A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: the IMPROVED study

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Annals of the Rheumatic Diseases

• Publication date

  2013-05-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/annrheumdis-2013-203243PMID 23716067
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Remission induction therapy with methotrexate and prednisone in patients with early rheumatoid and undifferentiated arthritis (the IMPROVED study)

  2012influential reference
• Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: first results of the tREACH trial

  2012cited by this paper
• The Need to Better Classify and Diagnose Early and Very Early Rheumatoid Arthritis

  2012cited by this paper
• American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials

  2011influential reference
• The window of opportunity in ACPA-positive rheumatoid arthritis is not explained by ACPA characteristics

  2011cited by this paper
• The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study

  2011influential reference
• 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.

  2010cited by this paper
• Rheumatoid arthritis classifi cation criteria : an American College of Rheumatology / European League Against Rheumatism collaborative initiative

  2010cited by this paper
• Meta‐analysis of the Efficacy and Safety of Adalimumab, Etanercept, and Infliximab for the Treatment of Rheumatoid Arthritis

  2010cited by this paper
• Patients with Moderate Rheumatoid Arthritis (RA) Achieve Better Disease Activity States with Etanercept Treatment Than Patients with Severe RA

  2009cited by this paper
• Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial.

  2008cited by this paper
• Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis

  2008cited by this paper
• Comparison of Treatment Strategies in Early Rheumatoid Arthritis: A Randomized Trial

  2008influential reference
• Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial.

  2007influential reference
• Sustained remission and reduced radiographic progression with combination disease modifying antirheumatic drugs in early rheumatoid arthritis.

  2007cited by this paper
• Comparison of Treatment Strategies in Early Rheumatoid Arthritis

  2007cited by this paper
• Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.

  2006cited by this paper
• The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment.

  2006cited by this paper
• Adalimumab for treating rheumatoid arthritis.

  2005cited by this paper
• Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial.

  2005cited by this paper
• Adalimumab for treating rheumatoid arthritis.

  2005cited by this paper
• Undifferentiated arthritis--disease course assessed in several inception cohorts.

  2004cited by this paper
• Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial.

  2004influential reference
• The relationship between disease activity and radiologic progression in patients with rheumatoid arthritis: a longitudinal analysis.

  2004influential reference
• Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial.

  2004cited by this paper
• The relationship between disease activity, joint destruction, and functional capacity over the course of rheumatoid arthritis.

  2001influential reference
• Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

  2000influential reference
• How to read radiographs according to the Sharp/van der Heijde method.

  2000cited by this paper
• Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN-RACo trial group.

  1999cited by this paper
• How to read radiographs according to the Sharp/van der Heijde method.

  1999cited by this paper
• Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis.

  1997influential reference
• Remission in a prospective study of patients with rheumatoid arthritis. American Rheumatism Association preliminary remission criteria in relation to the disease activity score.

  1996influential reference
• Measurement of disability in Dutch rheumatoid arthritis patients

  1984influential reference
• Intraclass correlations: uses in assessing rater reliability.

  1979influential reference

• Structural and Functional Outcomes in Rheumatoid Arthritis After 10-Year Therapy with Disease-Modifying Antirheumatic Drugs Under Tight Control: Evidence from Real-World Cohort Data

  2025cites this paper
• Do MRI-detected erosions in the RA-risk phase of arthralgia reflect current or imminent radiographic erosions? A large longitudinal imaging study

  2025cites this paper
• Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets

  2025cites this paper
• Management of Late-Onset Rheumatoid Arthritis with Treat-to-Target Strategy

  2025cites this paper
• Can Pharmacological Conditioning as an Add-On Treatment Optimize Standard Pharmacological Treatment in Patients with Recent-Onset Rheumatoid Arthritis? A Proof-of-Principle Randomized Clinical Trial

  2024influential citation
• Routine radiographs of hands and feet do not have diagnostic or prognostic value in patients with clinically suspect arthralgia: a large longitudinal study

  2024cites this paper
• Management strategies in rheumatoid arthritis

  2024cites this paper
• Effectiveness of methotrexate and bridging glucocorticoids with or without early introduction of a 6-month course of etanercept in early RA: results of the 2-year, pragmatic, randomised CareRA2020 trial

  2024cites this paper
• Low-Dose Glucocorticoids in Older Patients with Rheumatoid Arthritis: What Does the Evidence Say?

  2024cites this paper
• Actualización del Documento de Consenso de la Sociedad Española de Reumatología sobre el uso de terapias biológicas y sintéticas dirigidas en la artritis reumatoide

  2024cites this paper
• Update of the Consensus Statement of the Spanish Society of Rheumatology on the use of biological and synthetic targeted therapies in rheumatoid arthritis.

  2024cites this paper
• Outcomes of undifferentiated peripheral inflammatory arthritis in real-world practice. A longitudinal cohort study

  2023influential citation
• Anti-inflammatory Effect of Gambier Catechin (Uncaria gambir Roxb) on Rheumatoid Arthritis: A Review

  2023cites this paper
• Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial

  2023cites this paper
• Systematic literature review of observational cohorts and clinical trials into the success rate of glucocorticoid discontinuation after their use as bridging therapy in patients with rheumatoid arthritis

  2022cites this paper
• Methotrexate in early rheumatoid arthritis: Is the anchor drug still holding?

  2022cites this paper
• IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross‐Sectional Study Encompassing ~1,500 Samples

  2022cites this paper
• Individual patient data meta-analysis on continued use of glucocorticoids after their initiation as bridging therapy in patients with rheumatoid arthritis

  2022cites this paper
• Glucocorticoids in rheumatoid arthritis: balancing benefits and harm by leveraging the therapeutic window of opportunity.

  2022cites this paper
• Patient-individual tapering of DMARDs in rheumatoid arthritis patients in a real-world setting.

  2022cites this paper
• Gut Microbiota Structure and Metabolites, Before and After Treatment in Early Rheumatoid Arthritis Patients: A Pilot Study

  2022cites this paper
• Controversies in rheumatology: Maintenance therapy with low-dose glucocorticoids in rheumatoid arthritis.

  2022cites this paper
• Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial

  2022cites this paper
• Intensive therapy for moderate established rheumatoid arthritis: the TITRATE research programme

  2021cites this paper
• ACPA-IgG variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter; a cross-sectional study encompassing over 1500 samples

  2021cites this paper
• Tapering of disease-modifying antirheumatic drugs: an overview for daily practice.

  2021cites this paper
• Effect of initiating biologics compared to intensifying conventional DMARDs on clinical and MRI outcomes in established rheumatoid arthritis patients in clinical remission: Secondary analyses of the IMAGINE-RA trial

  2021cites this paper
• Glucocorticoid discontinuation in patients with early rheumatoid and undifferentiated arthritis: a post-hoc analysis of the BeSt and IMPROVED studies

  2021cites this paper
• Characterization of patients with undifferentiated arthritis and evolution to other inflammatory diseases in a Colombian northwestern cohort: An observational study

  2021cites this paper
• Decreased numbers and sex-based differences of circulating regulatory T cells in patients with seropositive undifferentiated arthritis

  2021cites this paper
• Sustained Remission in Patients With Rheumatoid Arthritis Receiving Triple Therapy Compared to Biologic Therapy: A Swedish Nationwide Register Study

  2021cites this paper
• Association of Anti–Tumor Necrosis Factor Therapy With Mortality Among Veterans With Inflammatory Bowel Disease

  2021cites this paper
• Expert recommendations on the interleukin 6 blockade in patients with rheumatoid arthritis

  2020cites this paper
• Pharmacological conditioning in the treatment of recent-onset rheumatoid arthritis: a randomized controlled trial study protocol

  2020cites this paper
• Expert Recommendations on the Interleukin 6 Blockade in Patients with Rheumatoid Arthritis.

  2020cites this paper
• Towards stratified treatment of rheumatoid arthritis

  2020cites this paper
• Arthritis flare after stopping TNF inhibitor in RA: frequency, predictability and radiography

  2020cites this paper
• On Research Progress of Western and Chinese Medicine Treatment on Pre-Rheumatoid Arthritis

  2019cites this paper
• Does Triple Conventional Synthetic Disease-Modifying Antirheumatic Drug Therapy Improve upon Methotrexate as the Initial Treatment of Choice for a Rheumatoid Arthritis Patient?

  2019cites this paper
• Validation of a clinical pharmacogenetic model to predict methotrexate nonresponse in rheumatoid arthritis patients.

  2019cites this paper
• Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis: A European retrospective multicohort analysis.

  2019cites this paper
• Glucocorticoids for rheumatoid arthritis in the era of targeted therapies.

  2019cites this paper
• Assessing prognosis and prediction of treatment response in early rheumatoid arthritis: systematic reviews.

  2018cites this paper
• Efficacité de la triple association de méthotrexate, sulfasalazine et hydroxychloroquine dans le traitement précoce de la polyarthrite rhumatoïde lorsque la réponse au méthotrexate est insuffisante : méta-analyse d’essais comparatifs randomisés

  2018cites this paper
• Recent Therapeutics Policies of Arthritis Rheumatoid (part I)

  2018cites this paper
• Abatacept and tocilizumab tapering in rheumatoid arthritis patients: results of SONATA—a retrospective, exploratory cohort study

  2018cites this paper
• Rheumatoid arthritis: Moving towards IMPROVED drug-free remission

  2018cites this paper
• RHEUMATOID ARTHRITIS: THE PROBLEMS OF REMISSION AND THERAPY RESISTANCE

  2018cites this paper
• Comparison between low disease activity or DAS remission as treatment target in patients with early active rheumatoid arthritis

  2018cites this paper
• Ability of disease-modifying antirheumatic drugs to prevent or delay rheumatoid arthritis onset: a systematic literature review and meta-analysis

  2018cites this paper
• Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines

  2018cites this paper
• Intensive therapy and remissions in rheumatoid arthritis: a systematic review

  2018cites this paper
• S2e-Leitlinie: Therapie der rheumatoiden Arthritis mit krankheitsmodifizierenden Medikamenten

  2018cites this paper
• Neue Optionen für die Praxis

  2017cites this paper
• Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients with Rheumatoid Arthritis and Inadequate Response to MTX: A Systematic Literature Review

  2017cites this paper
• Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis.

  2017cites this paper
• Adaptation of the 2015 American College of Rheumatology treatment guideline for rheumatoid arthritis for the Eastern Mediterranean Region: an exemplar of the GRADE Adolopment

  2017cites this paper
• Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update.

  2017cites this paper
• Clinical and radiological outcomes of 5-year drug-free remission-steered treatment in patients with early arthritis: IMPROVED study

  2017cites this paper
• Correction to: Adaptation of the 2015 American College of Rheumatology treatment guideline for rheumatoid arthritis for the Eastern Mediterranean Region: an exemplar of the GRADE Adolopment

  2017cites this paper
• Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis.

  2017cites this paper
• Efficacy of triple association methotrexate, sulfasalazine and hydroxychloroquine in early treatment of rheumatoid arthritis with insufficient response to methotrexate: Meta-analysis of randomized controlled trials.

  2017cites this paper
• Remission-induction therapies for early rheumatoid arthritis: evidence to date and clinical implications

  2016cites this paper
• Evaluating Adherence to a Treat‐to‐Target Protocol in Recent‐Onset Rheumatoid Arthritis: Reasons for Compliance and Hesitation

  2016cites this paper
• Predictive factors of radiological progression after 2 years of remission-steered treatment in early arthritis patients: a post hoc analysis of the IMPROVED study

  2016cites this paper
• Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)

  2016cites this paper
• Two-year results of disease activity score (DAS)-remission-steered treatment strategies aiming at drug-free remission in early arthritis patients (the IMPROVED-study)

  2016influential citation
• Long-Term Outcomes of Patients With Recent-Onset Rheumatoid Arthritis After 10 Years of Tight Controlled Treatment

  2016cites this paper
• Seminar: Rheumatoid Arthritis

  2016cites this paper
• Initial combination therapy versus step-up therapy in treatment to the target of remission in daily clinical practice in early rheumatoid arthritis patients: results from the DREAM registry

  2016cites this paper
• Rheumatologists’ adherence to a disease activity score steered treatment protocol in early arthritis patients is less if the target is remission

  2016cites this paper
• Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis.

  2016cites this paper
• Combination therapy with biologic agents in rheumatic diseases: current and future prospects

  2016cites this paper
• Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA).

  2016cites this paper
• Efficacité de la triple association Méthotrexate Sulfasalazine et Hydroxychloroquine dans la polyarthrite récente ayant une réponse insuffisante au Méthotrexate : méta-analyse d'essais contrôlés randomisés

  2015cites this paper
• Turkish Compliance and Adaptation of EULAR 2013 Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-Modifying Antirheumatic Drugs: Expert Opinion of TLAR

  2015cites this paper
• Diagnosis and management of early inflammatory arthritis

  2015cites this paper
• An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting

  2015cites this paper
• Combination Therapy With and Without Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis: A Meta‐Analysis of Randomized Trials

  2015cites this paper
• How does established rheumatoid arthritis develop, and are there possibilities for prevention?

  2015cites this paper
• Clinical and radiographic outcome of a treat-to-target strategy using methotrexate and intra-articular glucocorticoids with or without adalimumab induction: a 2-year investigator-initiated, double-blinded, randomised, controlled trial (OPERA)

  2015cites this paper
• Medikamentenfreie Remission ist keine Utopie

  2015cites this paper
• Rational Usage of Disease Modifying Anti-Rheumatic Drugs with the Guidance of EULAR and ACR Suggestions

  2015cites this paper
• Flare Rate in Patients with Rheumatoid Arthritis in Low Disease Activity or Remission When Tapering or Stopping Synthetic or Biologic DMARD: A Systematic Review

  2015cites this paper
• The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients

  2015cites this paper
• The optimal combination therapy for the treatment of early rheumatoid arthritis

  2015cites this paper
• Determinants of reaching drug-free remission in patients with early rheumatoid or undifferentiated arthritis after one year of remission-steered treatment.

  2015cites this paper
• Evaluation of the Disease Activity Score in Twenty‐Eight Joints–Based Flare Definitions in Rheumatoid Arthritis: Data From a Three‐Year Clinical Trial

  2015cites this paper
• Effectiveness, tolerability, and safety of subcutaneous methotrexate in early rheumatoid arthritis: A retrospective analysis of real-world data from the St. Gallen cohort.

  2015cites this paper
• 2014 update of the Consensus Statement of the Spanish Society of Rheumatology on the use of biological therapies in rheumatoid arthritis.

  2015cites this paper
• New Applications for Traditional Drugs in Inflammatory Bowel Disease: What Do Cochrane Reviews Tell Us?

  2015cites this paper
• 2014 update of the Consensus Statement of the Spanish Society of Rheumatology on the use of biological therapies in rheumatoid arthritis.

  2015cites this paper
• Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force

  2015cites this paper
• Outcomes related to methotrexate dose and route of administration in patients with rheumatoid arthritis: a systematic literature review.

  2015cites this paper
• Induction Therapy with Combination TNF Inhibitor and Methotrexate in Early Rheumatoid Arthritis

  2014cites this paper
• Improving disease outcomes in early phases of rheumatoid arthritis

  2014cites this paper
• Personalized medicine in rheumatoid arthritis: Pharmacogenetics of anti-TNF and beyond.

  2014cites this paper
• The current relevance and use of prednisone in rheumatoid arthritis

  2014cites this paper
• Actualización en el tratamiento de la artritis reumatoide

  2014cites this paper
• Can we prevent rapid radiological progression in patients with early rheumatoid arthritis?

  2014cites this paper