Genetic deletion of PKR abrogates TNF-induced activation of IκBα kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Oncogene

• Publication date

  2007-02-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1209906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of Double-stranded RNA-activated Protein Kinase PKR in Bacillus Calmette Guerin (BCG)-induced Cell Death

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• Protein Kinase R (PKR) Interacts with and Activates Mitogen-activated Protein Kinase Kinase 6 (MKK6) in Response to Double-stranded RNA Stimulation*

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• NF-κB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-κB-Inducing Kinase and IκB Kinase

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• The B56α Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR

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  2000influential reference
• Induction of E-Selectin Expression by Double-Stranded RNA and TNF-α Is Attenuated in Murine Aortic Endothelial Cells Derived from Double-Stranded RNA-Activated Kinase (PKR)-Null Mice1

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• Activation of NF-κB by the dsRNA-dependent protein kinase, PKR involves the IκB kinase complex

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• NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

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• Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons*

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• Double-Stranded-RNA-Activated Protein Kinase PKR Enhances Transcriptional Activation by Tumor Suppressor p53

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• RAX, a Cellular Activator for Double-stranded RNA-dependent Protein Kinase during Stress Signaling*

  1999cited by this paper
• Human Immunodeficiency Virus Type 1 Tat Protein Activates Transcription Factor NF-κB through the Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase, PKR

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• Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis.

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• Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription.

  1999cited by this paper
• Involvement of PKR in the regulation of myogenesis.

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