Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Biological Psychiatry

• Publication date

  2017-12-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.biopsych.2017.11.033PMID 29373121PMCID PMC5862785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia.

  2017cited by this paper
• Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice

  2017cited by this paper
• Thalamic amplification of cortical connectivity sustains attentional control

  2017cited by this paper
• Thalamic projections sustain prefrontal activity during working memory maintenance

  2017cited by this paper
• DREADDs for Neuroscientists.

  2016cited by this paper
• Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders.

  2015cited by this paper
• Connectivity of Mouse Somatosensory and Prefrontal Cortex Examined with Trans-synaptic Tracing

  2015cited by this paper
• Thalamic control of sensory selection in divided attention

  2015cited by this paper
• Mediodorsal thalamus hypofunction impairs flexible goal-directed behavior.

  2015cited by this paper
• Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice.

  2015cited by this paper
• Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.

  2015cited by this paper
• Target-Specific Properties of Thalamocortical Synapses onto Layer 4 of Mouse Primary Visual Cortex

  2014cited by this paper
• Prefrontal Cortical GABA Modulation of Spatial Reference and Working Memory

  2014cited by this paper
• Linking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model.

  2014cited by this paper
• Designer Receptors Show Role for Ventral Pallidum Input to Ventral Tegmental Area in Cocaine Seeking

  2014cited by this paper
• Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition.

  2013cited by this paper
• Prefrontal cortical microcircuits bind perception to executive control

  2013cited by this paper
• GABA system dysfunction in autism and related disorders: from synapse to symptoms.

  2012cited by this paper
• Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia.

  2012cited by this paper
• Schizophrenia-Like Attentional Deficits Following Blockade of Prefrontal Cortex GABAA Receptors

  2011cited by this paper
• How inhibition shapes cortical activity.

  2011cited by this paper
• Neocortical excitation/inhibition balance in information processing and social dysfunction

  2011cited by this paper
• Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types

  2009cited by this paper
• Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks

  2008cited by this paper
• Prefrontal cortex and hippocampus subserve different components of working memory in rats.

  2008cited by this paper
• Pre‐synaptic GABAB receptors inhibit glutamate release through GIRK channels in rat cerebral cortex

  2008cited by this paper
• The Magnocellular Mediodorsal Thalamus is Necessary for Memory Acquisition, But Not Retrieval

  2008cited by this paper
• Behavioral phenotypes of Disc1 missense mutations in mice.

  2007cited by this paper
• Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat

  2007cited by this paper
• Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

  2007cited by this paper
• Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex.

  2006cited by this paper
• Indiplon Is a High-Affinity Positive Allosteric Modulator with Selectivity for α1 Subunit-Containing GABAA Receptors

  2006cited by this paper
• Cerebral Cortex doi:10.1093/cercor/bhl073 Thalamic--Prefrontal Cortical--Ventral Striatal Circuitry Mediates Dissociable Components of Strategy Set Shifting

  2006cited by this paper
• Mediodorsal thalamic afferents to layer III of the rat prefrontal cortex: Synaptic relationships to subclasses of interneurons

  2005cited by this paper
• Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice

  2004cited by this paper
• Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and γ‐aminobutyric acidergic cortical cells in the prelimbic cortex of the rat

  2004cited by this paper
• Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.

  2004cited by this paper
• Delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in Japanese macaque monkeys

  2004cited by this paper
• Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex

  2003cited by this paper
• Model of autism: increased ratio of excitation/inhibition in key neural systems

  2003cited by this paper
• Interlaminar connections in the neocortex.

  2003cited by this paper
• Gating of Hippocampal-Evoked Activity in Prefrontal Cortical Neurons by Inputs from the Mediodorsal Thalamus and Ventral Tegmental Area

  2003cited by this paper
• Activation of a Cortical Column by a Thalamocortical Impulse

  2002cited by this paper
• Thalamic relay functions and their role in corticocortical communication: generalizations from the visual system.

  2002cited by this paper
• Destruction and Creation of Spatial Tuning by Disinhibition: GABAA Blockade of Prefrontal Cortical Neurons Engaged by Working Memory

  2000cited by this paper
• Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat

  2000cited by this paper
• Receptor system response kinetics reveal functional subtypes of native murine and recombinant human GABAA receptors

  1999influential reference
• Involvement of the Prelimbic–Infralimbic Areas of the Rodent Prefrontal Cortex in Behavioral Flexibility for Place and Response Learning

  1999cited by this paper
• Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform.

  1997influential reference
• Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and layer III pyramidal cells in the prelimbic cortex of the rat.

  1996cited by this paper
• Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat.

  1996cited by this paper
• Dissociation in prefrontal cortex of affective and attentional shifts

  1996cited by this paper
• G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain

  1996cited by this paper
• GABAA‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits

  1995cited by this paper
• Thalamocortical synapses between axons from the mediodorsal thalamic nucleus and pyramidal cells in the prelimbic cortex of the rat

  1995cited by this paper
• Direct synaptic connections between thalamocortical axon terminals from the mediodorsal thalamic nucleus (MD) and corticothalamic neurons to MD in the prefrontal cortex.

  1993cited by this paper
• Different glutamate receptor channels mediate fast excitatory synaptic currents in inhibitory and excitatory cortical neurons.

  1993cited by this paper
• Mediodorsal thalamic lesions impair "reference" and "working" memory in rats.

  1990cited by this paper

• Mapping the neural basis of selected cognitive functions: A combined functional, structural, and diffusion MRI study.

  2026cites this paper
• Chemogenetic Restoration of the “Excitation‐Inhibition” Imbalance in the Medial Prefrontal Cortex Ameliorates Schizophrenia‐Like Sensory Gating Deficits

  2026cites this paper
• Transient Inhibition of the Mediodorsal Thalamus During Early Adolescence Induces Hypofrontality and Social Memory Deficits in Young Adulthood

  2025cites this paper
• SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection

  2025cites this paper
• Parvalbumin neurons mediate neurological phenotypes of anti-NMDAR encephalitis

  2025cites this paper
• Modulating excitation of the mediodorsal thalamus rescues dysfunction after administration of MK-801 in rats.

  2025cites this paper
• Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility

  2025cites this paper
• An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology

  2025cites this paper
• Disrupted Development of the mPFC-Thalamic Circuit in Shank3-/- mice, an autism-associated model.

  2025cites this paper
• Differential Implications of the mediodorsal thalamic nucleus subdivisions in regulating prefrontal cortex GAD67 and GABAB receptors expression: behavioral and cognitive outcomes.

  2025cites this paper
• Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus

  2025influential citation
• The Psychopathological Domains of Attachment Trauma: A Proposal for a Clinical Conceptualization

  2025cites this paper
• Kmt2c/Mll3 Haploinsufficiency Causes Autism-like Behavioral Deficits in Mice

  2025cites this paper
• Prefrontal inhibitory mechanisms associated with Putamen activity during valence learning revealed by multimodal fMRI-fMRS

  2025cites this paper
• The impact of response latency on working memory assessment in mice.

  2025cites this paper
• HCN channel currents underlie distinct neurophysiology of mediodorsal thalamus subnuclei

  2025cites this paper
• Noradrenergic Modulation of an Amygdalo-thalamic Circuit

  2025cites this paper
• Mechanical Properties of the Developing Brain in a Model of Fetal Alcohol Spectrum Disorders and Relationships to Perineuronal Net Integrity

  2025cites this paper
• Thalamic hyperperfusion in early schizophrenia: Associations with cognitive deficits and negative symptoms.

  2025cites this paper
• Prefrontal cortex astrocytes modulate distinct neuronal populations to control anxiety-like behavior

  2025cites this paper
• Gα13 Overexpression in the Medial Prefrontal Cortex Disrupts Social Behavior Through the Adcyap1/cAMP/PKA/NMDAR Pathway.

  2025cites this paper
• Molecular and neural control of social hierarchy by forebrain-thalamocortical circuit

  2025cites this paper
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis

  2025cites this paper
• nNOS-expressing neurons in the mPFC mediate depression-related behaviors in mice through pPVT-mPFC projections

  2025cites this paper
• Cerebello-Thalamo-Cortical Dysconnectivity in Schizophrenia Spectrum Disorders: A Resting-State fMRI Meta-Analysis.

  2025cites this paper
• Measurement of Excitation-Inhibition Imbalance in Autism spectrum Disorder Using EEG Proxy Markers: A Pilot Study

  2025cites this paper
• The “psychiatric” neuron: the psychic neuron of the cerebral cortex, revisited

  2024cites this paper
• Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex

  2024cites this paper
• Parvalbumin interneuron deficiency in the prefrontal and motor cortices of spontaneously hypertensive rats: an attention-deficit hyperactivity disorder animal model insight

  2024cites this paper
• Two contrasting mediodorsal thalamic circuits target the mouse medial prefrontal cortex

  2024cites this paper
• Effects of fluorene-9-bisphenol exposure on anxiety-like and social behavior in mice and protective potential of exogenous melatonin

  2024cites this paper
• Influence of GABAA and GABAB receptor activation on auditory sensory gating and its association with anxiety in healthy volunteers

  2024cites this paper
• Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder.

  2024cites this paper
• Novel pharmacological targets for GABAergic dysfunction in ADHD.

  2024cites this paper
• Interneuron-Selective HCN Channel Knockdown in Prelimbic Cortex of Female Rats Mimics Effects of Chronic Ethanol Exposure.

  2024cites this paper
• Inhibitory mechanisms in the prefrontal-cortex differentially mediate Putamen activity during valence-based learning

  2024cites this paper
• Adolescent Thalamoprefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity

  2024cites this paper
• Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study

  2024cites this paper
• Discovering functional interactions among schizophrenia-risk genes by combining behavioral genetics with cell biology.

  2024cites this paper
• GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders

  2024cites this paper
• Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice

  2024cites this paper
• Subregion‐specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders

  2024cites this paper
• Astrocyte Activation in the ACC Contributes to Comorbid Anxiety in Chronic Inflammatory Pain and Involves in The Excitation-Inhibition Imbalance

  2024cites this paper
• Prelimbic cortex perineuronal net expression and social behavior: Impact of adolescent intermittent ethanol exposure

  2024cites this paper
• Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus.

  2024cites this paper
• Time-sensitive changes in the maternal brain and their influence on mother-child attachment

  2024cites this paper
• MEF2C Hypofunction in GABAergic Cells Alters Sociability and Prefrontal Cortex Inhibitory Synaptic Transmission in a Sex-Dependent Manner

  2024cites this paper
• Prefrontal regulation of social behavior and related deficits: insights from rodent studies.

  2024cites this paper
• Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors

  2024cites this paper
• Neurometabolic and brain functional alterations associated with cognitive impairment in patients with myasthenia gravis: A combined 1 H-MRS and fMRI study.

  2024cites this paper
• p75 neurotrophin receptor in pre-adolescent prefrontal PV interneurons promotes cognitive flexibility in adult mice

  2023influential citation
• A phylogenetically-conserved axis of thalamocortical connectivity in the human brain

  2023influential citation
• Improvements in gait and balance in patients with multiple sclerosis after treatment with coconut oil and epigallocatechin gallate. A pilot study.

  2023cites this paper
• Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype‐specific signatures, clinical correlates, and practical relevance

  2023cites this paper
• The autism-associated loss of δ-catenin functions disrupts social behaviors

  2023cites this paper
• The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice

  2023cites this paper
• Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure

  2023cites this paper
• Pharmacogenetic activation of parvalbumin interneurons in the prefrontal cortex rescues cognitive deficits induced by adolescent MK801 administration

  2023influential citation
• The effects of serotonergic psychedelics in synaptic and intrinsic properties of neurons in layer II/III of the orbitofrontal cortex

  2023cites this paper
• Cortical dopamine D5 receptors regulate neuronal circuit oscillatory activity and memory in rats

  2023cites this paper
• Connecting Neurobiological Features with Interregional Dysconnectivity in Social-Cognitive Impairments of Schizophrenia

  2023cites this paper
• Dorsal peduncular cortex activity modulates 1 affective behaviors in mice 2

  2023cites this paper
• Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice

  2023cites this paper
• The autism-associated loss of δ-catenin functions disrupts social behavior

  2023cites this paper
• Trait and state-related characteristics of thalamo-cortical circuit disruption in bipolar disorder: a prospective cross-sectional study

  2023cites this paper
• Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

  2023cites this paper
• The role of medial prefrontal cortex in cognition, aging and Parkinson disease

  2023cites this paper
• Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure.

  2023cites this paper
• Accelerated social representational drift in the nucleus accumbens in a model of autism

  2023cites this paper
• Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons

  2023cites this paper
• Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity

  2023cites this paper
• Decreased grey matter volume in dorsolateral prefrontal cortex and thalamus accompanied by compensatory increases in middle cingulate gyrus of premature ejaculation patients

  2023cites this paper
• Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice

  2023cites this paper
• Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review.

  2023cites this paper
• The Impact of Maternal Immune Activation on GABAergic Interneuron Development: A Systematic Review of Rodent Studies and their Translational Implications.

  2023cites this paper
• Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia

  2023cites this paper
• mGlu1-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice

  2022cites this paper
• VIP-expressing interneurons in the anterior insular cortex contribute to sensory processing to regulate adaptive behavior.

  2022cites this paper
• Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action

  2022cites this paper
• Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

  2022cites this paper
• The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia

  2022cites this paper
• Chronic methamphetamine administration produces cognitive deficits through augmentation of GABAergic synaptic transmission in the prefrontal cortex

  2022cites this paper
• Early Life Stress Induces Different Behaviors in Adolescence and Adulthood May Related With Abnormal Medial Prefrontal Cortex Excitation/Inhibition Balance

  2022cites this paper
• Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder

  2022cites this paper
• Nests of dividing neuroblasts sustain interneuron production for the developing human brain

  2022cites this paper
• Prefrontal Cortical Control of Anxiety: Recent Advances

  2022influential citation
• Mediodorsal Thalamus Is Critical for Updating during Extradimensional Shifts But Not Reversals in the Attentional Set-Shifting Task

  2022influential citation
• Repeated methamphetamine administration produces cognitive deficits through augmentation of GABAergic synaptic transmission in the prefrontal cortex

  2022cites this paper
• Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia.

  2022cites this paper
• Brain-wide electrical dynamics encode individual appetitive social behavior.

  2022cites this paper
• Prefrontal PV interneurons facilitate attention and are linked to attentional dysfunction in a mouse model of absence epilepsy

  2022cites this paper
• Pathway-specific inhibition of critical projections from the mediodorsal thalamus to the frontal cortex controls kindled seizures.

  2022cites this paper
• Cognitive outcome is related to functional thalamo-cortical connectivity after paediatric stroke

  2022cites this paper
• Thalamocortical interactions in cognition and disease: the mediodorsal and anterior thalamic nuclei.

  2021cites this paper
• Environmental exposure to 17β-trenbolone during adolescence inhibits social interaction in male mice.

  2021cites this paper
• Prefrontal GABAergic Interneurons Gate Long-Range Afferents to Regulate Prefrontal Cortex-Associated Complex Behaviors

  2021cites this paper
• Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure

  2021cites this paper
• Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction

  2021cites this paper
• Optical mini-stroke of thalamic networks impairs sleep stability, topography and cognition

  2021cites this paper
• Enhancement of Oxytocin in the Medial Prefrontal Cortex Reverses Behavioral Deficits Induced by Repeated Ketamine Administration in Mice

  2021cites this paper