Multiscale Mechanics of Fibrin Polymer: Gel Stretching with Protein Unfolding and Loss of Water

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Science

• Publication date

  2009-08-07

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1126/science.1172484PMID 19661428PMCID PMC2846107
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nonlinear elasticity of stiff filament networks: strain stiffening, negative normal stress, and filament alignment in fibrin gels.

  2009cited by this paper
• Molecular basis of fibrin clot elasticity.

  2008cited by this paper
• Forced Unfolding of Proteins Within Cells

  2007cited by this paper
• Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM.

  2007cited by this paper
• Fibrin Fibers Have Extraordinary Extensibility and Elasticity

  2006cited by this paper
• Fibrin structure and wound healing

  2006cited by this paper
• Mechanics of Biomacromolecular Networks Containing Folded Domains

  2006cited by this paper
• Fibrinogen and fibrin.

  2005cited by this paper
• IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A

  2005cited by this paper
• Tissue Cells Feel and Respond to the Stiffness of Their Substrate

  2005cited by this paper
• The mechanical properties of fibrin for basic scientists and clinicians.

  2004cited by this paper
• Structure

  2004cited by this paper
• Nonlinear elasticity in biological gels

  2004cited by this paper
• Fibrin sealants in clinical practice.

  2003cited by this paper
• Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructure.

  2002cited by this paper
• Protein compressibility, dynamics, and pressure.

  2000cited by this paper
• Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy.

  2000cited by this paper
• A critical review of the structural mechanics of wool and hair fibres.

  2000cited by this paper
• Principles of Polymer Chemistry

  1995influential reference
• Entropic elasticity of lambda-phage DNA.

  1994cited by this paper
• The effect of fibrin structure on fibrinolysis.

  1992cited by this paper
• Hemostasis and thrombosis: Basic principles and clinical practice

  1987cited by this paper
• Twisting of fibrin fibers limits their radial growth.

  1987cited by this paper
• Concentration of protein in fibrin fibers and fibrinogen polymers determined by refractive index matching

  1986cited by this paper
• Biopolymers

  1984cited by this paper
• Electron microscopy of fine fibrin clots and fine and coarse fibrin films. Observations of fibers in cross-section and in deformed states.

  1984cited by this paper
• Rheology of Fibrin Clots. VI. Stress Relaxation, Creep, and Differential Dynamic Modulus of Fine Clots in Large Shearing Deformations

  1983cited by this paper
• Studies of fibrin film. II. Small‐angle x‐ray scattering

  1982cited by this paper
• X-ray diffraction methods in polymer science

  1969cited by this paper
• Axial Period of Fibrinogen and Fibrin

  1963cited by this paper
• The physics of rubber elasticity

  1949cited by this paper
• Advances in Protein Chemistry

  1946cited by this paper
• Fibrinogen and Fibrin as Members of the Keratin-Myosin Group

  1943cited by this paper
• X-Ray Studies of the Structure of Hair, Wool, and Related Fibres. II. The Molecular Structure and Elastic Properties of Hair Keratin

  1934cited by this paper

• Fibrin as a Versatile Fibrous Biopolymer.

  2026cites this paper
• Improved Peripheral Intravenous Catheter Maintenance by In-Line Mechanical Pulse

  2026cites this paper
• Microstructure-dependent transport properties in blood clots: Roles of fiber volume fraction and orientation on permeability and diffusivity.

  2026cites this paper
• Study on Waveform Superposition and Ultrasonic Gain During Nonlinear Propagation of Ultrasound in Fibrin Clots

  2026cites this paper
• Electrohydrodynamic bioprinting-induced orientation of cell-laden fibrin-alginate hydrogel for highly-aligned skeletal muscle constructs

  2026cites this paper
• Molecular Creep Induced Fatigue Rupture of Fibrin Clots

  2025cites this paper
• Topoarchitected Polymer Network Hydrogels with High Toughness and Anisotropic Properties

  2025cites this paper
• Exploring the thrombus niche: Lessons learned and potential therapeutic opportunities.

  2025cites this paper
• Exploring the inverse poroelastic behavior of hydrogels: the roles of finite extensibility of polymer chains and unfolding of polymer domains

  2025cites this paper
• Multiscale Insights of Domain Unfolding in Fibrin Mechanical Response

  2025cites this paper
• Advanced polyelectrolyte complexes for ultrafast hemostasis and blood superabsorption.

  2025cites this paper
• Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage

  2025cites this paper
• A Shape‐Recovery Polycationic Fibroin for Hemostasis‐Regeneration Transition by Recapitulating Natural Coagulation Networks

  2025cites this paper
• Design of Stiff, Tough, and Fast‐Recovery Protein Hydrogels

  2025cites this paper
• Effect of protein unfolding on the mechanical behavior of fibrin network

  2025cites this paper
• Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity

  2025cites this paper
• Fluid effects on the fracture toughness of gels

  2025cites this paper
• Fatty acid albumin conjugates mechanically weaken and disrupt degradation of fibrin networks.

  2025cites this paper
• One-step fabrication of 3D-aligned human skeletal muscle tissue and measurement of contractile force for preclinical drug testing

  2025cites this paper
• Pneumatic conveying inkjet bioprinting for the processing of living cells

  2025cites this paper
• Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction

  2025influential citation
• Stiffening of a fibrous matrix after recovery of contracted inclusions.

  2025cites this paper
• Biomechanical profiling of in vitro blood clots: sensitivity to sex, age, and blood composition in a healthy adult population

  2025cites this paper
• Thrombolytic potential of the "hydrodynamic cavitation on a chip" concept: insights into clot degradation.

  2025cites this paper
• Strength, Deformability, Damage and Fracture Toughness of Fibrous Material Networks: Application to Fibrin Clots.

  2025cites this paper
• Mechanical Strain Modulates Enzymatic Remodeling of Fibrin Networks

  2025cites this paper
• Revisiting the biophysical aspects of extracellular-matrix-mimicking hydrogels: what cells see vs. what cells feel

  2025cites this paper
• Water-regulated viscosity-plasticity phase transitions in a peptide self-assembled muscle-like hydrogel

  2025cites this paper
• Structural Mechanisms of Forced Unfolding of Double-Stranded Fibrin Oligomers

  2025cites this paper
• Rupture mechanics of blood clots: Influence of fibrin network structure on the rupture resistance

  2024influential citation
• Moderation-excess interactions of epigallocatechin gallate and CaCl2 modulate the gelation performance of egg white transparent gels

  2024cites this paper
• A Methodological Approach for Interpreting and Comparing the Viscoelastic Behaviors of Soft Biological Tissues and Hydrogels at the Cell-Length Scale

  2024cites this paper
• Water content for clot composition prediction in acute ischemic stroke

  2024cites this paper
• Capturing Dynamic Assembly of Nanoscale Proteins During Network Formation

  2024cites this paper
• 2-D multistable structures under shear: equilibrium configurations, transition patterns, and boundary effects

  2024cites this paper
• The Precise Synthesis of Ultradense Bottlebrush Polymers Unearths Unique Trends in Lyotropic Ordering.

  2024cites this paper
• Fibrinogen post‐translational modifications are biochemical determinants of fibrin clot properties and interactions

  2024cites this paper
• A theoretical framework for multi-physics modeling of poro-visco-hyperelasticity-induced time-dependent fracture of blood clots

  2024influential citation
• Piezo1 is a mechanosensor of soft matrix viscoelasticity

  2024cites this paper
• Molecularly Shielded, On-Demand, Ultrasound-Cured Polymer Networks.

  2024cites this paper
• Reviewing the Rich History of Fibrin Clot Research with a Focus on Clinical Relevance

  2024cites this paper
• Designing Biomimetic Strain-Stiffening into Synthetic Hydrogels.

  2024cites this paper
• Viscoelasticity of ECM and cells—origin, measurement and correlation

  2024cites this paper
• Ultra-long-range force transmission in fiber networks enabled by multiaxial mechanical coupling

  2024cites this paper
• A kinetic theory for the mechanics and remodeling of transient anisotropic networks

  2024cites this paper
• Mechanics and microstructure of blood plasma clots in shear driven rupture

  2024cites this paper
• Fibrin Clot Fracture under Cyclic Fatigue and Variable Rate Loading.

  2024cites this paper
• Hyperelasticity of blood clots: Bridging the gap between microscopic and continuum scales.

  2024influential citation
• Fibrinogen αC-region acts as a functional safety latch: implications for a fibrin biomechanical behaviour model.

  2024cites this paper
• Evolving properties of biological materials captured via needle-based cavity expansion method

  2024cites this paper
• Nonlinear Poisson effect in affine semiflexible polymer networks.

  2024cites this paper
• Magnetic fibrin nanofiber hydrogel delivering iron oxide magnetic nanoparticles promotes peripheral nerve regeneration

  2024cites this paper
• Fibrinolysis: an illustrated review

  2023cites this paper
• Cell–extracellular matrix mechanotransduction in 3D

  2023cites this paper
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  2023cites this paper
• Integrated colloidal deformation to advanced polymer network design through polymer-nanoparticle alternating hybrids

  2023cites this paper
• Cracks in tensile-contracting and tensile-dilating poroelastic materials.

  2023cites this paper
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  2023cites this paper
• Porous biomaterial scaffolds for skeletal muscle tissue engineering

  2023cites this paper
• Matrix Nonlinear Viscoelasticity Regulates Skeletal Myogenesis through MRTF Nuclear Localization and Nuclear Mechanotransduction.

  2023cites this paper
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  2023cites this paper
• A Multiscale Framework for Modeling Fibrin Fiber Networks: Theory Development and Validation

  2023cites this paper
• Interplay of fibrinogen αEC globular domains and FXIIIa-crosslinking dictates the extensibility and strain-stiffening of fibrin networks.

  2023cites this paper
• Super-Stretchable Hydrogel Films with High Fracture Energy Enabled by Coordination Nanoparticles as Multifunctional Wound Dressings

  2023cites this paper
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  2023cites this paper
• Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation

  2023cites this paper
• Hemoadhican, a Tissue Adhesion Hemostatic Material Independent of Blood Coagulation

  2023cites this paper
• Fracture toughness of fibrin gels as a function of protein volume fraction: Mechanical origins.

  2023cites this paper
• Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction

  2023cites this paper
• Spatial Heterogeneity Directs Energy Dissipation in Condylar Fibrocartilage.

  2023cites this paper
• Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots

  2023cites this paper
• Visualizing molecular deformation in fibrin networks under tensile loading via FLIM–FRET

  2023cites this paper
• Statistical field theory for nonlinear elasticity of polymer networks with excluded volume interactions.

  2023cites this paper
• Strain Measures and Energies for Crimped Fibres and Novel Analytical Expressions for Fibre Populations: Ingredients for Structural Fibre Network Models

  2022cites this paper
• Fatigue-free artificial ionic skin toughened by self-healable elastic nanomesh

  2022cites this paper
• Energy release rate for cracks in hydrogels undergoing finite deformations.

  2022cites this paper
• Injectable Adhesive Hydrogels for Soft tissue Reconstruction: A Materials Chemistry Perspective

  2022cites this paper
• Optimal Sacrificial Domains in Mechanical Polyproteins: S. epidermidis Adhesins Are Tuned for Work Dissipation

  2022cites this paper
• Biomimetic Strain-Stiffening in Chitosan Self-Healing Hydrogels.

  2022cites this paper
• Engineered Molecular Therapeutics Targeting Fibrin and the Coagulation System: a Biophysical Perspective

  2022cites this paper
• Computational Biomechanical Modeling of Fibrin Networks and Platelet-Fiber Network Interactions.

  2022cites this paper
• Numerical simulation of non-linear loading–unloading hysteresis behavior of blood clots

  2022cites this paper
• Biomechanical origins of inherent tension in fibrin networks.

  2022cites this paper
• Nanomechanics of Blood Clot and Thrombus Formation.

  2022cites this paper
• Multiscale mechanobiology: coupling models of adhesion kinetics and nonlinear tissue mechanics.

  2022cites this paper
• Microstructure-based engineering of soft biological materials

  2022cites this paper
• Strain Gradient Programming in 3D Fibrous Hydrogels to Direct Graded Cell Alignment

  2022cites this paper
• Blood clot behaves as a poro-visco-elastic material.

  2022cites this paper
• In-vitro Fibrin Assembly: From the Bulk to the Interface

  2022cites this paper
• “Going with the flow” in modeling fibrinolysis

  2022cites this paper
• Multiscale Mechanical Characterization and Computational Modeling of Fibrin Gels

  2022influential citation
• Finite element analysis of blood clots based on the non-linear visco-hyperelastic model.

  2021cites this paper
• Why fibrin biomechanical properties matter for hemostasis and thrombosis

  2021cites this paper
• Intermediate structural hierarchy in biological networks modulates the fractal dimension and force distribution of percolating clusters

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