Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Immunology and Cell Biology

• Publication date

  2009-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/icb.2009.45PMID 19546879PMCID PMC2850593
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

  2010cited by this paper
• Mepolizumab and exacerbations of refractory eosinophilic asthma.

  2009cited by this paper
• Bronchiolitis: Age and Previous Wheezing Episodes Are Linked to Viral Etiology and Atopic Characteristics

  2009cited by this paper
• Asthma caused by occupational exposures is common – A systematic analysis of estimates of the population-attributable fraction

  2009cited by this paper
• Genome-wide association studies in the genetics of asthma

  2009cited by this paper
• Copper Regulation of Hypoxia-Inducible Factor-1 Activity

  2009cited by this paper
• A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma.

  2009cited by this paper
• Blockade of sphingosine‐1‐phosphate reduces macrophage influx and retinal and choroidal neovascularization

  2009cited by this paper
• Modulation of beta1-integrins on hemopoietic progenitor cells after allergen challenge in asthmatic subjects.

  2008cited by this paper
• Developmental regulation of NO-mediated VEGF-induced effects in the lung.

  2008cited by this paper
• Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling.

  2008cited by this paper
• HIF-1α Is Up-Regulated in Activated Mast Cells by a Process That Involves Calcineurin and NFAT1

  2008cited by this paper
• Induction of vascular remodeling in the lung by chronic house dust mite exposure.

  2008cited by this paper
• Viral infection in asthma.

  2008cited by this paper
• The role of Mycoplasma pneumoniae in acute exacerbation of asthma in children.

  2008cited by this paper
• The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma1

  2008cited by this paper
• Sphingolipids in the lungs.

  2008cited by this paper
• Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood

  2008cited by this paper
• “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

  2008cited by this paper
• Hypoxia and Hypoxia-Inducible Factor-1α Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function1

  2008cited by this paper
• Immunology of asthma and chronic obstructive pulmonary disease

  2008cited by this paper
• Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

  2008cited by this paper
• The cytokine network in asthma and chronic obstructive pulmonary disease.

  2008cited by this paper
• NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

  2008cited by this paper
• Oxygen-Independent Stabilization of Hypoxia Inducible Factor (HIF)-1 during RSV Infection

  2008cited by this paper
• Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axis.

  2008cited by this paper
• Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis

  2008cited by this paper
• Feasibility and interpretation of FE(NO) measurements in asthma patients in general practice.

  2008cited by this paper
• Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung.

  2008cited by this paper
• Lymphatics in Lung Disease

  2008cited by this paper
• The alliance of sphingosine-1-phosphate and its receptors in immunity

  2008cited by this paper
• Allergy as an organ and a systemic disease

  2008cited by this paper
• Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells.

  2008cited by this paper
• The role of sphingosine-1-phosphate and its receptors in asthma.

  2008cited by this paper
• Treatment with anti‐CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34+ progenitor cells in an allergic mouse model

  2008cited by this paper
• Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

  2008cited by this paper
• HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.

  2008cited by this paper
• Association between asthma and serum adiponectin concentration in women

  2008cited by this paper
• Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.

  2008cited by this paper
• Update in asthma 2007.

  2008cited by this paper
• Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.

  2008cited by this paper
• Mast cell-derived tumour necrosis factor is essential for allergic airway disease

  2008cited by this paper
• Induction of Vascular Permeability by the Sphingosine-1-Phosphate Receptor–2 (S1P2R) and its Downstream Effectors ROCK and PTEN

  2007cited by this paper
• Nitric Oxide Modulates Oxygen Sensing by Hypoxia-inducible Factor 1-dependent Induction of Prolyl Hydroxylase 2*

  2007cited by this paper
• Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice.

  2007cited by this paper
• Sphingosine 1-Phosphate Causes Airway Hyper-Reactivity by Rho-Mediated Myosin Phosphatase Inactivation

  2007cited by this paper
• Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion After Limb Ischemia

  2007cited by this paper
• Hypoxia inducible factor (HIF) function in innate immunity and infection

  2007cited by this paper
• CD34 facilitates the development of allergic asthma.

  2007cited by this paper
• Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma.

  2007cited by this paper
• Th1- and Th2-Dependent Endothelial Progenitor Cell Recruitment and Angiogenic Switch in Asthma1

  2007cited by this paper
• Angiogenesis is induced by airway smooth muscle strain.

  2007cited by this paper
• Hypoxia causes an increase in phagocytosis by macrophages in a HIF‐1α‐dependent manner

  2007cited by this paper
• Hypoxia-Induced Endothelial Proliferation Requires Both mTORC1 and mTORC2

  2007cited by this paper
• Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model.

  2007cited by this paper
• Microvascular theory of exercise-induced bronchoconstriction in asthma: potential implication of vascular endothelial growth factor.

  2007cited by this paper
• Effect of inhaled interleukin‐5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non‐asthmatic volunteers

  2007cited by this paper
• Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1{alpha} and airway responsiveness to ACh.

  2007cited by this paper
• Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma.

  2007cited by this paper
• Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.

  2007cited by this paper
• Fibrocytes in lung disease

  2007cited by this paper
• Time for a paradigm shift in asthma treatment: from relieving bronchospasm to controlling systemic inflammation.

  2007cited by this paper
• Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate‐induced asthma

  2006cited by this paper
• Pulmonary and vascular pharmacology of sphingosine 1-phosphate.

  2006cited by this paper
• Role of anti-IgE monoclonal antibody (omalizumab) in the treatment of bronchial asthma and allergic respiratory diseases.

  2006cited by this paper
• Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1*

  2006cited by this paper
• Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients.

  2006cited by this paper
• The importance of the airway microvasculature in asthma

  2006cited by this paper
• Tissue fibrocytes in patients with mild asthma: A possible link to thickness of reticular basement membrane?

  2006cited by this paper
• Vascular remodeling is airway generation-specific in a primate model of chronic asthma.

  2006cited by this paper
• Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.

  2006cited by this paper
• Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.

  2006cited by this paper
• Increased serum vascular endothelial growth factor level in Churg-Strauss syndrome.

  2006cited by this paper
• HIF1alpha delays premature senescence through the activation of MIF.

  2006cited by this paper
• Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin.

  2006cited by this paper
• HIF1α delays premature senescence through the activation of MIF

  2006cited by this paper
• Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

  2005cited by this paper
• Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

  2005cited by this paper
• Structural changes in the airways in asthma: observations and consequences.

  2005cited by this paper
• Progenitor egress from the bone marrow after allergen challenge: role of stromal cell-derived factor 1alpha and eotaxin.

  2005cited by this paper
• Vascular endothelial growth factor up‐regulation and bronchial wall remodelling in asthma

  2005cited by this paper
• GeneNotes – A novel information management software for biologists

  2005cited by this paper
• RSV Causes HIF-1α Stabilization via NO Release in Primary Bronchial Epithelial Cells

  2004cited by this paper
• Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors.

  2004cited by this paper
• Cytoskeletal Rearrangement and Caspase Activation in Sphingosine 1-Phosphate-Induced Lung Capillary Tube Formation

  2004cited by this paper
• Decreased arginine bioavailability and increased serum arginase activity in asthma.

  2004cited by this paper
• Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent.

  2004cited by this paper
• The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma.

  2004cited by this paper
• Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways.

  2004cited by this paper
• Cytomegalovirus infection and development of allergic diseases in early childhood: interaction with EBV infection?

  2004cited by this paper
• A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma1

  2004cited by this paper
• Update on asthma.

  2003cited by this paper
• VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors

  2003cited by this paper
• Mast-cell infiltration of airway smooth muscle in asthma.

  2002cited by this paper
• Transactivation of Vascular Endothelial Growth Factor (VEGF) Receptor Flk-1/KDR Is Involved in Sphingosine 1-Phosphate-stimulated Phosphorylation of Akt and Endothelial Nitric-oxide Synthase (eNOS)*

  2002cited by this paper
• Epstein-barr virus latent membrane protein 1 induces and causes release of fibroblast growth factor-2.

  2002cited by this paper
• Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice.

  2002cited by this paper
• Angiogenesis and remodeling of airway vasculature in chronic inflammation.

  2001cited by this paper
• Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.

  2001cited by this paper
• Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood?

  2001cited by this paper

• Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma

  2015cites this paper
• Neutraligands de la chimiokine CXCL12 dans l'asthme

  2013cites this paper
• Fenretinide Causes Emphysema, Which Is Prevented by Sphingosine 1-Phoshate

  2013cites this paper
• СРАВНИТЕЛЬНАЯ ОЦЕНКА ДИФФЕРЕНЦИАЛЬНОЙ ЭКСПРЕССИИ ГЕНОВ ПРИ ТЯЖЕЛОЙ БРОНХИАЛЬНОЙ АСТМЕ

  2013cites this paper
• Extracorporeal shock wave therapy as a treatment for heterotopic ossification

  2013cites this paper
• Experimentelle Untersuchungen zur Rolle des Sphingosinkinase/ Sphingosin-1-Phosphat-Systems bei pulmonaler Inflammation

  2012cites this paper
• 13 – Exercise and Lung Function in Child Health and Disease

  2012cites this paper
• Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway

  2011cites this paper
• Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population

  2011cites this paper
• The relationship between the management and control of asthma in primary health care

  2011cites this paper
• Why do we look at asthma through the keyhole

  2010cites this paper
• [Why do we look at asthma through the keyhole?].

  2010cites this paper
• Por qué miramos el asma a través del ojo de la cerradura

  2010cites this paper
• JCB: REPORT

  2009cites this paper