Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules

No abstract is available for this paper.

• Publication year

  1987

• Venue

  Molecular and Cellular Biology

• Publication date

  1987-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.7.10.3527-3537.1987PMID 3316980PMCID PMC368005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Many random sequences functionally replace the secretion signal sequence of yeast invertase.

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  1986influential reference
• Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal.

  1986cited by this paper
• Nucleolar structure and ribosome biogenesis

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  1986cited by this paper
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  1986cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984influential reference
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1982cited by this paper
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  1982cited by this paper
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  1980cited by this paper
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  1975cited by this paper
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  1975cited by this paper
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  1975cited by this paper
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  1972cited by this paper
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