Retardation in the slow axonal transport of cytoskeletal elements during maturation and aging.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Neurobiology of Aging

• Publication date

  1989-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0197-4580(89)90049-3PMID 2478905
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Axons grow in the aging rat but fast transport and acetylcholinesterase content remain unchanged.

  1988cited by this paper
• Do axons grow during adulthood? A study of caliber and microtubules of sural nerve axons in young, mature, and aging rats

  1988cited by this paper
• Mechanisms at the axon tip regulate metabolic processes critical to axonal elongation.

  1987cited by this paper
• Axonal transport of cytoskeletal proteins in oculomotor axons and their residence times in the axon terminals

  1987cited by this paper
• Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway.

  1987cited by this paper
• Cytotypic differences in the protein composition of the axonally transported cytoskeleton in mammalian neurons

  1987cited by this paper
• Morphology of freeze-substituted myelinated axon in mouse peripheral nerves.

  1986cited by this paper
• Polymer Sliding in Axons

  1986cited by this paper
• Diversity in the axonal transport of structural proteins: major differences between optic and spinal axons in the rat

  1986cited by this paper
• Experimental diabetic neuropathy: impairment of slow transport with changes in axon cross-sectional area.

  1985cited by this paper
• Axonal transport of the cytoplasmic matrix

  1984cited by this paper
• Control of axonal caliber by neurofilament transport

  1984cited by this paper
• Neurofilament accumulation induced in synapses by leupeptin.

  1983cited by this paper
• Slowing of the axonal transport of neurofilament proteins during development

  1983cited by this paper
• Molecular biology of neuronal geometry: expression of neurofilament genes influences axonal diameter.

  1983cited by this paper
• Axoplasmic transport in aged rats.

  1982cited by this paper
• Axonal transport: each major rate component reflects the movement of distinct macromolecular complexes.

  1981cited by this paper
• Clathrin is axonally transported as part of slow component b: the microfilament complex

  1981cited by this paper
• Slowing with age of the rate of slow axonal flow in bifurcating axons of rat dorsal root ganglion cells.

  1980cited by this paper
• The composition and organization of axonally transported proteins in the retinal ganglion cells of the guinea pig.

  1980cited by this paper
• Slow components of axonal transport: two cytoskeletal networks

  1980cited by this paper
• Decreased axonal transport of structural proteins in streptozotocin diabetic rats.

  1980cited by this paper
• Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats1

  1977cited by this paper
• The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons

  1975cited by this paper
• Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.

  1975cited by this paper
• A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.

  1974cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age.

  2025cites this paper
• A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans.

  2023cites this paper
• The ultrastructural study of human cochlear nerve at different ages.

  2022cites this paper
• The lifecycle of the neuronal microtubule transport machinery.

  2020cites this paper
• Investigation of the Effect of Age on Regenerative Outcomes Following Treatment of Volumetric Muscle Loss Injuries

  2019cites this paper
• Temporal Control of Axonal Transport: The Extreme Case of Organismal Ageing

  2019cites this paper
• Neurological Aging and Cancer

  2019cites this paper
• The role of Schwann cell c-Jun in restoring axon regeneration deficits in the peripheral nervous system

  2018cites this paper
• The Virtuous Cycle of Axon Growth: Axonal Transport of Growth‐Promoting Machinery as an Intrinsic Determinant of Axon Regeneration

  2018cites this paper
• The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms.

  2017cites this paper
• Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves

  2017cites this paper
• Older but not slower: aging does not alter axonal transport dynamics of signalling endosomes in vivo

  2016cites this paper
• Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons

  2016cites this paper
• Impaired regeneration in aged nerves: Clearing out the old to make way for the new.

  2016cites this paper
• Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease.

  2016cites this paper
• Endurance training induces structural and morphoquantitative changes in rat vagus nerve

  2015cites this paper
• Axonal transport declines with age in two distinct phases separated by a period of relative stability☆

  2015cites this paper
• The Axon: Normal Structure and Pathological Alterations

  2015cites this paper
• V. The Structure of Neurons

  2015cites this paper
• Characterisation of novel mutations within Heat Shock Protein 27 causing motor neuropathies

  2012cites this paper
• Specificity of peripheral nerve regeneration: interactions at the axon level.

  2012cites this paper
• Aging profoundly delays functional recovery from gustatory nerve injury.

  2012cites this paper
• Changing the Intrinsic Growth Capacity of motor and sensory neurons to promote axonal growth after injury

  2012cites this paper
• Age affects reciprocal cellular interactions in neuromuscular synapses following peripheral nerve injury.

  2011cites this paper
• Molecular signaling how do axons die?

  2011cites this paper
• Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle

  2011cites this paper
• Expression and regulation of excitation-contraction coupling proteins in aging skeletal muscle.

  2011cites this paper
• Morphological changes in nerve cells during normal aging

  2011cites this paper
• Myelination and the trophic support of long axons

  2010cites this paper
• Aging impairs collateral sprouting of nociceptive axons in the rat.

  2010cites this paper
• Effect of Aging on Recovery of Cutaneous Nociception After End-to-Side Nerve Repair in the Rat

  2009cites this paper
• Chapter 26: Age-related differences in the reinnervation after peripheral nerve injury.

  2009cites this paper
• In vivo imaging of axonal transport using MRI: aging and Alzheimer’s disease

  2008cites this paper
• Age-related decrease in axonal transport measured by MR imaging in vivo

  2008influential citation
• Organization and slow axonal transport of cytoskeletal proteins under normal and regenerating conditions

  2007cites this paper
• Aging Delays the Regeneration Process following Sciatic Nerve Injury in Rats

  2007cites this paper
• Stimulation de la survie et de la régénération des cellules ganglionnaires de la rétine par inactivation de la GTPase Rho après lésion du nerf optique du rat adulte

  2007cites this paper
• Changes in cytoskeletal protein synthesis following axon injury and during axon regeneration

  2007cites this paper
• Age‐related change in duration of afterhyperpolarization of human motoneurones

  2007cites this paper
• La sous-unité lourde des neurofilaments (NFH): du gène à la pathologie

  2007cites this paper
• Plasticity of Excitation-Contraction Coupling in Skeletal Muscle

  2006cites this paper
• Investigation of the pathogenic agent in a Drosophila model of polyglutamine disease

  2006cites this paper
• Cytoskeletal Transport in the Aging Brain: Focus on the Cholinergic System

  2006cites this paper
• JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport

  2006cites this paper
• Age related optic nerve axonal loss in adult Brown Norway rats.

  2005cites this paper
• Application of Rho Antagonist to Neuronal Cell Bodies Promotes Neurite Growth in Compartmented Cultures and Regeneration of Retinal Ganglion Cell Axons in the Optic Nerve of Adult Rats

  2005cites this paper
• Chapter 22 – Aging in the Peripheral Nervous System

  2005cites this paper
• Age-related ultrastructural changes in hypocretinergic terminals in the brainstem and spinal cord of cats.

  2005cites this paper
• Involvement of clathrin light chains in the pathology of Alzheimer's disease

  2004cites this paper
• Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease

  2004cites this paper
• Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport.

  2003cites this paper
• Neural control of aging skeletal muscle

  2003cites this paper
• Axonal transport of human α‐synuclein slows with aging but is not affected by familial Parkinson's disease‐linked mutations

  2003cites this paper
• Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats.

  2003cites this paper
• ON AGE RELATED CHANGES IN AXONS AND GLIA OF THE CENTRAL NERVOUS SYSTEM

  2002cites this paper
• Abnormal ubiquitination of axons in normally myelinated white matter in multiple sclerosis brain

  2002cites this paper
• Resul ts Low Concentrations of Vinblastine Inhibit Neurite Outgrowth

  2002cites this paper
• Effects of endothelin-1 on components of anterograde axonal transport in optic nerve.

  2002cites this paper
• Age differences in morphological patterns of axonal sprouting and multiple innervation of neuromuscular junctions during muscle reinnervation following nerve crush injury.

  2002cites this paper
• Slow axonal transport: fast motors in the slow lane.

  2002cites this paper
• Neuropathic pain in aged rats: behavioral responses and astrocytic activation

  2001cites this paper
• Neurofilaments of Klotho, the mutant mouse prematurely displaying symptoms resembling human aging

  2001cites this paper
• The spatiotemporal relationship among schwann cells, axons and postsynaptic acetylcholine receptor regions during muscle reinnervation in aged rats

  2001influential citation
• Axonal transport of tubulin and actin

  2000cites this paper
• Unwrapping new layers of complexity in axon/glial relationships

  2000cites this paper
• Age-dependent changes in the midsized neurofilament subunit in sensory-motor systems of the cat brainstem: an immunocytochemical study.

  2000cites this paper
• Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones.

  2000cites this paper
• Influence of aging on peripheral nerve function and regeneration.

  2000cites this paper
• Influence of aging on peripheral nerve function and regeneration

  2000cites this paper
• Transgenic Mice with Neurofilament Abnormalities

  1999cites this paper
• Cytoplasmic dynein and microtubule transport in the axon: The action connection

  1999cites this paper
• Overexpression of α-Internexin Causes Abnormal Neurofilamentous Accumulations and Motor Coordination Deficits in Transgenic Mice

  1999cites this paper
• Morphometry of Axon Cytoskeleton at Internodal Regions of Rat Sciatic Nerve during Aging

  1999cites this paper
• The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms.

  1999cites this paper
• Neurofilament and tubulin gene expression in progressive experimental diabetes: failure of synthesis and export by sensory neurons.

  1999cites this paper
• Acceleration of axonal outgrowth in motor axons from mature and old F344 rats after a conditioning lesion.

  1998cites this paper
• The effect of aging on the morphological nerve changes during muscle reinnervation after nerve crush

  1998cites this paper
• Lumbar motor neuron size and number is affected by age in male F344 rats.

  1998cites this paper
• Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.

  1998cites this paper
• Neurofilaments in health and disease.

  1998cites this paper
• Transgenic Mouse Models with Neurofilament-Induced Pathologies

  1998cites this paper
• Effects of long-term physical exercise on age-related changes of spinal motoneurons and peripheral nerves in rats.

  1998cites this paper
• Neurofilaments and motor neuron disease.

  1997cites this paper
• Age-related alterations in immunoreactivity of the midsized neurofilament subunit in the brainstem reticular formation of the cat.

  1997cites this paper
• Factors determining the development of mammalian sensory neurons and cutaneous innervation in vivo.

  1997cites this paper
• Alterations in tau protein metabolism during normal aging.

  1996cites this paper
• Tubulin transport in neurons

  1996cites this paper
• Neuronal intermediate filaments.

  1996cites this paper
• A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis.

  1995cites this paper
• Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

  1995cites this paper
• Fast axonal transport rates are unchanged in 6- and 24-month F344 rats.

  1995cites this paper
• Axonal atrophy in aging is associated with a decline in neurofilament gene expression

  1995cites this paper
• Development of the Axonal and Dendritic Cytoskeleton

  1995cites this paper
• Early effects of beta,beta'-iminodipropionitrile on tubulin solubility and neurofilament phosphorylation in the axon.

  1994cites this paper
• Age‐related increases in glial fibrillary acidic protein do not show proportionate changes in transcription rates or DNA methylation in the cerebral cortex and hippocampus of male rats

  1994cites this paper
• Expression of neurofilament proteins in the rat cerebellar cortex as a function of age: an immunohistochemical study.

  1994cites this paper
• Involvement of clathrin light chains in the pathology of Pick's disease; implication for impairment of axonal transport.

  1994cites this paper
• Accumulation of amyloid β-protein precursor (APP) in Purkinje cells and increase of amino-terminal fragments of APP in cerebrum and cerebellum of aged rat brain

  1994cites this paper
• Therapeutic targets in Alzheimer's disease: suggestions for the NIA.

  1994cites this paper
• Impairment of cytoskeletal protein transport due to aging or beta,beta'-iminodipropionitrile intoxication in the rat sciatic nerve.

  1994cites this paper