Akt/protein kinase B in skeletal muscle physiology and pathology

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Cellular Physiology

• Publication date

  2011-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcp.22353PMID 20672327
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of aging on cellular mechanotransduction.

  2011cited by this paper
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  2010cited by this paper
• Acetaminophen Improves Protein Translational Signaling in Aged Skeletal Muscle

  2010cited by this paper
• A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

  2010cited by this paper
• Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat

  2010cited by this paper
• Important roles of Akt/PKB signaling in the aging process.

  2010cited by this paper
• Effects of aging and gender on muscle mass and regulation of Akt-mTOR-p70s6k related signaling in the F344BN rat model.

  2010cited by this paper
• Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation

  2009cited by this paper
• Acetaminophen prevents aging‐associated hyperglycemia in aged rats: effect of aging‐associated hyperactivation of p38‐MAPK and ERK1/2

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• Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity

  2009cited by this paper
• Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation

  2009influential reference
• Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high‐force muscle contraction

  2009cited by this paper
• Effects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts.

  2009cited by this paper
• Aging-Associated Dysfunction of Akt/Protein Kinase B: S-Nitrosylation and Acetaminophen Intervention

  2009cited by this paper
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  2009cited by this paper
• Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3.

  2008cited by this paper
• Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise

  2008cited by this paper
• Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor.

  2008cited by this paper
• Dietary Energy Balance Modulates Signaling through the Akt/Mammalian Target of Rapamycin Pathways in Multiple Epithelial Tissues

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• Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice.

  2008cited by this paper
• Follistatin-like 1, a Secreted Muscle Protein, Promotes Endothelial Cell Function and Revascularization in Ischemic Tissue through a Nitric-oxide Synthase-dependent Mechanism*

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• A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle

  2008influential reference
• siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle

  2008cited by this paper
• Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins.

  2008cited by this paper
• Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle.

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• Understanding PTEN regulation: PIP2, polarity and protein stability

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• Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway.

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• The role of PTEN signaling perturbations in cancer and in targeted therapy

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• Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

  2008influential reference
• Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

  2007cited by this paper
• Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression.

  2007cited by this paper
• Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle.

  2007cited by this paper
• Tissue-Specific Effects of Rosiglitazone and Exercise in the Treatment of Lipid-Induced Insulin Resistance

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• Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival.

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• PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound

  2007cited by this paper
• C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport

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• Selective Control of Skeletal Muscle Differentiation by Akt1*

  2007cited by this paper
• PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.

  2007cited by this paper
• Spatial and temporal regulation of GLUT4 translocation by flotillin‐1 and caveolin‐3 in skeletal muscle cells

  2006cited by this paper
• Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle.

  2006influential reference
• Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy.

  2006influential reference
• Spatial and temporal regulation of GLUT 4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells

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• Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.

  2006cited by this paper
• Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle.

  2006cited by this paper
• siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.

  2006influential reference
• Protein kinase Cdelta participates in insulin-induced activation of PKB via PDK1.

  2006cited by this paper
• Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice.

  2006influential reference
• Protein kinase Cδ participates in insulin-induced activation of PKB via PDK1

  2006cited by this paper
• S-Nitrosylation-dependent Inactivation of Akt/Protein Kinase B in Insulin Resistance*

  2005influential reference
• Role for Akt3/protein kinase Bgamma in attainment of normal brain size.

  2005cited by this paper
• S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.

  2005influential reference
• Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

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• Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes

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• PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.

  2005cited by this paper
• Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation

  2005influential reference
• Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects.

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• Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice.

  2005cited by this paper
• Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

  2005cited by this paper
• Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity.

  2005cited by this paper
• Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle.

  2005cited by this paper
• Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle.

  2005influential reference
• Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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• Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers.

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• Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase*♦

  2004cited by this paper
• The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis.

  2004cited by this paper
• Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner*

  2004influential reference
• Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy

  2004influential reference
• Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans

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• Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway

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  2004cited by this paper
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  2004influential reference
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• Phosphorylation of insulin receptor substrate‐1 serine 307 correlates with JNK activity in atrophic skeletal muscle

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• Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance.

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• Ceramide and Reactive Oxygen Species Generated by H2O2 Induce Caspase-3-independent Degradation of Akt/Protein Kinase B*

  2002cited by this paper
• Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis.

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• Myogenic Akt Signaling Regulates Blood Vessel Recruitment during Myofiber Growth

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• A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification

  2002influential reference
• Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice*

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• Effects of concentric and eccentric contractions on phosphorylation of MAPKerk1/2 and MAPKp38 in isolated rat skeletal muscle

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  2001influential reference
• Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

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• Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.

  2001influential reference
• Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).

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• Functional limitations to glucose uptake in muscles comprised of different fiber types.

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• Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

  2001influential reference
• Comparison of techniques to estimate total body skeletal muscle mass in people of different age groups.

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• A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain*

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• Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

  1999cited by this paper
• Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis*

  1998cited by this paper
• Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

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• Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

  1998cited by this paper
• Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

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• Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.

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• 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

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• Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

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