Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Psychopharmacology

• Publication date

  2012-06-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1177/0269881111409265PMID 21768159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001influential reference
• Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum.

  2001influential reference
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  1999influential reference
• The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia.

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• The effects of clozapine on cognitive functioning in schizophrenia.

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• Clozapine potently stimulates mesocortical dopamine neurons.

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• Risperidone versus haloperidol on secondary memory: can newer medications aid learning?

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• Correction for partial volume effects in PET: principle and validation.

  1998influential reference
• No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET.

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• Carbon-11-NNC 112: a radioligand for PET examination of striatal and neocortical D1-dopamine receptors.

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• Alterations in the cortical serotonergic system in schizophrenia: a postmortem study.

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• Supranormal Stimulation of D1 Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance

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• Does risperidone improve verbal working memory in treatment-resistant schizophrenia?

  1997influential reference
• Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

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• Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation.

  1997influential reference
• Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs.

  1997influential reference
• Increase of extracellular dopamine in primate prefrontal cortex during a working memory task.

  1997cited by this paper
• Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys.

  1996cited by this paper
• Dopamine and Spatial Working Memory in Rats and Monkeys: Pharmacological Reversal of Stress-Induced Impairment

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• Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

  1994influential reference
• Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI

  1994cited by this paper
• A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex.

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  1994influential reference
• The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task.

  1994cited by this paper
• Statistical parametric maps in functional imaging: A general linear approach

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• Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study.

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  1991cited by this paper
• The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia

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• The effect of apomorphine on regional cerebral blood flow in schizophrenia.

  1989cited by this paper
• Modification of the function of D1 and D2 dopamine receptors in striatum and nucleus accumbens of rats chronically treated with haloperidol.

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• The positive and negative syndrome scale (PANSS) for schizophrenia.

  1987influential reference
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• Tritiated LSD binding in frontal cortex in schizophrenia.

  1981cited by this paper
• Neurotransmitter receptors in frontal cortex of schizophrenics.

  1979cited by this paper
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  1975cited by this paper

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