Exosome‐mediated activation of toll‐like receptor 3 in stellate cells stimulates interleukin‐17 production by γδ T cells in liver fibrosis

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Hepatology

• Publication date

  2016-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.28644PMID 27178735
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pathobiology of liver fibrosis: a translational success story

  2015influential reference
• Hepatic inflammation and fibrosis: Functional links and key pathways

  2015influential reference
• Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3

  2014influential reference
• Epigenetic regulation of connective tissue growth factor by MicroRNA‐214 delivery in exosomes from mouse or human hepatic stellate cells

  2014cited by this paper
• Chemokine receptor CCR6‐dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

  2014cited by this paper
• The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

  2014cited by this paper
• Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice

  2014cited by this paper
• Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases.

  2013cited by this paper
• Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

  2013cited by this paper
• Extracellular vesicles: biology and emerging therapeutic opportunities

  2013cited by this paper
• Interaction of hepatic stellate cells with diverse types of immune cells: Foe or friend?

  2013cited by this paper
• IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

  2013influential reference
• High‐mobility group box 1 (HMGB1)‐toll‐like receptor (TLR)4‐interleukin (IL)‐23‐IL‐17A axis in drug‐induced damage‐associated lethal hepatitis: Interaction of γδ T cells with macrophages

  2013cited by this paper
• Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice.

  2013cited by this paper
• Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver

  2012cited by this paper
• Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

  2012cited by this paper
• Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.

  2012cited by this paper
• CD11b+ Gr1+ bone marrow cells ameliorate liver fibrosis by producing interleukin‐10 in mice

  2012cited by this paper
• Epigenetic signatures and temporal expression of lineage-specific genes in hESCs during differentiation to hepatocytes in vitro.

  2011cited by this paper
• Vγ4 γδ T Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis

  2011cited by this paper
• Toll-Like Receptor 3 in Liver Diseases

  2010cited by this paper
• Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.

  2009cited by this paper
• Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals.

  2009cited by this paper
• Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

  2009influential reference
• Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways.

  2009influential reference
• Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.

  2007cited by this paper
• Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll‐like receptor 9

  2007influential reference
• Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

  2007cited by this paper
• Liver: An organ with predominant innate immunity

  2007cited by this paper
• The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

  2006cited by this paper
• STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity

  2006cited by this paper
• The liver as an immunological organ

  2006cited by this paper
• mRNA Is an Endogenous Ligand for Toll-like Receptor 3*

  2004cited by this paper
• The liver as an immunological organ

  2004cited by this paper
• Involvement of natural killer cells in PolyI:C-induced liver injury.

  2004influential reference
• Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model

  2003influential reference
• Mechanisms of carbon tetrachloride toxicity.

  1989cited by this paper
• Preferential expression of double-stranded ribonucleic acid in tumor versus normal cells: biological and clinical implications.

  1985cited by this paper
• Binding of carbon tetrachloride metabolites to rat hepatic mitochondrial DNA.

  1984cited by this paper
• Double-stranded RNA.

  1980cited by this paper
• The Orphan Nuclear Receptor ROR g t Directs the Differentiation Program of Proinflammatory IL-17 + T Helper Cells

  year unknowncited by this paper

• Hepatocyte–hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications

  2026cites this paper
• Targeted blockade of extracellular vesicles-mediated profibrotic vicious circle using EVs-based dual-drug delivery system to prevent liver fibrosis

  2025cites this paper
• Immunological liver-skin axis: a systemic Vγ4+ γδT17 cell response links psoriasis-like inflammation and MASLD

  2025cites this paper
• Therapeutic potential of exosomes in periodontal regeneration: Immunomodulatory and tissue-repair mechanisms

  2025cites this paper
• γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response

  2025cites this paper
• Exploring hepatic stellate cell-driven fibrosis: therapeutic advances and future perspectives

  2025cites this paper
• Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice

  2025cites this paper
• Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis

  2025cites this paper
• Identification of CTSK as a TLR-related critical biomarker in liver cirrhosis via integrative bioinformatics and pathological characterization

  2025cites this paper
• Pro-inflammatory effects of endogenous and recombinant MDA-7/IL-24 with RGD peptide on human hepatic stellate cells

  2025cites this paper
• Aluminum adjuvant promotes liver inflammation and fibrosis in mice: A novel approach to establish a liver fibrosis animal model

  2025cites this paper
• Diverse Subsets of γδT Cells and Their Specific Functions Across Liver Diseases

  2025cites this paper
• The role of the interleukin family in liver fibrosis

  2025cites this paper
• Immune Dysfunction and Infection Risk in Advanced Liver Disease.

  2025cites this paper
• Therapeutic Actions of Hepatocyte Extracellular Vesicles in a Murine Model of Diet-Induced Steatohepatitis with Fibrosis

  2025cites this paper
• Cutting-edge insights into liver fibrosis: advanced therapeutic strategies and future perspectives using engineered mesenchymal stem cell-derived exosomes

  2025cites this paper
• γδ T Cells: A Game Changer in the Future of Hepatocellular Carcinoma Immunotherapy

  2024cites this paper
• Extracellular Vesicles in Viral Liver Diseases

  2024cites this paper
• The Role of Extracellular Vesicles in Liver Fibrosis: Friends or Foes?

  2024cites this paper
• Organ Crosstalk: The Role of Spleen

  2024cites this paper
• Hepatic-derived extracellular vesicles in late pregnancy promote mammary gland development by stimulating prolactin receptor-mediated JAK2/STAT5/mTOR signalling.

  2024cites this paper
• Advances in the pharmacological mechanisms of berberine in the treatment of fibrosis

  2024cites this paper
• Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy.

  2024cites this paper
• Role of the type 3 cytokines IL-17 and IL-22 in modulating metabolic dysfunction-associated steatotic liver disease

  2024cites this paper
• Innate-like T cells in liver disease.

  2024cites this paper
• IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway

  2024cites this paper
• Gut microbiota in MAFLD: therapeutic and diagnostic implications

  2024cites this paper
• Hepatocyte‐derived exosomes deliver the lncRNA CYTOR to hepatic stellate cells and promote liver fibrosis

  2024cites this paper
• The potential role of extracellular vesicles as hepatic diagnostic and therapeutic tools: Can the dream come true?

  2024cites this paper
• Tissue damage from chronic liver injury inhibits peripheral NK cell abundance and proinflammatory function.

  2024cites this paper
• Immune Regulatory Networks and Therapy of γδ T Cells in Liver Cancer: Recent Trends and Advancements

  2024cites this paper
• Role of Extracellular Vesicles in Liver Diseases

  2023cites this paper
• Potential applications of using tissue-specific EVs in targeted therapy and vaccinology.

  2023cites this paper
• The role of SEVs in the promoting and treating liver fibrosis-MASP-1-enriched SEVs promote liver fibrosis while MSCs’ SEVs treating it

  2023cites this paper
• Gamma Delta T Cells: Role in Immunotherapy of Hepatocellular Carcinoma.

  2023cites this paper
• Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis

  2023cites this paper
• Tissue-resident and innate-like T cells in patients with advanced chronic liver disease

  2023cites this paper
• Hepatic inflammatory responses in liver fibrosis

  2023cites this paper
• Aldosterone inhibits EVs secretion through autophagic degradation of MVBs in LSECs leads to the activation of HSC

  2023cites this paper
• Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation

  2023cites this paper
• Isolation of Hepatic Stellate Cells and Lymphocytes for Co-culture Systems.

  2023cites this paper
• Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

  2023cites this paper
• Exosomes: Nomenclature, Isolation, and Biological Roles in Liver Diseases

  2023cites this paper
• Exosomes in liver fibrosis: The role of modulating hepatic stellate cells and immune cells, and prospects for clinical applications

  2023cites this paper
• A review of the effect of exosomes from different cells on liver fibrosis.

  2023cites this paper
• Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment

  2023cites this paper
• Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis.

  2023cites this paper
• Liver Regeneration and Immunity: A Tale to Tell

  2023cites this paper
• Contribution of Hepatic Steatosis-intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice.

  2023cites this paper
• The Relationship between Intestinal Dysbacteriosis and Liver Cirrhosis

  2022cites this paper
• Clinical implications of exosome-derived noncoding RNAs in liver

  2022cites this paper
• Extracellular Vesicles as Biomarkers in Liver Disease

  2022influential citation
• The Tumor Microenvironment of Hepatocellular Carcinoma: Untying an Intricate Immunological Network

  2022cites this paper
• The emerging roles of extracellular vesicles as intercellular messengers in liver physiology and pathology

  2022cites this paper
• Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles

  2022cites this paper
• Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases

  2022cites this paper
• Toll-like receptors and metabolic (dysfunction)-associated fatty liver disease.

  2022cites this paper
• New insights in the pathogenesis of alcohol-related liver disease: The metabolic, immunologic, and neurologic pathways☆

  2022cites this paper
• Nucleic acids and proteins carried by exosomes from various sources: Potential role in liver diseases

  2022cites this paper
• γδ T cells: The potential role in liver disease and implications for cancer immunotherapy

  2022cites this paper
• Extracellular vesicles and particles impact the systemic landscape of cancer

  2022cites this paper
• TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis

  2022cites this paper
• Hepatocyte‐derived MASP1‐enriched small extracellular vesicles activate HSCs to promote liver fibrosis

  2022cites this paper
• Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications

  2022cites this paper
• Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis

  2022cites this paper
• T cells and liver fibrosis

  2022cites this paper
• The Role of Extracellular Vesicles in Liver Pathogenesis.

  2022cites this paper
• LPS‐induced macrophage exosomes promote the activation of hepatic stellate cells and the intervention study of total astragalus saponins combined with glycyrrhizic acid

  2022cites this paper
• Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells

  2022cites this paper
• ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells

  2022cites this paper
• Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?

  2021cites this paper
• Extracellular Vesicles as Drivers of Non-Alcoholic Fatty Liver Disease: Small Particles with Big Impact

  2021cites this paper
• Diverse Functions of γδ T Cells in the Progression of Hepatitis B Virus and Hepatitis C Virus Infection

  2021cites this paper
• Emerging role and therapeutic application of exosome in hepatitis virus infection and associated diseases

  2021cites this paper
• Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes

  2021cites this paper
• Exosomes and Obesity-Related Insulin Resistance

  2021cites this paper
• Novel Immune Subsets and Related Cytokines: Emerging Players in the Progression of Liver Fibrosis

  2021cites this paper
• Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)

  2021cites this paper
• Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells

  2021cites this paper
• Cross-talk between hepatic stellate cells and T lymphocytes in liver fibrosis.

  2021cites this paper
• Fasting Enhances Biochemical and Histopathological Changes of Isoniazid Induced Liver Injury in Mouse

  2021cites this paper
• Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis

  2021cites this paper
• Retinoic Acid: A New Old Friend of IL-17A in the Immune Pathogeny of Liver Fibrosis

  2021cites this paper
• Extracellular Vesicles in Organ Fibrosis: Mechanisms, Therapies, and Diagnostics

  2021cites this paper
• Exosomes secreted by palmitic acid-treated hepatocytes promote LX-2 cell activation by transferring miRNA-107

  2021cites this paper
• Crosstalk between hepatic stellate cells and surrounding cells in hepatic fibrosis.

  2021cites this paper
• TLR3 Mediates Senescence and Immunosurveillance of Hepatic Stellate Cells

  2021cites this paper
• Targeting Gut–Liver Axis for Treatment of Liver Fibrosis and Portal Hypertension

  2021cites this paper
• Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice

  2021cites this paper
• Liver fibrosis: Extracellular vesicles mediated intercellular communication in perisinusoidal space

  2021cites this paper
• The Role of Exosomes in Viral Hepatitis and Its Associated Liver Diseases

  2021cites this paper
• Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome

  2021cites this paper
• Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

  2021cites this paper
• Narrative review of bovine milk exosomes as a potential therapeutic option for hepatic fibrosis

  2021cites this paper
• Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver

  2020cites this paper
• The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution

  2020cites this paper
• Immunopathogenesis of Liver Cirrhosis

  2020cites this paper
• Advances on liver cell‐derived exosomes in liver diseases

  2020cites this paper
• Immunopathobiology and therapeutic targets related to cytokines in liver diseases

  2020cites this paper
• Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

  2020influential citation