Monocytes are primed to produce the Th1 type cytokine IL‐12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Clinical and Experimental Immunology

• Publication date

  2003-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1365-2249.2003.02082.xPMID 12605703PMCID PMC1808641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1986cited by this paper
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  1985cited by this paper
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  1981cited by this paper
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