Growth Factors in the Nucleolus?

In eukaryotic cells containing tandem repeated ribosomal RNA genes, there appears a specialized region of chromatin, carrying out gene transcription, rRNA processing, and nascent ribosomal subunit assembly—the nucleolus. One of the first intracellular structures to be described ([Montgomery, 1898

• Publication year

  1998

• Venue

  Journal of Cell Biology

• Publication date

  1998-10-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.143.2.279PMID 9786941PMCID 2132844
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Localization of signal recognition particle RNA in the nucleolus of mammalian cells.

  1998influential reference
• Nucleolar localization of the Werner syndrome protein in human cells.

  1998cited by this paper
• Molecular Cloning Reveals that the p160 Myb-Binding Protein Is a Novel, Predominantly Nucleolar Protein Which May Play a Role in Transactivation by Myb

  1998cited by this paper
• The nucleus: A target site for parathyroid hormone‐related peptide (PTHrP) action

  1998cited by this paper
• Neomycin inhibits angiogenin-induced angiogenesis.

  1998cited by this paper
• The plurifunctional nucleolus.

  1998cited by this paper
• Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells.

  1997cited by this paper
• Nuclear accumulation of fibroblast growth factor receptors in human glial cells-association with cell proliferation

  1997cited by this paper
• Casein Kinase II Catalyzes Tyrosine Phosphorylation of the Yeast Nucleolar Immunophilin Fpr3*

  1997influential reference
• Fibroblast Growth Factor-2 Binds to the Regulatory β Subunit of CK2 and Directly Stimulates CK2 Activity toward Nucleolin*

  1996influential reference
• Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells

  1996cited by this paper
• A Major Tyrosine-phosphorylated Protein of Trypanosoma brucei Is a Nucleolar RNA-binding Protein*

  1996cited by this paper
• Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death

  1995cited by this paper
• Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity.

  1994cited by this paper
• Nuclear signaling pathways for polypeptide ligands and their membrane receptors?

  1994cited by this paper
• Differential nuclear localization of protein kinase C isoforms in neuroblastoma x glioma hybrid cells.

  1994cited by this paper
• Nuclear lipid metabolism in NEST: Nuclear envelope signal transduction

  1994cited by this paper
• PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.

  1993cited by this paper
• A nuclear tyrosine phosphatase downregulates interferon-induced gene expression

  1993cited by this paper
• Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila.

  1993cited by this paper
• The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin.

  1993cited by this paper
• p63cdc13, a B-type cyclin, is associated with both the nucleolar and chromatin domains of the fission yeast nucleus.

  1993cited by this paper
• Inositides and the nucleus and inositides in the nucleus.

  1993cited by this paper
• BN46/51, a new nucleolar protein, binds to the basal body region in Naegleria gruberi flagellates

  1992cited by this paper
• Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells

  1992cited by this paper
• Megascopic eukaryotic algae from the 2.1-billion-year-old negaunee iron-formation, Michigan.

  1992cited by this paper
• Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

  1992cited by this paper
• Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction.

  1992cited by this paper
• The NH2‐terminal extension of high molecular weight bFGF is a nuclear targeting signal

  1991cited by this paper
• Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

  1990cited by this paper
• Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells.

  1990cited by this paper
• The alternatively spliced exon of the platelet-derived growth factor A chain encodes a nuclear targeting signal

  1989cited by this paper
• Matthias Jacob Schleiden and the definition of the cell nucleus.

  1988cited by this paper
• Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

  1987influential reference
• The association of polypeptide hormones and growth factors with the nuclei of target cells

  1987cited by this paper
• Visualization of Nucleolar Genes

  1969cited by this paper
• Perspectives for the conference on the nucleolus.

  1966cited by this paper
• Turnover of Ribosomal RNA in Rat Liver

  1965cited by this paper
• Comparative cytological studies, with especial regard to the morphology of the nucleolus

  1898cited by this paper

• Morphokinetic features in human embryos: Analysis by our original high‐resolution time‐lapse cinematography—Summary of the past two decades

  2024cites this paper
• FGF2 antiproliferative effect in K-ras-driven tumor cells involves modulation of rRNA and nucleolus.

  2023cites this paper
• Migration speed of nucleolus precursor bodies in human male pronuclei: a novel parameter for predicting live birth

  2021cites this paper
• Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: Transcriptional regulation and DNA damage response.

  2020cites this paper
• Matrix Metalloprotease-7 Mediates Nucleolar Assembly and Intra-nucleolar Cleaving p53 in Gefitinib-Resistant Cancer Stem Cells

  2020cites this paper
• Effect of serum starvation and cell density in the expression of VEGF , bFGF and Angiogenin , and also the effect of VEGF up regulate in the expression of bFGF and Angiogenin

  2015cites this paper
• The Impact of Statins on FGF–2—Stimulated Human Umbilical Vein Endothelial Cells

  2014cites this paper
• Human Embryonic Behavior Observed with Time-Lapse Cinematography

  2014cites this paper
• Differentially regulated expression of neurokinin B (NKB)/NK3 receptor system in uterine leiomyomata.

  2013cites this paper
• Human Eb Peptide: Not just a By-product of Pre-pro-IGF1b Processing?

  2013cites this paper
• The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest

  2013cites this paper
• Bewertung von Eizellen und Embryonen

  2013cites this paper
• The zygote.

  2012cites this paper
• Pronuclear Scoring in Human In Vitro Fertilization

  2012cites this paper
• The nuclear localization of MGF receptor in osteoblasts under mechanical stimulation

  2012cites this paper
• Nucleolar Sik-similar protein (Sik-SP) is required for the maintenance of uterine estrogen signaling mechanism via ERα.

  2012cites this paper
• Atlas of human embryology: from oocytes to preimplantation embryos. Preface.

  2012cites this paper
• NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

  2011cites this paper
• The nucleolus.

  2011influential citation
• PNAC: a protein nucleolar association classifier

  2011cites this paper
• Morphometric analyses of embryos

  2011cites this paper
• Basic Fibroblast Growth Factor Affects the Expression of Angiogenin and Cell Proliferation in A375 Human Melanoma Cells

  2011cites this paper
• Evaluation and Selection of Preimplantation Embryos for Transfer

  2010cites this paper
• Characterization and prediction of protein nucleolar localization sequences

  2010cites this paper
• Effects of basic fibroblast growth factor on angiogenin expression and cell proliferation in H7402 human hepatoma cells.

  2009cites this paper
• MicroRNAs with a nucleolar location.

  2009cites this paper
• Modulatory effect of rRNA synthesis and ppUL83 nucleolar compartmentalization on human cytomegalovirus gene expression in vitro

  2009cites this paper
• Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells.

  2008cites this paper
• Developmental regulation of Hand1 via nucleolar sequestration

  2008cites this paper
• Two wobble-splicing events affect ING4 protein subnuclear localization and degradation.

  2008cites this paper
• Nucleostemin: a multiplex regulator of cell-cycle progression.

  2008cites this paper
• Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway.

  2007cites this paper
• Phospho-eNOS Ser-1176 is associated with the nucleoli and the Golgi complex in C6 rat glioma cells.

  2007cites this paper
• Ribosomal protein mutations in Diamond‐Blackfan anemia: might they operate upstream from protein synthesis?

  2007cites this paper
• Localization of ZO-1 in the nucleolus of corneal fibroblasts.

  2007cites this paper
• Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneurons.

  2007cites this paper
• Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates.

  2007cites this paper
• Dyskeratosis congenita

  2007cites this paper
• The ABCs of IGF-I isoforms: impact on muscle hypertrophy and implications for repair.

  2006cites this paper
• New insights into nucleolar architecture and activity.

  2006influential citation
• Subcellular Localization of CIAPIN1

  2006cites this paper
• A europium complex that selectively stains nucleoli of cells.

  2006cites this paper
• Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells

  2005cites this paper
• Direct Regulation of rRNA Transcription by Fibroblast Growth Factor 2

  2005influential citation
• A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin.

  2005cites this paper
• Nucleolar localization of cirhin, the protein mutated in North American Indian childhood cirrhosis.

  2005cites this paper
• Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation

  2005cites this paper
• Conformational determinants of the intracellular localization of midkine.

  2005cites this paper
• Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes

  2005cites this paper
• NGF and IL-1beta are co-localized in the developing nervous system of the frog, Xenopus laevis.

  2005cites this paper
• Cell-specific nucleolar localization of TBP-related factor 2.

  2004cites this paper
• Nuclear and Nucleolar Localization of 18-kDa Fibroblast Growth Factor-2 Is Controlled by C-terminal Signals*

  2004cites this paper
• Nuclear bodies and compartments: functional roles and cellular signalling in health and disease.

  2004cites this paper
• EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes

  2004cites this paper
• Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination

  2004cites this paper
• Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancer

  2004cites this paper
• Cell and molecular biology of nucleolar assembly and disassembly.

  2004cites this paper
• Mapping nucleolar and spliceosome localization sequences of neuregulin1-beta3.

  2004cites this paper
• Immunolocalization of Upstream Binding Factor and Pocket Protein p130 During Final Stages of Bovine Oocyte Growth1

  2004cites this paper
• The Biological Basis of Oocyte and Embryo Competence: Morphodynamic Criteria for Embryo Selection in In-Vitro Fertilization

  2004cites this paper
• development Lynette Scott, PhD, has been working in the field of human IVF for 18 years having started

  2003cites this paper
• The biological basis of non-invasive strategies for selection of human oocytes and embryos.

  2003cites this paper
• Differential Intranuclear Localization of Fibroblast Growth Factor-2 Isoforms and Specific Interaction with the Survival of Motoneuron Protein*

  2003cites this paper
• Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.

  2003cites this paper
• Nuclear localization and possible functions of receptor tyrosine kinases.

  2003cites this paper
• Autoradiographic and ultrastructural studies of the effect of chilling on soybean root meristem nucleoli

  2003cites this paper
• Pronuclear scoring as a predictor of embryo development.

  2003influential citation
• Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization.

  2003cites this paper
• Translocation of ErbB receptors into the nucleus

  2003cites this paper
• Nuclear localization and function of polypeptide ligands and their receptors: a new paradigm for hormone specificity within the mammary gland?

  2003cites this paper
• Signalling shortcuts: cell-surface receptors in the nucleus?

  2002cites this paper
• Nucleolar localization of an isoform of the IGF-I precursor

  2002cites this paper
• c-erbB-3

  2002cites this paper
• Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis

  2002cites this paper
• * Following Angiogenin during Angiogenesis : a Journey from the Cell Surface to the Nucleolus

  2002cites this paper
• Proteasome-dependent processing of nuclear proteins is correlated with their subnuclear localization.

  2002cites this paper
• Proteasome-dependent processing of nuclear proteins is correlated with their subnuclear localization

  2002cites this paper
• Proteomics of the nucleolus: more proteins, more functions?

  2002cites this paper
• ESSAI SUR LE NUCLEOLE

  2002cites this paper
• Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules.

  2002cites this paper
• Nuclear Transport of Parathyroid Hormone (PTH)-Related Protein Is Dependent on Microtubules

  2002cites this paper
• Novel properties of the nucleolar targeting signal of human angiogenin.

  2001cites this paper
• A novel nucleolar G-protein conserved in eukaryotes.

  2001cites this paper
• UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences.

  2001cites this paper
• Paradoxical actions of exogenous and endogenous parathyroid hormone‐related protein on renal vascular smooth muscle cell proliferation: reversion in the SHR model of genetic hypertension

  2001cites this paper
• The Nucleolus and the Four Ribonucleoproteins of Translation

  2000cites this paper
• Nuclear and nucleolar localization of parathyroid hormone‐related protein

  2000cites this paper
• Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes.

  2000cites this paper
• Mutant loricrin is not crosslinked into the cornified cell envelope but is translocated into the nucleus in loricrin keratoderma.

  2000cites this paper
• Galectins: a new family of regulators of inflammation.

  2000cites this paper
• To be or not to be in the nucleolus

  2000cites this paper
• Galectins: A new family of regulators of inflammation

  2000cites this paper
• The nucleolus.

  2000cites this paper
• Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives

  2000cites this paper
• Movement and localization of RNA in the cell nucleus

  1999cites this paper
• Phosphorylation at the Cyclin-dependent Kinases Site (Thr85) of Parathyroid Hormone-related Protein Negatively Regulates Its Nuclear Localization*

  1999cites this paper
• Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals.

  1999cites this paper
• Pch2 links chromatin silencing to meiotic checkpoint control.

  1999cites this paper
• The nature of intracrine peptide hormone action.

  1999cites this paper
• Structure and function of the nucleolus.

  1999cites this paper