ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background

No abstract is available for this paper.

• Publication year

  2004

• Venue

  EMBO Journal

• Publication date

  2004-08-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.emboj.7600315PMID 15282542PMCID PMC514932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress*

  2004cited by this paper
• Recruitment of the Cell Cycle Checkpoint Kinase ATR to Chromatin during S-phase*

  2004cited by this paper
• MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

  2003influential reference
• Chk1 and Chk2 kinases in checkpoint control and cancer.

  2003cited by this paper
• The mismatch repair system is required for S-phase checkpoint activation

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• Genomic instability and endoreduplication triggered by RAD17 deletion.

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• A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

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• ATM and related protein kinases: safeguarding genome integrity

  2003cited by this paper
• Methylation‐induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

  2003cited by this paper
• Role of DNA mismatch repair defects in the pathogenesis of human cancer.

  2003influential reference
• Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.

  2003influential reference
• Fragile sites: breaking up over a slowdown.

  2003influential reference
• A unified view of the DNA-damage checkpoint.

  2002cited by this paper
• Exploring and Exploiting Instability

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• Pleiotropic defects in TCR signaling in a Vav‐1‐null Jurkat T‐cell line

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• Modeling of genetic instability--looking for "Newton's binomial" of colon cancer.

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• Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability.

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• ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

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• Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.

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• Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress*

  2001cited by this paper
• Cell cycle checkpoint signaling through the ATM and ATR kinases.

  2001influential reference
• DNA mismatch repair and genetic instability.

  2000influential reference
• Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.

  2000cited by this paper
• Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting.

  2000cited by this paper
• ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

  2000influential reference
• Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

  1999influential reference
• Genetic instability and darwinian selection in tumours.

  1999cited by this paper
• Genetic instabilities in human cancers

  1998cited by this paper
• Mutations of mitotic checkpoint genes in human cancers

  1998cited by this paper
• Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair

  1998cited by this paper
• Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

  1998cited by this paper
• Requirement for p53 and p21 to sustain G2 arrest after DNA damage.

  1998cited by this paper
• Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts.

  1997cited by this paper
• Cell Cycle Checkpoints: Preventing an Identity Crisis

  1996cited by this paper
• Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

  1996influential reference
• Transcription-Coupled Repair Deficiency and Mutations in Human Mismatch Repair Genes

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  1995cited by this paper
• p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

  1995influential reference
• Mutation of a mutL homolog in hereditary colon cancer.

  1994cited by this paper
• Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

  1994cited by this paper
• Analysis of Sister‐Chromatid Exchanges

  1994cited by this paper
• Induction of gene amplification by 5-aza-2'-deoxycytidine.

  1992cited by this paper
• Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells.

  1992cited by this paper
• Sister chromatid exchange analysis.

  1980cited by this paper
• Radiosensitivity in ataxia-telangiectasia: a new explanation.

  1980cited by this paper

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• Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan

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• Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis

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• A microglia clonal inflammatory disorder in Alzheimer’s Disease

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• An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress

  2023cites this paper
• Could Inhibiting the DNA Damage Repair Checkpoint Rescue Immune-Checkpoint-Inhibitor-Resistant Endometrial Cancer?

  2023cites this paper
• Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy

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• ATR-I774Yfs*5 promotes genomic instability through micronuclei formation

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• Der Rolle der DNA-Schadensantwort bei granulomatösen Erkrankungen

  2022cites this paper
• DNA repair defects in cancer and therapeutic opportunities

  2022cites this paper
• LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin

  2022cites this paper
• RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability

  2020cites this paper
• Somatic genetic aberrations in benign breast disease and the risk of subsequent breast cancer

  2020cites this paper
• Somatic genetic aberrations in benign breast disease and the risk of subsequent breast cancer

  2019cites this paper
• Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

  2019cites this paper
• ATM, DNA-PKcs and ATR: shaping development through the regulation of the DNA damage responses

  2019cites this paper
• Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

  2018cites this paper
• DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications.

  2018cites this paper
• Targeting ATR in cancer

  2018cites this paper
• Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates

  2018cites this paper
• Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure.

  2018cites this paper
• Metabolic dysfunction and impairments in the DNA Damage Response: dissecting a pathomechanistic link betweenMicrocephalic Primordial Dwarfisms and cancer cachexia

  2017cites this paper
• Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin

  2017cites this paper
• Cellular responses to replication stress: Implications in cancer biology and therapy.

  2017cites this paper
• Insulin-like Growth Factor 1 Receptor Signaling Is Required for Optimal ATR-CHK1 Kinase Signaling in Ultraviolet B (UVB)-irradiated Human Keratinocytes*

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• DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

  2016cites this paper
• Signaling of DNA Replication Stress Through the ATR Checkpoint

  2016cites this paper
• Replication stress and cancer

  2015cites this paper
• ATR suppresses apoptosis after UVB irradiation by controlling both translesion synthesis and alternative tolerance pathways

  2015cites this paper
• Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy

  2015cites this paper
• Cancer therapy and replication stress: forks on the road to perdition.

  2015cites this paper
• DNA Damage Response Genes and the Development of Cancer Metastasis

  2014cites this paper
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  2014cites this paper
• A Majority of Human Melanoma Cell Lines Exhibits an S Phase-Specific Defect in Excision of UV-Induced DNA Photoproducts

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  2014cites this paper
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  2014cites this paper
• Role of DNA Repair in Carcinogenesis and Cancer Therapeutics

  2014cites this paper
• Targeting Homologous Recombination Repair In Cancer Cells

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• Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors

  2014cites this paper
• Genetic Analysis of Mental Retardation in Pakistan

  2013cites this paper
• Biological Responses to Ultraviolet Radiation and the Effect of Intra-S Checkpoint Inhibition on Ultraviolet Radiation-Induced Mutagenesis

  2013influential citation
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  2013cites this paper
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  2013cites this paper
• Charity begins at home: non-coding RNA functions in DNA repair

  2013cites this paper
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  2013cites this paper
• Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.

  2012cites this paper
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  2012cites this paper
• Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach

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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
• Importance of DNA damage checkpoints in the pathogenesis of human cancers.

  2010cites this paper
• Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.

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  2010influential citation
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  2009cites this paper
• Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response

  2009cites this paper
• Reduced ATR or Chk 1 Expression Leads to Chromosome Instability and Chemosensitization of Mismatch Repair – deficient Colorectal Cancer Cells

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• Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.

  2009cites this paper
• Mechanisms of Common Fragile Site Instability and Cancer.

  2009cites this paper
• ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress*

  2009cites this paper
• Mouse models for ATR deficiency.

  2009cites this paper
• Facilitating replication under stress: an oncogenic function of MYC?

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• MLH1 Deficiency Enhances Tumor Cell Sensitivity to Ganciclovir

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  2007cites this paper
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  2007cites this paper
• Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice.

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  2007cites this paper
• Mutations in the ataxia telangiectasia and rad3‐related–checkpoint kinase 1 DNA damage response axis in colon cancers

  2007cites this paper
• Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling.

  2007cites this paper
• Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation

  2006cites this paper
• BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.

  2006influential citation
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  2006cites this paper
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