Combined Steroid Treatment for Congenital Heart Surgery Improves Oxygen Delivery and Reduces Postbypass Inflammatory Mediator Expression

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Circulation

• Publication date

  2003-06-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.0000070955.55636.25PMID 12756159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Sialyl lewis oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs.

  2000cited by this paper
• Gene expression of inflammatory mediators in different chambers of the human heart.

  2000cited by this paper
• Oxygen consumption after cardiopulmonary bypass surgery in children: determinants and implications.

  2000cited by this paper
• Preoperative and postoperative endotoxemia in children with congenital heart disease.

  2000cited by this paper
• Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children.

  2000cited by this paper
• Up-regulation of ICAM-1 by cytokines in human tracheal smooth muscle cells involves an NF-kappa B-dependent signaling pathway that is only partially sensitive to dexamethasone.

  1999cited by this paper
• Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: timing of dose is important.

  1999cited by this paper
• Reducing the Post-Pump Syndrome by Using Heparin-Coated Circuits, Steroids, or Aprotinin

  1999cited by this paper
• Does high-dose methylprednisolone in aprotinin-treated patients attenuate the systemic inflammatory response during coronary artery bypass grafting procedures?

  1999cited by this paper
• Influence of methylprednisolone on cytokine balance during cardiac surgery.

  1999cited by this paper
• Left ventricular dysfunction after open repair of simple congenital heart defects in infants and children: quantitation with the use of a conductance catheter immediately after bypass.

  1998cited by this paper
• Clinical Investigations: SurgeryInflammatory Response to Cardiopulmonary Bypass: Mechanisms Involved and Possible Therapeutic Strategies

  1997cited by this paper
• Steroid administration in heart and heart-lung transplantation: is the timing adequate?

  1996cited by this paper
• Induction of interleukin-8 messenger RNA in heart and skeletal muscle during pediatric cardiopulmonary bypass.

  1995cited by this paper
• Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest.

  1995cited by this paper
• A Mechanism for the Antiinflammatory Effects of Corticosteroids

  1993cited by this paper
• A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

  1992cited by this paper
• Pharmacokinetics of high-dose methylprednisolone in children.

  1992cited by this paper
• Pharmacokinetics of Methylprednisolone Sodium Succinate and Methylprednisolone in Patients Undergoing Cardiopulmonary Bypass

  1990cited by this paper
• Steroids in heart surgery: a clinical double-blind and randomized study.

  1980cited by this paper
• Oximetric detection of intracardiac left-to-right shunts.

  1979cited by this paper
• Effects of Glucocorticosteriods in Patients Undergoing Coronary Artery Bypass Surgery

  1979cited by this paper
• Effects of glucocorticosteroids in patients undergoing coronary artery bypass surgery.

  1979cited by this paper
• The use of methylprednisolone during cardiopulmonary bypass. A review of 427 cases.

  1975cited by this paper

• Cardiac Intensive Care.

  2025cites this paper
• Endocrine Effects of Arginine-Vasopressin After Pediatric Cardiac Surgery.

  2025cites this paper
• Methylprednisolone and postoperative pulmonary function following minimally invasive cardiac surgery under ultra-fast-track anesthesia

  2025cites this paper
• High Dose Methylprednisolone versus Low Dose in Correction of Congenital Acyanotic Heart Disease

  2022cites this paper
• Lung Injury After Neonatal Congenital Cardiac Surgery Is Mild and Modifiable by Corticosteroids.

  2021cites this paper
• The Current Status of Neuroprotection in Congenital Heart Disease

  2021cites this paper
• Clinical and Laboratory Predictors for the Development of Low Cardiac Output Syndrome in Infants Undergoing Cardiopulmonary Bypass: A Pilot Study

  2021cites this paper
• Perioperative Corticosteroid Therapy in Children Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis

  2020cites this paper
• Effect of Intraoperative Dexamethasone on Major Complications and Mortality Among Infants Undergoing Cardiac Surgery: The DECISION Randomized Clinical Trial.

  2020cites this paper
• Impact of Corticosteroids on Cardiopulmonary Bypass Induced Inflammation in Children:A Meta-Analysis.

  2020cites this paper
• Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass

  2019cites this paper
• Anesthesia for Children Undergoing Heart Surgery

  2019cites this paper
• Corticosteroids for Congenital Heart Surgery: When Is a Negative Trial Not a Negative Trial?

  2019cites this paper
• Endocrine Function in Critical Heart Disease

  2019cites this paper
• Reduction of Inflammation by High-Dose Methylprednisolone Does not Attenuate Oxidative Stress in Children Undergoing Bidirectional Glenn Procedure With or Without Aortic Arch or Pulmonary Arterial Repair.

  2019cites this paper
• Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass: Randomized Controlled Trial.

  2019cites this paper
• Adrenal insufficiency in neonates undergoing cardiopulmonary bypass and postoperative hypothalamic-pituitary-adrenal function after prophylactic glucocorticoids

  2019cites this paper
• Oxidation Reduction Potential (ORP) is Predictive of Complications Following Pediatric Cardiac Surgery

  2018cites this paper
• Useful References in Pediatric Cardiac Intensive Care: The 2017 Update*

  2018cites this paper
• Corticosteroids in Pediatric Heart Surgery: Myth or Reality

  2018cites this paper
• Primary prevention of post-pericardiotomy syndrome using corticosteroids: a systematic review

  2018cites this paper
• Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association.

  2018cites this paper
• Steroids in paediatric heart surgery: eminence or evidence-based practice?

  2018cites this paper
• Recognition and Treatment of Low Cardiac Output States in Pediatric Cardiac Intensive Care

  2018cites this paper
• Steroids for Adult and Pediatric Cardiac Surgery: A Clinical Update.

  2018cites this paper
• Minimally invasive perventricular versus open surgical ventricular septal defect closure in infants and children: a randomised clinical trial

  2018cites this paper
• Clinical guidelines for the management of patients with transposition of the great arteries with intact ventricular septum

  2017cites this paper
• Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial.

  2017cites this paper
• First nights, the adrenal axis, and steroids

  2017cites this paper
• Heart-Type Fatty Acid Binding Protein and High-Dose Methylprednisolone in Pediatric Cardiac Surgery.

  2017cites this paper
• Clinical guidelines for the management of patients with transposition of the great arteries with intact ventricular septum

  2017cites this paper
• Invited Commentary.

  2017cites this paper
• Cardiopulmonary Bypass-Induced Inflammatory Response: Pathophysiology and Treatment

  2016cites this paper
• Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Hormone Replacement Therapy

  2016cites this paper
• High‐dose methylprednisolone and endothelial glycocalyx in paediatric heart surgery

  2016cites this paper
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  2016cites this paper
• Intraoperative Steroid Use and Outcomes Following the Norwood Procedure: An Analysis of the Pediatric Heart Network’s Public Database

  2016cites this paper
• Perioperative Steroids in Pediatric Cardiopulmonary Bypass: We Still Do Not Have All the Answers.

  2016cites this paper
• Effect of steroids on inflammatory markers and clinical parameters in congenital open heart surgery: a randomised controlled trial

  2015cites this paper
• The Role of Prophylactic Postoperative Steroids in Pediatric Cardiac Operations.

  2015cites this paper
• A Single-Center Analysis of Methylprednisolone Use during Pediatric Cardiopulmonary Bypass.

  2015cites this paper
• WITHDRAWN: Prophylactic steroids for pediatric open heart surgery.

  2015cites this paper
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  2015cites this paper
• Implementation of enhanced recovery after surgery in pediatric cardiac practice: a synopsis

  2015cites this paper
• Anesthesia for cardiac surgery in neonates

  2015cites this paper
• Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures.

  2015cites this paper
• Immunologic and Infectious Diseases in Pediatric Cardiac Critical Care

  2015cites this paper
• Inflammatory response after neonatal cardiac surgery and its relationship to clinical outcomes.

  2014cites this paper
• The Systemic Inflammatory Response to Cardiopulmonary Bypass: Pathophysiology and Treatment

  2014cites this paper
• Perioperative Steroids Administration in Pediatric Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials*

  2014cites this paper
• P. Preoperative Use of Steroids in Pediatric Cardiac Surgery: New Directions for Future Research

  2014cites this paper
• A comparison of three dose timings of methylprednisolone in infant cardiopulmonary bypass

  2014influential citation
• Serum Cortisol and Early Postoperative Outcome After Stage-1 Palliation for Hypoplastic Left Heart Syndrome

  2014cites this paper
• Risk Factors and Outcome of Fontan‐Associated Plastic Bronchitis: A Case‐Control Study

  2014cites this paper
• [I Guidelines of heart failure and heart transplantation in the fetus, in children and adults with congenital cardiopathy, The Brazilian Society of Cardiology].

  2014cites this paper
• Preoperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates: results from a randomized trial.

  2014cites this paper
• Systemic Inflammatory Response to Cardiopulmonary Bypass in Pediatric Patients and Related Strategies for Prevention

  2014cites this paper
• Cardiac SERCA2A/B: therapeutic targets for heart failure.

  2014cites this paper
• Preoperative use of steroids in pediatric cardiac surgery: new directions for future research?

  2013cites this paper
• Methylprednisolone in neonatal cardiac surgery: reduced inflammation without improved clinical outcome.

  2013cites this paper
• Advances in pediatric cardiac intensive care.

  2013cites this paper
• Reply: To PMID 22289904.

  2013cites this paper
• Comparing the Effect of Preoperative Administration of Methylprednisolone and its Administration Before and During Surgery on the Clinical Outcome in Pediatric Open Heart Surgeries

  2013cites this paper
• Comparison Between Preoperative Administration of Methylprednisolone With its Administration Before and During Congenital Heart Surgery on Serum Levels of IL-6 And IL-10

  2013influential citation
• Identification of inflammatory mediators and their modulation by strategies for the management of the systemic inflammatory response during cardiac surgery.

  2013cites this paper
• Cumulative corticosteroid exposure and infection risk after complex pediatric cardiac surgery.

  2013cites this paper
• Management of Pediatric Cardiopulmonary Bypass

  2013cites this paper
• cardiopulmonary bypass and circulatory arrest Preoperative glucocorticoids decrease pulmonary hypertension in piglets after

  2013cites this paper
• Reply to: « Vitale V, Ricci Z, Cogo P. Preoperative Use of Steroids in Pediatric Cardiac Surgery: New Directions for Future Research?. Ann Thorac Surg 2013 Jul;96(1):375. »

  2013cites this paper
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  2012cites this paper
• CPB management of G6PD deficient patient – a case report

  2012cites this paper
• Invited commentary.

  2012cites this paper
• Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: Results of a prospective, randomized, controlled clinical trial*

  2012cites this paper
• Comparison of Maximum Vasoactive Inotropic Score and Low Cardiac Output Syndrome As Markers of Early Postoperative Outcomes After Neonatal Cardiac Surgery

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Uso Profiláctico de Esteroides en niños con Cardiopatías Congénitas, operados con apoyo de Circulación Extracorpórea

  2012cites this paper
• Post-operative Cardiac Care

  2012cites this paper
• Use of the cardioprotectants thymosin β4 and dexrazoxane during congenital heart surgery: proposal for a randomized, double‐blind, clinical trial

  2012cites this paper
• Transfusion of washed red blood cells and platelets : What is left behind ?

  2012cites this paper
• Identification of Inflammatory Mediators and Their Modulation by Strategies for the Management of the Systemic Inflammatory Response During Cardiac Surgery

  2012cites this paper
• Correlation Between Pediatric Open Heart Surgery Outcomes and Arterial-mixed Venous Oxygen Saturation Differences.

  2012cites this paper
• Intensive care management of neonates with d-transposition of the great arteries and common arterial trunk

  2012cites this paper
• Hemodynamic correlates of serum cortisol in neonates after cardiopulmonary bypass*

  2011cites this paper
• Glucocorticoids improve calcium cycling in cardiac myocytes after cardiopulmonary bypass.

  2011cites this paper
• Standardized preoperative corticosteroid treatment in neonates undergoing cardiac surgery: results from a randomized trial.

  2011influential citation
• Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications

  2011influential citation
• Outcomes and Risk Factors for Mortality in Premature Neonates With Critical Congenital Heart Disease

  2011cites this paper
• Chapter 30 – Cardiac Bypass for Repair of Congenital Heart Disease in Infants and Children

  2011cites this paper
• Management of the postoperative pediatric cardiac surgical patient

  2011cites this paper
• Han YY, Carcillo JA, Venkataraman ST, Clark RS, Watson RS, Nguyen TC, Bayir H, Orr RA. Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system. Pediatrics

  2011cites this paper
• Improved outcomes associated with intraoperative steroid use in high-risk pediatric cardiac surgery.

  2011cites this paper
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  2011cites this paper
• Corticosteroids and Outcome in Children Undergoing Congenital Heart Surgery: Analysis of the Pediatric Health Information Systems Database

  2010cites this paper
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  2010cites this paper
• Effects of the corticosteroids in the lesions by radiofrequency on rats' thigh in different age groups.

  2010cites this paper
• Care of the pediatric cardiac surgery patient--part 1.

  2010cites this paper
• Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered

  2010cites this paper
• Management of perioperative low cardiac output state without extracorporeal life support: What is feasible?

  2010cites this paper