Where Are We in the Quest for Vaccines for Malaria?

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Drugs

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.2165/00003495-199141010-00001PMID 1706981
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phase-I study of intravenous modified lipid A

  2004cited by this paper
• Plasmodium falciparum antigens as target molecules for a protective immunization against malaria: an up-to-date review

  2004cited by this paper
• The malaria vaccine: anti-parasite or anti-disease?

  1990cited by this paper
• Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria

  1990cited by this paper
• Role of Adjuvants in Malaria Vaccines

  1990cited by this paper
• Characterization of antibody responses induced by different synthetic adjuvants to the Plasmodium falciparum major merozoite surface precursor protein, gp 195.

  1990cited by this paper
• Immunization of Aotus monkeys with Plasmodium falciparum blood-stage recombinant proteins.

  1990cited by this paper
• Roles of tumour necrosis factor in the illness and pathology of malaria.

  1989cited by this paper
• Restricted or absent immune responses in human populations to Plasmodium falciparum gamete antigens that are targets of malaria transmission-blocking antibodies

  1989cited by this paper
• Differential non-responsiveness in humans of candidate Plasmodium falciparum vaccine antigens.

  1989cited by this paper
• Genetic recombination in malaria parasites.

  1989cited by this paper
• Class II restriction in mice to the malaria candidate vaccine ring infected erythrocyte surface antigen (RESA) as synthetic peptides or as expressed in recombinant vaccinia.

  1989cited by this paper
• Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

  1989cited by this paper
• Adjuvants for anti-parasite vaccines.

  1989cited by this paper
• Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax.

  1989cited by this paper
• An update on candidate malaria vaccines

  1989cited by this paper
• Generalized immunological recognition of the major merozoite surface antigen (gp195) of Plasmodium falciparum.

  1989cited by this paper
• Antibodies to Plasmodium falciparum gamete surface antigens in Papua New Guinea sera

  1988cited by this paper
• Immunization against Plasmodium falciparum with recombinant polypeptides produced in Escherichia coli

  1988cited by this paper
• Natural antibodies against three distinct and defined antigens of Plasmodium falciparum in residents of a mesoendemic area in Gabon.

  1988cited by this paper
• Malaria vaccines: immunogen selection and epitope mapping.

  1988cited by this paper
• T cell functions in Plasmodium falciparum and other malarias.

  1988cited by this paper
• The role of T cells in immunity to malaria.

  1988cited by this paper
• The Role of T Cells in Immunity to Malaria (Part 2 of 2)

  1988cited by this paper
• A vaccine candidate from the sexual stage of human malaria that contains EGF-like domains

  1988cited by this paper
• Comparison of antibody avidity and titre elicited by peptide as a protein conjugate or as expressed in vaccinia.

  1988cited by this paper
• A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

  1988cited by this paper
• Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.

  1988cited by this paper
• Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum.

  1988cited by this paper
• Plasmodium falciparum: inhibition/reversal of cytoadherence of Thai isolates to melanoma cells by local immune sera.

  1988cited by this paper
• Development of malaria vaccines.

  1988cited by this paper
• Recombinant human IL-2 overcomes genetic nonresponsiveness to malaria sporozoite peptides. Correlation of effect with biologic activity of IL-2.

  1988cited by this paper
• Multiple T helper cell epitopes of the circumsporozoite protein of Plasmodium berghei

  1988cited by this paper
• CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

  1988cited by this paper
• Plasmodium falciparum: gene structure and hydropathy profile of the major merozoite surface antigen (gp195) of the Uganda-Palo Alto isolate.

  1988cited by this paper
• The main obstacle to a malaria vaccine: the malaria parasite.

  1988cited by this paper
• Nonpolymorphic regions of p190, a protein of the Plasmodium falciparum erythrocytic stage, contain both T and B cell epitopes.

  1988cited by this paper
• Genetic restriction of the murine humoral response to a recombinant Plasmodium vivax circumsporozoite protein

  1988cited by this paper
• Liposomes, lipid A, and aluminum hydroxide enhance the immune response to a synthetic malaria sporozoite antigen

  1988cited by this paper
• Limited immunological recognition of critical malaria vaccine candidate antigens.

  1988cited by this paper
• Expression and function of erythrocyte‐associated surface antigens in malaria

  1988cited by this paper
• Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites

  1987cited by this paper
• Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein.

  1987cited by this paper
• Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.

  1987cited by this paper
• Strain variation in the circumsporozoite protein gene of Plasmodium falciparum.

  1987cited by this paper
• Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria.

  1987cited by this paper
• Vaccination-induced variation in the 140 kD merozoite surface antigen of Plasmodium knowlesi malaria

  1987cited by this paper
• Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine.

  1987cited by this paper
• The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies.

  1987influential reference
• Malaria transmission-blocking immunity induced by natural infections of Plasmodium vivax in humans

  1987cited by this paper
• Induction of protective immunity against experimental infection with malaria using synthetic peptides

  1987cited by this paper
• Repetitive proteins and genes of malaria.

  1987cited by this paper
• Antibodies to the repetitive epitope of Plasmodium falciparum circumsporozoite protein in a rural Tanzanian community: a longitudinal study of 132 children.

  1987cited by this paper
• The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines.

  1986cited by this paper
• A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptor

  1986cited by this paper
• Immunization with synthetic peptides of a Plasmodium falciparum surface antigen induces antimerozoite antibodies.

  1986cited by this paper
• Immunization of Aotus monkeys with recombinant proteins of an erythrocyte surface antigen of Plasmodium falciparum

  1986cited by this paper
• Variation in the gene encoding a major merozoite surface antigen of the human malaria parasite Plasmodium falciparum.

  1986cited by this paper
• Antigen-specific, interleukin 2-propagated T lymphocytes confer resistance to a murine malarial parasite, Plasmodium chabaudi adami.

  1986cited by this paper
• Structure of the RESA gene of Plasmodium falciparum.

  1986cited by this paper
• Multiple cross‐reactivities amongst antigens of Plasmodium falciparum impair the development of protective immunity against malaria

  1986cited by this paper
• Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants.

  1986cited by this paper
• Synthetic peptides as antigens for the detection of humoral immunity to Plasmodium falciparum sporozoites.

  1986cited by this paper
• Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine

  1986cited by this paper
• Defined Plasmodium falciparum antigens in malaria serology.

  1986cited by this paper
• Development of a sporozoite malaria vaccine.

  1986cited by this paper
• Epitope map and processing scheme for the 195,000-dalton surface glycoprotein of Plasmodium falciparum merozoites deduced from cloned overlapping segments of the gene.

  1986cited by this paper
• Isolation of the gene for a glycophorin-binding protein implicated in erythrocyte invasion by a malaria parasite.

  1985cited by this paper
• Polymorphism of a high molecular weight schizont antigen of the human malaria parasite Plasmodium falciparum

  1985cited by this paper
• A 50 kilodalton exoantigen specific to the merozoite release-reinvasion stage of Plasmodium falciparum.

  1985cited by this paper
• Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito

  1985influential reference
• A Plasmodium falciparum antigen that binds to host erythrocytes and merozoites.

  1985cited by this paper
• Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites

  1985cited by this paper
• Localization of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum in merozoites and ring-infected erythrocytes

  1985cited by this paper
• Effects of transmission-blocking monoclonal antibodies on different isolates of Plasmodium falciparum

  1985cited by this paper
• POLYMORPHISM OF A HIGH MOLECULAR WEIGHT SCHIZONT ANTIGEN OF THE HUMAN MALARIA PARASITE

  1985cited by this paper
• Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level.

  1985cited by this paper
• Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration.

  1985cited by this paper
• Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria.

  1985cited by this paper
• Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum.

  1985cited by this paper
• Isolation of a Plasmodium falciparum rhoptry protein.

  1985cited by this paper
• Identification of a strain-specific malarial antigen exposed on the surface of Plasmodium falciparum-infected erythrocytes

  1984cited by this paper
• Passive immunization against murine malaria with an IgG3 monoclonal antibody.

  1984cited by this paper
• Antibodies in malarial sera to parasite antigens in the membrane of erythrocytes infected with early asexual stages of Plasmodium falciparum

  1984cited by this paper
• DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope.

  1984cited by this paper
• Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria

  1984cited by this paper
• Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum.

  1984influential reference
• Vaccination against malaria: its plausibility and the present state of research.

  1984cited by this paper
• Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stages

  1984cited by this paper
• Perspectives for malaria vaccination.

  1984cited by this paper
• Development of sporozoite vaccines.

  1984cited by this paper
• Malaria vaccination: two steps forward, one backward.

  1983cited by this paper
• Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells

  1983cited by this paper
• Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum

  1983influential reference
• The genetic basis of diversity in malaria parasites.

  1983cited by this paper
• The role of cell-mediated immune responses in resistance to malaria, with special reference to oxidant stress.

  1983cited by this paper
• Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes

  1983cited by this paper
• Successful immunization with a totally synthetic diphtheria vaccine.

  1982cited by this paper
• Immunity to Asexual Erythrocytic Stages of Plasmodium Falciparum: Role of Defined Antigens in the Humoral Response 1

  1982cited by this paper
• Dexamethasone proves deleterious in cerebral malaria. A double-blind trial in 100 comatose patients.

  1982cited by this paper

• [Research for new antimalarial molecules: an emergency, a hope].

  1994cites this paper
• Quantification of antibody‐secreting lymphocytes that react with Pf155/RESA from Plasmodium falciparum: an ELISPOT assay for field studies

  1993cites this paper
• Testosterone impairs efficacy of protective vaccination against P. chabaudi malaria.

  1993cites this paper
• Bacterial cell surface biological response modifiers and their synthetic counterparts.

  1992cites this paper