Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome?

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current pharmaceutical design

• Publication date

  2007-06-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/138161207781039599PMID 17627548
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes

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• Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes

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• Adiponectin Receptors in Human Adipose Tissue: Effects of Obesity, Weight Loss, and Fat Depots

  2006cited by this paper
• Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus.

  2006cited by this paper
• High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes.

  2006cited by this paper
• Intra-abdominal Fat Adiponectin Receptors Expression and Cardiovascular Metabolic Risk Factors in Obesity and Diabetes

  2006cited by this paper
• Adipocytokines: mediators linking adipose tissue, inflammation and immunity

  2006cited by this paper
• Polymorphisms in the interleukin‐6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome

  2006cited by this paper
• TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue — influence of BMI and adipose distribution

  2006cited by this paper
• Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome.

  2006cited by this paper
• Visceral Fat Is an Independent Predictor of All‐cause Mortality in Men

  2006cited by this paper
• Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

  2006cited by this paper
• Traditional risk factors for coronary atherosclerosis in Indo Asians: the need for a reappraisal.

  2006cited by this paper
• Resistin is secreted from macrophages in atheromas and promotes atherosclerosis.

  2006cited by this paper
• Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study.

  2006cited by this paper
• Retinol-Binding Protein 4 in Human Obesity

  2006influential reference
• Is visceral obesity the cause of the metabolic syndrome?

  2006cited by this paper
• Resistin Is an Inflammatory Marker of Atherosclerosis in Humans

  2005cited by this paper
• Does a NEAT difference in energy expenditure lead to obesity?

  2005cited by this paper
• Direct interaction of dietary lipids carried in chylomicron remnants with cells of the artery wall: implications for atherosclerosis development.

  2005cited by this paper
• Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

  2005cited by this paper
• Evidence for the involvement of resistin in inflammation and cardiovascular disease.

  2005cited by this paper
• Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha.

  2005cited by this paper
• Adipose tissue, inflammation, and cardiovascular disease.

  2005cited by this paper
• Plasma visfatin concentrations and fat depot-specific mRNA expression in humans.

  2005cited by this paper
• Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study.

  2005cited by this paper
• Serum uric acid and risk of coronary heart disease.

  2005cited by this paper
• A review of the metabolic effects of sibutramine

  2005cited by this paper
• Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.

  2005cited by this paper
• Metabolic syndrome.

  2005cited by this paper
• The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity.

  2004cited by this paper
• Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome.

  2004cited by this paper
• Gene expression profile of omental adipose tissue in human obesity

  2004cited by this paper
• The adipose tissue as a source of vasoactive factors.

  2004influential reference
• corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

  2004cited by this paper
• Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects.

  2004cited by this paper
• Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk.

  2004cited by this paper
• Effects of obesity surgery on the metabolic syndrome.

  2004cited by this paper
• Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity.

  2004cited by this paper
• Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults.

  2004cited by this paper
• Obesity is associated with macrophage accumulation in adipose tissue.

  2003cited by this paper
• The metabolic syndrome.

  2003cited by this paper
• Comparative studies of resistin expression and phylogenomics in human and mouse.

  2003cited by this paper
• Serum resistin (FIZZ3) protein is increased in obese humans.

  2003cited by this paper
• Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance.

  2003cited by this paper
• Involvement of a cGMP-dependent Pathway in the Natriuretic Peptide-mediated Hormone-sensitive Lipase Phosphorylation in Human Adipocytes*

  2003influential reference
• Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes

  2003cited by this paper
• Correlation between serum resistin level and adiposity in obese individuals.

  2003cited by this paper
• Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

  2003cited by this paper
• Do regional differences in adipocyte biology provide new pathophysiological insights?

  2003influential reference
• Lipotoxic diseases.

  2002cited by this paper
• Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone.

  2002cited by this paper
• Bariatric surgery and long-term control of morbid obesity.

  2002cited by this paper
• Differences in adiponectin protein expression: effect of fat depots and type 2 diabetic status.

  2002cited by this paper
• Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

  2002cited by this paper
• Depot-specific differences in the lipolytic effect of leptin on isolated white adipocytes.

  2002cited by this paper
• Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

  2002cited by this paper
• The hormone resistin links obesity to diabetes

  2001cited by this paper
• Leptin‐induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes

  2001cited by this paper
• Depot-specific variation in protein-tyrosine phosphatase activities in human omental and subcutaneous adipose tissue: a potential contribution to differential insulin sensitivity.

  2001cited by this paper
• Genetic variance and lipolysis regulation: implications for obesity

  2001cited by this paper
• Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.

  2000cited by this paper
• Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.

  2000cited by this paper
• Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes.

  2000cited by this paper
• Free fatty acids and pathogenesis of type 2 diabetes mellitus.

  2000cited by this paper
• Natriuretic peptides: a new lipolytic pathway in human adipocytes

  2000cited by this paper
• Potential Role of TNF-a in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

  2000cited by this paper
• Insulin regulation of regional free fatty acid metabolism.

  1999cited by this paper
• Activation of antilipolytic alpha(2)-adrenergic receptors by epinephrine during exercise in human adipose tissue.

  1999cited by this paper
• Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.

  1999cited by this paper
• Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein

  1999cited by this paper
• Endurance training increases the β-adrenergic lipolytic response in subcutaneous adipose tissue in obese subjects

  1999cited by this paper
• Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

  1999cited by this paper
• Leptin secretion from subcutaneous and visceral adipose tissue in women.

  1998cited by this paper
• Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.

  1998cited by this paper
• Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway

  1998cited by this paper
• Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice.

  1998cited by this paper
• Depot-related gene expression in human subcutaneous and omental adipocytes.

  1998cited by this paper
• Depot-Specific Differences in Adipose Tissue Gene Expression in Lean and Obese Subjects

  1998cited by this paper
• Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.

  1998influential reference
• Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase.

  1998cited by this paper
• Lipolytic Effect ofin VivoLeptin Administration on Adipocytes of Lean andob/obMice, but Notdb/dbMice

  1998cited by this paper
• Leptin and the regulation of body weight in mammals

  1998cited by this paper
• The metabolically obese, normal-weight individual revisited.

  1998cited by this paper
• Depot- and Sex-Specific Differences in Human Leptin mRNA Expression: Implications for the Control of Regional Fat Distribution

  1997cited by this paper
• Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

  1997cited by this paper
• Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

  1997cited by this paper
• In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin.

  1997cited by this paper
• Noradrenaline-induced lipolysis in isolated mesenteric, omental and subcutaneous adipocytes from obese subjects

  1997cited by this paper
• Lipolytic catecholamine resistance linked to α2-adrenoceptor sensitivity—a metabolic predictor of weight loss in obese subjects

  1997cited by this paper
• Leptin: The Tale of an Obesity Gene

  1996cited by this paper
• Differences in lipolysis between human subcutaneous and omental adipose tissues.

  1995influential reference
• Abnormal A1 adenosine receptor function in genetic obesity

  1994cited by this paper
• Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

  1994cited by this paper
• Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

  1993cited by this paper
• Improvement of glucose and lipid metabolism associated with selective reduction of intra-abdominal visceral fat in premenopausal women with visceral fat obesity.

  1991cited by this paper

• Progressive increase of cardiometabolic risk in Brazilian children according to obesity phenotypes.

  2026cites this paper
• The evolution of the understanding of obesity over the last 100 years

  2024cites this paper
• Cardiometabolic risk stratification using a novel obesity phenotyping system based on body adiposity and waist circumference.

  2024cites this paper
• Genetic Polymorphisms Associated with Insulin Resistance Risk in Normal BMI Indians

  2024cites this paper
• Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota

  2023cites this paper
• The impact of prior obesity surgery on glucose metabolism after body contouring surgery: A pilot study

  2023cites this paper
• The relationship between the CUN-BAE body fatness index and incident diabetes: a longitudinal retrospective study

  2023cites this paper
• Chronic docosahexaenoic acid supplementation improves metabolic plasticity in subcutaneous adipose tissue of aged obese female mice.

  2022cites this paper
• The visceral adiposity index and lipid accumulation product as predictors of cardiovascular events in normal weight subjects.

  2022cites this paper
• GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning

  2022cites this paper
• Continuous and intermittent exercise training responses in liver and white adipose tissue aquaglyceroporins

  2021cites this paper
• Prevalencia de diabesidad en población laboral española: influencia de variables sociodemográficas y consumo de tabaco

  2021cites this paper
• Angiogenesis in obesity.

  2020cites this paper
• Impact of adipokines and myokines on fat browning

  2020cites this paper
• Periaortic adipose tissue volume is associated with sclerotic changes in the adjacent aortic valve

  2020cites this paper
• Metabolic Syndrome Pathophysiology and Predisposing Factors

  2020cites this paper
• Health Effects of Alternate-Day Fasting in Adults: A Systematic Review and Meta-Analysis

  2020cites this paper
• Pathophysiology of Obesity-Related Non-communicable Chronic Diseases and Advancements in Preventive Strategies

  2020cites this paper
• Magnetic Resonance Imaging and Bioelectrical Impedance Analysis to Assess Visceral and Abdominal Adipose Tissue

  2020cites this paper
• Effects of diets on adipose tissue.

  2019cites this paper
• Adipose Tissue

  2019cites this paper
• How the association between obesity and inflammation may lead to insulin resistance and cancer.

  2019cites this paper
• Natural Products and Obesity: A Focus on the Regulation of Mitotic Clonal Expansion during Adipogenesis

  2019cites this paper
• Measures of obesity and accepted cardio-metabolic disease risk factors from a peri-urban female farm working population in South Africa

  2019cites this paper
• Characterization of Cardiometabolic Risks in Different Combination of Anthropometric Parameters and Percentage Body Fat

  2019cites this paper
• Human In Vitro Vascularization, Adipocytes and Vascularized Adipose Tissue : Three relevant models for studies of vascularization, adipocytes and their interaction

  2019influential citation
• Oral processing and texture perception influences satiation.

  2018cites this paper
• Adipokine dysregulation and adipose tissue inflammation in human obesity

  2018cites this paper
• Effect of Ziziphus Jujube fruit on serum levels Tumor necrosis factor alpha and Interleukin-6 in sedentary men Following the implementation of the Wingate test

  2018cites this paper
• Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model

  2018cites this paper
• Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins

  2018cites this paper
• Longitudinally evaluated the relationship between body fat percentage and the risk for type 2 diabetes mellitus: Korean Genome and Epidemiology Study (KoGES).

  2018cites this paper
• Association between Percentage of Body Fat in Normal Body Mass Index Subjects and Type 2 Diabetes Mellitus in Iraqi Population: Case Control Study

  2017cites this paper
• Molecular implications of adenosine in obesity.

  2017cites this paper
• Clinical usefulness of abdominal bioimpedance (ViScan) in the determination of visceral fat and its application in the diagnosis and management of obesity and its comorbidities.

  2017cites this paper
• Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain

  2017cites this paper
• The cytoskeletal protein septin 11 is associated with human obesity and is involved in adipocyte lipid storage and metabolism

  2017cites this paper
• Role of aquaporins in the improvement of adiposity and non-alcoholic fatty liver disease after bariatric surgery

  2017cites this paper
• Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome

  2017cites this paper
• Septina 11, un nuevo biomarcador del tejido adiposo y su relación con el metabolismo en humanos

  2017cites this paper
• The Associations between Various Ectopic Visceral Adiposity and Body Surface Electrocardiographic Alterations: Potential Differences between Local and Remote Systemic Effects

  2016cites this paper
• Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes

  2016cites this paper
• CORN SILK OFFERS MULTIMECHANISTIC APPROACHES IN MITIGATING OBESITY IN RODENTS

  2016cites this paper
• The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis.

  2015cites this paper
• Nonlinear relationship between waist to hip ratio, weight and strength in elders: is gender the key?

  2015cites this paper
• Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver.

  2015cites this paper
• Morbidly “Healthy” Obese Are Not Metabolically Healthy but Less Metabolically Imbalanced Than Those with Type 2 Diabetes or Dyslipidemia

  2015influential citation
• Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism.

  2015cites this paper
• Relationship of coronary artery disease with pericardial and periaortic adipose tissue and their volume detected by MSCT.

  2015cites this paper
• Can low-level laser therapy when associated to exercise decrease adipocyte area?

  2015cites this paper
• The effects of garlic supplements and exercise on the levels of Lipocalin-2 and insulin resistance among middle-aged obese women

  2015cites this paper
• Nrg4 and Gpr120 signalling in brown fat

  2015cites this paper
• Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

  2014cites this paper
• Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation.

  2014cites this paper
• Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion

  2014cites this paper
• Regulation of adipocyte lipolysis

  2014cites this paper
• Novel Molecular Aspects of Ghrelin and Leptin in the Control of Adipobiology and the Cardiovascular System

  2014cites this paper
• AGE DISTRIBUTION AND SIGNIFICANCE OF BODY MASS INDEX AND WAIST TO HIP RATIO IN NORMOTENSIVE MIDDLE AGED MALES

  2014cites this paper
• Adipositas und deren Bedeutung für ausgewählte neurologische Erkrankungen

  2014cites this paper
• Biochemical and molecular mechanisms for the association between obesity, chronic Inflammation, and breast cancer

  2014cites this paper
• Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis.

  2014influential citation
• Adiponectin/T-cadherin and apelin/APJ expression in human arteries and periadventitial fat: implication of local adipokine signaling in atherosclerosis?

  2014cites this paper
• ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange

  2014cites this paper
• Metabolic effects of gastrectomy with or without omentectomy in gastric cancer.

  2014cites this paper
• Serum Visfatin Levels and Coronary Artery Disease ; Serum Visfatin Seviyesi ve Koroner Arter Hastalığı

  2014cites this paper
• FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues

  2014cites this paper
• A Prospective Randomized Study Comparing Patients with Morbid Obesity Submitted to Sleeve Gastrectomy With or Without Omentectomy

  2013cites this paper
• Metabolism and satiety

  2013cites this paper
• Cellulite: advances in treatment: facts and controversies.

  2013cites this paper
• Body adiposity in a sample of prediabetic and diabetic adult Egyptian patients

  2013cites this paper
• A Pilot Study of Telmisartan for Visceral Adiposity in HIV Infection: The Metabolic Abnormalities, Telmisartan, and HIV Infection (MATH) Trial

  2013cites this paper
• Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients.

  2013cites this paper
• Serum Adiponectin in Relation to Race–Ethnicity and Vascular Risk Factors in the Northern Manhattan Study

  2013cites this paper
• Several statins increase body and liver fat accumulation in a model of metabolic syndrome.

  2013cites this paper
• The Obesity-Inflammation-Eicosanoid Axis in Breast Cancer

  2013cites this paper
• Sobrepeso e obesidade na gravidez: marcadores bioquímicos e resultados maternos e perinatais

  2013cites this paper
• Short-Term Effects of Sleeve Gastrectomy and Caloric Restriction on Blood Pressure in Diet-Induced Obese Rats

  2012influential citation
• The Value of Visfatin in the Prediction of Metabolic Syndrome: A Multi-Factorial Analysis

  2012cites this paper
• Physiological, pathological and potential therapeutic roles of adipokines.

  2012influential citation
• Sleeve Gastrectomy Reduces Blood Pressure in Obese (fa/fa) Zucker Rats

  2012cites this paper
• Targeting adipose tissue

  2012cites this paper
• Fetuin-A and angiopoietins in obesity and type 2 diabetes mellitus

  2012cites this paper
• Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations

  2012cites this paper
• The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes

  2012cites this paper
• Increased tenascin C and Toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity.

  2012cites this paper
• Serum levels of visfatin and omentin‐1 in patients with psoriasis and their relation to disease severity

  2012cites this paper
• Aquaglyceroporin-7 Overexpression in Women with the Polycystic Ovary Syndrome

  2012cites this paper
• Effect of substituting saturated with monounsaturated fatty acids on serum visfatin levels and insulin resistance in overweight women: A randomized cross-over clinical trial

  2012cites this paper
• Age and sex influence the relationship between waist circumference and abdominal fat distribution measured by bioelectrical impedance.

  2012cites this paper
• Peripheral signalling involved in energy homeostasis control

  2012cites this paper
• Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients.

  2012cites this paper
• Adiposidad, estado pro-inflamatorio y resistencia a la insulina durante la menopausia.

  2012cites this paper
• Diabetes obesity link: how to lower your risk of diabetes with weight management

  2012cites this paper
• Comorbilitats associades a l'obesitat mòrbida i la seva evolució amb la cirurgia bariàtrica: diabetis, dislipèmia i esteatosi hepàtica

  2012influential citation
• Review article: fructose in non‐alcoholic fatty liver disease

  2012cites this paper
• Adipokine Production by Adipose Tissue: A Novel Target for Treating Metabolic Syndrome and its Sequelae

  2011cites this paper
• Role of ghrelin gene-derived peptides in the control of energy balance and cardiometabolic homeostasis

  2011cites this paper
• La promoción de la salud en los lugares de trabajo: experiencia en les Illes Balears y Comunitat Valenciana

  2011cites this paper
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  2011cites this paper
• Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass.

  2011cites this paper