Transport of interleukin‐1 across cerebromicrovascular endothelial cells

No abstract is available for this paper.

• Publication year

  2009

• Venue

  British Journal of Pharmacology

• Publication date

  2009-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1476-5381.2008.00129.xPMID 19298391PMCID PMC2697691
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2005cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
• Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells.

  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

  1990cited by this paper
• Evidence for different interleukin 1 receptors in murine B- and T-cell lines.

  1989cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1986cited by this paper
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  1980cited by this paper
• Role of microtubules in low density lipoprotein processing by cultured cells.

  1979cited by this paper
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