WWOX, large common fragile site genes, and cancer

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Experimental biology and medicine

• Publication date

  2015-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/1535370214565992PMID 25595185PMCID PMC4935220
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• WW domain-containing oxidoreductase’s role in myriad cancers: Clinical significance and future implications

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• Molecular alterations of the WWOX gene in nasopharyngeal carcinoma.

  2014cited by this paper
• A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas

  2014cited by this paper
• The WWOX Gene Modulates High-Density Lipoprotein and Lipid Metabolism

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• PARK2 orchestrates cyclins to avoid cancer

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• WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response

  2014cited by this paper
• Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

  2013cited by this paper
• WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer Cells

  2013cited by this paper
• Genome-wide DNA profiling of HIV-related B-cell lymphomas.

  2013cited by this paper
• Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss‐induced global genome instability

  2013cited by this paper
• Characterization of WWOX inactivation in murine mammary gland development

  2013cited by this paper
• Expression of fragile histidine triad (FHIT) and WW-domain oxidoreductase gene (WWOX) in nasopharyngeal carcinoma.

  2013cited by this paper
• LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin.

  2012cited by this paper
• Genetic alterations of the WWOX gene in breast cancer

  2012cited by this paper
• Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma.

  2012cited by this paper
• Molecular and Cellular Pathobiology LRP 1 B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

  2012cited by this paper
• Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

  2012cited by this paper
• Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma

  2012cited by this paper
• WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway.

  2012cited by this paper
• Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality.

  2012cited by this paper
• The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype

  2011cited by this paper
• Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.

  2011cited by this paper
• Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

  2011cited by this paper
• Functional and Clinical Characterization of the Putative Tumor Suppressor WWOX in Non-small Cell Lung Cancer

  2011cited by this paper
• The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.

  2010cited by this paper
• Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

  2010cited by this paper
• Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma.

  2010cited by this paper
• PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

  2010cited by this paper
• Genome wide DNA‐profiling of HIV‐related B‐cell lymphomas

  2010cited by this paper
• Reversing effect of exogenous WWOX gene expression on malignant phenotype of primary cultured lung carcinoma cells.

  2010cited by this paper
• Neurobeachin (NBEA) is a target of recurrent interstitial deletions at 13q13 in patients with MGUS and multiple myeloma.

  2009cited by this paper
• WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.

  2009cited by this paper
• Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.

  2009cited by this paper
• Coordinate Loss of Fragile Gene Expression in Pancreatobiliary Cancers: Correlations Among Markers and Clinical Features

  2009cited by this paper
• WWOX: Its genomics, partners, and functions

  2009cited by this paper
• MPP+‐induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain‐containing oxidoreductase WOX1

  2008cited by this paper
• The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism*

  2008cited by this paper
• Expression of Yes-associated protein in common solid tumors.

  2008cited by this paper
• The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.

  2008cited by this paper
• Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping array.

  2008cited by this paper
• Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma.

  2007cited by this paper
• WWOX hypomorphic mice display a higher incidence of B‐cell lymphomas and develop testicular atrophy

  2007cited by this paper
• Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.

  2007cited by this paper
• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

  2007cited by this paper
• Targeted deletion of Wwox reveals a tumor suppressor function

  2007cited by this paper
• Association of Wwox with ErbB4 in breast cancer.

  2007cited by this paper
• Non-random inactivation of large common fragile site genes in different cancers

  2007cited by this paper
• Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer

  2007cited by this paper
• DMD and IL1RAPL1: two large adjacent genes localized within a common fragile site (FRAXC) have reduced expression in cultured brain tumors

  2007cited by this paper
• Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.

  2006cited by this paper
• Physical association with WWOX suppresses c-Jun transcriptional activity.

  2006cited by this paper
• Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer

  2006cited by this paper
• Common fragile sites, extremely large genes, neural development and cancer.

  2006cited by this paper
• RORA, a large common fragile site gene, is involved in cellular stress response

  2006cited by this paper
• WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis.

  2006cited by this paper
• The neurobeachin gene spans the common fragile site FRA13A

  2005cited by this paper
• Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR

  2005cited by this paper
• The Fragile Histidine Triad Gene: A Molecular Link Between Cigarette Smoking and Cervical Cancer

  2005cited by this paper
• Loss of WWOX Expression in Gastric Carcinoma

  2004cited by this paper
• The most common fragile site in man is 3p14

  2004cited by this paper
• Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma

  2004cited by this paper
• Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

  2004cited by this paper
• Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.

  2004cited by this paper
• DNA Methylation , Cancer Susceptibility , and Nutrient Interactions

  2004cited by this paper
• DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

  2004cited by this paper
• Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status

  2004cited by this paper
• Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma

  2004cited by this paper
• The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis

  2004cited by this paper
• Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.

  2003cited by this paper
• Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer

  2003cited by this paper
• Alterations in the common fragile site gene Parkin in ovarian and other cancers

  2003cited by this paper
• WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.

  2003cited by this paper
• An opposing view on WWOX protein function as a tumor suppressor.

  2003cited by this paper
• WWOX, the common chromosomal fragile site, FRA16D, cancer gene

  2003cited by this paper
• Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma.

  2002cited by this paper
• Direct correlation between FRA3B expression and cigarette smoking

  2002cited by this paper
• Evidence that instability within the FRA3B region extends four megabases

  2002cited by this paper
• The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1

  2002influential reference
• Involvement of the mt1 melatonin receptor in human breast cancer.

  2002cited by this paper
• Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors

  2002cited by this paper
• Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.

  2001cited by this paper
• Transcriptional repression of ROR activity in human breast cancer cells by melatonin

  2001cited by this paper
• Chromosome translocations in multiple myeloma

  2001cited by this paper
• FHIT gene therapy prevents tumor development in Fhit-deficient mice

  2001cited by this paper
• Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.

  2001cited by this paper
• The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations.

  2000cited by this paper
• WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.

  2000influential reference
• Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.

  2000cited by this paper
• M6P/IGF2R is mutated in squamous cell carcinoma of the lung

  2000cited by this paper
• A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D.

  2000cited by this paper
• Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high‐risk HPV infection but is independent of histopathological features

  2000cited by this paper
• Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity*

  2000cited by this paper
• A novel region of deletion on chromosome 6q23.3 spanning less than 500 Kb in high grade invasive epithelial ovarian cancer

  1999cited by this paper
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  1998influential reference
• The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene

  1998cited by this paper
• Loss of FHIT expression in cervical carcinoma cell lines and primary tumors.

  1997cited by this paper
• FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.

  1997cited by this paper
• Deletion of the short arm of chromosome 3 in breast tumors

  1997cited by this paper
• Association between cigarette smoking and FHIT gene alterations in lung cancer.

  1997cited by this paper

• Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

  2025cites this paper
• WWOX Modulates ROS-Dependent Senescence in Bladder Cancer

  2022cites this paper
• Novel Mutation With Literature Review WW Domain-Containing Oxidoreductase (WWOX) Gene

  2022cites this paper
• Genome Instability in Multiple Myeloma: Facts and Factors

  2021cites this paper
• Robust somatic copy number estimation using coarse-to-fine segmentation

  2021cites this paper
• Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination.

  2021cites this paper
• The impact of transcription-mediated replication stress on genome instability and human disease

  2020cites this paper
• 3D genome organization contributes to genome instability at fragile sites

  2020cites this paper
• Immunology of EBV-Related Lymphoproliferative Disease in HIV-Positive Individuals

  2020cites this paper
• Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer

  2019cites this paper
• Replication Timing and Transcription Identifies a Novel Fragility Signature Under Replication Stress

  2019cites this paper
• Immunohistochemical WWOX Expression and Association with Angiogenesis, p53 Expression, Cell Proliferation and Clinicopathological Parameters in Cervical Cancer

  2018cites this paper
• Exogenous WWOX enhances apoptosis and weakens metastasis in CNE2 nasopharyngeal carcinoma cells through the intrinsic apoptotic pathway.

  2017cites this paper
• HumCFS: a database of fragile sites in human chromosomes

  2017cites this paper
• Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair

  2017cites this paper
• Fragile sites in cancer: more than meets the eye

  2017cites this paper
• Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival

  2017cites this paper
• Genetic association study identifies a functional CNV in the WWOX gene contributes to the risk of intracranial aneurysms

  2016cites this paper
• WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis

  2015cites this paper