994cites this paper
• Assessment of the efficacy of purging by using gene marked autologous marrow transplantation for children with AML in first complete remission.

  1994cites this paper
• Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells.

  1994cites this paper
• Stable correction of maple syrup urine disease in cells from a Mennonite patient by retroviral-mediated gene transfer.

  1993cites this paper
• Medical Fetal Therapy

  1993cites this paper
• An improved retroviral vector for assaying promoter activity

  1993cites this paper
• 11 Bone marrow transplant for the haemoglobinopathies: past, present and future

  1993cites this paper
• High frequency expression of integrated proviruses derived from enhancer trap retroviruses.

  1993cites this paper
• Importance of 3' non-coding sequences for efficient retrovirus-mediated gene transfer in avian cells revealed by self-inactivating vectors.

  1993cites this paper
• Gene transfer in situ and in cells for intracerebral transplantation

  1993cites this paper
• Evaluation of Expression of Transferred Genes in Differentiating Myeloid Cells: Expression of Human Glucocerebrosidase in Murine Macrophages

  1993cites this paper
• Gene Therapy for Human Hemoglobinopathies

  1993cites this paper
• Analysis of multistage mouse skin carcinogenesis by retroviral mediated gene transfer

  1993cites this paper
• Bone marrow transplant for the haemoglobinopathies: past, present and future.

  1993cites this paper
• Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR.

  1993cites this paper
• Gene Therapy in Animal Models of Neurological Disorders

  1992cites this paper
• Enhanced expression of interleukin-3 and granulocyte-macrophage colony-stimulating factor receptor subunits in murine hematopoietic cells stimulated with hematopoietic growth factors.

  1992cites this paper
• Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors.

  1992cites this paper
• A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression.

  1992cites this paper
• Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected]

  1992cites this paper
• Autologous bone marrow transplant for children with AML in first complete remission: use of marker genes to investigate the biology of marrow reconstitution and the mechanism of relapse.

  1991cites this paper
• Somatic gene therapy.

  1991cites this paper
• Expression of a foreign gene in cats reconstituted with retroviral vector infected autologous bone marrow.

  1991cites this paper